Gene Symbol: Ggamma30A
Description: G protein subunit gamma at 30A
Alias: CG18511, CG3694, CG43733, Dmel\CG3694, Dmel_CG43733, G-gamma30A, GNG gene like, G[[gamma30A]], G[[gamma]], Galpha30A, Ggamma, Ggamma[[e]], Ggammae, lincRNA.S701, G protein subunit gamma at 30A, CG3694-PA, CG3694-PB, CG3694-PC, CG3694-PF, CG3694-PG, CG3694-PH, CG3694-PI, CG3694-PJ, G protein gamma30A, Ggamma30A-PA, Ggamma30A-PB, Ggamma30A-PC, Ggamma30A-PF, Ggamma30A-PG, Ggamma30A-PH, Ggamma30A-PI, Ggamma30A-PJ
Species: fruit fly

Top Publications

  1. Izumi Y, Ohta N, Itoh Furuya A, Fuse N, Matsuzaki F. Differential functions of G protein and Baz-aPKC signaling pathways in Drosophila neuroblast asymmetric division. J Cell Biol. 2004;164:729-38 pubmed
    ..We thus suggest that the two apical signaling pathways have overlapping but different roles in asymmetric NB division. ..
  2. Schulz S, Huber A, Schwab K, Paulsen R. A novel Ggamma isolated from Drosophila constitutes a visual G protein gamma subunit of the fly compound eye. J Biol Chem. 1999;274:37605-10 pubmed
    ..We cloned the cDNA coding for the visual Ggamma (Ggamma(e)) subunit from Drosophila which had so far eluded identification at the molecular level...
  3. Zemelman B, Lee G, Ng M, Miesenbock G. Selective photostimulation of genetically chARGed neurons. Neuron. 2002;33:15-22 pubmed
    ..Distributed activity may thus be fed directly into a circumscribed population of neurons in intact tissue, irrespective of the spatial arrangement of its elements. ..
  4. Vecsey C, P rez N, Griffith L. The Drosophila neuropeptides PDF and sNPF have opposing electrophysiological and molecular effects on central neurons. J Neurophysiol. 2014;111:1033-45 pubmed publisher
  5. Schillo S, Belusic G, Hartmann K, Franz C, Kühl B, Brenner Weiss G, et al. Targeted mutagenesis of the farnesylation site of Drosophila Ggammae disrupts membrane association of the G protein betagamma complex and affects the light sensitivity of the visual system. J Biol Chem. 2004;279:36309-16 pubmed
    ..The gamma subunit of this G protein (Ggammae) as well as gamma subunits of vertebrate transducins contain a carboxyl-terminal CAAX motif (C, cysteine; A, ..
  6. Landry C, Castillo Davis C, Ogura A, Liu J, Hartl D. Systems-level analysis and evolution of the phototransduction network in Drosophila. Proc Natl Acad Sci U S A. 2007;104:3283-8 pubmed
    ..These results provide a preliminary quantification of variation and divergence of gene expression between species in a known gene network and provide a foundation for a system-level understanding of functional and evolutionary change. ..
  7. Im S, Takle K, Jo J, Babcock D, Ma Z, Xiang Y, et al. Tachykinin acts upstream of autocrine Hedgehog signaling during nociceptive sensitization in Drosophila. elife. 2015;4:e10735 pubmed publisher
    ..Our results highlight a conserved role for Tachykinin signaling in regulating nociception and the power of Drosophila for genetic dissection of nociception. ..
  8. Krishnan A, Mustafa A, Almén M, Fredriksson R, Williams M, Schiöth H. Evolutionary hierarchy of vertebrate-like heterotrimeric G protein families. Mol Phylogenet Evol. 2015;91:27-40 pubmed publisher
    ..Our robust classification/hierarchy is essential to further understand the differential roles of GPCR/G protein mediated intracellular signaling system across various metazoan lineages. ..
  9. Yao C, Carlson J. Role of G-proteins in odor-sensing and CO2-sensing neurons in Drosophila. J Neurosci. 2010;30:4562-72 pubmed publisher
    ..Genetic mosaic analysis confirmed that odor responses are normal in the absence of Galpha(q). Ggamma30A is also required for normal CO2 response...

More Information


  1. Gao S, Giansanti M, Buttrick G, Ramasubramanyan S, Auton A, Gatti M, et al. Australin: a chromosomal passenger protein required specifically for Drosophila melanogaster male meiosis. J Cell Biol. 2008;180:521-35 pubmed publisher
  2. Lee S, Xu H, Montell C. Rhodopsin kinase activity modulates the amplitude of the visual response in Drosophila. Proc Natl Acad Sci U S A. 2004;101:11874-9 pubmed
    ..These data point to an evolutionarily conserved role for GPRK1 in modulating the amplitude of the visual response. ..
  3. Harris B, Lim W. Mechanism and role of PDZ domains in signaling complex assembly. J Cell Sci. 2001;114:3219-31 pubmed
    ..The predominance of PDZ domains in metazoans indicates that this highly specialized scaffolding module probably evolved in response to the increased signaling needs of multicellular organisms. ..
  4. Katanayeva N, Kopein D, Portmann R, Hess D, Katanaev V. Competing activities of heterotrimeric G proteins in Drosophila wing maturation. PLoS ONE. 2010;5:e12331 pubmed publisher
    ..Our results provide a comprehensive functional analysis of the heterotrimeric G protein proteome in the late stages of Drosophila wing development. ..
  5. Zelhof A, Koundakjian E, Scully A, Hardy R, Pounds L. Mutation of the photoreceptor specific homeodomain gene Pph13 results in defects in phototransduction and rhabdomere morphogenesis. Development. 2003;130:4383-92 pubmed
    ..In addition, we demonstrate that Pph13 exerts its effect by the regulation of photoreceptor specific gene expression. ..
  6. Murali T, Pacifico S, Finley R. Integrating the interactome and the transcriptome of Drosophila. BMC Bioinformatics. 2014;15:177 pubmed publisher
    ..This organization implies that tissue or stage specific networks can be best identified from interactome data by using filters designed to include both ubiquitously expressed and specifically expressed genes and proteins. ..
  7. Ishimoto H, Takahashi K, Ueda R, Tanimura T. G-protein gamma subunit 1 is required for sugar reception in Drosophila. EMBO J. 2005;24:3259-65 pubmed
    ..We also demonstrated that responses to sugars were lowered in Ggamma1 null mutant, Ggamma1(N159). These results are consistent with the hypothesis that Ggamma1 participates in the signal transduction of sugar taste reception. ..
  8. Boto T, Gomez Diaz C, Alcorta E. Expression analysis of the 3 G-protein subunits, Galpha, Gbeta, and Ggamma, in the olfactory receptor organs of adult Drosophila melanogaster. Chem Senses. 2010;35:183-93 pubmed publisher
    ..6 Galpha (G(s), G(i), G(q), G(o), G(f), and concertina), 3 Gbeta (G(beta5), G(beta13F), and G(beta76C)), and 2 Ggamma genes (G(gamma1) and G(gamma30A))...
  9. Blake B, Wing M, Zhou J, Lei Q, Hillmann J, Behe C, et al. G beta association and effector interaction selectivities of the divergent G gamma subunit G gamma(13). J Biol Chem. 2001;276:49267-74 pubmed