Gene Symbol: GluClalpha
Description: GluClalpha
Alias: BcDNA:HL07853, CG7535, CT23049, Dm-GluCl, DmGlu, DmGluClalpha, Dmel\CG7535, DrosGlu-Cl-alpha, DrosGluCl, DrosGluCl-alpha, DrosGluCl-alpha1, GLUCL, GluCl, GluCla, dGluCl-alpha, glc, glu, GluClalpha, CG7535-PE, CG7535-PF, CG7535-PH, CG7535-PI, CG7535-PJ, CG7535-PK, CG7535-PL, CG7535-PM, CG7535-PN, CG7535-PO, CG7535-PP, GluClalpha-PE, GluClalpha-PF, GluClalpha-PH, GluClalpha-PI, GluClalpha-PJ, GluClalpha-PK, GluClalpha-PL, GluClalpha-PM, GluClalpha-PN, GluClalpha-PO, GluClalpha-PP, glutamate-gated chloride channel, indefinite
Species: fruit fly

Top Publications

  1. Semenov E, Pak W. Diversification of Drosophila chloride channel gene by multiple posttranscriptional mRNA modifications. J Neurochem. 1999;72:66-72 pubmed
    We have identified and analyzed a Drosophila melanogaster gene that encodes a chloride channel subunit (DrosGluCl-alpha) previously shown to function as a glutamate-gated chloride channel in an in vitro expression system...
  2. Palladino M, Keegan L, O Connell M, Reenan R. A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity. Cell. 2000;102:437-49 pubmed
    ..Surprisingly, dADAR mutants are not short-lived. Thus, A-to-I editing of pre-mRNAs in Drosophila acts predominantly through nervous system targets to affect adult nervous system function, integrity, and behavior. ..
  3. Collins B, Kane E, Reeves D, Akabas M, Blau J. Balance of activity between LN(v)s and glutamatergic dorsal clock neurons promotes robust circadian rhythms in Drosophila. Neuron. 2012;74:706-18 pubmed publisher
    ..Thus, the changing balance in activity between clock neurons with opposing behavioral effects generates robust circadian behavior and probably helps organisms transition between discrete behavioral states, such as sleep and wakefulness. ..
  4. Hu W, Wang T, Wang X, Han J. Ih channels control feedback regulation from amacrine cells to photoreceptors. PLoS Biol. 2015;13:e1002115 pubmed publisher
    ..These results provide new mechanistic insight into how synaptic feedback regulation can participate in network processing by modulating neural information transfer and circuit excitability. ..
  5. Iovchev M, Boutanaev A, Ivanov I, Wolstenholme A, Nurminsky D, Semenov E. Phylogenetic shadowing of a histamine-gated chloride channel involved in insect vision. Insect Biochem Mol Biol. 2006;36:10-7 pubmed publisher
    ..Real-time PCR analysis demonstrated that hclA-mRNA is abundant in heads of adult Drosophila. However, species- and sex-specific variations of the hclA expression levels were also observed...
  6. Copley R. Evolutionary convergence of alternative splicing in ion channels. Trends Genet. 2004;20:171-6 pubmed
    ..The result has important implications for the analysis of regulation of alternative splicing using comparative genomics and our understanding of molecular evolution. ..
  7. Stapleton M, Carlson J, Brokstein P, Yu C, Champe M, George R, et al. A Drosophila full-length cDNA resource. Genome Biol. 2002;3:RESEARCH0080 pubmed
    ..Clones were eliminated either because they carry single nucleotide discrepancies, which most probably result from reverse transcriptase errors, or because they are truncated and contain only part of the protein-coding sequence. ..
  8. Witte I, Kreienkamp H, Gewecke M, Roeder T. Putative histamine-gated chloride channel subunits of the insect visual system and thoracic ganglion. J Neurochem. 2002;83:504-14 pubmed
    ..These ion-channels are the first specific molecular markers for postsynaptic cells in the insect visual system, thus representing ideal tools to study its physiology and development. ..
  9. Gengs C, Leung H, Skingsley D, Iovchev M, Yin Z, Semenov E, et al. The target of Drosophila photoreceptor synaptic transmission is a histamine-gated chloride channel encoded by ort (hclA). J Biol Chem. 2002;277:42113-20 pubmed
    ..Moreover, the present work shows that this function of the HCLA (ORT) protein is its native function in vivo. ..

More Information


  1. Lansdell S, Millar N. Dbeta3, an atypical nicotinic acetylcholine receptor subunit from Drosophila : molecular cloning, heterologous expression and coassembly. J Neurochem. 2002;80:1009-18 pubmed
  2. Ma E, Gu X, Wu X, Xu T, Haddad G. Mutation in pre-mRNA adenosine deaminase markedly attenuates neuronal tolerance to O2 deprivation in Drosophila melanogaster. J Clin Invest. 2001;107:685-93 pubmed
    ..Disruption of the dADAR gene results in totally unedited sodium (Para), calcium (Dmca1A), and chloride (DrosGluCl-alpha) channels, a very prolonged recovery from anoxic stupor, a vulnerability to heat shock and increased O2 ..
  3. Zheng Y, Hirschberg B, Yuan J, Wang A, Hunt D, Ludmerer S, et al. Identification of two novel Drosophila melanogaster histamine-gated chloride channel subunits expressed in the eye. J Biol Chem. 2002;277:2000-5 pubmed
    ..The insecticide ivermectin reversibly activated homomeric HisCl1 channels and, more potently, HisCl1 and HisCl2 heteromeric channels. ..
  4. Kane N, Hirschberg B, Qian S, Hunt D, Thomas B, Brochu R, et al. Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin. Proc Natl Acad Sci U S A. 2000;97:13949-54 pubmed
    ..a proline to serine mutation (P299S) in the gene coding for the glutamate-gated chloride channel subunit DmGluClalpha. To examine the effect of this mutation on the biophysical properties of DmGluClalpha channels, it was ..
  5. Liu W, Wilson R. Glutamate is an inhibitory neurotransmitter in the Drosophila olfactory system. Proc Natl Acad Sci U S A. 2013;110:10294-9 pubmed publisher the antennal lobe, and this effect is blocked by picrotoxin or by transgenic RNAi-mediated knockdown of the GluCl? gene, which encodes a glutamate-gated chloride channel...
  6. Cully D, Paress P, Liu K, Schaeffer J, Arena J. Identification of a Drosophila melanogaster glutamate-gated chloride channel sensitive to the antiparasitic agent avermectin. J Biol Chem. 1996;271:20187-91 pubmed
    ..We report the cloning of a Drosophila melanogaster glutamate-gated chloride channel, DrosGluCl-alpha, which shares 48% amino acid and 60% nucleotide identity with the C. elegans GluCl channels...
  7. Ludmerer S, Warren V, Williams B, Zheng Y, Hunt D, Ayer M, et al. Ivermectin and nodulisporic acid receptors in Drosophila melanogaster contain both gamma-aminobutyric acid-gated Rdl and glutamate-gated GluCl alpha chloride channel subunits. Biochemistry. 2002;41:6548-60 pubmed
    ..complexes by gel filtration, antisera specific for both the Drosophila glutamate-gated chloride channel subunit GluCl alpha (DmGluCl alpha) and the GABA-gated chloride channel subunit Rdl (DmRdl) proteins were generated and used to ..
  8. Gassel M, Wolf C, Noack S, Williams H, Ilg T. The novel isoxazoline ectoparasiticide fluralaner: selective inhibition of arthropod ?-aminobutyric acid- and L-glutamate-gated chloride channels and insecticidal/acaricidal activity. Insect Biochem Mol Biol. 2014;45:111-24 pubmed publisher
    ..In this study, the effects of the isoxazoline drug fluralaner on insect and acarid GABACl (RDL) and GluCl and its parasiticidal potency were investigated. We report the identification and cDNA cloning of Rhipicephalus (R...
  9. Collins B, Kaplan H, Cavey M, Lelito K, Bahle A, Zhu Z, et al. Differentially timed extracellular signals synchronize pacemaker neuron clocks. PLoS Biol. 2014;12:e1001959 pubmed publisher
    ..We propose that differentially timed signals that drive cAMP oscillations and synchronize pacemaker neurons in circadian neural circuits will be conserved across species. ..