Galphaq

Summary

Gene Symbol: Galphaq
Description: G protein alpha q subunit
Alias: CG17759, DGalpha[[q]], DGalphaq, DGq, DGqalpha, Dgq, DmGalpha[[q]], Dmel\CG17759, Dromel_CG17759_galpha49b_mORF, G alpha 49B, GNAQ/11/14, G[[alphaq]], G[[q]]alpha, G[[qalpha]], Galpha, Galpha49B, Galpha49b, Galpha[[q]], Gaq, Gq/11, Gqa-3, Gqalpha, Gqalpha[[e]], Gqalphae, Gqalpha{e}, dG[[alphaq]], dG[[q]]alpha, dGaalpha, dGq, dGqa-49b, dGqalpha, dGqalpha-3, dGqalpha-49b, dgq, dgqalpha, galpha49B, sast, G protein alpha q subunit, CG17759-PA, CG17759-PC, CG17759-PD, CG17759-PE, CG17759-PG, CG17759-PJ, CG17759-PK, G protein 49B, G protein alpha49B, G-protein alpha subunit, G-protein alpha49B, G-protein-alpha[[q]], Galphaq-PA, Galphaq-PC, Galphaq-PD, Galphaq-PE, Galphaq-PG, Galphaq-PJ, Galphaq-PK, small amplify and slow termination
Species: fruit fly

Top Publications

  1. Kalidas S, Smith D. Novel genomic cDNA hybrids produce effective RNA interference in adult Drosophila. Neuron. 2002;33:177-84 pubmed
    ..We targeted three Drosophila genes: lush, white, and dGq(alpha)...
  2. Kopein D, Katanaev V. Drosophila GoLoco-protein Pins is a target of Galpha(o)-mediated G protein-coupled receptor signaling. Mol Biol Cell. 2009;20:3865-77 pubmed publisher
    ..GPCRs) transduce their signals through trimeric G proteins, inducing guanine nucleotide exchange on their Galpha-subunits; the resulting Galpha-GTP transmits the signal further inside the cell...
  3. Alvarez C, Robison K, Gilbert W. Novel Gq alpha isoform is a candidate transducer of rhodopsin signaling in a Drosophila testes-autonomous pacemaker. Proc Natl Acad Sci U S A. 1996;93:12278-82 pubmed
    b>DGq is the alpha subunit of the heterotrimeric GTPase (G alpha), which couples rhodopsin to phospholipase C in Drosophila vision...
  4. Voolstra O, Bartels J, Oberegelsbacher C, Pfannstiel J, Huber A. Phosphorylation of the Drosophila transient receptor potential ion channel is regulated by the phototransduction cascade and involves several protein kinases and phosphatases. PLoS ONE. 2013;8:e73787 pubmed publisher
    ..A candidate screen to identify kinases and phosphatases provided in vivo evidence for an involvement of eye-PKC as well as other kinases and phosphatases in TRP phosphorylation. ..
  5. Cronin M, Diao F, Tsunoda S. Light-dependent subcellular translocation of Gqalpha in Drosophila photoreceptors is facilitated by the photoreceptor-specific myosin III NINAC. J Cell Sci. 2004;117:4797-806 pubmed
  6. Scott K, Becker A, Sun Y, Hardy R, Zuker C. Gq alpha protein function in vivo: genetic dissection of its role in photoreceptor cell physiology. Neuron. 1995;15:919-27 pubmed
    ..rhodopsin to PLC, and to study its function, we isolated a mutant defective in a photoreceptor-specific Gq protein, DGq. We now demonstrate that Gq is essential for the activation of the phototransduction cascade in vivo...
  7. Shen W, Kwon Y, Adegbola A, Luo J, Chess A, Montell C. Function of rhodopsin in temperature discrimination in Drosophila. Science. 2011;331:1333-6 pubmed publisher
    ..We propose that rhodopsins represent a class of evolutionarily conserved GPCRs that are required for initiating thermosensory signaling cascades. ..
  8. Zuker C. The biology of vision of Drosophila. Proc Natl Acad Sci U S A. 1996;93:571-6 pubmed
    ..In this manuscript I review some of our recent findings and the strategies used to dissect this process. ..
  9. Wes P, Xu X, Li H, Chien F, Doberstein S, Montell C. Termination of phototransduction requires binding of the NINAC myosin III and the PDZ protein INAD. Nat Neurosci. 1999;2:447-53 pubmed
    ..Disruption of the NINAC/INAD interaction delayed termination of the photoreceptor response. Thus one role of this signaling complex is in rapid deactivation of the photoresponse. ..

More Information

Publications82

  1. Chyb S, Raghu P, Hardie R. Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL. Nature. 1999;397:255-9 pubmed
    ..As arachidonic acid may not be found in Drosophila, we suggest that another polyunsaturated fatty acid, such as linolenic acid, may be a messenger of excitation in Drosophila photoreceptors. ..
  2. Kwon Y, Shim H, Wang X, Montell C. Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade. Nat Neurosci. 2008;11:871-3 pubmed publisher
    ..We propose that activation of TRPA1 through a signaling cascade promotes amplification of small differences in temperature and facilitates adaptation to temperatures within the comfortable range. ..
  3. Hardie R, Gu Y, Martin F, Sweeney S, Raghu P. In vivo light-induced and basal phospholipase C activity in Drosophila photoreceptors measured with genetically targeted phosphatidylinositol 4,5-bisphosphate-sensitive ion channels (Kir2.1). J Biol Chem. 2004;279:47773-82 pubmed
  4. Voolstra O, Beck K, Oberegelsbacher C, Pfannstiel J, Huber A. Light-dependent phosphorylation of the drosophila transient receptor potential ion channel. J Biol Chem. 2010;285:14275-84 pubmed publisher
    ..Light-dependent changes in the phosphorylation state of this site occurred within minutes. The dephosphorylation of TRP at Ser(936) required activation of the phototransduction cascade. ..
  5. Talluri S, Bhatt A, Smith D. Identification of a Drosophila G protein alpha subunit (dGq alpha-3) expressed in chemosensory cells and central neurons. Proc Natl Acad Sci U S A. 1995;92:11475-9 pubmed
    We have identified another Drosophila GTP-binding protein (G protein) alpha subunit, dGq alpha-3...
  6. Lee Y, Dobbs M, Verardi M, Hyde D. dgq: a drosophila gene encoding a visual system-specific G alpha molecule. Neuron. 1990;5:889-98 pubmed
    We describe the isolation and preliminary characterization of a new G alpha gene (dgq) in Drosophila...
  7. Kain P, Chakraborty T, Sundaram S, Siddiqi O, Rodrigues V, Hasan G. Reduced odor responses from antennal neurons of G(q)alpha, phospholipase Cbeta, and rdgA mutants in Drosophila support a role for a phospholipid intermediate in insect olfactory transduction. J Neurosci. 2008;28:4745-55 pubmed publisher
    ..We show that mutations in the Drosophila gene for G(q)alpha (dgq) significantly reduce both the amplitude of the field potentials recorded from the whole antenna in responses to ..
  8. Lee S, Montell C. Suppression of constant-light-induced blindness but not retinal degeneration by inhibition of the rhodopsin degradation pathway. Curr Biol. 2004;14:2076-85 pubmed
    ..Our results support a model in which visual impairment caused by continuous illumination occurs through an arrestin-dependent pathway that promotes degradation of rhodopsin. ..
  9. Ratnaparkhi A, Banerjee S, Hasan G. Altered levels of Gq activity modulate axonal pathfinding in Drosophila. J Neurosci. 2002;22:4499-508 pubmed
    ..We have explored the role of a G-protein, Galphaq, in altering this balance in Drosophila...
  10. Ni J, Liu L, Binari R, Hardy R, Shim H, Cavallaro A, et al. A Drosophila resource of transgenic RNAi lines for neurogenetics. Genetics. 2009;182:1089-100 pubmed publisher
  11. Banerjee S, Joshi R, Venkiteswaran G, Agrawal N, Srikanth S, Alam F, et al. Compensation of inositol 1,4,5-trisphosphate receptor function by altering sarco-endoplasmic reticulum calcium ATPase activity in the Drosophila flight circuit. J Neurosci. 2006;26:8278-88 pubmed
    ..In contrast, maintenance of flight patterns probably requires fast modulation of Ca2+ levels, in which the intrinsic properties of the InsP3R play a pivotal role. ..
  12. Kwon Y, Kim S, Ronderos D, Lee Y, Akitake B, Woodward O, et al. Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal. Curr Biol. 2010;20:1672-8 pubmed publisher
  13. Strathmann M, Simon M. G protein diversity: a distinct class of alpha subunits is present in vertebrates and invertebrates. Proc Natl Acad Sci U S A. 1990;87:9113-7 pubmed
    ..We suggest that these alpha subunits may be involved in pertussis toxin-insensitive pathways coupled to phospholipase C. ..
  14. Vinós J, Jalink K, Hardy R, Britt S, Zuker C. A G protein-coupled receptor phosphatase required for rhodopsin function. Science. 1997;277:687-90 pubmed
    ..These results suggest the existence of a family of receptor phosphatases involved in the regulation of G protein-coupled signaling cascades. ..
  15. Lee Y, Shah S, Suzuki E, Zars T, O Day P, Hyde D. The Drosophila dgq gene encodes a G alpha protein that mediates phototransduction. Neuron. 1994;13:1143-57 pubmed
    We examined the roles of the Drosophila Gq alpha proteins (DGq) in the phototransduction pathway. The DGq proteins immunolocalized to the ocelli and all eight retinular photoreceptor cell rhabdomeres...
  16. Tsunoda S, Sierralta J, Sun Y, Bodner R, Suzuki E, Becker A, et al. A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade. Nature. 1997;388:243-9 pubmed
    ..A picture emerges of a highly organized unit of signalling, a 'transduclisome', with PDZ domains functioning as key elements in the organization of transduction complexes in vivo. ..
  17. Zars T, Hyde D. rdgE: a novel retinal degeneration mutation in Drosophila melanogaster. Genetics. 1996;144:127-38 pubmed
    ..Thus, rdgE may define a mutational class that exhibits both light-enhanced retinal degeneration and a recessive null lethality by perturbing neuronal membrane biosynthesis and/or recycling. ..
  18. Liu M, Parker L, Wadzinski B, Shieh B. Reversible phosphorylation of the signal transduction complex in Drosophila photoreceptors. J Biol Chem. 2000;275:12194-9 pubmed
    ..Furthermore, dephosphorylation of INAD and TRP is catalyzed by PP1/PP2A-like enzymes preferentially expressed in photoreceptor cells. ..
  19. Yao C, Carlson J. Role of G-proteins in odor-sensing and CO2-sensing neurons in Drosophila. J Neurosci. 2010;30:4562-72 pubmed publisher
    ..2007; Kwon et al., 2007). Using single-sensillum recordings, we systematically investigate the role of Galpha proteins in vivo, initially with RNA interference constructs, competitive peptides, and constitutively active ..
  20. Kosloff M, Elia N, Joel Almagor T, Timberg R, Zars T, Hyde D, et al. Regulation of light-dependent Gqalpha translocation and morphological changes in fly photoreceptors. EMBO J. 2003;22:459-68 pubmed
    ..Here we show, using live Drosophila flies, that light causes massive and reversible translocation of the visual Gqalpha to the cytosol, associated with marked architectural changes in the signaling compartment...
  21. Schulz S, Huber A, Schwab K, Paulsen R. A novel Ggamma isolated from Drosophila constitutes a visual G protein gamma subunit of the fly compound eye. J Biol Chem. 1999;274:37605-10 pubmed
    ..characteristics with the visual Ggamma subunits of human rod and cone photoreceptors although different classes of Galpha subunits are employed in vertebrate and invertebrate phototransduction...
  22. Boto T, Gomez Diaz C, Alcorta E. Expression analysis of the 3 G-protein subunits, Galpha, Gbeta, and Ggamma, in the olfactory receptor organs of adult Drosophila melanogaster. Chem Senses. 2010;35:183-93 pubmed publisher
    ..Using RT-polymerase chain reaction, we analyzed 6 Galpha (G(s), G(i), G(q), G(o), G(f), and concertina), 3 Gbeta (G(beta5), G(beta13F), and G(beta76C)), and 2 Ggamma genes ..
  23. Knox B, Salcedo E, Mathiesz K, Schaefer J, Chou W, Chadwell L, et al. Heterologous expression of limulus rhodopsin. J Biol Chem. 2003;278:40493-502 pubmed
    ..This may be a general property of invertebrate opsins and may underlie some of the functional differences between invertebrate and vertebrate visual pigments...
  24. Running Deer J, Hurley J, Yarfitz S. G protein control of Drosophila photoreceptor phospholipase C. J Biol Chem. 1995;270:12623-8 pubmed
    ..These results indicate that G beta e functions as the beta subunit of the G protein coupling rhodopsin to NorpA PLC. ..
  25. Rosenbaum E, Brehm K, Vasiljevic E, Liu C, Hardie R, Colley N. XPORT-dependent transport of TRP and rhodopsin. Neuron. 2011;72:602-15 pubmed publisher
    ..Our results identify XPORT as a molecular chaperone and provide a mechanistic link between TRP channels and their GPCRs during biosynthesis and transport. ..
  26. Lee S, Montell C. Light-dependent translocation of visual arrestin regulated by the NINAC myosin III. Neuron. 2004;43:95-103 pubmed
    ..These data demonstrate that the light-dependent translocation of Arr2 into the rhabdomeres requires PI-mediated interactions between Arr2 and the NINAC myosin III. ..
  27. Lee K, Kim S, Kim E, Ha E, You H, Kim B, et al. Bacterial-derived uracil as a modulator of mucosal immunity and gut-microbe homeostasis in Drosophila. Cell. 2013;153:797-811 pubmed publisher
    ..These results reveal that bacteria with distinct abilities to activate uracil-induced gut inflammation, in terms of intensity and duration, act as critical factors that determine homeostasis or pathogenesis in gut-microbe interactions. ..
  28. Meyer N, Joel Almagor T, Frechter S, Minke B, Huber A. Subcellular translocation of the eGFP-tagged TRPL channel in Drosophila photoreceptors requires activation of the phototransduction cascade. J Cell Sci. 2006;119:2592-603 pubmed
    ..to the cell body in flies carrying severe mutations in essential phototransduction proteins, including rhodopsin, Galphaq, phospholipase Cbeta and the TRP ion channel, or in proteins required for TRP function...
  29. Frechter S, Elia N, Tzarfaty V, Selinger Z, Minke B. Translocation of Gq alpha mediates long-term adaptation in Drosophila photoreceptors. J Neurosci. 2007;27:5571-83 pubmed
    ..The slow time scale of this adaptation fits well with day/night light intensity changes, because there is no need to maintain single photon sensitivity during daytime. ..
  30. Meyer N, Oberegelsbacher C, Dürr T, Schäfer A, Huber A. An eGFP-based genetic screen for defects in light-triggered subcelluar translocation of the Drosophila photoreceptor channel TRPL. Fly (Austin). 2008;2:36-46 pubmed
    ..The absence of TRP or rhodopsin in the isolated mutants readily explains the defect in TRPL internalization and proves the feasibility of our genetic screen. ..
  31. Zhang Y, Raghuwanshi R, Shen W, Montell C. Food experience-induced taste desensitization modulated by the Drosophila TRPL channel. Nat Neurosci. 2013;16:1468-76 pubmed publisher
    ..We propose that dynamic regulation of taste receptors by ubiquitin-mediated protein degradation comprises an important molecular mechanism that allows an animal to alter its taste behavior in response to a changing food environment. ..
  32. Burack W, Shaw A. Signal transduction: hanging on a scaffold. Curr Opin Cell Biol. 2000;12:211-6 pubmed
    ..Finally, the identification of new mitogen-activated protein kinase pathway scaffolds suggests the existence of multiple 'signalosomes' or 'transducisomes'. ..
  33. Van Raamsdonk C, Fitch K, Fuchs H, de Angelis M, Barsh G. Effects of G-protein mutations on skin color. Nat Genet. 2004;36:961-8 pubmed
    ..identified three of four such mutations as hypermorphic alleles of Gnaq and Gna11, which encode widely expressed Galphaq subunits, act in an additive and quantitative manner, and require Ednrb...
  34. Cook B, Bar Yaacov M, Cohen Ben Ami H, Goldstein R, Paroush Z, Selinger Z, et al. Phospholipase C and termination of G-protein-mediated signalling in vivo. Nat Cell Biol. 2000;2:296-301 pubmed
    ..The inactivation of the G protein by its target, the PLC, is crucial for reliable production of single-photon responses and for the high temporal and intensity resolution of the response to light. ..
  35. Bahner M, Sander P, Paulsen R, Huber A. The visual G protein of fly photoreceptors interacts with the PDZ domain assembled INAD signaling complex via direct binding of activated Galpha(q) to phospholipase cbeta. J Biol Chem. 2000;275:2901-4 pubmed
    ..Light-activated Galpha(q)- guanosine 5'-O-(thiotriphosphate) and AlF(4)(-)-activated Galpha(q), but not Gbetagamma, form a stable complex ..
  36. Wilkie T. G proteins, chemosensory perception, and the C. elegans genome project: An attractive story. Bioessays. 1999;21:713-7 pubmed
    ..used sequence searches of the C. elegans genome database to identify all heterotrimeric G protein genes (20 Galpha, 2 Gbeta, 2 Ggamma). C...
  37. Tian Y, Li T, Sun M, Wan D, Li Q, Li P, et al. Neurexin regulates visual function via mediating retinoid transport to promote rhodopsin maturation. Neuron. 2013;77:311-22 pubmed publisher
    ..Our results reveal a role for Neurexin in mediating retinoid transport and subsequent rhodopsin maturation and suggest that Neurexin regulates lipoprotein function. ..
  38. Sanxaridis P, Cronin M, Rawat S, Waro G, Acharya U, Tsunoda S. Light-induced recruitment of INAD-signaling complexes to detergent-resistant lipid rafts in Drosophila photoreceptors. Mol Cell Neurosci. 2007;36:36-46 pubmed
    ..Finally, selective recruitment of phosphorylated, and therefore activatable, eye-PKC to DRM rafts suggests that DRM domains are likely to function in signaling, rather than trafficking. ..
  39. Hardie R. Phototransduction: shedding light on translocation. Curr Biol. 2003;13:R775-7 pubmed
    ..New work has identified a phosphoinositide lipid binding domain in Drosophila arrestin and implicates PIP(3) in control of arrestin translocation. ..
  40. Baumann O. Spatial pattern of nonmuscle myosin-II distribution during the development of the Drosophila compound eye and implications for retinal morphogenesis. Dev Biol. 2004;269:519-33 pubmed
    ..The observation that the myosin-II/F-actin arrays are incomplete or disorganized in R7/R8 and in rhodopsin-1-null R1-6 suggests further that the establishment and stability of this cytoskeletal system depend on rhodopsin-1 expression. ..
  41. Wang Y, Wang H, Li X, Li Y. Epithelial microRNA-9a regulates dendrite growth through Fmi-Gq signaling in Drosophila sensory neurons. Dev Neurobiol. 2016;76:225-37 pubmed publisher
  42. Hu W, Wan D, Yu X, Cao J, Guo P, Li H, et al. Protein Gq modulates termination of phototransduction and prevents retinal degeneration. J Biol Chem. 2012;287:13911-8 pubmed publisher
    ..Our study revealed the roles of G(q) in mediating photoresponse termination and in preventing retinal degeneration. This pathway may represent a general rapid feedback regulation of G protein-coupled receptor signaling. ..
  43. Brusich D, Spring A, Frank C. A single-cross, RNA interference-based genetic tool for examining the long-term maintenance of homeostatic plasticity. Front Cell Neurosci. 2015;9:107 pubmed publisher
    ..Our findings expand the scope of signaling pathways and processes that contribute to the durable strength of the NMJ. ..
  44. Kain P, Badsha F, Hussain S, Nair A, Hasan G, Rodrigues V. Mutants in phospholipid signaling attenuate the behavioral response of adult Drosophila to trehalose. Chem Senses. 2010;35:663-73 pubmed publisher
    ..Animals heterozygous for dgq mutations and RNA interference-mediated knockdown of dgq showed reduced responses to trehalose in the proboscis ..
  45. Bernardo Garcia F, Fritsch C, Sprecher S. The transcription factor Glass links eye field specification with photoreceptor differentiation in Drosophila. Development. 2016;143:1413-23 pubmed publisher
    ..Together, our results provide a transcriptional link between eye field specification and photoreceptor differentiation in Drosophila, placing Glass at a central position in this developmental process. ..
  46. Agrawal T, Sadaf S, Hasan G. A genetic RNAi screen for IP?/Ca²? coupled GPCRs in Drosophila identifies the PdfR as a regulator of insect flight. PLoS Genet. 2013;9:e1003849 pubmed publisher
  47. Ni L, Guo P, Reddig K, Mitra M, Li H. Mutation of a TADR protein leads to rhodopsin and Gq-dependent retinal degeneration in Drosophila. J Neurosci. 2008;28:13478-87 pubmed publisher
    ..We propose that TADR-like proteins may also protect photoreceptors from degeneration in mammals including humans. ..
  48. Wang T, Wang X, Xie Q, Montell C. The SOCS box protein STOPS is required for phototransduction through its effects on phospholipase C. Neuron. 2008;57:56-68 pubmed publisher
    ..Moreover, this work demonstrates that a PLCbeta derivative that does not promote TRP channel activation, still contributes to signaling in vivo. ..
  49. Landry C, Castillo Davis C, Ogura A, Liu J, Hartl D. Systems-level analysis and evolution of the phototransduction network in Drosophila. Proc Natl Acad Sci U S A. 2007;104:3283-8 pubmed
    ..These results provide a preliminary quantification of variation and divergence of gene expression between species in a known gene network and provide a foundation for a system-level understanding of functional and evolutionary change. ..
  50. Agam K, von Campenhausen M, Levy S, Ben Ami H, Cook B, Kirschfeld K, et al. Metabolic stress reversibly activates the Drosophila light-sensitive channels TRP and TRPL in vivo. J Neurosci. 2000;20:5748-55 pubmed
  51. Deng Y, Zhang W, Farhat K, Oberland S, Gisselmann G, Neuhaus E. The stimulatory G?(s) protein is involved in olfactory signal transduction in Drosophila. PLoS ONE. 2011;6:e18605 pubmed publisher
    ..Together, we provide evidence that G?(s) plays a role in the OR mediated signaling cascade in Drosophila. ..
  52. Harris B, Lim W. Mechanism and role of PDZ domains in signaling complex assembly. J Cell Sci. 2001;114:3219-31 pubmed
    ..The predominance of PDZ domains in metazoans indicates that this highly specialized scaffolding module probably evolved in response to the increased signaling needs of multicellular organisms. ..
  53. Kain P, Chandrashekaran S, Rodrigues V, Hasan G. Drosophila mutants in phospholipid signaling have reduced olfactory responses as adults and larvae. J Neurogenet. 2009;23:303-12 pubmed publisher
    ..The results suggest that larval olfactory transduction, like that of the adult, utilizes a phospholipid second messenger, generated by the activation of G(q)alpha and Plcbeta21c, and modulated by the stmA gene product. ..
  54. Milligan S, Alb J, Elagina R, Bankaitis V, Hyde D. The phosphatidylinositol transfer protein domain of Drosophila retinal degeneration B protein is essential for photoreceptor cell survival and recovery from light stimulation. J Cell Biol. 1997;139:351-63 pubmed
    ..This in vivo analysis of PITP function in a metazoan system provides further insights into the links between PITP dysfunction and an inherited disease in a higher eukaryote. ..
  55. Venkatachalam K, van Rossum D, Patterson R, Ma H, Gill D. The cellular and molecular basis of store-operated calcium entry. Nat Cell Biol. 2002;4:E263-72 pubmed
    ..Here we review new insights into the exchange of signals between the endoplasmic reticulum (ER) and plasma membrane that result in activation of calcium entry channels mediating crucial long-term calcium signals. ..
  56. Murali T, Pacifico S, Finley R. Integrating the interactome and the transcriptome of Drosophila. BMC Bioinformatics. 2014;15:177 pubmed publisher
    ..This organization implies that tissue or stage specific networks can be best identified from interactome data by using filters designed to include both ubiquitously expressed and specifically expressed genes and proteins. ..
  57. Leventis P, Chow B, Stewart B, Iyengar B, Campos A, Boulianne G. Drosophila Amphiphysin is a post-synaptic protein required for normal locomotion but not endocytosis. Traffic. 2001;2:839-50 pubmed
    ..However, Drosophila Amphiphysin function is required in both larvae and adults for normal locomotion. ..
  58. Vaqué J, Dorsam R, Feng X, Iglesias Bartolomé R, Forsthoefel D, Chen Q, et al. A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors. Mol Cell. 2013;49:94-108 pubmed publisher
  59. Schillo S, Belusic G, Hartmann K, Franz C, Kühl B, Brenner Weiss G, et al. Targeted mutagenesis of the farnesylation site of Drosophila Ggammae disrupts membrane association of the G protein betagamma complex and affects the light sensitivity of the visual system. J Biol Chem. 2004;279:36309-16 pubmed
    ..This loss in light sensitivity reveals that post-translational farnesylation is a critical step for the formation of membrane-associated Galphabetagamma required for transmitting light activation from rhodopsin to phospholipase Cbeta. ..
  60. Pumir A, Graves J, Ranganathan R, Shraiman B. Systems analysis of the single photon response in invertebrate photoreceptors. Proc Natl Acad Sci U S A. 2008;105:10354-9 pubmed publisher
    ..The system-level analysis enabled by modeling phototransduction provides a foundation for understanding G protein signaling pathways less amenable to quantitative approaches. ..
  61. Adams J. Characterization of a Drosophila melanogaster orthologue of muskelin. Gene. 2002;297:69-78 pubmed
    ..These findings provide new information on the modular structure of muskelin and indicate potential for conserved mechanisms of function. ..
  62. Im S, Takle K, Jo J, Babcock D, Ma Z, Xiang Y, et al. Tachykinin acts upstream of autocrine Hedgehog signaling during nociceptive sensitization in Drosophila. elife. 2015;4:e10735 pubmed publisher
    ..Our results highlight a conserved role for Tachykinin signaling in regulating nociception and the power of Drosophila for genetic dissection of nociception. ..
  63. Rosenbaum E, Hardie R, Colley N. Calnexin is essential for rhodopsin maturation, Ca2+ regulation, and photoreceptor cell survival. Neuron. 2006;49:229-41 pubmed
    ..Our results illustrate a critical role for calnexin in Rh1 maturation and Ca2+ regulation and provide genetic evidence that defects in calnexin lead to retinal degeneration. ..
  64. Ranganathan R, Harris W, Zuker C. The molecular genetics of invertebrate phototransduction. Trends Neurosci. 1991;14:486-93 pubmed
    ..The results of a combination of molecular, genetic, physiological and biochemical studies are beginning to produce a clearer model for the complex mechanisms involved in invertebrate visual transduction. ..
  65. Lee S, Xu H, Montell C. Rhodopsin kinase activity modulates the amplitude of the visual response in Drosophila. Proc Natl Acad Sci U S A. 2004;101:11874-9 pubmed
    ..These data point to an evolutionarily conserved role for GPRK1 in modulating the amplitude of the visual response. ..
  66. McGurk L, Pathirana S, Rothwell K, Trimbuch T, Colombini P, Yu F, et al. The RGS gene loco is essential for male reproductive system differentiation in Drosophila melanogaster. BMC Dev Biol. 2008;8:37 pubmed publisher
    ..Thus, we conclude that specific isoforms of loco are required for the differentiation of the male gonad and genital disc. ..
  67. Vasiliauskas D, Mazzoni E, Sprecher S, Brodetskiy K, Johnston R, Lidder P, et al. Feedback from rhodopsin controls rhodopsin exclusion in Drosophila photoreceptors. Nature. 2011;479:108-12 pubmed publisher
    ..Our observations reveal a thus far unappreciated spectral plasticity of R8 photoreceptors, and identify rhodopsin feedback as an exclusion mechanism. ..
  68. Smith D. Olfactory mechanisms in Drosophila melanogaster. Curr Opin Neurobiol. 1996;6:500-5 pubmed
    ..In addition, members of the family of invertebrate odorant-binding proteins have been identified in Drosophila and may play an important role in the olfactory process. ..
  69. Han J, Reddig K, Li H. Prolonged G(q) activity triggers fly rhodopsin endocytosis and degradation, and reduces photoreceptor sensitivity. EMBO J. 2007;26:4966-73 pubmed
    ..Our work has identified an arrestin-independent endocytic pathway of G protein-coupled receptor in the fly. This pathway may also function in mammals and mediate an early feedback regulation of receptor signaling. ..
  70. Hiramoto M, Hiromi Y. ROBO directs axon crossing of segmental boundaries by suppressing responsiveness to relocalized Netrin. Nat Neurosci. 2006;9:58-66 pubmed
    ..The absence of suppression causes the robo phenotype: longitudinal axons project toward the midline, as if running around a roundabout (rotary). ..
  71. Montell C. Drosophila TRP channels. Pflugers Arch. 2005;451:19-28 pubmed
    ..As a result, the repertoire of biological roles attributed to Drosophila TRPs has increased considerably and is likely to lead to many additional surprises over the next few years. ..
  72. Zemelman B, Lee G, Ng M, Miesenbock G. Selective photostimulation of genetically chARGed neurons. Neuron. 2002;33:15-22 pubmed
    ..Distributed activity may thus be fed directly into a circumscribed population of neurons in intact tissue, irrespective of the spatial arrangement of its elements. ..
  73. Kiselev A, Socolich M, Vinós J, Hardy R, Zuker C, Ranganathan R. A molecular pathway for light-dependent photoreceptor apoptosis in Drosophila. Neuron. 2000;28:139-52 pubmed
    ..Together, these data define the proapoptotic molecules in Drosophila photoreceptors and indicate a novel signaling pathway for light-activated rhodopsin molecules in control of photoreceptor viability. ..