Gene Symbol: Gga
Description: Golgi-localized, gamma-adaptin ear containing, ARF binding protein
Alias: CG3002, DmGGA1, Dmel\CG3002, GGA, dGGA, dmGGA, Golgi-localized, gamma-adaptin ear containing, ARF binding protein, CG3002-PB, Gga-PB, Golgi-localised, gamma-ear containing, ADP ribosylation factor-binding
Species: fruit fly
Boehm M, Bonifacino J. Adaptins: the final recount. Mol Biol Cell. 2001;12:2907-20 pubmed
..Finally, we extend our survey to adaptin-related proteins such as the GGAs and stonins, which contain domains homologous to the adaptins. ..
Dennes A, Cromme C, Suresh K, Kumar N, Eble J, Hahnenkamp A, et al
. The novel Drosophila lysosomal enzyme receptor protein mediates lysosomal sorting in mammalian cells and binds mammalian and Drosophila GGA adaptors. J Biol Chem. 2005;280:12849-57 pubmed
..The LERP cytoplasmic domain shows highly conserved interactions with Drosophila and mammalian GGA adaptors known to mediate Golgi-endosome traffic of MPRs and other transmembrane cargo...
Hirst J, Sahlender D, Choma M, Sinka R, Harbour M, Parkinson M, et al
. Spatial and functional relationship of GGAs and AP-1 in Drosophila and HeLa cells. Traffic. 2009;10:1696-710 pubmed
..We have used two complementary systems, HeLa cells and Drosophila Dmel2 cells, to investigate GGA and AP-1 function...
Kametaka S, Sawada N, Bonifacino J, Waguri S. Functional characterization of protein-sorting machineries at the trans-Golgi network in Drosophila melanogaster. J Cell Sci. 2010;123:460-71 pubmed publisher
..We found that a clathrin adaptor Drosophila GGA (dGGA), a homolog of mammalian GGA proteins, localizes to the trans-Golgi network (TGN) and is capable of recruiting ..
Hirst J, Carmichael J. A potential role for the clathrin adaptor GGA in Drosophila spermatogenesis. BMC Cell Biol. 2011;12:22 pubmed publisher
..Knockout and knockdown studies to determine GGA function are confounded by the fact that there are 3 GGA genes in mammalian cells...
Kametaka S, Kametaka A, Yonekura S, Haruta M, Takenoshita S, Goto S, et al
. AP-1 clathrin adaptor and CG8538/Aftiphilin are involved in Notch signaling during eye development in Drosophila melanogaster. J Cell Sci. 2012;125:634-48 pubmed publisher
..to interact directly with the ear domain of ?-adaptin of Drosophila AP-1, but not with the GAE domain of Drosophila GGA. In S2 cells, Drosophila Aftiphilin and AP-1 formed a complex and colocalized at the Golgi compartment...
Eissenberg J, Ilvarsonn A, Sly W, Waheed A, Krzyzanek V, Pohlmann R, et al
. Drosophila GGA model: an ultimate gateway to GGA analysis. Traffic. 2011;12:1821-38 pubmed publisher
Golgi-localized, ?-ear-containing, ADP ribosylation factor-binding (GGA) proteins are monomeric adaptors implicated in clathrin-mediated vesicular transport between the trans Golgi network and endosomes, characterized mainly from cell ..
Luan S, Ilvarsonn A, Eissenberg J. The unique GGA clathrin adaptor of Drosophila melanogaster is not essential. PLoS ONE. 2012;7:e45163 pubmed publisher
..GGA RNAi knockdowns in Drosophila have resulted in conflicting data concerning whether the Drosophila GGA (dGGA) is essential. The goal of this study was to define the null phenotype for the unique Drosophila GGA...
Jiang K, Liu Y, Fan J, Zhang J, Li X, Evers B, et al
. PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail. PLoS Biol. 2016;14:e1002375 pubmed publisher