ft

Summary

Gene Symbol: ft
Description: fat
Alias: 79/18, CG3352, CT11259, Dm Fat, Dmel\CG3352, Fat, l(2)24Da, l(2)79/18, l(2)fat, l(2)fd, l(2)ft, l(2)gd-1, l(2)gd-l, l(2)gd2, l(2)k07918, fat, CG3352-PA, floppy-discs, ft-PA, giant discs 2, giant-discs-1
Species: fruit fly

Top Publications

  1. Jursnich V, Fraser S, Held L, Ryerse J, Bryant P. Defective gap-junctional communication associated with imaginal disc overgrowth and degeneration caused by mutations of the dco gene in Drosophila. Dev Biol. 1990;140:413-29 pubmed
    ..The results suggest that gap-junctional cell communication may be involved in the cell interactions that limit cell proliferation in vivo. ..
  2. Garoia F, Guerra D, Pezzoli M, López Varea A, Cavicchi S, Garcia Bellido A. Cell behaviour of Drosophila fat cadherin mutations in wing development. Mech Dev. 2000;94:95-109 pubmed
    We have studied several cell behaviour parameters of mutant alleles of fat (ft) in Drosophila imaginal wing disc development...
  3. Devenport D. The cell biology of planar cell polarity. J Cell Biol. 2014;207:171-9 pubmed publisher
    ..Together, these findings are shedding light on how global cues integrate with local cell interactions to organize cellular polarity at the tissue level. ..
  4. Matis M, Russler Germain D, Hu Q, Tomlin C, Axelrod J. Microtubules provide directional information for core PCP function. elife. 2014;3:e02893 pubmed publisher
    ..Two molecular modules composed of Fat(Ft)/Dachsous(Ds)/Four-jointed(Fj) and a 'PCP-core' including Frizzled(Fz) and Dishevelled(Dsh) contribute to ..
  5. Clark H, Brentrup D, Schneitz K, Bieber A, Goodman C, Noll M. Dachsous encodes a member of the cadherin superfamily that controls imaginal disc morphogenesis in Drosophila. Genes Dev. 1995;9:1530-42 pubmed
    ..and shown to encode a huge transmembrane protein that is a member of the cadherin superfamily, similar to the fat gene reported previously...
  6. Harumoto T, Ito M, Shimada Y, Kobayashi T, Ueda H, Lu B, et al. Atypical cadherins Dachsous and Fat control dynamics of noncentrosomal microtubules in planar cell polarity. Dev Cell. 2010;19:389-401 pubmed publisher
    ..This characteristic alignment and asymmetry of MT growth was controlled by atypical cadherins Dachsous (Ds) and Fat (Ft). Furthermore, the action of Ft was mediated in part by PAR-1...
  7. Tyler D, Baker N. Expanded and fat regulate growth and differentiation in the Drosophila eye through multiple signaling pathways. Dev Biol. 2007;305:187-201 pubmed
    ..Mutations in ft show effects on proliferation, Wg signaling and sterols very similar to those of ex mutations...
  8. Robinson B, Huang J, Hong Y, Moberg K. Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded. Curr Biol. 2010;20:582-90 pubmed publisher
  9. Lawrence P, Struhl G, Casal J. Planar cell polarity: one or two pathways?. Nat Rev Genet. 2007;8:555-63 pubmed
    ..We argue that the prevailing opinion that planar polarity depends on a single genetic pathway is wrong and conclude that there are (at least) two independently acting processes. This conclusion has major consequences for the PCP field. ..
  10. Matakatsu H, Blair S. Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins. Development. 2006;133:2315-24 pubmed
    The protocadherins Fat (Ft) and Dachsous (Ds) are required for several processes in the development of Drosophila, including controlling growth of imaginal discs, planar cell polarity (PCP) and the proximodistal patterning of appendages...

Detail Information

Publications75

  1. Jursnich V, Fraser S, Held L, Ryerse J, Bryant P. Defective gap-junctional communication associated with imaginal disc overgrowth and degeneration caused by mutations of the dco gene in Drosophila. Dev Biol. 1990;140:413-29 pubmed
    ..The results suggest that gap-junctional cell communication may be involved in the cell interactions that limit cell proliferation in vivo. ..
  2. Garoia F, Guerra D, Pezzoli M, López Varea A, Cavicchi S, Garcia Bellido A. Cell behaviour of Drosophila fat cadherin mutations in wing development. Mech Dev. 2000;94:95-109 pubmed
    We have studied several cell behaviour parameters of mutant alleles of fat (ft) in Drosophila imaginal wing disc development...
  3. Devenport D. The cell biology of planar cell polarity. J Cell Biol. 2014;207:171-9 pubmed publisher
    ..Together, these findings are shedding light on how global cues integrate with local cell interactions to organize cellular polarity at the tissue level. ..
  4. Matis M, Russler Germain D, Hu Q, Tomlin C, Axelrod J. Microtubules provide directional information for core PCP function. elife. 2014;3:e02893 pubmed publisher
    ..Two molecular modules composed of Fat(Ft)/Dachsous(Ds)/Four-jointed(Fj) and a 'PCP-core' including Frizzled(Fz) and Dishevelled(Dsh) contribute to ..
  5. Clark H, Brentrup D, Schneitz K, Bieber A, Goodman C, Noll M. Dachsous encodes a member of the cadherin superfamily that controls imaginal disc morphogenesis in Drosophila. Genes Dev. 1995;9:1530-42 pubmed
    ..and shown to encode a huge transmembrane protein that is a member of the cadherin superfamily, similar to the fat gene reported previously...
  6. Harumoto T, Ito M, Shimada Y, Kobayashi T, Ueda H, Lu B, et al. Atypical cadherins Dachsous and Fat control dynamics of noncentrosomal microtubules in planar cell polarity. Dev Cell. 2010;19:389-401 pubmed publisher
    ..This characteristic alignment and asymmetry of MT growth was controlled by atypical cadherins Dachsous (Ds) and Fat (Ft). Furthermore, the action of Ft was mediated in part by PAR-1...
  7. Tyler D, Baker N. Expanded and fat regulate growth and differentiation in the Drosophila eye through multiple signaling pathways. Dev Biol. 2007;305:187-201 pubmed
    ..Mutations in ft show effects on proliferation, Wg signaling and sterols very similar to those of ex mutations...
  8. Robinson B, Huang J, Hong Y, Moberg K. Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded. Curr Biol. 2010;20:582-90 pubmed publisher
  9. Lawrence P, Struhl G, Casal J. Planar cell polarity: one or two pathways?. Nat Rev Genet. 2007;8:555-63 pubmed
    ..We argue that the prevailing opinion that planar polarity depends on a single genetic pathway is wrong and conclude that there are (at least) two independently acting processes. This conclusion has major consequences for the PCP field. ..
  10. Matakatsu H, Blair S. Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins. Development. 2006;133:2315-24 pubmed
    The protocadherins Fat (Ft) and Dachsous (Ds) are required for several processes in the development of Drosophila, including controlling growth of imaginal discs, planar cell polarity (PCP) and the proximodistal patterning of appendages...
  11. Ling C, Zheng Y, Yin F, Yu J, Huang J, Hong Y, et al. The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded. Proc Natl Acad Sci U S A. 2010;107:10532-7 pubmed publisher
    ..Furthermore, our studies implicate Crb as a putative cell surface receptor for Hippo signaling by uncovering a transmembrane protein that directly binds to an apical component of the Hippo pathway. ..
  12. Poon C, Lin J, Zhang X, Harvey K. The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway. Dev Cell. 2011;21:896-906 pubmed publisher
    ..Given that SWH pathway activity is subverted in many human cancers, our findings identify human TAO kinases as potential tumor suppressor genes. ..
  13. Pan G, Feng Y, Ambegaonkar A, Sun G, Huff M, Rauskolb C, et al. Signal transduction by the Fat cytoplasmic domain. Development. 2013;140:831-42 pubmed publisher
    The large atypical cadherin Fat is a receptor for both Hippo and planar cell polarity (PCP) pathways...
  14. Feng Y, Irvine K. Processing and phosphorylation of the Fat receptor. Proc Natl Acad Sci U S A. 2009;106:11989-94 pubmed publisher
    The Drosophila tumor suppressors fat and discs overgrown (dco) function within an intercellular signaling pathway that controls growth and polarity...
  15. Hogan J, Valentine M, Cox C, Doyle K, Collier S. Two frizzled planar cell polarity signals in the Drosophila wing are differentially organized by the Fat/Dachsous pathway. PLoS Genet. 2011;7:e1001305 pubmed publisher
    ..Normal wing PCP requires both the Frizzled (Fz) PCP pathway and the Fat/Dachsous (Ft/Ds) pathway, although the functional relationship between these pathways remains under debate...
  16. Bossuyt W, Chen C, Chen Q, Sudol M, McNeill H, Pan D, et al. An evolutionary shift in the regulation of the Hippo pathway between mice and flies. Oncogene. 2014;33:1218-28 pubmed publisher
    ..Here we show that the mouse Fat4 cadherin, the ortholog of the Hippo pathway regulator Fat in Drosophila, does not apparently regulate the Hippo pathway in the murine liver...
  17. Ishikawa H, Takeuchi H, Haltiwanger R, Irvine K. Four-jointed is a Golgi kinase that phosphorylates a subset of cadherin domains. Science. 2008;321:401-4 pubmed publisher
    The atypical cadherin Fat acts as a receptor for a signaling pathway that regulates growth, gene expression, and planar cell polarity. Genetic studies in Drosophila identified the four-jointed gene as a regulator of Fat signaling...
  18. Ambegaonkar A, Pan G, Mani M, Feng Y, Irvine K. Propagation of Dachsous-Fat planar cell polarity. Curr Biol. 2012;22:1302-8 pubmed publisher
    The Fat pathway controls both planar cell polarity (PCP) and organ growth. Fat signaling is regulated by the graded expression of the Fat ligand Dachsous (Ds) and the cadherin-domain kinase Four-jointed (Fj)...
  19. Mao Y, Kucuk B, Irvine K. Drosophila lowfat, a novel modulator of Fat signaling. Development. 2009;136:3223-33 pubmed publisher
    The Fat-Hippo-Warts signaling network regulates both transcription and planar cell polarity...
  20. Repiso A, Saavedra P, Casal J, Lawrence P. Planar cell polarity: the orientation of larval denticles in Drosophila appears to depend on gradients of Dachsous and Fat. Development. 2010;137:3411-5 pubmed publisher
    ..We present evidence that denticle orientation is determined almost entirely by Dachsous and Fat, one of two planar cell polarity systems...
  21. Marcinkevicius E, Zallen J. Regulation of cytoskeletal organization and junctional remodeling by the atypical cadherin Fat. Development. 2013;140:433-43 pubmed publisher
    The atypical cadherin Fat is a conserved regulator of planar cell polarity, but the mechanisms by which Fat controls cell shape and tissue structure are not well understood...
  22. Genevet A, Polesello C, Blight K, Robertson F, Collinson L, Pichaud F, et al. The Hippo pathway regulates apical-domain size independently of its growth-control function. J Cell Sci. 2009;122:2360-70 pubmed publisher
    ..Therefore, Hippo signalling controls growth and apical domain size by distinct mechanisms. ..
  23. Feng Y, Irvine K. Fat and expanded act in parallel to regulate growth through warts. Proc Natl Acad Sci U S A. 2007;104:20362-7 pubmed
    The conserved Drosophila tumor suppressors Fat and Expanded have both recently been implicated in regulating the activity of the Warts tumor suppressor...
  24. Chen C, Gajewski K, Hamaratoglu F, Bossuyt W, Sansores Garcia L, Tao C, et al. The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila. Proc Natl Acad Sci U S A. 2010;107:15810-5 pubmed publisher
    ..mislocalized in both crb mutant cells and Crb overexpressing tissues, whereas the other Hippo pathway components, Fat and Merlin, are unaffected...
  25. Silva E, Tsatskis Y, Gardano L, Tapon N, McNeill H. The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway. Curr Biol. 2006;16:2081-9 pubmed
    ..We find that another Drosophila tumor-suppressor gene, the atypical cadherin fat, regulates both cell proliferation and cell death in developing imaginal discs...
  26. Simon M. Planar cell polarity in the Drosophila eye is directed by graded Four-jointed and Dachsous expression. Development. 2004;131:6175-84 pubmed
    ..gradients were proposed to specify the direction of polarization by producing an activity gradient of the cadherin Fat within each ommatidium...
  27. Bryant P, Huettner B, Held L, Ryerse J, Szidonya J. Mutations at the fat locus interfere with cell proliferation control and epithelial morphogenesis in Drosophila. Dev Biol. 1988;129:541-54 pubmed
    Lethal mutations at the fat locus in Drosophila cause imaginal discs to continue to grow by cell proliferation far beyond their normal final size...
  28. Ayukawa T, Akiyama M, Mummery Widmer J, Stoeger T, Sasaki J, Knoblich J, et al. Dachsous-dependent asymmetric localization of spiny-legs determines planar cell polarity orientation in Drosophila. Cell Rep. 2014;8:610-21 pubmed publisher
    ..When the amount of Sple is increased in the wing, Sple induces a reversal of PCP using the Ds-Ft system. A mathematical model demonstrates that Sple is the key regulator connecting Ds and the core proteins...
  29. Strutt H, Strutt D. Planar polarity: photoreceptors on a high fat diet. Curr Biol. 2002;12:R384-5 pubmed
    Differential activity of Frizzled in the R3/R4 photo-receptors of Drosophila regulates the orientation of ommatidia. New evidence suggests that the cadherins Dachsous and Fat act upstream of Frizzled in this process.
  30. Ren F, Wang B, Yue T, Yun E, Ip Y, Jiang J. Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. Proc Natl Acad Sci U S A. 2010;107:21064-9 pubmed publisher
    ..Finally, we show that the Hpo pathway mediator Yorkie (Yki) is also required in precursor cells for injury-induced ISC proliferation in response to tissue-damaging reagent DSS. ..
  31. Matakatsu H, Blair S. The DHHC palmitoyltransferase approximated regulates Fat signaling and Dachs localization and activity. Curr Biol. 2008;18:1390-5 pubmed publisher
    Signaling via the large protocadherin Fat (Ft), regulated in part by its binding partner Dachsous (Ds) and the Golgi-resident kinase Four-jointed (Fj), is required for a variety of developmental functions in Drosophila...
  32. Zhai B, Villen J, Beausoleil S, Mintseris J, Gygi S. Phosphoproteome analysis of Drosophila melanogaster embryos. J Proteome Res. 2008;7:1675-82 pubmed publisher
    ..63% at the peptide level. Because of the large size of the data set, both novel and known phosphorylation motifs were extracted using the Motif-X algorithm, including those representative of potential ordered phosphorylation events. ..
  33. Donoughe S, Dinardo S. dachsous and frizzled contribute separately to planar polarity in the Drosophila ventral epidermis. Development. 2011;138:2751-9 pubmed publisher
    ..Furthermore, we find that the requirement for the Ds system changes as field size increases. Lastly, we find that Ds and its putative receptor Fat (Ft) are enriched in distinct patterns in the epithelium during embryonic development.
  34. Rawls A, Guinto J, Wolff T. The cadherins fat and dachsous regulate dorsal/ventral signaling in the Drosophila eye. Curr Biol. 2002;12:1021-6 pubmed
    ..We report the role of two cadherins, Fat (Ft) and Dachsous (Ds), in conveying the polarizing signal from the D/V midline in the Drosophila eye...
  35. Hamaratoglu F, Gajewski K, Sansores Garcia L, Morrison C, Tao C, Halder G. The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth. J Cell Sci. 2009;122:2351-9 pubmed publisher
    ..The Hippo pathway includes the Fat cadherin, a transmembrane protein, which acts upstream of several other components that form a kinase cascade that ..
  36. Ma D, Amonlirdviman K, Raffard R, Abate A, Tomlin C, Axelrod J. Cell packing influences planar cell polarity signaling. Proc Natl Acad Sci U S A. 2008;105:18800-5 pubmed publisher
    ..A Frizzled-mediated feedback loop coordinates PCP between neighboring cells, and the cadherin Fat transduces a global directional cue that orients PCP with respect to the tissue axes...
  37. Strutt D. Organ shape: controlling oriented cell division. Curr Biol. 2005;15:R758-9 pubmed
    ..One mechanism by which organisms control the shape of growing organs is by regulating the orientation of cell divisions. This occurs in the Drosophila wing under the control of genes previously implicated in regulating cell polarity. ..
  38. Karpowicz P, Perez J, Perrimon N. The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. Development. 2010;137:4135-45 pubmed publisher
    ..further show that prior to injury, Yki activity is constitutively repressed by the upstream Hippo pathway members Fat and Dachsous (Ds)...
  39. Matakatsu H, Blair S. Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing. Development. 2004;131:3785-94 pubmed
    ..PCP) in the Drosophila wing, orienting cell-cell interactions by inhibiting the activity of the protocadherin Fat (Ft)...
  40. Amonlirdviman K, Khare N, Tree D, Chen W, Axelrod J, Tomlin C. Mathematical modeling of planar cell polarity to understand domineering nonautonomy. Science. 2005;307:423-6 pubmed
    ..The sufficiency of this model and the experimental validation of model predictions reveal how specific protein-protein interactions produce autonomy or domineering nonautonomy. ..
  41. Oh H, Irvine K. In vivo regulation of Yorkie phosphorylation and localization. Development. 2008;135:1081-8 pubmed publisher
    Yorkie (Yki), a transcription factor of the Fat and Hippo signaling pathways, is negatively regulated by the Warts kinase...
  42. Rauskolb C, Pan G, Reddy B, Oh H, Irvine K. Zyxin links fat signaling to the hippo pathway. PLoS Biol. 2011;9:e1000624 pubmed publisher
    ..Through epistasis tests, we position the requirement for Zyx within the Fat branch of Hippo signaling, downstream of Fat and Dco, and upstream of the Yorkie kinase Warts, and we find that Zyx ..
  43. Garoia F, Grifoni D, Trotta V, Guerra D, Pezzoli M, Cavicchi S. The tumor suppressor gene fat modulates the EGFR-mediated proliferation control in the imaginal tissues of Drosophila melanogaster. Mech Dev. 2005;122:175-87 pubmed
    ..The Fat cadherin is a tumor suppressor protein required in Drosophila for epithelial morphogenesis, proliferation control ..
  44. Brittle A, Thomas C, Strutt D. Planar polarity specification through asymmetric subcellular localization of Fat and Dachsous. Curr Biol. 2012;22:907-14 pubmed publisher
    Two pathways regulate planar polarity: the core proteins and the Fat-Dachsous-Four-jointed (Ft-Ds-Fj) system. Morphogens specify complementary expression patterns of Ds and Fj that potentially act as polarizing cues...
  45. Goulev Y, Fauny J, Gonzalez Marti B, Flagiello D, Silber J, Zider A. SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila. Curr Biol. 2008;18:435-41 pubmed publisher
    ..induces vg and dE2F1 expression and that proliferation induced by YKI or by a dominant-negative form of FAT in wing disc is significantly reduced in a sd hypomorphic mutant context...
  46. Meignin C, Alvarez Garcia I, Davis I, Palacios I. The salvador-warts-hippo pathway is required for epithelial proliferation and axis specification in Drosophila. Curr Biol. 2007;17:1871-8 pubmed
    ..This work highlights a novel connection between cell proliferation, cell growth, and axis specification in egg chambers. ..
  47. Cho E, Irvine K. Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling. Development. 2004;131:4489-500 pubmed
    ..Here, we show that three genes that act together during the establishment of tissue polarity, fat, four-jointed and dachsous, also influence the expression of Wingless in the proximal wing...
  48. Ma D, Yang C, McNeill H, Simon M, Axelrod J. Fidelity in planar cell polarity signalling. Nature. 2003;421:543-7 pubmed
    ..The first tier, mediated by the cadherin Fat, dictates global orientation by transducing a directional signal to individual cells...
  49. Oh H, Reddy B, Irvine K. Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling. Dev Biol. 2009;335:188-97 pubmed publisher
    The Fat-Hippo signaling pathway plays an important role in the regulation of normal organ growth during development, and in pathological growth during cancer...
  50. Grusche F, Degoutin J, Richardson H, Harvey K. The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster. Dev Biol. 2011;350:255-66 pubmed publisher
    ..Several proteins serve as upstream modulators of this pathway including the atypical cadherins, Dachsous and Fat, whilst the atypical myosin, Dachs, functions downstream of Fat to activate Yorkie...
  51. Yang C, Axelrod J, Simon M. Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye. Cell. 2002;108:675-88 pubmed
    ..We show that two cadherin superfamily members, Fat and Dachsous, and the transmembrane/secreted protein Four-jointed play important roles in this process...
  52. Matakatsu H, Blair S. Separating planar cell polarity and Hippo pathway activities of the protocadherins Fat and Dachsous. Development. 2012;139:1498-508 pubmed publisher
    The giant Drosophila protocadherin Fat (Ft) affects planar cell polarity (PCP). Ft also inhibits the overgrowth of imaginal discs via the Hippo pathway, repressing the activity of the transcription co-factor Yorkie (Yki)...
  53. Baena Lopez L, Rodriguez I, Baonza A. The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating dally and dally-like. Proc Natl Acad Sci U S A. 2008;105:9645-50 pubmed publisher
    ..The Drosophila tumor suppressor genes dachsous (ds) and fat (ft) modulate organ size and pattern formation during imaginal disc development...
  54. Cho E, Feng Y, Rauskolb C, Maitra S, Fehon R, Irvine K. Delineation of a Fat tumor suppressor pathway. Nat Genet. 2006;38:1142-50 pubmed
    Recent studies in Drosophila melanogaster of the protocadherins Dachsous and Fat suggest that they act as ligand and receptor, respectively, for an intercellular signaling pathway that influences tissue polarity, growth and gene ..
  55. Fanto M, Clayton L, Meredith J, Hardiman K, Charroux B, Kerridge S, et al. The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor. Development. 2003;130:763-74 pubmed
    b>Fat is an atypical cadherin that controls both cell growth and planar polarity...
  56. Brittle A, Repiso A, Casal J, Lawrence P, Strutt D. Four-jointed modulates growth and planar polarity by reducing the affinity of dachsous for fat. Curr Biol. 2010;20:803-10 pubmed publisher
    The Drosophila genes fat (ft) and dachsous (ds) encode large atypical cadherins that collaborate to coordinately polarize cells in the plane of the epithelium (planar cell polarity) and to affect growth via the Warts/Hippo pathway...
  57. Willecke M, Hamaratoglu F, Sansores Garcia L, Tao C, Halder G. Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation. Proc Natl Acad Sci U S A. 2008;105:14897-902 pubmed publisher
    ..To date a signal transduction cascade from the Cadherin Fat at the plasma membrane into the nucleus has been discovered...
  58. Lawrence P, Casal J. The mechanisms of planar cell polarity, growth and the Hippo pathway: some known unknowns. Dev Biol. 2013;377:1-8 pubmed publisher
    ..afresh how the Hippo pathway might be linked both to growth and to PCP through the gigantic cadherin molecule Fat. We offer some new ways of making sense of published results, particularly those relating to the Frizzled/Starry ..
  59. Casal J, Struhl G, Lawrence P. Developmental compartments and planar polarity in Drosophila. Curr Biol. 2002;12:1189-98 pubmed
    ..We report here that the three genes, four-jointed, dachsous, and fat, cause opposite effects in anterior and posterior compartments...
  60. Hafezi Y, Bosch J, Hariharan I. Differences in levels of the transmembrane protein Crumbs can influence cell survival at clonal boundaries. Dev Biol. 2012;368:358-69 pubmed publisher
    ..Thus, Crb may be part of a "surveillance mechanism" that is responsible for the cell death that is observed at the boundaries of mutant clones in these cases. ..
  61. Zhao M, Szafranski P, Hall C, Goode S. Basolateral junctions utilize warts signaling to control epithelial-mesenchymal transition and proliferation crucial for migration and invasion of Drosophila ovarian epithelial cells. Genetics. 2008;178:1947-71 pubmed publisher
    ..Apicolateral junction proteins Fat (Ft), Expanded (Ex), and Merlin (Mer) either are not involved in these processes, or have highly spatio-temporally ..
  62. Hariharan I. Growth regulation: a beginning for the hippo pathway. Curr Biol. 2006;16:R1037-9 pubmed
    A signaling pathway involving two protein kinases, Hippo and Warts, restricts the growth of imaginal discs in Drosophila. Four recent studies taken together show that the protocadherin Fat can regulate Warts in two different ways.
  63. Mahoney P, Weber U, Onofrechuk P, Biessmann H, Bryant P, Goodman C. The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily. Cell. 1991;67:853-68 pubmed
    Recessive lethal mutations in the fat locus of Drosophila cause hyperplastic, tumor-like overgrowth of larval imaginal discs, defects in differentiation and morphogenesis, and death during the pupal stage...
  64. Sopko R, Silva E, Clayton L, Gardano L, Barrios Rodiles M, Wrana J, et al. Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown. Curr Biol. 2009;19:1112-7 pubmed publisher
    The Drosophila tumor suppressor gene fat encodes a large cadherin that regulates growth and a form of tissue organization known as planar cell polarity (PCP)...
  65. Rogulja D, Rauskolb C, Irvine K. Morphogen control of wing growth through the Fat signaling pathway. Dev Cell. 2008;15:309-21 pubmed publisher
    ..We show that the Dpp morphogen gradient in the Drosophila wing influences growth by modulating the activity of the Fat signaling pathway...
  66. Polesello C, Tapon N. Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch. Curr Biol. 2007;17:1864-70 pubmed
    ..The PCP members of the SWH network are not involved in this process, indicating that signaling upstream of Hpo varies according to developmental context. ..
  67. Casal J, Lawrence P, Struhl G. Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity. Development. 2006;133:4561-72 pubmed
    ..it depends on at least two sets of genes: one set, the Ds system, encodes the cadherins Dachsous (Ds) and Fat (Ft), as well as the Golgi protein Four-jointed...
  68. Mao Y, Rauskolb C, Cho E, Hu W, Hayter H, Minihan G, et al. Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila. Development. 2006;133:2539-51 pubmed
    ..dachs gene, characterize the localization of Dachs protein, and investigate the relationship between Dachs and the Fat pathway. Mutation of dachs reduces, but does not abolish, the growth of legs and wings...
  69. Baena Lopez L, Baonza A, García Bellido A. The orientation of cell divisions determines the shape of Drosophila organs. Curr Biol. 2005;15:1640-4 pubmed
    ..In addition, we find that a subset of planar cell polarity genes is required for the proper orientation of cell division during organ development. ..
  70. Boggiano J, Vanderzalm P, Fehon R. Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway. Dev Cell. 2011;21:888-95 pubmed publisher
    ..These results demonstrate that one family of Ste20 kinases can activate another and identify Tao-1 as a component of the regulatory network controlling HSW pathway signaling, and therefore tissue growth, during development. ..
  71. Zhu H. Is anisotropic propagation of polarized molecular distribution the common mechanism of swirling patterns of planar cell polarization?. J Theor Biol. 2009;256:315-25 pubmed publisher
    ..Damaged global directional cue caused by mutations in four-jointed, fat, and dachsous, impaired cellular hexagonal packing caused by mutations in frizzled, or weakened intracellular ..
  72. Hazelwood L, Hancock J. Functional modelling of planar cell polarity: an approach for identifying molecular function. BMC Dev Biol. 2013;13:20 pubmed publisher
    ..The predictions from the model allow direct assignment of functional roles of genes from genetic mosaic analysis of Drosophila wings. ..
  73. Zecca M, Struhl G. A feed-forward circuit linking wingless, fat-dachsous signaling, and the warts-hippo pathway to Drosophila wing growth. PLoS Biol. 2010;8:e1000386 pubmed publisher
    ..Here, we identify the protocadherins Fat (Ft) and Dachsous (Ds), the Warts-Hippo tumor suppressor pathway, and the transcriptional co-activator Yorkie (Yki, ..
  74. Zhao X, Yang C, Simon M. The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains. PLoS ONE. 2013;8:e62998 pubmed publisher
    The Drosophila Cadherin Fat (Ft) has been identified as a crucial regulator of tissue size and Planar Cell Polarity (PCP). However, the precise mechanism by which Ft regulates these processes remains unclear...
  75. Bennett F, Harvey K. Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway. Curr Biol. 2006;16:2101-10 pubmed
    The atypical Fat cadherin has long been known to control cell proliferation and organ size in Drosophila, but the mechanism by which Fat controls these processes has remained elusive...