Gene Symbol: Fur2
Description: Furin 2
Alias: 154521_at, CG18734, CG4235, DMH#11, Dfur2, Dfurin2, Dmel\CG18734, FUR2, Furin, fur2, furin, furin 2, CG18734-PA, CG18734-PB, CG18734-PC, CG18734-PD, CG18734-PE, CG18734-PF, CG18734-PG, CG18734-PH, CG18734-PI, Dfurin2, Fur2-PA, Fur2-PB, Fur2-PC, Fur2-PD, Fur2-PE, Fur2-PF, Fur2-PG, Fur2-PH, Fur2-PI, Furin-like protease, furin2
Species: fruit fly

Top Publications

  1. Roebroek A, Creemers J, Pauli I, Bogaert T, Van de Ven W. Generation of structural and functional diversity in furin-like proteins in Drosophila melanogaster by alternative splicing of the Dfur1 gene. EMBO J. 1993;12:1853-70 pubmed
    ..The apparently complete open reading frames of three Dfur1 cDNAs revealed that these coded for three furin-like proteins, Dfurin1 (892 residues), Dfurin1-CRR (1101 residues) and Dfurin1-X (1269 residues), which possessed ..
  2. Siekhaus D, Fuller R. A role for amontillado, the Drosophila homolog of the neuropeptide precursor processing protease PC2, in triggering hatching behavior. J Neurosci. 1999;19:6942-54 pubmed
    Accurate proteolytic processing of neuropeptide and peptide hormone precursors by members of the kexin/furin family of proteases is key to determining both the identities and activities of signaling peptides...
  3. Artavanis Tsakonas S, Rand M, Lake R. Notch signaling: cell fate control and signal integration in development. Science. 1999;284:770-6 pubmed
    ..Notch activity affects the implementation of differentiation, proliferation, and apoptotic programs, providing a general developmental tool to influence organ formation and morphogenesis. ..
  4. Larschan E, Alekseyenko A, Gortchakov A, Peng S, Li B, Yang P, et al. MSL complex is attracted to genes marked by H3K36 trimethylation using a sequence-independent mechanism. Mol Cell. 2007;28:121-33 pubmed
    ..Our results support a model in which MSL complex uses high-affinity sites to initially recognize the X chromosome and then associates with many of its targets through sequence-independent features of transcribed genes. ..
  5. Künnapuu J, Björkgren I, Shimmi O. The Drosophila DPP signal is produced by cleavage of its proprotein at evolutionary diversified furin-recognition sites. Proc Natl Acad Sci U S A. 2009;106:8501-6 pubmed publisher
    ..Both Dfurin1 and Dfurin2 are involved in the processing of DPP proproteins...
  6. Roebroek A, Ayoubi T, Creemers J, Pauli I, Van de Ven W. The Dfur2 gene of Drosophila melanogaster: genetic organization, expression during embryogenesis, and pro-protein processing activity of its translational product Dfurin2. DNA Cell Biol. 1995;14:223-34 pubmed
    ..expression of the Dfur2 gene of Drosophila melanogaster, which encodes the subtilisin-like serine endoprotease Dfurin2, was studied...
  7. Roebroek A, Creemers J, Pauli I, Kurzik Dumke U, Rentrop M, Gateff E, et al. Cloning and functional expression of Dfurin2, a subtilisin-like proprotein processing enzyme of Drosophila melanogaster with multiple repeats of a cysteine motif. J Biol Chem. 1992;267:17208-15 pubmed
    ..This Dfur2 cDNA has an open reading frame for a 1680-residue protein, called Dfurin2. Dfurin2 contains similar protein domains as mammalian furin, however, it has an extended amino-terminal region ..
  8. De Bie I, Savaria D, Roebroek A, Day R, Lazure C, Van de Ven W, et al. Processing specificity and biosynthesis of the Drosophila melanogaster convertases dfurin1, dfurin1-CRR, dfurin1-X, and dfurin2. J Biol Chem. 1995;270:1020-8 pubmed
    ..However, in the media of cells containing secretory granules, such as GH4C1 and AtT-20, dfurin1-CRR and dfurin2 predominate over dfurin1, whereas dfurin1-X is never detected...
  9. Sappington T, Raikhel A. Molecular characteristics of insect vitellogenins and vitellogenin receptors. Insect Biochem Mol Biol. 1998;28:277-300 pubmed

More Information


  1. Brüning M, Lummer M, Bentele C, Smolenaars M, Rodenburg K, Ragg H. The Spn4 gene from Drosophila melanogaster is a multipurpose defence tool directed against proteases from three different peptidase families. Biochem J. 2007;401:325-31 pubmed
    ..synthesis of multiple protease inhibitor isoforms, one of which has been shown to be a potent inhibitor of human furin. Here, we have investigated the inhibitory spectrum of all Spn4 RSL variants...
  2. Johnson T, Henstridge M, Herr A, Moore K, Whisstock J, Warr C. Torso-like mediates extracellular accumulation of Furin-cleaved Trunk to pattern the Drosophila embryo termini. Nat Commun. 2015;6:8759 pubmed publisher
    ..Here we find that Trunk is cleaved intracellularly by Furin proteases...
  3. Kim Y, Igiesuorobo O, Ramos C, Bao H, Zhang B, Serpe M. Prodomain removal enables neto to stabilize glutamate receptors at the Drosophila neuromuscular junction. PLoS Genet. 2015;11:e1004988 pubmed publisher
    ..However, Neto prodomain must be removed to enable iGluRs synaptic stabilization and proper postsynaptic differentiation. ..
  4. Roebroek A, Pauli I, Zhang Y, Van de Ven W. cDNA sequence of a Drosophila melanogaster gene, Dfur1, encoding a protein structurally related to the subtilisin-like proprotein processing enzyme furin. FEBS Lett. 1991;289:133-7 pubmed
    ..This protein, designated Dfurin1, exhibited striking sequence homology to human furin and contained the same protein domains except for the cysteine-rich region...
  5. Hessle V, Bjork P, Sokolowski M, González de Valdivia E, Silverstein R, Artemenko K, et al. The exosome associates cotranscriptionally with the nascent pre-mRNP through interactions with heterogeneous nuclear ribonucleoproteins. Mol Biol Cell. 2009;20:3459-70 pubmed publisher
    ..Our results lead to a revised mechanistic model for cotranscriptional quality control in which the exosome is constantly recruited to newly synthesized RNAs through direct interactions with specific hnRNP proteins. ..
  6. Lake R, Grimm L, Veraksa A, Banos A, Artavanis Tsakonas S. In vivo analysis of the Notch receptor S1 cleavage. PLoS ONE. 2009;4:e6728 pubmed publisher
    ..Our results demonstrate a correlation between loss of cleavage and loss of in vivo function of the Notch receptor, supporting the notion that S1 cleavage is an in vivo mechanism of Notch signal control. ..
  7. Zhou D, Udpa N, Gersten M, Visk D, Bashir A, Xue J, et al. Experimental selection of hypoxia-tolerant Drosophila melanogaster. Proc Natl Acad Sci U S A. 2011;108:2349-54 pubmed publisher
    ..Unique analytical tools and genetic and bioinformatic strategies allowed us to discover that Notch activation plays a major role in this hypoxia tolerance in Drosophila melanogaster. ..
  8. Zhang L, Syed Z, van Dijk Härd I, Lim J, Wells L, Ten Hagen K. O-glycosylation regulates polarized secretion by modulating Tango1 stability. Proc Natl Acad Sci U S A. 2014;111:7296-301 pubmed publisher
    ..Golgi/endoplasmic reticulum protein, Tango1 (Transport and Golgi organization 1), and conferring protection from furin-mediated proteolysis...
  9. Gelbart M, Larschan E, Peng S, Park P, Kuroda M. Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation. Nat Struct Mol Biol. 2009;16:825-32 pubmed publisher
  10. Hessle V, von Euler A, González de Valdivia E, Visa N. Rrp6 is recruited to transcribed genes and accompanies the spliced mRNA to the nuclear pore. RNA. 2012;18:1466-74 pubmed publisher
    ..These observations suggest that the quality control of pre-mRNA splicing is not based on the selective recruitment of the exoribonuclease Rrp6 to unprocessed mRNAs. ..
  11. Meng X, Wahlström G, Immonen T, Kolmer M, Tirronen M, Predel R, et al. The Drosophila hugin gene codes for myostimulatory and ecdysis-modifying neuropeptides. Mech Dev. 2002;117:5-13 pubmed