Gene Symbol: Gr61a
Description: Gustatory receptor 61a
Alias: CG13888, Dmel61a, Dmel\CG13888, GR61a, Gr61D1, gustatory receptor 61a, CG13888-PA, CG13888-PB, CG13888-PC, Gr61a-PA, Gr61a-PB, Gr61a-PC, gustatory receptor 61D1
Species: fruit fly
Ueno K, Ohta M, Morita H, Mikuni Y, Nakajima S, Yamamoto K, et al
. Trehalose sensitivity in Drosophila correlates with mutations in and expression of the gustatory receptor gene Gr5a. Curr Biol. 2001;11:1451-5 pubmed
..Taken together, the mutation analyses support that Gr5a is allelic to Tre. ..
Jiao Y, Moon S, Montell C. A Drosophila gustatory receptor required for the responses to sucrose, glucose, and maltose identified by mRNA tagging. Proc Natl Acad Sci U S A. 2007;104:14110-5 pubmed
..We found that all seven Grs most related to Gr5a (Gr64a-f and Gr61a) were expressed in Gr5a-expressing cells, whereas none of the other Grs examined were enriched in these Gr neurons ..
Dahanukar A, Lei Y, Kwon J, Carlson J. Two Gr genes underlie sugar reception in Drosophila. Neuron. 2007;56:503-16 pubmed
..The simplest interpretation of our results is that Gr5a and Gr64a are each capable of functioning independently of each other within individual sugar neurons and that they are the primary receptors used in the labellum to detect sugars. ..
Miyamoto T, Slone J, Song X, Amrein H. A fructose receptor functions as a nutrient sensor in the Drosophila brain. Cell. 2012;151:1113-25 pubmed publisher
..Thus, our studies indicate that the Gr43a-expressing brain neurons function as a nutrient sensor for hemolymph fructose and assign opposing valence to feeding experiences in a satiation-dependent manner. ..
Miyamoto T, Chen Y, Slone J, Amrein H. Identification of a Drosophila glucose receptor using Ca2+ imaging of single chemosensory neurons. PLoS ONE. 2013;8:e56304 pubmed publisher
..Furthermore, we employed this novel method to identify glucose as the primary ligand for the sugar receptor Gr61a, which is not only expressed in sweet sensing neurons of classical chemosensory sensilla, but also in two ..
Ledue E, Chen Y, Jung A, Dahanukar A, Gordon M. Pharyngeal sense organs drive robust sugar consumption in Drosophila. Nat Commun. 2015;6:6667 pubmed publisher
Yavuz A, Jagge C, Slone J, Amrein H. A genetic tool kit for cellular and behavioral analyses of insect sugar receptors. Fly (Austin). 2014;8:189-96 pubmed publisher
..Thus, the precisely engineered genetic mutations of single Gr genes and construction of a sugar-blind strain provide powerful analytical tools for examining the roles of Drosophila and other insect sugar Gr genes in sweet taste. ..
Matsunami H, Amrein H. Taste and pheromone perception in mammals and flies. Genome Biol. 2003;4:220 pubmed
..Comparison of these systems in Drosophila and mouse uncovers clear differences and a few surprising similarities. ..
Kent L, Robertson H. Evolution of the sugar receptors in insects. BMC Evol Biol. 2009;9:41 pubmed publisher
..the gustatory receptor (Gr) family has been identified as sugar receptors (SRs) in Drosophila melanogaster (Gr5a, Gr61a, and Gr64a-f)...