Gene Symbol: fz4
Description: frizzled 4
Alias: CG4626, DFz4, Dfz4, Dm Fz4, Dmel\CG4626, Fz4, anon-WO0170980.10, anon-WO0170980.11, frizzled 4, CG4626-PA, CG4626-PB, Frizzled4, fz4-PA, fz4-PB
Species: fruit fly
Products:     fz4

Top Publications

  1. Wu C, Nusse R. Ligand receptor interactions in the Wnt signaling pathway in Drosophila. J Biol Chem. 2002;277:41762-9 pubmed
    ..We have therefore examined whether a soluble form of the Arrow molecule can bind to Wingless and Frizzled, but no interactions were detected. ..
  2. Chen W, ten Berge D, Brown J, Ahn S, Hu L, Miller W, et al. Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science. 2003;301:1391-4 pubmed
    ..Endocytosis of Frizzled 4 (Fz4) in human embryonic kidney 293 cells was dependent on added Wnt5A protein and was accomplished by the ..
  3. Bartscherer K, Pelte N, Ingelfinger D, Boutros M. Secretion of Wnt ligands requires Evi, a conserved transmembrane protein. Cell. 2006;125:523-33 pubmed
    ..Our results show that Wg is retained by evi mutant cells and suggest that evi is the founding member of a gene family specifically required for Wg/Wnt secretion. ..
  4. Zhao Y, Tong C, Jiang J. Transducing the Hedgehog signal across the plasma membrane. Fly (Austin). 2007;1:333-6 pubmed
    ..We discuss how Smo conformational change regulates the intracellular signaling complex and how Smo transduces the graded Hh signaling activities through different conformational states. ..
  5. McElwain M, Ko D, Gordon M, Fyrst H, Saba J, Nusse R. A suppressor/enhancer screen in Drosophila reveals a role for wnt-mediated lipid metabolism in primordial germ cell migration. PLoS ONE. 2011;6:e26993 pubmed publisher
    ..Using an algorithm to narrow down our hits from the screen, we found two novel WntD signaling components: Fz4, a member of the Frizzled family, and the Drosophila Ceramide Kinase homolog, Dcerk...
  6. Alekseyenko A, Larschan E, Lai W, Park P, Kuroda M. High-resolution ChIP-chip analysis reveals that the Drosophila MSL complex selectively identifies active genes on the male X chromosome. Genes Dev. 2006;20:848-57 pubmed
    ..Distinguishing expressed genes from the bulk of the genome is likely to be an important function common to many chromatin organizing and modifying activities. ..
  7. Beermann A, Prühs R, Lutz R, Schröder R. A context-dependent combination of Wnt receptors controls axis elongation and leg development in a short germ insect. Development. 2011;138:2793-805 pubmed publisher
    ..and combinatorial functions of the three Wnt receptors, Frizzled-1 (Tc-Fz1), Frizzled-2 (Tc-Fz2) and Frizzled-4 (Tc-Fz4), and their co-receptor Arrow (Tc-Arr) in the beetle Tribolium...
  8. Ghezzi A, Liebeskind B, Thompson A, Atkinson N, Zakon H. Ancient association between cation leak channels and Mid1 proteins is conserved in fungi and animals. Front Mol Neurosci. 2014;7:15 pubmed publisher
    ..The relationship between Mid1 and leak channels has therefore persisted over a billion years of evolution, despite drastic changes to both proteins and the organisms in which they exist. ..
  9. Rahimi N, Averbukh I, Haskel Ittah M, Degani N, Schejter E, Barkai N, et al. A WntD-Dependent Integral Feedback Loop Attenuates Variability in Drosophila Toll Signaling. Dev Cell. 2016;36:401-14 pubmed publisher
    ..WntD protein is secreted and disperses in the extracellular milieu, associates with its receptor Frizzled4, and inhibits the Toll pathway by blocking the Toll extracellular domain...

More Information


  1. Schweizer L, Varmus H. Wnt/Wingless signaling through beta-catenin requires the function of both LRP/Arrow and frizzled classes of receptors. BMC Cell Biol. 2003;4:4 pubmed
  2. Furlong E. A functional genomics approach to identify new regulators of Wnt signaling. Dev Cell. 2005;8:624-6 pubmed
    ..Supporting in vivo studies are in progress. The fact that such an impressive number of potential modulators had eluded detection in genetic screens underscores the potential of applying new, high-throughput approaches to old problems. ..
  3. Huang H, Klein P. The Frizzled family: receptors for multiple signal transduction pathways. Genome Biol. 2004;5:234 pubmed
    ..It is not yet clear how Frizzleds couple to downstream effectors, and this is a focus of intense study. ..
  4. Janson K, Cohen E, Wilder E. Expression of DWnt6, DWnt10, and DFz4 during Drosophila development. Mech Dev. 2001;103:117-20 pubmed
    ..We find that DFz4 is also expressed in a dynamic pattern in the mesoderm, gut, and central nervous system.
  5. Magnacca K, Price D. Rapid adaptive radiation and host plant conservation in the Hawaiian picture wing Drosophila (Diptera: Drosophilidae). Mol Phylogenet Evol. 2015;92:226-42 pubmed publisher
    ..The existence of several apparently relictual taxa suggests that extinction has also played a major role in assembly of the present Hawaiian Drosophila fauna. ..