Gene Symbol: Gbeta76C
Description: G protein beta-subunit 76C
Alias: CG8770, DGqbeta, Dmel\CG8770, G&bgr76C, G[[beta76C]], G[[beta]], G[[beta]]e, Galpha76C, Gbe, Gbeta, Gbeta76c, Gbeta[[e]], Gbetae, Gbeta{e}, Gqbeta, eGbeta, eye Gbeta, gbe, G protein beta-subunit 76C, CG8770-PA, G[[beta]] eye, Gbeta76C-PA, guanine nucleotide regulatory protein beta subunit
Species: fruit fly

Top Publications

  1. Kosloff M, Elia N, Joel Almagor T, Timberg R, Zars T, Hyde D, et al. Regulation of light-dependent Gqalpha translocation and morphological changes in fly photoreceptors. EMBO J. 2003;22:459-68 pubmed
    ..Furthermore, mutant analysis indicated that Gqbeta is essential for targeting of Gqalpha to the membrane and suggested that Gqbeta is also needed for efficient ..
  2. Schulz S, Huber A, Schwab K, Paulsen R. A novel Ggamma isolated from Drosophila constitutes a visual G protein gamma subunit of the fly compound eye. J Biol Chem. 1999;274:37605-10 pubmed
    ..determined for Ggamma(e) as well as co-immunoprecipitation experiments demonstrated that Ggamma(e) dimerizes with Gbeta(e) to form the heterodimeric Gbetagamma subunit which functions in visual transduction in the Drosophila compound ..
  3. Dolph P, Man Son Hing H, Yarfitz S, Colley N, Deer J, Spencer M, et al. An eye-specific G beta subunit essential for termination of the phototransduction cascade. Nature. 1994;370:59-61 pubmed
    ..Remarkably, G beta mutants are also severely defective in the deactivation of the light response, demonstrating an essential role for the G beta subunit in terminating the active state of this signalling cascade. ..
  4. Katanayeva N, Kopein D, Portmann R, Hess D, Katanaev V. Competing activities of heterotrimeric G proteins in Drosophila wing maturation. PLoS ONE. 2010;5:e12331 pubmed publisher
    ..Our results provide a comprehensive functional analysis of the heterotrimeric G protein proteome in the late stages of Drosophila wing development. ..
  5. Frechter S, Elia N, Tzarfaty V, Selinger Z, Minke B. Translocation of Gq alpha mediates long-term adaptation in Drosophila photoreceptors. J Neurosci. 2007;27:5571-83 pubmed
    ..The slow time scale of this adaptation fits well with day/night light intensity changes, because there is no need to maintain single photon sensitivity during daytime. ..
  6. Zelhof A, Koundakjian E, Scully A, Hardy R, Pounds L. Mutation of the photoreceptor specific homeodomain gene Pph13 results in defects in phototransduction and rhabdomere morphogenesis. Development. 2003;130:4383-92 pubmed
    ..In addition, we demonstrate that Pph13 exerts its effect by the regulation of photoreceptor specific gene expression. ..
  7. Yarfitz S, Running Deer J, Froelick G, Colley N, Hurley J. In situ assay of light-stimulated G protein activity in Drosophila photoreceptor G protein beta mutants. J Biol Chem. 1994;269:30340-4 pubmed
    ..These results suggest that G beta e functions as the beta subunit of a heterotrimeric G protein that couples photoactivation of rhodopsin to downstream components in the Drosophila phototransduction cascade. ..
  8. Boto T, Gomez Diaz C, Alcorta E. Expression analysis of the 3 G-protein subunits, Galpha, Gbeta, and Ggamma, in the olfactory receptor organs of adult Drosophila melanogaster. Chem Senses. 2010;35:183-93 pubmed publisher
    ..Using RT-polymerase chain reaction, we analyzed 6 Galpha (G(s), G(i), G(q), G(o), G(f), and concertina), 3 Gbeta (G(beta5), G(beta13F), and G(beta76C)), and 2 Ggamma genes (G(gamma1) and G(gamma30A))...
  9. Zuker C. The biology of vision of Drosophila. Proc Natl Acad Sci U S A. 1996;93:571-6 pubmed
    ..In this manuscript I review some of our recent findings and the strategies used to dissect this process. ..

More Information


  1. Krishnan A, Mustafa A, Almén M, Fredriksson R, Williams M, Schiöth H. Evolutionary hierarchy of vertebrate-like heterotrimeric G protein families. Mol Phylogenet Evol. 2015;91:27-40 pubmed publisher
    ..Our robust classification/hierarchy is essential to further understand the differential roles of GPCR/G protein mediated intracellular signaling system across various metazoan lineages. ..
  2. Running Deer J, Hurley J, Yarfitz S. G protein control of Drosophila photoreceptor phospholipase C. J Biol Chem. 1995;270:12623-8 pubmed
    ..These results indicate that G beta e functions as the beta subunit of the G protein coupling rhodopsin to NorpA PLC. ..
  3. Vecsey C, P rez N, Griffith L. The Drosophila neuropeptides PDF and sNPF have opposing electrophysiological and molecular effects on central neurons. J Neurophysiol. 2014;111:1033-45 pubmed publisher
  4. Elia N, Frechter S, Gedi Y, Minke B, Selinger Z. Excess of Gbetae over Gqalphae in vivo prevents dark, spontaneous activity of Drosophila photoreceptors. J Cell Biol. 2005;171:517-26 pubmed
    ..Studies of Gbetae mutants in which the excess of Gbeta was genetically eliminated showed dramatic dark, spontaneous activity of the ..
  5. Im S, Takle K, Jo J, Babcock D, Ma Z, Xiang Y, et al. Tachykinin acts upstream of autocrine Hedgehog signaling during nociceptive sensitization in Drosophila. elife. 2015;4:e10735 pubmed publisher
    ..Our results highlight a conserved role for Tachykinin signaling in regulating nociception and the power of Drosophila for genetic dissection of nociception. ..
  6. Yao C, Carlson J. Role of G-proteins in odor-sensing and CO2-sensing neurons in Drosophila. J Neurosci. 2010;30:4562-72 pubmed publisher
    ..Ggamma30A is also required for normal CO2 response. The simplest interpretation of these results is that Galpha(q) and Ggamma30A play a role in the response of CO2-sensing neurons, but are not required for Or-mediated odor signaling. ..
  7. Hardie R, Martin F, Cochrane G, Juusola M, Georgiev P, Raghu P. Molecular basis of amplification in Drosophila phototransduction: roles for G protein, phospholipase C, and diacylglycerol kinase. Neuron. 2002;36:689-701 pubmed
  8. Yarfitz S, Niemi G, McConnell J, Fitch C, Hurley J. A G beta protein in the Drosophila compound eye is different from that in the brain. Neuron. 1991;7:429-38 pubmed
    A G protein beta subunit gene (Gbe) is expressed only in the eyes of adult D. melanogaster...
  9. Zuker C. Phototransduction in Drosophila: a paradigm for the genetic dissection of sensory transduction cascades. Curr Opin Neurobiol. 1992;2:622-7 pubmed
    ..The availability of Drosophila mutants with defects in visual physiology allows for an in vivo dissection of this complex sensory signal transduction process. ..
  10. Sun J, Smith L, Armento A, Deng W. Regulation of the endocycle/gene amplification switch by Notch and ecdysone signaling. J Cell Biol. 2008;182:885-96 pubmed publisher
  11. Wang T, Wang X, Xie Q, Montell C. The SOCS box protein STOPS is required for phototransduction through its effects on phospholipase C. Neuron. 2008;57:56-68 pubmed publisher
    ..Moreover, this work demonstrates that a PLCbeta derivative that does not promote TRP channel activation, still contributes to signaling in vivo. ..
  12. Schillo S, Belusic G, Hartmann K, Franz C, Kühl B, Brenner Weiss G, et al. Targeted mutagenesis of the farnesylation site of Drosophila Ggammae disrupts membrane association of the G protein betagamma complex and affects the light sensitivity of the visual system. J Biol Chem. 2004;279:36309-16 pubmed
    ..In the transgenic flies, mutated Ggammae forms a dimeric complex with Gbetae, with the consequence that the fraction of non-membrane-bound Gbetagamma is increased...
  13. Murali T, Pacifico S, Finley R. Integrating the interactome and the transcriptome of Drosophila. BMC Bioinformatics. 2014;15:177 pubmed publisher
    ..This organization implies that tissue or stage specific networks can be best identified from interactome data by using filters designed to include both ubiquitously expressed and specifically expressed genes and proteins. ..
  14. Hardie R. Phototransduction in Drosophila melanogaster. J Exp Biol. 2001;204:3403-9 pubmed
  15. Harris B, Lim W. Mechanism and role of PDZ domains in signaling complex assembly. J Cell Sci. 2001;114:3219-31 pubmed
    ..The predominance of PDZ domains in metazoans indicates that this highly specialized scaffolding module probably evolved in response to the increased signaling needs of multicellular organisms. ..
  16. Katz B, Minke B. Phospholipase C-mediated suppression of dark noise enables single-photon detection in Drosophila photoreceptors. J Neurosci. 2012;32:2722-33 pubmed publisher
    ..We thus demonstrate how a G-protein-mediated transduction system, with PLC as its target, selectively suppresses its intrinsic noise while preserving reliable signaling. ..
  17. Lee S, Xu H, Montell C. Rhodopsin kinase activity modulates the amplitude of the visual response in Drosophila. Proc Natl Acad Sci U S A. 2004;101:11874-9 pubmed
    ..These data point to an evolutionarily conserved role for GPRK1 in modulating the amplitude of the visual response. ..
  18. Landry C, Castillo Davis C, Ogura A, Liu J, Hartl D. Systems-level analysis and evolution of the phototransduction network in Drosophila. Proc Natl Acad Sci U S A. 2007;104:3283-8 pubmed
    ..These results provide a preliminary quantification of variation and divergence of gene expression between species in a known gene network and provide a foundation for a system-level understanding of functional and evolutionary change. ..
  19. Zemelman B, Lee G, Ng M, Miesenbock G. Selective photostimulation of genetically chARGed neurons. Neuron. 2002;33:15-22 pubmed
    ..Distributed activity may thus be fed directly into a circumscribed population of neurons in intact tissue, irrespective of the spatial arrangement of its elements. ..
  20. Sapir A, Assa Kunik E, Tsruya R, Schejter E, Shilo B. Unidirectional Notch signaling depends on continuous cleavage of Delta. Development. 2005;132:123-32 pubmed
    ..Proteolytic cleavage of Dl by Kul represents a general mechanism for refining and maintaining the asymmetric distribution of Dl, in cases where transcriptional repression of Dl expression does not suffice to eliminate Dl protein. ..
  21. Alvarez C, Robison K, Gilbert W. Novel Gq alpha isoform is a candidate transducer of rhodopsin signaling in a Drosophila testes-autonomous pacemaker. Proc Natl Acad Sci U S A. 1996;93:12278-82 pubmed
    ..This proposal is supported by the finding that rhodopsin 2 and arrestin 1, two photoreceptor-cell-specific genes, are also expressed in male gonads. ..
  22. Ranganathan R, Harris W, Zuker C. The molecular genetics of invertebrate phototransduction. Trends Neurosci. 1991;14:486-93 pubmed
    ..The results of a combination of molecular, genetic, physiological and biochemical studies are beginning to produce a clearer model for the complex mechanisms involved in invertebrate visual transduction. ..
  23. Hu W, Wan D, Yu X, Cao J, Guo P, Li H, et al. Protein Gq modulates termination of phototransduction and prevents retinal degeneration. J Biol Chem. 2012;287:13911-8 pubmed publisher
    ..Our study revealed the roles of G(q) in mediating photoresponse termination and in preventing retinal degeneration. This pathway may represent a general rapid feedback regulation of G protein-coupled receptor signaling. ..