fwd

Summary

Gene Symbol: fwd
Description: four wheel drive
Alias: CG7004, Dmel\CG7004, Fwd, PI4K, anon-WO0118547.259, four wheel drive, CG7004-PA, CG7004-PB, CG7004-PC, CG7004-PD, Four-wheel drive, fwd-PA, fwd-PB, fwd-PC, fwd-PD
Species: fruit fly

Top Publications

  1. Giansanti M, Farkas R, Bonaccorsi S, Lindsley D, Wakimoto B, Fuller M, et al. Genetic dissection of meiotic cytokinesis in Drosophila males. Mol Biol Cell. 2004;15:2509-22 pubmed
    ..These include 16 novel loci and three genes, diaphanous, four wheel drive, and pebble, already known to be involved in Drosophila cytokinesis...
  2. Giansanti M, Bonaccorsi S, Kurek R, Farkas R, Dimitri P, Fuller M, et al. The class I PITP giotto is required for Drosophila cytokinesis. Curr Biol. 2006;16:195-201 pubmed
    ..This change in membrane composition would ultimately facilitate vesicle fusion, allowing membrane addition to the furrow and/or targeted delivery of proteins required for cytokinesis. ..
  3. Polevoy G, Wei H, Wong R, Szentpetery Z, Kim Y, Goldbach P, et al. Dual roles for the Drosophila PI 4-kinase four wheel drive in localizing Rab11 during cytokinesis. J Cell Biol. 2009;187:847-58 pubmed publisher
    ..Here, we identify the phosphatidylinositol (PI) 4-kinase III beta four wheel drive (Fwd) as a key regulator of Rab11 during cytokinesis in Drosophila melanogaster spermatocytes...
  4. Goldbach P, Wong R, Beise N, Sarpal R, Trimble W, Brill J. Stabilization of the actomyosin ring enables spermatocyte cytokinesis in Drosophila. Mol Biol Cell. 2010;21:1482-93 pubmed publisher
    ..Our results show that the anillin-septin and cadherin-catenin complexes can serve as alternative cassettes to promote tight physical coupling of F-actin and myosin II to the cleavage furrow and successful completion of cytokinesis. ..
  5. Yavari A, Nagaraj R, Owusu Ansah E, Folick A, Ngo K, Hillman T, et al. Role of lipid metabolism in smoothened derepression in hedgehog signaling. Dev Cell. 2010;19:54-65 pubmed publisher
    ..Taken together, our results suggest a model in which Ptc directly or indirectly functions to suppress the accumulation of PI4P. Binding of Hh to Ptc derepresses the levels of PI4P, which, in turn, promotes Smo activation. ..
  6. Somma M, Fasulo B, Cenci G, Cundari E, Gatti M. Molecular dissection of cytokinesis by RNA interference in Drosophila cultured cells. Mol Biol Cell. 2002;13:2448-60 pubmed
  7. Brill J, Hime G, Scharer Schuksz M, Fuller M. A phospholipid kinase regulates actin organization and intercellular bridge formation during germline cytokinesis. Development. 2000;127:3855-64 pubmed
    ..Here we show that the four wheel drive (fwd) gene of Drosophila melanogaster is required for intercellular bridge formation during cytokinesis in ..
  8. Giansanti M, Belloni G, Gatti M. Rab11 is required for membrane trafficking and actomyosin ring constriction in meiotic cytokinesis of Drosophila males. Mol Biol Cell. 2007;18:5034-47 pubmed
    ..These cytokinesis phenotypes are identical to those elicited by mutations in giotto (gio) and four wheel drive (fwd) that encode a phosphatidylinositol transfer protein and a phosphatidylinositol 4-kinase, respectively...
  9. Muraro N, Moffat K. Down-regulation of torp4a, encoding the Drosophila homologue of torsinA, results in increased neuronal degeneration. J Neurobiol. 2006;66:1338-53 pubmed

More Information

Publications24

  1. Bothe I, Deng S, Baylies M. PI(4,5)P2 regulates myoblast fusion through Arp2/3 regulator localization at the fusion site. Development. 2014;141:2289-301 pubmed publisher
    ..Thus, PI(4,5)P2 enrichment at the fusion site encodes spatial and temporal information that regulates fusion progression through the localization of activators of actin polymerization. ..
  2. Anderson M, Jodoin J, Lee E, Hales K, Hays T, Lee L. Asunder is a critical regulator of dynein-dynactin localization during Drosophila spermatogenesis. Mol Biol Cell. 2009;20:2709-21 pubmed publisher
  3. Tan J, Oh K, Burgess J, Hipfner D, Brill J. PI4KIII? is required for cortical integrity and cell polarity during Drosophila oogenesis. J Cell Sci. 2014;127:954-66 pubmed publisher
    ..a unique requirement for PI4KIII?, as egg chambers from flies mutant for either of the other Drosophila PI4Ks, fwd or PI4KII, show Golgi but not plasma membrane phenotypes...
  4. Gupta A, Toscano S, Trivedi D, Jones D, Mathre S, Clarke J, et al. Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signaling and cell growth during Drosophila development. Proc Natl Acad Sci U S A. 2013;110:5963-8 pubmed publisher
    ..Together, these results define dPIP4K activity as a regulator of cell growth and TOR signaling during larval development. ..
  5. Forrest S, Chai A, Sanhueza M, Marescotti M, Parry K, Georgiev A, et al. Increased levels of phosphoinositides cause neurodegeneration in a Drosophila model of amyotrophic lateral sclerosis. Hum Mol Genet. 2013;22:2689-704 pubmed publisher
    ..These data underscore the importance of DVAP-Sac1 interaction in controlling phosphoinositide metabolism and provide mechanistic evidence for a crucial role of phosphoinositide levels in VAP-induced ALS. ..
  6. Das A, Shah S, Fan B, Paik D, DiSanto D, Hinman A, et al. Spindle Assembly and Chromosome Segregation Requires Central Spindle Proteins in Drosophila Oocytes. Genetics. 2016;202:61-75 pubmed publisher
    ..In combination our results support a model where the meiotic central spindle and associated proteins are essential for acentrosomal chromosome segregation. ..
  7. Sechi S, Colotti G, Belloni G, Mattei V, Frappaolo A, Raffa G, et al. GOLPH3 is essential for contractile ring formation and Rab11 localization to the cleavage site during cytokinesis in Drosophila melanogaster. PLoS Genet. 2014;10:e1004305 pubmed publisher
    ..Because cytokinesis failures have been associated with premalignant disease and cancer, our studies suggest novel insight into molecular circuits involving the oncogene GOLPH3 in cytokinesis. ..
  8. Axelsson E, Sandmann T, Horn T, Boutros M, Huber W, Fischer B. Extracting quantitative genetic interaction phenotypes from matrix combinatorial RNAi. BMC Bioinformatics. 2011;12:342 pubmed publisher
    ..The reliable extraction of presence, absence, and strength of interactions provides insights into molecular mechanisms. ..
  9. Davidson G, Shen J, Huang Y, Su Y, Karaulanov E, Bartscherer K, et al. Cell cycle control of wnt receptor activation. Dev Cell. 2009;17:788-99 pubmed publisher
    ..G2/M priming of LRP6 by a Cyclin/CDK complex introduces an unexpected new layer of regulation of Wnt signaling. ..
  10. Dason J, Romero Pozuelo J, Marin L, Iyengar B, Klose M, Ferrús A, et al. Frequenin/NCS-1 and the Ca2+-channel alpha1-subunit co-regulate synaptic transmission and nerve-terminal growth. J Cell Sci. 2009;122:4109-21 pubmed publisher
    ..Overall, Frq modulates Ca(2+) entry through a functional interaction with the alpha(1) voltage-gated Ca(2+)-channel subunit; this interaction regulates neurotransmission and nerve-terminal growth. ..
  11. Leandro L, Szewczyk N, Benguria A, Herranz R, LaVan D, Medina F, et al. Comparative analysis of Drosophila melanogaster and Caenorhabditis elegans gene expression experiments in the European Soyuz flights to the International Space Station. Adv Space Res. 2007;40:506-512 pubmed
  12. Landis G, Bhole D, Tower J. A search for doxycycline-dependent mutations that increase Drosophila melanogaster life span identifies the VhaSFD, Sugar baby, filamin, fwd and Cctl genes. Genome Biol. 2003;4:R8 pubmed
    ..b>four wheel drive (fwd) encodes a phosphatidylinositol-4-kinase (PI 4-kinase) and CTP:phosphocholine cytidylyltransferase-l (..
  13. Burgess J, Del Bel L, Ma C, Barylko B, Polevoy G, Rollins J, et al. Type II phosphatidylinositol 4-kinase regulates trafficking of secretory granule proteins in Drosophila. Development. 2012;139:3040-50 pubmed publisher
    ..Our genetic analysis of PI4KII in flies thus reveals a novel role for PI4KII in regulating the fidelity of granule protein trafficking in secretory tissues. ..
  14. ROBINETT C, Giansanti M, Gatti M, Fuller M. TRAPPII is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells of Drosophila. J Cell Sci. 2009;122:4526-34 pubmed publisher
    ..bru also genetically interacts with four wheel drive (fwd), which encodes a PI4Kbeta, such that double mutants exhibit enhanced failure of male meiotic ..
  15. Sechi S, Frappaolo A, Belloni G, Giansanti M. The roles of the oncoprotein GOLPH3 in contractile ring assembly and membrane trafficking during cytokinesis. Biochem Soc Trans. 2015;43:117-21 pubmed publisher
    ..Because cytokinesis failures have been linked with pre-malignant disease and cancer, the novel connection between GOLPH3 and cytokinesis imposes new fields of investigation in cancer biology and therapy. ..