Gene Symbol: Gp93
Description: Glycoprotein 93
Alias: CG5520, CT17486, Dmel\CG5520, GP93, HSP90B1, Hsp90, Q9VAY2, dGRP94, gp93, p93, glycoprotein 93, CG5520-PA, Gp93-PA, glycoprotein93
Species: fruit fly

Top Publications

  1. Chen B, Zhong D, Monteiro A. Comparative genomics and evolution of the HSP90 family of genes across all kingdoms of organisms. BMC Genomics. 2006;7:156 pubmed
    b>HSP90 proteins are essential molecular chaperones involved in signal transduction, cell cycle control, stress management, and folding, degradation, and transport of proteins...
  2. Duerfeldt A, Peterson L, Maynard J, Ng C, Eletto D, Ostrovsky O, et al. Development of a Grp94 inhibitor. J Am Chem Soc. 2012;134:9796-804 pubmed publisher
    Heat shock protein 90 (Hsp90) represents a promising therapeutic target for the treatment of cancer and other diseases...
  3. Xu J, Xue C, Xue D, Zhao J, Gai J, Guo N, et al. Overexpression of GmHsp90s, a heat shock protein 90 (Hsp90) gene family cloning from soybean, decrease damage of abiotic stresses in Arabidopsis thaliana. PLoS ONE. 2013;8:e69810 pubmed publisher
    b>Hsp90 is one of the most conserved and abundant molecular chaperones and is an essential component of the protective stress response; however, its roles in abiotic stress responses in soybean (Glycine max) remain obscure...
  4. Benbahouche N, Iliopoulos I, Török I, Marhold J, Henri J, Kajava A, et al. Drosophila Spag is the homolog of RNA polymerase II-associated protein 3 (RPAP3) and recruits the heat shock proteins 70 and 90 (Hsp70 and Hsp90) during the assembly of cellular machineries. J Biol Chem. 2014;289:6236-47 pubmed publisher
    The R2TP is a recently identified Hsp90 co-chaperone, composed of four proteins as follows: Pih1D1, RPAP3, and the AAA(+)-ATPases RUVBL1 and RUVBL2...
  5. Griciuc A, Roux M, Merl J, Giangrande A, Hauck S, Aron L, et al. Proteomic survey reveals altered energetic patterns and metabolic failure prior to retinal degeneration. J Neurosci. 2014;34:2797-812 pubmed publisher
    ..Our study offers a glimpse into the intricate higher order interactions that underlie PN dysfunction and provides a useful resource for identifying other molecular networks that mediate Rho toxicity in PNs. ..
  6. Metzendorf C, Lind M. Drosophila mitoferrin is essential for male fertility: evidence for a role of mitochondrial iron metabolism during spermatogenesis. BMC Dev Biol. 2010;10:68 pubmed publisher
    ..Furthermore, due to the similar expression patterns of some mitochondrial iron metabolism genes in Drosophila and mammals, it is likely that our results are applicable for mammals as well. ..
  7. Breloy I, Schwientek T, Althoff D, Holz M, Koppen T, Krupa A, et al. Functional Analysis of the Glucuronyltransferases GlcAT-P and GlcAT-S of Drosophila melanogaster: Distinct Activities towards the O-linked T-antigen. Biomolecules. 2016;6:8 pubmed publisher
  8. Walker M, Rylett C, Keen J, Audsley N, Sajid M, Shirras A, et al. Proteomic identification of Drosophila melanogaster male accessory gland proteins, including a pro-cathepsin and a soluble gamma-glutamyl transpeptidase. Proteome Sci. 2006;4:9 pubmed publisher
    ..Therefore, the present study has identified seven new secreted accessory gland proteins, including GGT-1, which was not recognised previously as a secreted accessory gland product...
  9. Pantzartzi C, Drosopoulou E, Scouras Z. Assessment and reconstruction of novel HSP90 genes: duplications, gains and losses in fungal and animal lineages. PLoS ONE. 2013;8:e73217 pubmed publisher
    ..In order to determine the number of hsp90 gene copies and encoded proteins in fungal and animal lineages and through that key duplication events that this ..

More Information


  1. Morales C, Li Z. Drosophila canopy b is a cochaperone of glycoprotein 93. J Biol Chem. 2017;292:6657-6666 pubmed publisher
    ..A better understanding of this simpler Drosophila system will enable application to the mammalian system, such as has been done with Escherichia coli, yeast, and mammalian HSP90.
  2. Morales C, Wu S, Yang Y, Hao B, Li Z. Drosophila glycoprotein 93 Is an ortholog of mammalian heat shock protein gp96 (grp94, HSP90b1, HSPC4) and retains disulfide bond-independent chaperone function for TLRs and integrins. J Immunol. 2009;183:5121-8 pubmed publisher
    ..We have identified gp93 in Drosophila having high sequence homology to gp96. However, no functions were previously attributed to gp93...
  3. Williams M, Klockars A, Eriksson A, Voisin S, Dnyansagar R, Wiemerslage L, et al. The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder. PLoS Genet. 2016;12:e1006104 pubmed publisher
    ..Finally, a connection between the obesity-linked gene ETV5 and bipolar disorder emphasizes a functional relationship between obesity and BD at the molecular level. ..
  4. Maynard J, Pham T, Zheng T, Jockheck Clark A, Rankin H, Newgard C, et al. Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control. Dev Biol. 2010;339:295-306 pubmed publisher
    GRP94, the endoplasmic reticulum Hsp90, is a metazoan-restricted chaperone essential for early development in mammals, yet dispensable for mammalian cell viability...