Gene Symbol: fws
Description: four way stop
Alias: CG6549, COG5, Cog5, Dmel\CG6549, FWS, Fws, anon-EST:Posey162, anon-EST:Posey186, dCOG5, four way stop, CG6549-PA, CG6549-PC, CG6549-PD, CG6549-PH, CG6549-PI, Four-way stop, drosophila Cog5, four Way stop, fws-PA, fws-PC, fws-PD, fws-PH, fws-PI
Species: fruit fly

Top Publications

  1. Farkas R, Giansanti M, Gatti M, Fuller M. The Drosophila Cog5 homologue is required for cytokinesis, cell elongation, and assembly of specialized Golgi architecture during spermatogenesis. Mol Biol Cell. 2003;14:190-200 pubmed
    ..Here, we show that function of the gene four way stop (fws), which encodes the Drosophila Cog5 homologue, is necessary for dramatic changes in cellular and subcellular morphology during spermatogenesis...
  2. Herpers B, Rabouille C. mRNA localization and ER-based protein sorting mechanisms dictate the use of transitional endoplasmic reticulum-golgi units involved in gurken transport in Drosophila oocytes. Mol Biol Cell. 2004;15:5306-17 pubmed
    ..We propose that this pretranslational mechanism could be a general way for targeted secretion in polarized cells, such as neurons. ..
  3. Giansanti M, Bonaccorsi S, Kurek R, Farkas R, Dimitri P, Fuller M, et al. The class I PITP giotto is required for Drosophila cytokinesis. Curr Biol. 2006;16:195-201 pubmed
    ..This change in membrane composition would ultimately facilitate vesicle fusion, allowing membrane addition to the furrow and/or targeted delivery of proteins required for cytokinesis. ..
  4. Wei H, Rollins J, Fabian L, Hayes M, Polevoy G, Bazinet C, et al. Depletion of plasma membrane PtdIns(4,5)P2 reveals essential roles for phosphoinositides in flagellar biogenesis. J Cell Sci. 2008;121:1076-84 pubmed publisher
    ..They further suggest that phosphoinositides play evolutionarily conserved roles in flagella and cilia, across phyla and in structurally diverse cell types. ..
  5. Belloni G, Sechi S, Riparbelli M, Fuller M, Callaini G, Giansanti M. Mutations in Cog7 affect Golgi structure, meiotic cytokinesis and sperm development during Drosophila spermatogenesis. J Cell Sci. 2012;125:5441-52 pubmed publisher
    ..Similar to the Cog5 homologue, four way stop (Fws), Cog7 enables furrow ingression during cytokinesis...
  6. ROBINETT C, Giansanti M, Gatti M, Fuller M. TRAPPII is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells of Drosophila. J Cell Sci. 2009;122:4526-34 pubmed publisher
    ..These results suggest that Bru cooperates with Rab11 and PI4Kbeta to regulate the efficiency of membrane addition to the cleavage furrow, thus promoting cytokinesis in Drosophila male meiotic cells. ..
  7. Morris E, Michaud W, Ji J, Moon N, Rocco J, Dyson N. Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. PLoS Genet. 2006;2:e196 pubmed
    ..Therefore, inhibition of Api5 function might offer a possible mechanism for antitumor exploitation. ..
  8. Zhou X, Fabian L, Bayraktar J, Ding H, Brill J, Chang H. Auxilin is required for formation of Golgi-derived clathrin-coated vesicles during Drosophila spermatogenesis. Development. 2011;138:1111-20 pubmed publisher
    ..Our data suggest that Aux participates in forming these Golgi-derived clathrin-positive vesicles and that Aux, therefore, has a role in the secretory pathway. ..
  9. Polevoy G, Wei H, Wong R, Szentpetery Z, Kim Y, Goldbach P, et al. Dual roles for the Drosophila PI 4-kinase four wheel drive in localizing Rab11 during cytokinesis. J Cell Biol. 2009;187:847-58 pubmed publisher
    ..Moreover, activated Rab11 partially suppresses loss of fwd. Our data suggest Fwd plays catalytic and noncatalytic roles in regulating Rab11 during cytokinesis...

More Information


  1. Giansanti M, Farkas R, Bonaccorsi S, Lindsley D, Wakimoto B, Fuller M, et al. Genetic dissection of meiotic cytokinesis in Drosophila males. Mol Biol Cell. 2004;15:2509-22 pubmed
  2. Fari K, Tak√°cs S, Ungar D, Sinka R. The role of acroblast formation during Drosophila spermatogenesis. Biol Open. 2016;5:1102-10 pubmed publisher
    ..When testing a mutation in a second retrograde transport protein, Fws, a subunit of the conserved oligomeric Golgi (COG) tethering complex, the acroblast structure, was again disrupted...
  3. Fan S, Marchand V, Ephrussi A. Drosophila Ge-1 promotes P body formation and oskar mRNA localization. PLoS ONE. 2011;6:e20612 pubmed publisher
    ..Our findings suggest an important role of dGe-1 in optimization of the osk mRNA localization process required for patterning the Drosophila embryo. ..
  4. Smith R, Lupashin V. Role of the conserved oligomeric Golgi (COG) complex in protein glycosylation. Carbohydr Res. 2008;343:2024-31 pubmed publisher
    ..The COG protein complex consists of eight subunits, distributed in two lobes, Lobe A (Cog1-4) and Lobe B (Cog5-8)...
  5. Koch R, Ledermann R, Urwyler O, Heller M, Suter B. Systematic functional analysis of Bicaudal-D serine phosphorylation and intragenic suppression of a female sterile allele of BicD. PLoS ONE. 2009;4:e4552 pubmed publisher
    ..Remarkably, amongst the Drosophila serines we found phosphorylated, Ser(103) is the only one that is fully conserved in mammalian BicD. ..
  6. Nicolas E, Chenouard N, Olivo Marin J, Guichet A. A dual role for actin and microtubule cytoskeleton in the transport of Golgi units from the nurse cells to the oocyte across ring canals. Mol Biol Cell. 2009;20:556-68 pubmed publisher
    ..Finally, we show that actin networks may be involved in RC crossing through a myosin II step process, as well as in dispatching Golgi units inside the oocyte subcompartments. ..
  7. Lee S, Cooley L. Jagunal is required for reorganizing the endoplasmic reticulum during Drosophila oogenesis. J Cell Biol. 2007;176:941-52 pubmed
    ..We propose that ER reorganization is an important mechanism used by cells to prepare for an increased demand for membrane traffic, and Jagunal facilitates this process through ER clustering. ..
  8. Sechi S, Frappaolo A, Belloni G, Giansanti M. The roles of the oncoprotein GOLPH3 in contractile ring assembly and membrane trafficking during cytokinesis. Biochem Soc Trans. 2015;43:117-21 pubmed publisher
    ..Because cytokinesis failures have been linked with pre-malignant disease and cancer, the novel connection between GOLPH3 and cytokinesis imposes new fields of investigation in cancer biology and therapy. ..