Gene Symbol: GLaz
Description: Glial Lazarillo
Alias: CG4604, DGLaz, Dmel\CG4604, glial lazarillo, CG4604-PA, CG4604-PB, CG4604-PC, CG4604-PD, CG4604-PE, CG4604-PF, GLaz-PA, GLaz-PB, GLaz-PC, GLaz-PD, GLaz-PE, GLaz-PF
Species: fruit fly
Walker D, Muffat J, Rundel C, Benzer S. Overexpression of a Drosophila homolog of apolipoprotein D leads to increased stress resistance and extended lifespan. Curr Biol. 2006;16:674-9 pubmed
..to identify genes that protect Drosophila against acute oxidative stress, we isolated a fly homolog of ApoD, Glial Lazarillo (GLaz)...
Sanchez D, López Arias B, Torroja L, Canal I, Wang X, Bastiani M, et al
. Loss of glial lazarillo, a homolog of apolipoprotein D, reduces lifespan and stress resistance in Drosophila. Curr Biol. 2006;16:680-6 pubmed
..We have generated loss-of-function Drosophila mutants for the Glial Lazarillo (GLaz) gene , a homolog of ApoD in the fruit fly, mainly expressed in subsets of adult glial cells...
Hull Thompson J, Muffat J, Sanchez D, Walker D, Benzer S, Ganfornina M, et al
. Control of metabolic homeostasis by stress signaling is mediated by the lipocalin NLaz. PLoS Genet. 2009;5:e1000460 pubmed publisher
..The JNK pathway and Lipocalins are structurally and functionally conserved, suggesting that similar interactions represent an evolutionarily conserved system for the control of metabolic homeostasis. ..
Navarro J, Ohmann E, Sanchez D, Botella J, Liebisch G, Moltó M, et al
. Altered lipid metabolism in a Drosophila model of Friedreich's ataxia. Hum Mol Genet. 2010;19:2828-40 pubmed publisher
..Interestingly, co-expression of a Drosophila apolipoprotein D ortholog (glial lazarillo) has a strong protective effect in our frataxin models, mainly by controlling the level of lipid peroxidation...
Sanchez D, Ganfornina M, Torres Schumann S, Speese S, Lora J, Bastiani M. Characterization of two novel lipocalins expressed in the Drosophila embryonic nervous system. Int J Dev Biol. 2000;44:349-59 pubmed
..The mRNAs of DNLaz (for Drosophila neural Lazarillo) and DGLaz (for Drosophila glial Lazarillo) are expressed with different temporal patterns during embryogenesis...
Muffat J, Walker D, Benzer S. Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila. Proc Natl Acad Sci U S A. 2008;105:7088-93 pubmed publisher
..We show that the fly ortholog, Glial Lazarillo, is strongly up-regulated in response to these extrinsic stresses and also can protect in vitro-cultured ..
Diez Hermano S, Valero J, Rueda C, Ganfornina M, Sanchez D. An automated image analysis method to measure regularity in biological patterns: a case study in a Drosophila neurodegenerative model. Mol Neurodegener. 2015;10:9 pubmed publisher
LaFerriere H, Guarnieri D, Sitaraman D, Diegelmann S, Heberlein U, Zars T. Genetic dissociation of ethanol sensitivity and memory formation in Drosophila melanogaster. Genetics. 2008;178:1895-902 pubmed publisher
Ruiz M, Sanchez D, Canal I, Acebes A, Ganfornina M. Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz. Exp Gerontol. 2011;46:579-89 pubmed publisher
..Two homologues of ApoD expressed in the Drosophila brain, Glial Lazarillo (GLaz) and Neural Lazarillo (NLaz), are known to alter longevity in male flies...