Gap1

Summary

Gene Symbol: Gap1
Description: GTPase-activating protein 1
Alias: CG6721, Dmel\CG6721, GAP, GAP1, Gap, Gap 1, Ras-GAP, gap, gap1, mip, rI533, rasGAP, sxt, CG6721-PA, CG6721-PB, CG6721-PC, GTPase activating protein 1, GTPase activating protein1, Gap1-PA, Gap1-PB, Gap1-PC, more inner photoreceptors, seven extra, sextra
Species: fruit fly

Top Publications

  1. ncbi Homeotic proboscipedia cell identity functions respond to cell signaling pathways along the proximo-distal axis
    M Boube
    Centre de Biologie du Développement CNRS, Toulouse, France
    Int J Dev Biol 42:431-6. 1998
  2. ncbi phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila
    H C Chang
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley 94720 3200
    Cell 80:463-72. 1995
  3. ncbi The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling
    A Bergmann
    Massachusetts Institute of Technology, Howard Hughes Medical Institute, Department of Biology, Cambridge 02139, USA
    Cell 95:331-41. 1998
  4. ncbi A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase
    U Gaul
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Cell 68:1007-19. 1992
  5. pmc Identification of chromosome inheritance modifiers in Drosophila melanogaster
    K W Dobie
    Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genetics 157:1623-37. 2001
  6. pmc A gain-of-function germline mutation in Drosophila ras1 affects apoptosis and cell fate during development
    Christopher Gafuik
    Howard Hughes Medical Institute, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 6:e23535. 2011
  7. pmc 14-3-3ε couples protein kinase A to semaphorin signaling and silences plexin RasGAP-mediated axonal repulsion
    Taehong Yang
    Departments of Neuroscience and Pharmacology and Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 74:108-21. 2012
  8. ncbi The cell adhesion molecule Echinoid defines a new pathway that antagonizes the Drosophila EGF receptor signaling pathway
    J Bai
    Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan 30043, Republic of China
    Development 128:591-601. 2001
  9. pmc Fibroblast growth factor receptor-dependent morphogenesis of the Drosophila mesoderm
    R Wilson
    Institute of Genetics, University of Cologne, Germany
    Philos Trans R Soc Lond B Biol Sci 355:891-5. 2000
  10. ncbi D-cbl, a negative regulator of the Egfr pathway, is required for dorsoventral patterning in Drosophila oogenesis
    L M Pai
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Cell 103:51-61. 2000

Research Grants

Scientific Experts

  • Jose A Botella
  • DAVID BEGUN
  • P Rørth
  • Margaret J Sonnenfeld
  • N Perrimon
  • Taehong Yang
  • Christopher Gafuik
  • Sarah C Nicholson
  • Kimihiko Oishi
  • Hao A Duong
  • Nicolas Loncle
  • James A Walker
  • Caroline Baril
  • Nam Sung Moon
  • Clemens Cabernard
  • M Boube
  • Viola Gesellchen
  • J B Duffy
  • Hong Joo Kim
  • G M Rubin
  • Shweta Chandra
  • A Bernards
  • Y Zhong
  • Véronique Monnier
  • David del Alamo
  • M Okabe
  • M Freeman
  • J A Williams
  • J Bai
  • K W Dobie
  • Jonathan R Terman
  • I The
  • Hermann Steller
  • R Wilson
  • L M Pai
  • H Robertson
  • C Pazman
  • S J Boulton
  • Natalie Pica
  • In Kyong Kim
  • Cindy J Wang
  • Kenneth H Moberg
  • Brandon N Nicolay
  • Maxim V Frolov
  • Hui Zhang
  • Cheryl C Tan
  • Bruce D Gelb
  • M Melissa Gilbert
  • William J Gault
  • Huiwen Ying
  • Marco Tartaglia
  • Marek Mlodzik
  • Tabassum Rahman
  • S J Leevers
  • Albert J Courey
  • S Kramer
  • T Casci
  • A Baonza
  • Cheng W Wang
  • A C Powe
  • Girish Ratnaparkhi
  • Raghavendra Nagaraj
  • Y Henry Sun
  • Claire Boschiero
  • Laurent Joulia
  • David L Cribbs
  • Michel Werner
  • Henri Marc Bourbon
  • Muriel Boube
  • A Bergmann
  • Iswar K Hariharan
  • Peter T McKenney
  • Luisa Di Stefano
  • Marc Therrien
  • Dongyun Wu
  • T P Neufeld
  • Suzanne Brill
  • Nicholas Dyson
  • Glenn S Cowley
  • Anna V Tchoudakova
  • T Hayashi
  • P Meier
  • Y Yagi
  • Andre Bernards
  • Markus Affolter
  • David Kuttenkeuler
  • U Gaul
  • Y Hiromi
  • Michael Steckel
  • Michael Boutros

Detail Information

Publications72

  1. ncbi Homeotic proboscipedia cell identity functions respond to cell signaling pathways along the proximo-distal axis
    M Boube
    Centre de Biologie du Développement CNRS, Toulouse, France
    Int J Dev Biol 42:431-6. 1998
    ..This response for pb implicates at least two signal transduction pathways, those involving Ras1 and Notch...
  2. ncbi phyllopod functions in the fate determination of a subset of photoreceptors in Drosophila
    H C Chang
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley 94720 3200
    Cell 80:463-72. 1995
    ..phyl is also required for embryonic nervous system and sensory bristle development...
  3. ncbi The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling
    A Bergmann
    Massachusetts Institute of Technology, Howard Hughes Medical Institute, Department of Biology, Cambridge 02139, USA
    Cell 95:331-41. 1998
    ..These findings define a novel mechanism by which growth factor signaling directly inactivates a critical component of the intrinsic cell death machinery. These studies provide further insights into the function of ras as an oncogene...
  4. ncbi A putative Ras GTPase activating protein acts as a negative regulator of signaling by the Sevenless receptor tyrosine kinase
    U Gaul
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Cell 68:1007-19. 1992
    ..Inactivation of the locus, Gap1, mimics constitutive activation of the Sevenless receptor tyrosine kinase and eliminates the need for a functional ..
  5. pmc Identification of chromosome inheritance modifiers in Drosophila melanogaster
    K W Dobie
    Molecular Biology and Virology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genetics 157:1623-37. 2001
    ..Further, lethal insertions in replication factor complex 4 (rfc4) and GTPase-activating protein 1 (Gap1) exhibit specific mitotic chromosome defects, discovering previously unknown roles for these proteins in chromosome ..
  6. pmc A gain-of-function germline mutation in Drosophila ras1 affects apoptosis and cell fate during development
    Christopher Gafuik
    Howard Hughes Medical Institute, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 6:e23535. 2011
    ..II region of Ras causes a defective protein with reduced intrinsic GTPase activity, but with normal sensitivity to GAP stimulation...
  7. pmc 14-3-3ε couples protein kinase A to semaphorin signaling and silences plexin RasGAP-mediated axonal repulsion
    Taehong Yang
    Departments of Neuroscience and Pharmacology and Neuroscience Graduate Program, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 74:108-21. 2012
    ..Plexins are Ras/Rap family GTPase activating proteins (GAPs) and we find that the PlexA GAP domain is phosphorylated by the cAMP-dependent protein kinase (PKA)...
  8. ncbi The cell adhesion molecule Echinoid defines a new pathway that antagonizes the Drosophila EGF receptor signaling pathway
    J Bai
    Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan 30043, Republic of China
    Development 128:591-601. 2001
    ..Together, our results support a model whereby ED defines an independent pathway that antagonizes EGFR signaling by regulating the activity, but not the level, of the TTK88 transcriptional repressor...
  9. pmc Fibroblast growth factor receptor-dependent morphogenesis of the Drosophila mesoderm
    R Wilson
    Institute of Genetics, University of Cologne, Germany
    Philos Trans R Soc Lond B Biol Sci 355:891-5. 2000
    ..Analysis of the function of dof, which encodes a cytoplasmic protein required for FGF signal transduction may provide an insight into these issues...
  10. ncbi D-cbl, a negative regulator of the Egfr pathway, is required for dorsoventral patterning in Drosophila oogenesis
    L M Pai
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    Cell 103:51-61. 2000
    ..In addition, Egfr activity has to be repressed through the activity of D-cbl to ensure the absence of signaling in the ventral most follicle cells...
  11. pmc A role for Ebi in neuronal cell cycle control
    S J Boulton
    MGH Cancer Center, Laboratory of Molecular Oncology and Department of Pathology, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    EMBO J 19:5376-86. 2000
    ..We conclude that Ebi has two distinct functions; it promotes the degradation of a repressor of neuronal differentiation (Ttk88), and has a second independent function that limits S phase entry...
  12. ncbi A Drosophila analogue of v-Cbl is a dominant-negative oncoprotein in vivo
    H Robertson
    Trescowthick Research Laboratories, Peter MacCallum Cancer Institute, Melbourne, Vic, Australia
    Oncogene 19:3299-308. 2000
    ....
  13. ncbi Rasputin, the Drosophila homologue of the RasGAP SH3 binding protein, functions in ras- and Rho-mediated signaling
    C Pazman
    LMG, NICHD, NIH, MSC 2785, Bethesda, MD 20892, USA
    Development 127:1715-25. 2000
    ..Ras activity is negatively regulated by GTPase activating proteins (GAPs). It has been proposed that RasGAP may also function as an effector of Ras activity...
  14. ncbi What goes up must come down
    S J Leevers
    Nat Cell Biol 1:E10-1. 1999
  15. ncbi In vivo functional analysis of Drosophila Gap1: involvement of Ca2+ and IP4 regulation
    A C Powe
    Laboratory of Developmental Neurogenetics, The Rockefeller University, New York, NY 10021, USA
    Mech Dev 81:89-101. 1999
    ..Here we report the structural requirements for Gap1 activity in cone cell fate decisions during Drosophila eye development...
  16. ncbi Sprouty: a common antagonist of FGF and EGF signaling pathways in Drosophila
    S Kramer
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Development 126:2515-25. 1999
    ..These receptor tyrosine kinase-mediated pathways may share not only intracellular signaling components but also extracellular factors that modulate the strength of the signal...
  17. ncbi Sprouty, an intracellular inhibitor of Ras signaling
    T Casci
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Cell 96:655-65. 1999
    ..Sprouty binds to two intracellular components of the Ras pathway, Drk and Gap1. Our results indicate that Sprouty is a widespread inhibitor of Ras pathway signal transduction.
  18. ncbi Dual role of extramacrochaetae in cell proliferation and cell differentiation during wing morphogenesis in Drosophila
    A Baonza
    Centro de Biologia Molecular Severo Ochoa, Cantoblanco 28049, Madrid, Spain
    Mech Dev 80:133-46. 1999
    ..development reveal strong genetic interactions with genes of the Ras signalling pathway (torpedo, vein, veinlet and Gap), blistered, plexus and net, in both adult wing phenotypes and cell behaviour in genetic mosaics...
  19. ncbi Dying like flies
    P Meier
    Imperial Cancer Research Fund, London, United Kingdom
    Cell 95:295-8. 1998
  20. ncbi Interaction between Drosophila EGF receptor and vnd determines three dorsoventral domains of the neuroectoderm
    Y Yagi
    Laboratory of Neurobiophysics, School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Development 125:3625-33. 1998
    ..Thus nested expression of vnd and the DER activator rhomboid is crucial to subdivide the neuroectoderm into the three dorsoventral domains...
  21. ncbi Specification of primary pigment cell and outer photoreceptor fates by BarH1 homeobox gene in the developing Drosophila eye
    T Hayashi
    Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Dev Biol 200:131-45. 1998
    ....
  22. ncbi Alphabet, a Ser/Thr phosphatase of the protein phosphatase 2C family, negatively regulates RAS/MAPK signaling in Drosophila
    Caroline Baril
    Institute for Research in Immunology and Cancer, Laboratory of Intracellular Signaling, Universite de Montreal, C P 6128 Succursale Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Dev Biol 294:232-45. 2006
    ..Finally, despite the relatively large size of the PP2C gene family in metazoans, this study represents only the second genetic characterization of a PP2C in these organisms...
  23. ncbi Spitz/EGFr signalling via the Ras/MAPK pathway mediates the induction of bract cells in Drosophila legs
    David del Alamo
    Centro de Biología Molecular Severo Ochoa C S I C, Facultad de Ciencias CV, Universidad Autónoma Cantoblanco, 28049 Madrid, Spain
    Development 129:1975-82. 2002
    ..We have also studied the role of the poxn gene in the inhibition of bract induction in chemosensory bristles...
  24. pmc The archipelago tumor suppressor gene limits rb/e2f-regulated apoptosis in developing Drosophila tissues
    Sarah C Nicholson
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Biol 19:1503-10. 2009
    ..Its human ortholog, Fbw7, is commonly lost in cancers, suggesting that failure to degrade ago/Fbw7 targets drives excess tissue growth...
  25. pmc Phosphatase-defective LEOPARD syndrome mutations in PTPN11 gene have gain-of-function effects during Drosophila development
    Kimihiko Oishi
    Department of Pediatrics and the Center for Molecular Cardiology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Hum Mol Genet 18:193-201. 2009
    ....
  26. pmc Non-cell-autonomous inhibition of photoreceptor development by Dip3
    Hao A Duong
    Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E Young Drive, East, Los Angeles, CA 90095 1569, USA
    Dev Biol 323:105-13. 2008
    ....
  27. pmc Population genomics: whole-genome analysis of polymorphism and divergence in Drosophila simulans
    David J Begun
    Department of Evolution and Ecology, University of California Davis, Davis, California, United States of America
    PLoS Biol 5:e310. 2007
    ..simulans...
  28. pmc Distinct roles for Mediator Cdk8 module subunits in Drosophila development
    Nicolas Loncle
    Centre de Biologie du Developpement, UMR5544 du CNRS, Universite Paul Sabatier, Toulouse Cedex 09, France
    EMBO J 26:1045-54. 2007
    ..These data reveal functional attributes of the Cdk8 module, apart from its regulated kinase activity, that may contribute to the diversification of genetic programs...
  29. pmc Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons
    James A Walker
    Massachusetts General Hospital Center for Cancer Research and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Genes Dev 20:3311-23. 2006
    ..a large and highly conserved protein whose only known function is to serve as a GTPase-Activating Protein (GAP) for Ras...
  30. pmc A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis
    Nam Sung Moon
    Massachusetts General Hospital Cancer Research Center, Harvard Medical School, Building 149, Charlestown, MA 02129, USA
    Mol Cell Biol 26:7601-15. 2006
    ..rbf1 mutant cells is suppressed by the activation of DER, ras, or raf or by the inactivation of argos, sprouty, or gap1, and inhibition of DER strongly enhances apoptosis in rbf1 mutant discs...
  31. ncbi Mediation of PACAP-like neuropeptide transmission by coactivation of Ras/Raf and cAMP signal transduction pathways in Drosophila
    Y Zhong
    Cold Spring Harbor Laboratory, New York 11724, USA
    Nature 375:588-92. 1995
    ..Thus the Ras/Raf pathway also appears to be essential for G-protein-coupled neurotransmission...
  32. ncbi Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila
    Clemens Cabernard
    Department of Biology, Biozentrum der Universitat Basel, Klingelbergstrasse 70, CH 4056 Basel, Switzerland
    Dev Cell 9:831-42. 2005
    ..Ras and the Mapk pathway are also needed for Egf-regulated cell division/survival, but Pointed is dispensable...
  33. pmc An RNA interference screen identifies Inhibitor of Apoptosis Protein 2 as a regulator of innate immune signalling in Drosophila
    Viola Gesellchen
    German Cancer Research Center DKFZ, Boveri Group Signaling and Functional Genomics, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    EMBO Rep 6:979-84. 2005
    ..Our results indicate that IAP gene family members may have acquired other functions, such as the regulation of the tumour necrosis factor-like IMD pathway during innate immune responses...
  34. ncbi Modulation of signalling by Sprouty: a developing story
    Hong Joo Kim
    Graduate Program in Molecular and Cellular Biology, State University of New York, Stony Brook, New York 11794 5222, USA
    Nat Rev Mol Cell Biol 5:441-50. 2004
  35. ncbi The Drosophila IgC2 domain protein Friend-of-Echinoid, a paralogue of Echinoid, limits the number of sensory organ precursors in the wing disc and interacts with the Notch signaling pathway
    Shweta Chandra
    Molecular, Cellular and Developmental Biology Program, The Ohio State University, Columbus, OH 43210, USA
    Dev Biol 256:302-16. 2003
    ..Thus, fred acts in close concert with the Notch signaling pathway. Dosage-sensitive genetic interaction also suggests a close relationship between fred and ed...
  36. ncbi Control of oxidative stress resistance by IP3 kinase in Drosophila melanogaster
    Véronique Monnier
    Institut Jacques Monod, Universite Paris, France
    Free Radic Biol Med 33:1250-9. 2002
    ....
  37. ncbi Identifying loci required for follicular patterning using directed mosaics
    J B Duffy
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, MA 02115, USA
    Development 125:2263-71. 1998
    ..Finally, using different UAS-FLP, GAL4 and existing FRT lines, we have built stocks that permit the analysis of approximately 95% of the genome in follicular mosaics...
  38. ncbi Competition and position-dependent targeting in the development of the Drosophila R7 visual projections
    J A Ashley
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235 9038
    Development 120:1537-47. 1994
    ..The more inner photoreceptors mutation, an allele of gap1, results in the differentiation of excess R7s in the eye, whose axons invade ..
  39. ncbi Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila
    E Hafen
    Zoologisches Institut, Universitat Zurich, Switzerland
    Philos Trans R Soc Lond B Biol Sci 340:273-8. 1993
    ..In contrast to the receptor and its ligand, these components are shared between different signal transduction pathways not only in Drosophila but are also homologous to components involved in signal transduction in other organisms...
  40. ncbi Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila
    N Perrimon
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115
    Curr Opin Cell Biol 6:260-6. 1994
    ..In addition to molecules previously identified from vertebrate studies, i.e. Grb2, Sos, Ras-Gap, p21ras, Raf, MEK and MAPK, genetic studies have suggested that two novel proteins, the protein tyrosine ..
  41. ncbi Characterization of Star and its interactions with sevenless and EGF receptor during photoreceptor cell development in Drosophila
    A L Kolodkin
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Development 120:1731-45. 1994
    ..Based on the genetic interactions with Sos, we suggest that Star also has a later role in photoreceptor development including the recruitment of the R7 cell through the sevenless pathway...
  42. ncbi Signal transduction in the early Drosophila embryo: when genetics meets biochemistry
    N Perrimon
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, MA 02115
    Trends Biochem Sci 19:509-13. 1994
    ..This pathway involves a membrane-bound receptor tyrosine kinase (RTK) that is similar to other Drosophila RTKs, such as sevenless, and the mammalian RTKs, such as the epidermal growth factor or platelet-derived growth factor receptors...
  43. ncbi The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor
    M Freeman
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Mech Dev 48:25-33. 1994
    ..These data suggest that photoreceptors other than R7 use a Ras1 signalling pathway activated by the spitz/Egfr interaction, in a manner analogous to the Ras1 pathway activated by boss/sevenless in photoreceptor R7...
  44. ncbi The Ras signaling pathway in Drosophila
    D A Wassarman
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California at Berkeley 94720 3200, USA
    Curr Opin Genet Dev 5:44-50. 1995
    ..The Ras cascade functions in other Drosophila signal transduction pathways, eliciting a distinct response in each case, presumably through phosphorylation of specific transcription factors...
  45. ncbi The torso receptor tyrosine kinase can activate Raf in a Ras-independent pathway
    X S Hou
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 81:63-71. 1995
    ..Our study provides in vivo evidence that Raf can be activated by an RTK in a Ras-independent pathway...
  46. ncbi Inhibition of Drosophila EGF receptor activation by the secreted protein Argos
    R Schweitzer
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    Nature 376:699-702. 1995
    ..Thus the determination of cells by the DER pathway is regulated by a balance between extracellular activating and inhibiting signals. This is the first in vivo example of an extracellular inhibitor of a receptor tyrosine kinase...
  47. ncbi mip causes hyperinnervation of a retinotopic map in Drosophila by excessive recruitment of R7 photoreceptor cells
    G R Buckles
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235
    Neuron 8:1015-29. 1992
    ..Using this technique, we have identified a new mutant, mip (more inner photoreceptors), in which this map shows a striking hyperinnervation...
  48. pmc Neuronal development in the Drosophila retina: the sextra gene defines an inhibitory component in the developmental pathway of R7 photoreceptor cells
    R Rogge
    Department of Biology, University of California, Los Angeles 90024
    Proc Natl Acad Sci U S A 89:5271-5. 1992
    Mutations in a gene called sextra (sxt) have been isolated...
  49. ncbi Negative control of photoreceptor development in Drosophila by the product of the yan gene, an ETS domain protein
    Z C Lai
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Cell 70:609-20. 1992
    ..Our data suggest that yan functions as a cell-autonomous negative regulator of photoreceptor development; in the presumptive R7 and cone cells, yan appears to act antagonistically to the proneural signal mediated by sevenless and Ras1...
  50. ncbi Ectopic expression of seven-up causes cell fate changes during ommatidial assembly
    Y Hiromi
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Development 118:1123-35. 1993
    ..Our results also suggest that seven-up controls decisions not only between photoreceptor subtypes, but also between neuronal and non-neuronal fates...
  51. ncbi Rescue of a Drosophila NF1 mutant phenotype by protein kinase A
    I The
    Massachusetts General Hospital Cancer Center and Harvard Medical School Building 149, 13th Street, Charlestown, MA 02129, USA
    Science 276:791-4. 1997
    ..Thus, NF1 and PKA appear to interact in a pathway that controls the overall growth of Drosophila...
  52. pmc Ras1-mediated modulation of Drosophila homeotic function in cell and segment identity
    M Boube
    CBD CNRS, Toulouse, France
    Genetics 146:619-28. 1997
    ..Two identified interacting genes were the proto-oncogene Ras1 and its functional antagonist Gap1, prominent intermediaries in known signal transduction pathways...
  53. pmc Identification of genes required for Drosophila eye development using a phenotypic enhancer-trap
    F Pignoni
    Howard Hughes Medical Institute, School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 94:9220-5. 1997
    ..boss reporter gene in multiple cells assessed for homozygous mutant phenotypes, insertions in the marbles, glass, gap1, and fasciclin II genes were isolated...
  54. ncbi Two-step induction of chordotonal organ precursors in Drosophila embryogenesis
    M Okabe
    Department of Molecular Neurobiology, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Development 124:1045-53. 1997
    ..Three of these argos-expressing cells differentiate into the three remaining COPs and they prevent neighboring cells from becoming extra COPs...
  55. pmc A modular misexpression screen in Drosophila detecting tissue-specific phenotypes
    P Rørth
    Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210, USA
    Proc Natl Acad Sci U S A 93:12418-22. 1996
    ..Thus, biologically relevant phenotypes and genetic interactions are identified using this method. The screen is a powerful new tool for developmental genetics; similar approaches can also be developed for other organisms...
  56. ncbi Recent advances in understanding signal transduction pathways in worms and flies
    J B Duffy
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Alpert Building, 200 Longwood Avenue, Boston, MA 02115, USA
    Curr Opin Cell Biol 8:231-8. 1996
    ..Current work in both systems has provided new opportunities to investigate the potential for the cross-talk between these different signaling pathways...
  57. ncbi Requirement of Drosophila NF1 for activation of adenylyl cyclase by PACAP38-like neuropeptides
    H F Guo
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Science 276:795-8. 1997
    ..NF1 appears to regulate the rutabaga-encoded adenylyl cyclase rather than the Ras-Raf pathway. Moreover, the NF1 defect was rescued by the exposure of cells to pharmacological treatment that increased concentrations of cAMP...
  58. ncbi The division abnormally delayed (dally) gene: a putative integral membrane proteoglycan required for cell division patterning during postembryonic development of the nervous system in Drosophila
    H Nakato
    ARL Division of Neurobiology, University of Arizona, Tucson 85721, USA
    Development 121:3687-702. 1995
    ..The cell division defects found in dally mutants implicate the Glypican group of integral membrane proteoglycans in the control of cell division during development...
  59. ncbi The sidekick gene, a member of the immunoglobulin superfamily, is required for pattern formation in the Drosophila eye
    D N Nguyen
    Albert Einstein College of Medicine, Department of Developmental and Molecular Biology, Bronx, NY 10461, USA
    Development 124:3303-12. 1997
    ..The protein structure is consistent with its participation in cell-cell interaction during eye development...
  60. ncbi The Drosophila 14-3-3 protein Leonardo enhances Torso signaling through D-Raf in a Ras 1-dependent manner
    W Li
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Development 124:4163-71. 1997
    ..We propose that binding to 14-3-3 by Raf is necessary but not sufficient for the activation of Raf and that overexpressed Drosophila 14-3-3 requires Ras1 to activate D-Raf...
  61. ncbi Autosomal P[ovoD1] dominant female-sterile insertions in Drosophila and their use in generating germ-line chimeras
    T B Chou
    Howard Hughes Medical Institute, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Development 119:1359-69. 1993
    ..Specifically, we show that the Gap1 gene, which encodes a Drosophila homologue of mammalian GTPase-activating protein, is required in somatic follicle ..
  62. pmc A genetic screen to identify components of the sina signaling pathway in Drosophila eye development
    T P Neufeld
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720 3200, USA
    Genetics 148:277-86. 1998
    ....
  63. ncbi Reassessment of the effect of biological rhythm mutations on learning in Drosophila melanogaster
    D A Gailey
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254
    J Comp Physiol A 169:685-97. 1991
    ..From the perspective of learning theory, this can be viewed as a savings experiment...
  64. ncbi Signal transduction during the development of the Drosophila R7 photoreceptor
    M A Simon
    Department of Biological Sciences, Stanford University, California 94305 5020
    Dev Biol 166:431-42. 1994
  65. ncbi Signal transduction--a conserved pathway from the membrane to the nucleus
    T Pawson
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada
    Dev Genet 14:333-8. 1993
  66. ncbi Signal transduction pathway initiated by activation of the sevenless tyrosine kinase receptor
    M A Simon
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Cold Spring Harb Symp Quant Biol 57:375-80. 1992
  67. ncbi Neuronal development in the Drosophila retina
    T Venkatesh
    Department of Biology, City College, City University of New York, New York 10031
    J Neurobiol 24:740-56. 1993
    ..Recent genetic and molecular studies have provided important clues regarding the nature of the molecules involved in cellular signalling and neuronal differentiation...
  68. ncbi A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK
    J A Williams
    Howard Hughes Medical Institute, Center for Sleep and Respiratory Neurobiology, Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 293:2251-6. 2001
    ....
  69. ncbi Positive and negative signaling mechanisms in the regulation of photoreceptor induction in the developing Drosophila retina. Review
    D Yamamoto
    Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Genetica 88:153-64. 1993
    ..Pokkuri-mediated repression represents one such regulatory mechanism. The positive and negative signaling pathways operating in the fate determination of other photoreceptor cells are also discussed...

Research Grants6

  1. Natural variation in Drosophila female postmating traits
    DAVID BEGUN; Fiscal Year: 2007
    ..The proposed research aims to begin filling this basic gap in our understanding of Drosophila females...
  2. Genomic analysis of adaptation in Drosophila
    David J Begun; Fiscal Year: 2010
    ..These approaches could eventually be used in human populations. ..