Gene Symbol: gish
Description: gilgamesh
Alias: CG6963, CK1, CK1-gamma, CK1[[gamma]], CK1gamma, CKI-related, CKIgamma, Dmel\CG6963, Gish, Hrr25, NEST:bs27c08, Spider, anon-WO0118547.425, ms(3)89B, spider, gilgamesh, CG6963-PA, CG6963-PB, CG6963-PC, CG6963-PD, CG6963-PE, CG6963-PF, CG6963-PG, CG6963-PH, CG6963-PI, CG6963-PJ, CG6963-PK, CG6963-PL, CG6963-PM, CKIg-like, NEST:bs27c08, casein kinase 1gamma, gish-PA, gish-PB, gish-PC, gish-PD, gish-PE, gish-PF, gish-PG, gish-PH, gish-PI, gish-PJ, gish-PK, gish-PL, gish-PM, spider
Species: fruit fly

Top Publications

  1. Jia J, Zhang L, Zhang Q, Tong C, Wang B, Hou F, et al. Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing. Dev Cell. 2005;9:819-30 pubmed
    ..We propose that phosphorylation of Ci by CKI creates multiple Slimb/beta-TRCP binding sites that act cooperatively to recruit SCF(Slimb/beta-TRCP). ..
  2. Fernandez Gonzalez R, Simões S, Röper J, Eaton S, Zallen J. Myosin II dynamics are regulated by tension in intercalating cells. Dev Cell. 2009;17:736-43 pubmed publisher
    ..These results demonstrate that myosin II dynamics are regulated by tension in a positive feedback loop that leads to multicellular actomyosin cable formation and efficient tissue elongation. ..
  3. Frescas D, Mavrakis M, Lorenz H, DeLotto R, Lippincott Schwartz J. The secretory membrane system in the Drosophila syncytial blastoderm embryo exists as functionally compartmentalized units around individual nuclei. J Cell Biol. 2006;173:219-30 pubmed
  4. Zhang L, Jia J, Wang B, Amanai K, Wharton K, Jiang J. Regulation of wingless signaling by the CKI family in Drosophila limb development. Dev Biol. 2006;299:221-37 pubmed
    ..Moreover, loss of Gilgamesh (Gish)/CKIgamma attenuates Wg signaling activity...
  5. Tan Y, Yu D, Pletting J, Davis R. Gilgamesh is required for rutabaga-independent olfactory learning in Drosophila. Neuron. 2010;67:810-20 pubmed publisher
    ..From a screen for new memory mutants, we identified alleles of the gilgamesh (gish) gene, which encodes a casein kinase I? homolog that is preferentially expressed in the mushroom body ..
  6. Martin A, Gelbart M, Fernandez Gonzalez R, Kaschube M, Wieschaus E. Integration of contractile forces during tissue invagination. J Cell Biol. 2010;188:735-49 pubmed publisher
    ..Thus, pulsed actomyosin contractions require a supracellular, tensile meshwork to transmit cellular forces to the tissue level during morphogenesis. ..
  7. Davidson G, Wu W, Shen J, Bilic J, Fenger U, Stannek P, et al. Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature. 2005;438:867-72 pubmed publisher
    ..modification screen for regulators of LRP6, we describe the identification of Xenopus Casein kinase 1 gamma (CK1gamma), a membrane-bound member of the CK1 family...
  8. Nerusheva O, Dorogova N, Gubanova N, Yudina O, Omelyanchuk L. A GFP trap study uncovers the functions of Gilgamesh protein kinase in Drosophila melanogaster spermatogenesis. Cell Biol Int. 2009;33:586-93 pubmed publisher
    The function of the gene gilgamesh (89B9-12) encoding a casein kinase in Drosophila spermatogenesis was studied. The chimeric Gilgamesh-GFP protein in spermatocytes is cortically located...
  9. Martin A, Kaschube M, Wieschaus E. Pulsed contractions of an actin-myosin network drive apical constriction. Nature. 2009;457:495-9 pubmed publisher
    ..Our results suggest a new model for apical constriction in which a cortical actin-myosin cytoskeleton functions as a developmentally controlled subcellular ratchet to reduce apical area incrementally. ..

More Information


  1. Hummel T, Attix S, Gunning D, Zipursky S. Temporal control of glial cell migration in the Drosophila eye requires gilgamesh, hedgehog, and eye specification genes. Neuron. 2002;33:193-203 pubmed
    ..In gilgamesh (gish) mutants, glial cells invade anterior regions of the eye disc prior to R cell differentiation and R cell ..
  2. Abreu Blanco M, Verboon J, Parkhurst S. Cell wound repair in Drosophila occurs through three distinct phases of membrane and cytoskeletal remodeling. J Cell Biol. 2011;193:455-64 pubmed publisher
    ..Our results show that single-cell wound repair requires specific spatial and temporal cytoskeleton responses with distinct components and mechanisms required at different stages of the process. ..
  3. Gault W, Olguin P, Weber U, Mlodzik M. Drosophila CK1-?, gilgamesh, controls PCP-mediated morphogenesis through regulation of vesicle trafficking. J Cell Biol. 2012;196:605-21 pubmed publisher
    ..In this paper, we show that Drosophila CK1-?/gilgamesh (gish) regulates the PCP-associated process of trichome formation through effects on Rab11-mediated vesicle ..
  4. Howlett I, Rusan Z, Parker L, Tanouye M. Drosophila as a model for intractable epilepsy: gilgamesh suppresses seizures in para(bss1) heterozygote flies. G3 (Bethesda). 2013;3:1399-407 pubmed publisher
    ..We identify a second-site seizure-suppressor mutation, gilgamesh (gish), that reduces the severity of several seizure-like phenotypes of para(bss1)/+ heterozygotes...
  5. Cao J, Albertson R, Riggs B, Field C, Sullivan W. Nuf, a Rab11 effector, maintains cytokinetic furrow integrity by promoting local actin polymerization. J Cell Biol. 2008;182:301-13 pubmed publisher
    ..We propose a model in which RE-derived vesicles promote furrow integrity by regulating the rate of actin polymerization through the RhoGEF2-Rho1 pathway. ..
  6. Dylla K, Galili D, Szyszka P, Lüdke A. Trace conditioning in insects-keep the trace!. Front Physiol. 2013;4:67 pubmed publisher
    ..Moreover, we examine proposed molecular and computational models and reassess different experimental approaches used for trace conditioning. ..
  7. Price M. CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling. Genes Dev. 2006;20:399-410 pubmed
    ..Here I review these roles, including recent results on casein kinase I (CKI) phosphorylation and activation of LRP6, and CKI phosphorylation of Ci and mediation of Ci-Slimb/beta-TrCP binding. ..
  8. Chotard C, Salecker I. Neurons and glia: team players in axon guidance. Trends Neurosci. 2004;27:655-61 pubmed
    ..Equally, neurons provide crucial information to glia, supporting their migration and correct positioning. ..
  9. Firmino J, Tinevez J, Knust E. Crumbs affects protein dynamics in anterior regions of the developing Drosophila embryo. PLoS ONE. 2013;8:e58839 pubmed publisher
  10. Fernandez Gonzalez R, Zallen J. Oscillatory behaviors and hierarchical assembly of contractile structures in intercalating cells. Phys Biol. 2011;8:045005 pubmed publisher
    ..We discuss models to explain how the architecture of cytoskeletal networks regulates their contractile behavior and the mechanisms that give rise to oscillatory cell behaviors in intercalating cells...
  11. Sopko R, Foos M, Vinayagam A, Zhai B, Binari R, Hu Y, et al. Combining genetic perturbations and proteomics to examine kinase-phosphatase networks in Drosophila embryos. Dev Cell. 2014;31:114-27 pubmed publisher
    ..Further, we show how correlative phosphorylation at the site level can indicate function, as exemplified by Sterile20-like kinase-dependent regulation of Stat92E. ..
  12. Devenport D. The cell biology of planar cell polarity. J Cell Biol. 2014;207:171-9 pubmed publisher
    ..Together, these findings are shedding light on how global cues integrate with local cell interactions to organize cellular polarity at the tissue level. ..
  13. Perkins L, Holderbaum L, Tao R, Hu Y, Sopko R, McCall K, et al. The Transgenic RNAi Project at Harvard Medical School: Resources and Validation. Genetics. 2015;201:843-52 pubmed publisher, and stocks are available from three stock centers, the Bloomington Drosophila Stock Center (United States), National Institute of Genetics (Japan), and TsingHua Fly Center (China). ..
  14. Li S, Li S, Han Y, Tong C, Wang B, Chen Y, et al. Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase. PLoS Biol. 2016;14:e1002481 pubmed publisher
    ..Here we show that Hh stimulates the binding of Smo to a plasma membrane-associated kinase Gilgamesh (Gish)/CK1? and that Gish fine-tunes Hh pathway activity by phosphorylating a Ser/Thr cluster (CL-II) in the ..
  15. Tayler T, Garrity P. Axon targeting in the Drosophila visual system. Curr Opin Neurobiol. 2003;13:90-5 pubmed
    ..A role for the visual system glia in orienting photoreceptor axon outgrowth and target selection has also been uncovered. ..
  16. Jungreis I, Lin M, Spokony R, Chan C, Negre N, Victorsen A, et al. Evidence of abundant stop codon readthrough in Drosophila and other metazoa. Genome Res. 2011;21:2096-113 pubmed publisher
  17. Pandey R, Heidmann S, Lehner C. Epithelial re-organization and dynamics of progression through mitosis in Drosophila separase complex mutants. J Cell Sci. 2005;118:733-42 pubmed
  18. Daniels B, Rikhy R, Renz M, Dobrowsky T, Lippincott Schwartz J. Multiscale diffusion in the mitotic Drosophila melanogaster syncytial blastoderm. Proc Natl Acad Sci U S A. 2012;109:8588-93 pubmed publisher
  19. Meng Z, Capalbo L, Glover D, Dunphy W. Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1. Mol Biol Cell. 2011;22:2834-47 pubmed publisher
    ..By using a multifaceted approach, we have found that casein kinase 1 gamma 1 (CK1?1) carries out this function...
  20. Davidson G, Shen J, Huang Y, Su Y, Karaulanov E, Bartscherer K, et al. Cell cycle control of wnt receptor activation. Dev Cell. 2009;17:788-99 pubmed publisher
    ..G2/M priming of LRP6 by a Cyclin/CDK complex introduces an unexpected new layer of regulation of Wnt signaling. ..
  21. Bozas A, Beumer K, Trautman J, Carroll D. Genetic analysis of zinc-finger nuclease-induced gene targeting in Drosophila. Genetics. 2009;182:641-51 pubmed publisher
    ..They also demonstrate that the outcome can be biased toward gene replacement by disabling the major NHEJ pathway and toward simple mutagenesis by interfering with the major HR process...
  22. Nerusheva O, Dorogova N, Gubanova N, Omel ianchuk L. [The role of Gilgamesh protein kinase in Drosophila melanogaster spermatogenesis]. Genetika. 2008;44:1203-8 pubmed
    The cellular function of the gilgamesh mutation (89B9-12) of casein kinase gene in Drosophila spermatogenesis was studied...
  23. Jung S, Evans C, Uemura C, Banerjee U. The Drosophila lymph gland as a developmental model of hematopoiesis. Development. 2005;132:2521-33 pubmed
    ..The cellular events identified in this analysis further establish Drosophila as a model system for hematopoiesis. ..
  24. Han N, Chen C, Shi Z, Cheng D. Structure of the kinase domain of Gilgamesh from Drosophila melanogaster. Acta Crystallogr F Struct Biol Commun. 2014;70:438-43 pubmed publisher
    ..The kinase domain of Drosophila Gilgamesh isoform I (Gilgamesh-I), a homologue of human CK1-?, was purified and crystallized...
  25. Kim E, Edery I. Balance between DBT/CKIepsilon kinase and protein phosphatase activities regulate phosphorylation and stability of Drosophila CLOCK protein. Proc Natl Acad Sci U S A. 2006;103:6178-83 pubmed