Gene Symbol: Galphaf
Description: G protein alpha f subunit
Alias: CG12232, Dmel\CG12232, GNAS/L, Galpha73B, Galpha73b, Galpha[[f]]73B, Gfalpha, G protein alpha f subunit, CG12232-PA, G protein alpha 73B, GTP-binding protein alpha-subunit, Galphaf-PA, Gf alpha
Species: fruit fly

Top Publications

  1. Quan F, Wolfgang W, Forte M. A Drosophila G-protein alpha subunit, Gf alpha, expressed in a spatially and temporally restricted pattern during Drosophila development. Proc Natl Acad Sci U S A. 1993;90:4236-40 pubmed
    ..RNA isolated from early pupae (day 1), we have isolated a cDNA coding for a fly G alpha subunit, designated Gf alpha. This subunit is 30-38% identical to previously described vertebrate and Drosophila G alpha subunits and appears ..
  2. Martin M, Ahern Djamali S, Hoffmann F, Saxton W. Abl tyrosine kinase and its substrate Ena/VASP have functional interactions with kinesin-1. Mol Biol Cell. 2005;16:4225-30 pubmed
    ..A concomitant reduction in ena dosage rescued those defects. These results suggest that Ena/VASP, when not inhibited by the Abl pathway, can bind Khc and reduce its transport activity in axons. ..
  3. Vecsey C, P rez N, Griffith L. The Drosophila neuropeptides PDF and sNPF have opposing electrophysiological and molecular effects on central neurons. J Neurophysiol. 2014;111:1033-45 pubmed publisher
  4. Im S, Takle K, Jo J, Babcock D, Ma Z, Xiang Y, et al. Tachykinin acts upstream of autocrine Hedgehog signaling during nociceptive sensitization in Drosophila. elife. 2015;4:e10735 pubmed publisher
    ..Our results highlight a conserved role for Tachykinin signaling in regulating nociception and the power of Drosophila for genetic dissection of nociception. ..
  5. Katanayeva N, Kopein D, Portmann R, Hess D, Katanaev V. Competing activities of heterotrimeric G proteins in Drosophila wing maturation. PLoS ONE. 2010;5:e12331 pubmed publisher
    ..Our results provide a comprehensive functional analysis of the heterotrimeric G protein proteome in the late stages of Drosophila wing development. ..
  6. Doiguchi M, Nakagawa T, Imamura Y, Yoneda M, Higashi M, Kubota K, et al. SMARCAD1 is an ATP-dependent stimulator of nucleosomal H2A acetylation via CBP, resulting in transcriptional regulation. Sci Rep. 2016;6:20179 pubmed publisher
    ..The interplay between the remodeling activity of SMARCAD1 and histone acetylation by CBP sheds light on the function of chromatin and the genome-integrity network. ..
  7. McGurk L, Pathirana S, Rothwell K, Trimbuch T, Colombini P, Yu F, et al. The RGS gene loco is essential for male reproductive system differentiation in Drosophila melanogaster. BMC Dev Biol. 2008;8:37 pubmed publisher
    ..Thus, we conclude that specific isoforms of loco are required for the differentiation of the male gonad and genital disc. ..
  8. Boto T, Gomez Diaz C, Alcorta E. Expression analysis of the 3 G-protein subunits, Galpha, Gbeta, and Ggamma, in the olfactory receptor organs of adult Drosophila melanogaster. Chem Senses. 2010;35:183-93 pubmed publisher
    ..Finally, complete coexpression was found between Gi and Gq, which are mediators of the cyclic adenosine monophosphate and IP3 transduction cascades, respectively. ..
  9. Bredendiek N, Hütte J, Steingräber A, Hatt H, Gisselmann G, Neuhaus E. Go ? is involved in sugar perception in Drosophila. Chem Senses. 2011;36:69-81 pubmed publisher
    ..Because the perception of other sweet stimuli was not affected by mutations in Go?, we also found strong indication for the existence of multiple signaling pathways in the insect gustatory system. ..

More Information


  1. Bausek N, Zeidler M. G?73B is a downstream effector of JAK/STAT signalling and a regulator of Rho1 in Drosophila haematopoiesis. J Cell Sci. 2014;127:101-10 pubmed publisher
    ..As such, we suggest a mechanism by which JAK/STAT pathway signalling may promote metastasis. ..
  2. Krishnan A, Mustafa A, Almén M, Fredriksson R, Williams M, Schiöth H. Evolutionary hierarchy of vertebrate-like heterotrimeric G protein families. Mol Phylogenet Evol. 2015;91:27-40 pubmed publisher
    ..Our robust classification/hierarchy is essential to further understand the differential roles of GPCR/G protein mediated intracellular signaling system across various metazoan lineages. ..
  3. Jung A, Hollmann M, Schäfer M. The fatty acid elongase NOA is necessary for viability and has a somatic role in Drosophila sperm development. J Cell Sci. 2007;120:2924-34 pubmed
    ..An RNAi construct selectively driven in cyst cells leads to male sterility, demonstrating the necessity of noa function for male germline development and the interaction of the somatic cyst cells with the developing sperm. ..
  4. Yao C, Carlson J. Role of G-proteins in odor-sensing and CO2-sensing neurons in Drosophila. J Neurosci. 2010;30:4562-72 pubmed publisher
    ..Ggamma30A is also required for normal CO2 response. The simplest interpretation of these results is that Galpha(q) and Ggamma30A play a role in the response of CO2-sensing neurons, but are not required for Or-mediated odor signaling. ..