Gene Symbol: Gprk1
Description: G protein-coupled receptor kinase 1
Alias: CG40129, CT4320, Dmel\CG40129, GPRK1, Gprk-1, Rok, gprk1, G protein-coupled receptor kinase 1, CG40129-PA, CG40129-PB, CG40129-PC, Gprk1-PA, Gprk1-PB, Gprk1-PC, rhodopsin kinase
Species: fruit fly
Cassill J, Whitney M, Joazeiro C, Becker A, Zuker C. Isolation of Drosophila genes encoding G protein-coupled receptor kinases. Proc Natl Acad Sci U S A. 1991;88:11067-70 pubmed
..The presence of a conserved family of G protein-coupled receptor kinases in vertebrates and invertebrates points to the central role of these kinases in signal transduction cascades. ..
Lee S, Xu H, Montell C. Rhodopsin kinase activity modulates the amplitude of the visual response in Drosophila. Proc Natl Acad Sci U S A. 2004;101:11874-9 pubmed
..Despite extensive analyses of Drosophila phototransduction, the identity and function of the rhodopsin kinase (RK) have been elusive...
Cheng S, Maier D, Neubueser D, Hipfner D. Regulation of smoothened by Drosophila G-protein-coupled receptor kinases. Dev Biol. 2010;337:99-109 pubmed publisher
..Finally, we show that both Drosophila G-protein-coupled receptor kinase orthologues, Gprk1 and Gprk2, act in a partially redundant manner to promote Hh signaling...
Hardie R. Phototransduction: shedding light on translocation. Curr Biol. 2003;13:R775-7 pubmed
..New work has identified a phosphoinositide lipid binding domain in Drosophila arrestin and implicates PIP(3) in control of arrestin translocation. ..
Coulthard A, Alm C, Cealiac I, Sinclair D, Honda B, Rossi F, et al
. Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2. Genetics. 2010;185:479-95 pubmed publisher
Chen Y, Li S, Tong C, Zhao Y, Wang B, Liu Y, et al
. G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila. Genes Dev. 2010;24:2054-67 pubmed publisher
..Thus, Gprk2 forms a positive feedback loop and acts downstream from PKA and CK1 to facilitate high-level Hh signaling by promoting the active state of Smo through direct phosphorylation and molecular scaffolding. ..
Murali T, Pacifico S, Finley R. Integrating the interactome and the transcriptome of Drosophila. BMC Bioinformatics. 2014;15:177 pubmed publisher
..This organization implies that tissue or stage specific networks can be best identified from interactome data by using filters designed to include both ubiquitously expressed and specifically expressed genes and proteins. ..
Zuker C. The biology of vision of Drosophila. Proc Natl Acad Sci U S A. 1996;93:571-6 pubmed
..In this manuscript I review some of our recent findings and the strategies used to dissect this process. ..
Soibam B, Goldfeder R, Manson Bishop C, Gamblin R, Pletcher S, Shah S, et al
. Modeling Drosophila positional preferences in open field arenas with directional persistence and wall attraction. PLoS ONE. 2012;7:e46570 pubmed publisher
..Hence, the two-component model is an important step in defining how Drosophila interact with their environment. ..