Gene Symbol: gbb
Description: glass bottom boat
Alias: 60A, BMP, CG5562, Dm-GBB, Dmel\CG5562, GBB, Gbb, Gbb-60A, SixtyA, TGF-b, TGFbeta-60A, Tgfb-60, Tgfbeta-60A, gbb-60A, gcn, l(2)60A-J, tgfb-60A, vgr/60A, glass bottom boat, CG5562-PA, CG5562-PB, bone morphogenetic protein, bone morphogenic protein, gbb-PA, gbb-PB, glass bottom boat-60A, glass-bottom boat, glass-bottomed boat, transforming growth factor beta at 60A
Species: fruit fly
Products:     gbb

Top Publications

  1. Miguel Aliaga I, Allan D, Thor S. Independent roles of the dachshund and eyes absent genes in BMP signaling, axon pathfinding and neuronal specification. Development. 2004;131:5837-48 pubmed
    ..Fmrf expression is controlled by a combinatorial code of intrinsic factors and an extrinsic BMP signal. However, this previously identified code does not fully explain the regulation of Fmrf...
  2. Nahm M, Kim S, Paik S, Lee M, Lee S, Lee Z, et al. dCIP4 (Drosophila Cdc42-interacting protein 4) restrains synaptic growth by inhibiting the secretion of the retrograde Glass bottom boat signal. J Neurosci. 2010;30:8138-50 pubmed publisher
    The bone morphogenetic protein (BMP) ligand Glass bottom boat (Gbb) acts as a retrograde growth signal at the Drosophila neuromuscular junction (NMJ)...
  3. Ballard S, Jarolimova J, Wharton K. Gbb/BMP signaling is required to maintain energy homeostasis in Drosophila. Dev Biol. 2010;337:375-85 pubmed publisher
    ..Animals with mutations in the Drosophila BMP-5,7 orthologue, glass bottom boat (gbb), or in its signaling components, display phenotypes similar to nutrient-deprived and Tor mutant larvae...
  4. Higashi Kovtun M, Mosca T, Dickman D, Meinertzhagen I, Schwarz T. Importin-beta11 regulates synaptic phosphorylated mothers against decapentaplegic, and thereby influences synaptic development and function at the Drosophila neuromuscular junction. J Neurosci. 2010;30:5253-68 pubmed publisher
    ..b>Bone morphogenic protein (BMP) signaling was the apparent cause of the observed NMJ defects...
  5. Baines R. Synaptic strengthening mediated by bone morphogenetic protein-dependent retrograde signaling in the Drosophila CNS. J Neurosci. 2004;24:6904-11 pubmed
    ..Previous studies show that bone morphogenetic protein (BMP)-dependent retrograde signaling is required for the proper development of the neuromuscular ..
  6. Marques G, Haerry T, Crotty M, Xue M, Zhang B, O Connor M. Retrograde Gbb signaling through the Bmp type 2 receptor wishful thinking regulates systemic FMRFa expression in Drosophila. Development. 2003;130:5457-70 pubmed
    ..We demonstrate here that mutations in wishful thinking (wit) a gene encoding a Drosophila Bmp type 2 receptor that is required for proper neurotransmitter release at the neuromuscular junction, also eliminates ..
  7. Dejima K, Kanai M, Akiyama T, Levings D, Nakato H. Novel contact-dependent bone morphogenetic protein (BMP) signaling mediated by heparan sulfate proteoglycans. J Biol Chem. 2011;286:17103-11 pubmed publisher
    ..Two BMP-like molecules, Decapentaplegic (DPP) and Glass bottom boat, can mediate trans signaling through a heparan sulfate proteoglycan co-receptor in S2 cells...
  8. Haerry T, Khalsa O, O Connor M, Wharton K. Synergistic signaling by two BMP ligands through the SAX and TKV receptors controls wing growth and patterning in Drosophila. Development. 1998;125:3977-87 pubmed
    ..To enhance signaling at low DPP concentrations, we find that a second ligand, GBB, augments DPP/TKV activity...
  9. Haerry T. The interaction between two TGF-beta type I receptors plays important roles in ligand binding, SMAD activation, and gradient formation. Mech Dev. 2010;127:358-70 pubmed publisher
    ..contributions of the Drosophila TGF-beta type I receptors TKV and SAX to the activity gradient formed by the two BMP family members DPP and GBB that play important roles in growth and patterning of imaginal discs...

More Information


  1. Staehling Hampton K, Laughon A, Hoffmann F. A Drosophila protein related to the human zinc finger transcription factor PRDII/MBPI/HIV-EP1 is required for dpp signaling. Development. 1995;121:3393-403 pubmed
    ..We conclude that shn function is critical for cells to respond properly to dpp and propose that shn protein is the first identified downstream component of the signal transduction pathway used by dpp and its receptors. ..
  2. Berke B, Wittnam J, McNeill E, Van Vactor D, Keshishian H. Retrograde BMP signaling at the synapse: a permissive signal for synapse maturation and activity-dependent plasticity. J Neurosci. 2013;33:17937-50 pubmed publisher
    ..Similar results were found by genetic rescue tests involving the BMP4/5/6 ligand Glass bottom boat (Gbb) in muscle, and alternatively the type II BMP receptor Wishful Thinking (Wit) in the motoneuron...
  3. Fritsch C, Lanfear R, Ray R. Rapid evolution of a novel signalling mechanism by concerted duplication and divergence of a BMP ligand and its extracellular modulators. Dev Genes Evol. 2010;220:235-50 pubmed publisher
    ..In the fruit fly Drosophila, there are three BMPs: Decapentaplegic (Dpp) and Glass bottom boat (Gbb), which are the orthologues of vertebrate BMP2/4 and BMP5/6/7/8, respectively, and Screw (Scw), which, ..
  4. Wang X, Shaw W, Tsang H, Reid E, O Kane C. Drosophila spichthyin inhibits BMP signaling and regulates synaptic growth and axonal microtubules. Nat Neurosci. 2007;10:177-85 pubmed
    ..Spict is found on early endosomes. Loss of Spict leads to upregulation of bone morphogenetic protein (BMP) signaling and expansion of the neuromuscular junction...
  5. Keshishian H, Kim Y. Orchestrating development and function: retrograde BMP signaling in the Drosophila nervous system. Trends Neurosci. 2004;27:143-7 pubmed
    Recent work has shown that bone morphogenetic protein (BMP) growth factors regulate development of the larval neuromuscular junction (NMJ) of Drosophila...
  6. Zhang J, Li L. BMP signaling and stem cell regulation. Dev Biol. 2005;284:1-11 pubmed
    ..In this review, we focus on comparing the progress of recent research regarding the roles of the BMP signaling pathway in different stem cell systems, including embryonic stem cells, germline stem cells, ..
  7. Conley C, Silburn R, Singer M, Ralston A, Rohwer Nutter D, Olson D, et al. Crossveinless 2 contains cysteine-rich domains and is required for high levels of BMP-like activity during the formation of the cross veins in Drosophila. Development. 2000;127:3947-59 pubmed
    The BMP-like signaling mediated by the ligands Dpp and Gbb is required to reinforce the development of most veins in the Drosophila wing...
  8. Raftery L, Sutherland D. TGF-beta family signal transduction in Drosophila development: from Mad to Smads. Dev Biol. 1999;210:251-68 pubmed
    ..proteins with homology to vertebrate bone morphogenetic proteins (BMPs): Decapentaplegic (Dpp), Screw, and Glass bottom boat-60A...
  9. Kamimura K, Ueno K, Nakagawa J, Hamada R, Saitoe M, Maeda N. Perlecan regulates bidirectional Wnt signaling at the Drosophila neuromuscular junction. J Cell Biol. 2013;200:219-33 pubmed publisher
    ..These results suggest that Trol bidirectionally regulates both pre- and postsynaptic activities of Wg by precisely distributing Wg at the NMJ. ..
  10. Wharton K, Cook J, Torres Schumann S, de Castro K, Borod E, Phillips D. Genetic analysis of the bone morphogenetic protein-related gene, gbb, identifies multiple requirements during Drosophila development. Genetics. 1999;152:629-40 pubmed
    ..signaling molecule (formerly referred to as 60A) with highest sequence similarity to members of the bone morphogenetic protein (BMP) subgroup including vertebrate BMPs 5-8...
  11. Christoforou C, Greer C, Challoner B, Charizanos D, Ray R. The detached locus encodes Drosophila Dystrophin, which acts with other components of the Dystrophin Associated Protein Complex to influence intercellular signalling in developing wing veins. Dev Biol. 2008;313:519-32 pubmed
    ..In det and Dg mutant wings, the early BMP signalling that initiates crossvein specification is not maintained, particularly in the pro-vein territories ..
  12. O Connor M, Umulis D, Othmer H, Blair S. Shaping BMP morphogen gradients in the Drosophila embryo and pupal wing. Development. 2006;133:183-93 pubmed
    In the early Drosophila embryo, BMP-type ligands act as morphogens to suppress neural induction and to specify the formation of dorsal ectoderm and amnioserosa...
  13. Eaton B, Davis G. LIM Kinase1 controls synaptic stability downstream of the type II BMP receptor. Neuron. 2005;47:695-708 pubmed
    Here, we demonstrate that the BMP receptor Wishful Thinking (Wit) is required for synapse stabilization. In the absence of BMP signaling, synapse disassembly and retraction ensue...
  14. Staehling Hampton K, Jackson P, Clark M, Brand A, Hoffmann F. Specificity of bone morphogenetic protein-related factors: cell fate and gene expression changes in Drosophila embryos induced by decapentaplegic but not 60A. Cell Growth Differ. 1994;5:585-93 pubmed
    ..assays of developmental function to show that the two Drosophila homologues of the BMPs, decapentaplegic (dpp) and 60A, that both induce ectopic bone formation in mammalian assay systems, have distinct effects in Drosophila ..
  15. Shimmi O, Ralston A, Blair S, O Connor M. The crossveinless gene encodes a new member of the Twisted gastrulation family of BMP-binding proteins which, with Short gastrulation, promotes BMP signaling in the crossveins of the Drosophila wing. Dev Biol. 2005;282:70-83 pubmed
    In the early Drosophila embryo, Bone morphogenetic protein (BMP) activity is positively and negatively regulated by the BMP-binding proteins Short gastrulation (Sog) and Twisted gastrulation (Tsg)...
  16. Nahm M, Long A, Paik S, Kim S, Bae Y, Broadie K, et al. The Cdc42-selective GAP rich regulates postsynaptic development and retrograde BMP transsynaptic signaling. J Cell Biol. 2010;191:661-75 pubmed publisher
    Retrograde bone morphogenetic protein signaling mediated by the Glass bottom boat (Gbb) ligand modulates structural and functional synaptogenesis at the Drosophila melanogaster neuromuscular junction...
  17. Fuentes Medel Y, Ashley J, Barria R, Maloney R, FREEMAN M, Budnik V. Integration of a retrograde signal during synapse formation by glia-secreted TGF-? ligand. Curr Biol. 2012;22:1831-8 pubmed publisher the Drosophila neuromuscular junction (NMJ) depends on a muscle-secreted retrograde signal, the TGF-?/BMP Glass bottom boat (Gbb) [3, 4]...
  18. Gorostiza E, Ceriani M. Retrograde bone morphogenetic protein signaling shapes a key circadian pacemaker circuit. J Neurosci. 2013;33:687-96 pubmed publisher
    ..Presynaptic expression of constitutively active bone morphogenetic protein (BMP) receptors prevents pdfr mutants misrouting phenotype, while sLNv-restricted downregulation of BMP ..
  19. Doctor J, Jackson P, Rashka K, Visalli M, Hoffmann F. Sequence, biochemical characterization, and developmental expression of a new member of the TGF-beta superfamily in Drosophila melanogaster. Dev Biol. 1992;151:491-505 pubmed
    ..Because of its localization on the polytene chromosome map, we refer to this gene as 60A. Expression of a 60A cDNA in Drosophila S2 cells was used to determine that 60A encodes a preproprotein that is ..
  20. Wharton K, Thomsen G, Gelbart W. Drosophila 60A gene, another transforming growth factor beta family member, is closely related to human bone morphogenetic proteins. Proc Natl Acad Sci U S A. 1991;88:9214-8 pubmed
    The 60A gene, a member of the transforming growth factor beta superfamily of signaling proteins, has been identified in Drosophila melanogaster...
  21. McCabe B, Marques G, Haghighi A, Fetter R, Crotty M, Haerry T, et al. The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction. Neuron. 2003;39:241-54 pubmed
    We show that the BMP ortholog Gbb can signal by a retrograde mechanism to regulate synapse growth of the Drosophila neuromuscular junction (NMJ)...
  22. Ray R, Wharton K. Context-dependent relationships between the BMPs gbb and dpp during development of the Drosophila wing imaginal disk. Development. 2001;128:3913-25 pubmed
    The Drosophila BMP5/6/7/8 homolog, glass bottom boat (gbb), has been shown to be involved in proliferation and vein patterning in the wing disk...
  23. Dani N, Nahm M, Lee S, Broadie K. A targeted glycan-related gene screen reveals heparan sulfate proteoglycan sulfation regulates WNT and BMP trans-synaptic signaling. PLoS Genet. 2012;8:e1003031 pubmed publisher
    ..Consistently, hs6st and sulf1 nulls differentially elevate both WNT (Wingless; Wg) and BMP (Glass Bottom Boat; Gbb) ligand abundance in the synaptomatrix...
  24. Chen Y, Riese M, Killinger M, Hoffmann F. A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A. Development. 1998;125:1759-68 pubmed
    ..We also recovered mutations in the 60A gene which encodes another TGF-beta-related factor in Drosophila...
  25. Khalsa O, Yoon J, Torres Schumann S, Wharton K. TGF-beta/BMP superfamily members, Gbb-60A and Dpp, cooperate to provide pattern information and establish cell identity in the Drosophila wing. Development. 1998;125:2723-34 pubmed
    ..The Drosophila BMP gene, gbb-60A, exhibits a requirement in wing morphogenesis distinct from that shown previously for dpp, a well-characterized ..
  26. Newfeld S, Wisotzkey R, Kumar S. Molecular evolution of a developmental pathway: phylogenetic analyses of transforming growth factor-beta family ligands, receptors and Smad signal transducers. Genetics. 1999;152:783-95 pubmed
    ..We discuss these findings with respect to the coevolution of physically interacting genes. ..
  27. Ball R, Warren Paquin M, Tsurudome K, Liao E, Elazzouzi F, Cavanagh C, et al. Retrograde BMP signaling controls synaptic growth at the NMJ by regulating trio expression in motor neurons. Neuron. 2010;66:536-49 pubmed publisher
    ..We show that loss of retrograde bone morphogenic protein (BMP) signaling at the Drosophila larval neuromuscular junction (NMJ) leads to a significant reduction in ..
  28. Song X, Wong M, Kawase E, Xi R, Ding B, McCarthy J, et al. Bmp signals from niche cells directly repress transcription of a differentiation-promoting gene, bag of marbles, in germline stem cells in the Drosophila ovary. Development. 2004;131:1353-64 pubmed
    ..The niche for germline stem cells (GSCs) provides a Dpp/Bmp signal, which is essential for GSC maintenance...
  29. Allan D, St Pierre S, Miguel Aliaga I, Thor S. Specification of neuropeptide cell identity by the integration of retrograde BMP signaling and a combinatorial transcription factor code. Cell. 2003;113:73-86 pubmed
    ..There, the BMP ligand Glass bottom boat activates the Wishful thinking receptor, initiating a retrograde BMP signal in the Tv neuron...
  30. Goold C, Davis G. The BMP ligand Gbb gates the expression of synaptic homeostasis independent of synaptic growth control. Neuron. 2007;56:109-23 pubmed
    ..b>BMP signaling is necessary for normal synaptic growth and stability...
  31. O Connor Giles K, Ho L, Ganetzky B. Nervous wreck interacts with thickveins and the endocytic machinery to attenuate retrograde BMP signaling during synaptic growth. Neuron. 2008;58:507-18 pubmed publisher
    ..of the endocytic machinery, including dynamin and Dap160/intersectin, and negatively regulates retrograde BMP growth signaling through a direct interaction with the BMP receptor, thickveins...
  32. Piccioli Z, Littleton J. Retrograde BMP signaling modulates rapid activity-dependent synaptic growth via presynaptic LIM kinase regulation of cofilin. J Neurosci. 2014;34:4371-81 pubmed publisher
    ..we characterized this dynamic process and demonstrated that rapid bouton budding requires retrograde bone morphogenic protein (BMP) signaling and local alteration in the presynaptic actin cytoskeleton...
  33. Sato T, Ogata J, Niki Y. BMP and Hh signaling affects primordial germ cell division in Drosophila. Zoolog Sci. 2010;27:804-10 pubmed publisher
    ..To elucidate the roles of growth factors in larval PGC division, we examined expression patterns of a bone morphogenetic protein (BMP) growth factor, Decapentaplegic (Dpp), and Hedgehog (Hh), along with factors downstream of each, in ..
  34. Massague J, Chen Y. Controlling TGF-beta signaling. Genes Dev. 2000;14:627-44 pubmed
  35. Prpic N, Janssen R, Wigand B, Klingler M, Damen W. Gene expression in spider appendages reveals reversal of exd/hth spatial specificity, altered leg gap gene dynamics, and suggests divergent distal morphogen signaling. Dev Biol. 2003;264:119-40 pubmed
    ..Thus, the leg developmental system exhibits a propensity to evolutionary change, which probably forms the basis for the impressive diversity of arthropod leg morphologies. ..
  36. Ralston A, Blair S. Long-range Dpp signaling is regulated to restrict BMP signaling to a crossvein competent zone. Dev Biol. 2005;280:187-200 pubmed
    The sensitivity of the crossveins of the Drosophila wing to reductions in BMP signaling provides a valuable system for characterizing members of this signaling pathway. We demonstrate here two reasons for that sensitivity...
  37. Shivdasani A, Ingham P. Regulation of stem cell maintenance and transit amplifying cell proliferation by tgf-beta signaling in Drosophila spermatogenesis. Curr Biol. 2003;13:2065-72 pubmed
    ..upon their ability to transduce the activity of a somatically expressed TGF-beta ligand, the BMP5/8 ortholog Glass Bottom Boat. We further demonstrate that TGF-beta signaling represses the expression of the Bam protein, which is both ..
  38. Peterson A, O Connor M. You're going to need a bigger (glass bottom) boat. Sci Signal. 2012;5:pe14 pubmed publisher
    ..Glass bottom boat (Gbb), a Drosophila homolog of the bone morphogenetic protein 5/6/7/8 subfamily, is active as a carboxyl-terminal fragment of the proprotein (Gbb15) that is generated ..
  39. Pennetier D, Oyallon J, Morin Poulard I, Dejean S, Vincent A, Crozatier M. Size control of the Drosophila hematopoietic niche by bone morphogenetic protein signaling reveals parallels with mammals. Proc Natl Acad Sci U S A. 2012;109:3389-94 pubmed publisher
    ..Here, we show that Decapentaplegic/bone morphogenetic protein (Dpp/BMP) signaling activity in PSC cells controls niche size...
  40. Graf E, Heerssen H, Wright C, Davis G, DiAntonio A. Stathmin is required for stability of the Drosophila neuromuscular junction. J Neurosci. 2011;31:15026-34 pubmed publisher
  41. Payne C, Braun R. Glial cell line-derived neurotrophic factor maintains a POZ-itive influence on stem cells. Proc Natl Acad Sci U S A. 2006;103:9751-2 pubmed
  42. Bhadra R, Moretto M, Castillo J, Petrovas C, Ferrando Martinez S, Shokal U, et al. Intrinsic TGF-? signaling promotes age-dependent CD8+ T cell polyfunctionality attrition. J Clin Invest. 2014;124:2441-55 pubmed publisher
    ..Furthermore, elevated TGF-? levels are observed in the elderly human population and in aged Drosophila, suggesting that TGF-? represents an evolutionarily conserved negative regulator of the immune response in aging organisms. ..
  43. Verdier V, Guang Chao Chen -, Settleman J. Rho-kinase regulates tissue morphogenesis via non-muscle myosin and LIM-kinase during Drosophila development. BMC Dev Biol. 2006;6:38 pubmed
    ..These findings indicate widespread diverse roles for DRok in tissue morphogenesis during Drosophila development, in which multiple DRok substrates appear to be required. ..
  44. Nicholls R, Gelbart W. Identification of chromosomal regions involved in decapentaplegic function in Drosophila. Genetics. 1998;149:203-15 pubmed
    ..As neither of these regions has been previously implicated in dpp function, we propose that each of the deficiencies removes a novel factor or factors required for dpp function. ..
  45. Fuller M, Spradling A. Male and female Drosophila germline stem cells: two versions of immortality. Science. 2007;316:402-4 pubmed
    ..Comparing these two stem cells and their niches in detail is likely to reveal how a common heritage has been adapted to the differing requirements of male and female gamete production. ..
  46. Kawase E, Wong M, Ding B, Xie T. Gbb/Bmp signaling is essential for maintaining germline stem cells and for repressing bam transcription in the Drosophila testis. Development. 2004;131:1365-75 pubmed
    ..Here we show that Bmp signals from somatic cells are essential for maintaining GSCs in the Drosophila testis...
  47. Kirilly D, Spana E, Perrimon N, Padgett R, Xie T. BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary. Dev Cell. 2005;9:651-62 pubmed
    b>BMP signaling is essential for promoting self-renewal of mouse embryonic stem cells and Drosophila germline stem cells and for repressing stem cell proliferation in the mouse intestine and skin...
  48. Wall N, Hogan B. TGF-beta related genes in development. Curr Opin Genet Dev. 1994;4:517-22 pubmed
  49. Brummel T, Abdollah S, Haerry T, Shimell M, Merriam J, Raftery L, et al. The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development. Genes Dev. 1999;13:98-111 pubmed
    ..Babo specifically stimulates Smad2-dependent pathways to induce TGF-beta/Activin-responsive promoters but not BMP-responsive elements...
  50. Ohlstein B, Lavoie C, Vef O, Gateff E, McKearin D. The Drosophila cystoblast differentiation factor, benign gonial cell neoplasm, is related to DExH-box proteins and interacts genetically with bag-of-marbles. Genetics. 2000;155:1809-19 pubmed
    ..On the basis of known functions of DExH-box proteins, we propose that Bgcn and Bam may be involved in regulating translational events that are necessary for activation of the cystoblast differentiation program. ..
  51. Twombly V, Bangi E, Le V, Malnic B, Singer M, Wharton K. Functional analysis of saxophone, the Drosophila gene encoding the BMP type I receptor ortholog of human ALK1/ACVRL1 and ACVR1/ALK2. Genetics. 2009;183:563-79, 1SI-8SI pubmed publisher
    ..viable gain-of-function (GOF) alleles that exhibit (1) synthetic lethality in combination with mutations in BMP pathway components, and (2) significant maternal effect lethality that can be rescued by an increased dosage of the ..
  52. Pentek J, Parker L, Wu A, Arora K. Follistatin preferentially antagonizes activin rather than BMP signaling in Drosophila. Genesis. 2009;47:261-73 pubmed publisher
    ..One such regulator, Follistatin (Fst), functions as an inhibitor of both activin and bone morphogenetic protein (BMP) subfamilies of TGF-beta ligands in vertebrates...
  53. Hamada Kawaguchi N, Nore B, Kuwada Y, Smith C, Yamamoto D. Btk29A promotes Wnt4 signaling in the niche to terminate germ cell proliferation in Drosophila. Science. 2014;343:294-7 pubmed publisher
    ..This signaling mechanism likely represents a versatile developmental switch. ..
  54. Bickel D, Shah R, Gesualdi S, Haerry T. Drosophila Follistatin exhibits unique structural modifications and interacts with several TGF-beta family members. Mech Dev. 2008;125:117-29 pubmed
    ..We find that mutants of daw are rescued in significant numbers by expression of vertebrate FS proteins. Since two PiggyBac insertions in dfs are not lethal, it appears that the function of dFS is non-essential or functionally redundant. ..
  55. Schwank G, Dalessi S, Yang S, Yagi R, de Lachapelle A, Affolter M, et al. Formation of the long range Dpp morphogen gradient. PLoS Biol. 2011;9:e1001111 pubmed publisher
    ..The properties of this mechanism, in which only a minority of Dpp is receptor-bound, may facilitate long-range distribution. ..
  56. Rodal A, Motola Barnes R, Littleton J. Nervous wreck and Cdc42 cooperate to regulate endocytic actin assembly during synaptic growth. J Neurosci. 2008;28:8316-25 pubmed publisher
    ..the Drosophila larval neuromuscular junction (NMJ) and is required for regulation of synaptic growth via bone morphogenic protein signaling...
  57. Ayyaz A, Li H, Jasper H. Haemocytes control stem cell activity in the Drosophila intestine. Nat Cell Biol. 2015;17:736-48 pubmed publisher
    ..On tissue damage, haemocytes are recruited to the intestine and secrete the BMP homologue DPP, inducing ISC proliferation by activating the type I receptor Saxophone and the Smad homologue ..
  58. Sulkowski M, Han T, Ott C, Wang Q, Verheyen E, Lippincott Schwartz J, et al. A Novel, Noncanonical BMP Pathway Modulates Synapse Maturation at the Drosophila Neuromuscular Junction. PLoS Genet. 2016;12:e1005810 pubmed publisher
    At the Drosophila NMJ, BMP signaling is critical for synapse growth and homeostasis. Signaling by the BMP7 homolog, Gbb, in motor neurons triggers a canonical pathway-which modulates transcription of BMP target genes, and a noncanonical ..
  59. Barton L, Lovander K, Pinto B, Geyer P. Drosophila male and female germline stem cell niches require the nuclear lamina protein Otefin. Dev Biol. 2016;415:75-86 pubmed publisher
    ..Finally, our data add to growing evidence that LEM-D proteins have critical roles in stem cell survival and tissue homeostasis. ..
  60. Rojas Ríos P, Guerrero I, González Reyes A. Cytoneme-mediated delivery of hedgehog regulates the expression of bone morphogenetic proteins to maintain germline stem cells in Drosophila. PLoS Biol. 2012;10:e1001298 pubmed publisher
    ..the escort cells, where it activates transcription of the GSC essential factors Decapentaplegic (Dpp) and Glass bottom boat (Gbb)...
  61. Baumgardt M, Miguel Aliaga I, Karlsson D, Ekman H, Thor S. Specification of neuronal identities by feedforward combinatorial coding. PLoS Biol. 2007;5:e37 pubmed
    ..These results indicate that a limited number of regulators may constitute a potent combinatorial code that dictates unique neuronal cell fate, and that such codes show a surprising disregard for many global instructive cues. ..
  62. Hoffmann F. Transforming growth factor-beta-related genes in Drosophila and vertebrate development. Curr Opin Cell Biol. 1991;3:947-52 pubmed
    ..They exhibit elaborate patterns of expression during development, and the protein products have potent effects on the differentiation of specific cell types. ..
  63. Sawala A, Sutcliffe C, Ashe H. Multistep molecular mechanism for bone morphogenetic protein extracellular transport in the Drosophila embryo. Proc Natl Acad Sci U S A. 2012;109:11222-7 pubmed publisher
    In the Drosophila embryo, formation of a bone morphogenetic protein (BMP) morphogen gradient requires transport of a heterodimer of the BMPs Decapentaplegic (Dpp) and Screw (Scw) in a protein shuttling complex...
  64. Jensen P, Zheng X, Lee T, O Connor M. The Drosophila Activin-like ligand Dawdle signals preferentially through one isoform of the Type-I receptor Baboon. Mech Dev. 2009;126:950-7 pubmed publisher
    ..These results reveal a mechanism by which distinct cell types can discriminate between different Activin-type signals during development as a result of differential expression of Type-I receptor isoforms. ..
  65. Nakayama T, Cui Y, Christian J. Regulation of BMP/Dpp signaling during embryonic development. Cell Mol Life Sci. 2000;57:943-56 pubmed
    b>Bone morphogenetic protein-4 (BMP-4) and its Drosophila ortholog, decapentaplegic (Dpp), are multifunctional developmental regulators...
  66. Yu J, He X, Chen Y, Hao Y, Yang S, Wang L, et al. Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins. J Biol Chem. 2013;288:79-88 pubmed publisher
    ..regulators at different layers of the receptor-effectors axis have been identified, the mechanisms of homeostatic BMP signaling remain vague...
  67. Beckwith E, Gorostiza E, Berni J, Rezaval C, Pérez Santángelo A, Nadra A, et al. Circadian period integrates network information through activation of the BMP signaling pathway. PLoS Biol. 2013;11:e1001733 pubmed publisher
    ..Here we show that the BONE MORPHOGENETIC PROTEIN (BMP) signaling pathway plays a crucial role in setting the circadian period in PDF neurons in the adult ..
  68. Haines N, van den Heuvel M. A directed mutagenesis screen in Drosophila melanogaster reveals new mutants that influence hedgehog signaling. Genetics. 2000;156:1777-85 pubmed
    ..Another mutation affects a possible Hedgehog autoregulation mechanism, which stabilizes the same boundary. ..