ft

Summary

Gene Symbol: ft
Description: fat
Alias: 79/18, CG3352, CT11259, Dm Fat, Dmel\CG3352, Fat, l(2)24Da, l(2)79/18, l(2)fat, l(2)fd, l(2)ft, l(2)gd-1, l(2)gd-l, l(2)gd2, l(2)k07918, CG3352 gene product from transcript CG3352-RA, CG3352-PA, floppy-discs, ft-PA, giant discs 2, giant-discs-1
Species: fruit fly

Top Publications

  1. pmc Four-jointed is a Golgi kinase that phosphorylates a subset of cadherin domains
    Hiroyuki O Ishikawa
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Science 321:401-4. 2008
  2. ncbi Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing
    Hitoshi Matakatsu
    Department of Zoology, University of Wisconsin, 250 North Mills Street, Madison, WI 53706, USA
    Development 131:3785-94. 2004
  3. ncbi Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila
    Yaopan Mao
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 133:2539-51. 2006
  4. pmc Fat and expanded act in parallel to regulate growth through warts
    Yongqiang Feng
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 104:20362-7. 2007
  5. pmc The Hippo pathway regulates apical-domain size independently of its growth-control function
    Alice Genevet
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Cell Sci 122:2360-70. 2009
  6. pmc Processing and phosphorylation of the Fat receptor
    Yongqiang Feng
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway NJ 08854, USA
    Proc Natl Acad Sci U S A 106:11989-94. 2009
  7. pmc Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity
    José Casal
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 133:4561-72. 2006
  8. pmc Drosophila lowfat, a novel modulator of Fat signaling
    Yaopan Mao
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 136:3223-33. 2009
  9. ncbi The tumor suppressor gene fat modulates the EGFR-mediated proliferation control in the imaginal tissues of Drosophila melanogaster
    Flavio Garoia
    Alma Mater Studiorum, Universita di Bologna, CIRSA GenMAP Lab, via S Alberto 163, 48100 Ravenna, Italy
    Mech Dev 122:175-87. 2005
  10. ncbi Long-range coordination of planar polarity in Drosophila
    Helen Strutt
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield, UK
    Bioessays 27:1218-27. 2005

Research Grants

  1. MOLECULAR GENETIC OF TYROSINE KINASE AND RAS FUNCTION
    Michael Simon; Fiscal Year: 2001
  2. CYTOSKELETAL REGULATION BY SRC64/TEC29 KINASES
    Michael Simon; Fiscal Year: 2004
  3. Cadherin regulation of tissue polarity and growth
    Michael Simon; Fiscal Year: 2007
  4. CONFOCAL MICROSCOPE FOR LIVE CELL & MULTIWAVELENGTH WORK
    Mark Peifer; Fiscal Year: 2001
  5. Analysis of fringe-dependent cell-signaling
    Kenneth Irvine; Fiscal Year: 2004
  6. Transcriptional Repression and Cofactor Recruitment
    Susan Parkhurst; Fiscal Year: 2008
  7. Mechanisms of Wound Healing in Drosphila
    Susan Parkhurst; Fiscal Year: 2009
  8. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    Susan Parkhurst; Fiscal Year: 2002
  9. Mechanisms governing polarity in Drosophila oogenesis
    Daniel Kalderon; Fiscal Year: 2004
  10. Mechanisms of Rho GTPase Function in Drosophila
    Susan Parkhurst; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications120 found, 100 shown here

  1. pmc Four-jointed is a Golgi kinase that phosphorylates a subset of cadherin domains
    Hiroyuki O Ishikawa
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Science 321:401-4. 2008
    The atypical cadherin Fat acts as a receptor for a signaling pathway that regulates growth, gene expression, and planar cell polarity. Genetic studies in Drosophila identified the four-jointed gene as a regulator of Fat signaling...
  2. ncbi Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing
    Hitoshi Matakatsu
    Department of Zoology, University of Wisconsin, 250 North Mills Street, Madison, WI 53706, USA
    Development 131:3785-94. 2004
    ..PCP) in the Drosophila wing, orienting cell-cell interactions by inhibiting the activity of the protocadherin Fat (Ft)...
  3. ncbi Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila
    Yaopan Mao
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 133:2539-51. 2006
    ..dachs gene, characterize the localization of Dachs protein, and investigate the relationship between Dachs and the Fat pathway. Mutation of dachs reduces, but does not abolish, the growth of legs and wings...
  4. pmc Fat and expanded act in parallel to regulate growth through warts
    Yongqiang Feng
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 104:20362-7. 2007
    The conserved Drosophila tumor suppressors Fat and Expanded have both recently been implicated in regulating the activity of the Warts tumor suppressor...
  5. pmc The Hippo pathway regulates apical-domain size independently of its growth-control function
    Alice Genevet
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    J Cell Sci 122:2360-70. 2009
    ..Therefore, Hippo signalling controls growth and apical domain size by distinct mechanisms...
  6. pmc Processing and phosphorylation of the Fat receptor
    Yongqiang Feng
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway NJ 08854, USA
    Proc Natl Acad Sci U S A 106:11989-94. 2009
    The Drosophila tumor suppressors fat and discs overgrown (dco) function within an intercellular signaling pathway that controls growth and polarity...
  7. pmc Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity
    José Casal
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 133:4561-72. 2006
    ..it depends on at least two sets of genes: one set, the Ds system, encodes the cadherins Dachsous (Ds) and Fat (Ft), as well as the Golgi protein Four-jointed...
  8. pmc Drosophila lowfat, a novel modulator of Fat signaling
    Yaopan Mao
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 136:3223-33. 2009
    The Fat-Hippo-Warts signaling network regulates both transcription and planar cell polarity...
  9. ncbi The tumor suppressor gene fat modulates the EGFR-mediated proliferation control in the imaginal tissues of Drosophila melanogaster
    Flavio Garoia
    Alma Mater Studiorum, Universita di Bologna, CIRSA GenMAP Lab, via S Alberto 163, 48100 Ravenna, Italy
    Mech Dev 122:175-87. 2005
    ..The Fat cadherin is a tumor suppressor protein required in Drosophila for epithelial morphogenesis, proliferation control ..
  10. ncbi Long-range coordination of planar polarity in Drosophila
    Helen Strutt
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield, UK
    Bioessays 27:1218-27. 2005
    ..is less well understood, but is thought to involve gradients of activity of the atypical cadherins Dachsous and Fat. Subsequently, this long-range polarity signal is refined by local cell-cell interactions involving the ..
  11. pmc Planar cell polarity: one or two pathways?
    Peter A Lawrence
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Nat Rev Genet 8:555-63. 2007
    ..We argue that the prevailing opinion that planar polarity depends on a single genetic pathway is wrong and conclude that there are (at least) two independently acting processes. This conclusion has major consequences for the PCP field...
  12. ncbi Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch
    Cedric Polesello
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln s Inn Fields, London WC2 3PX, United Kingdom
    Curr Biol 17:1864-70. 2007
    ..The PCP members of the SWH network are not involved in this process, indicating that signaling upstream of Hpo varies according to developmental context...
  13. ncbi Defective gap-junctional communication associated with imaginal disc overgrowth and degeneration caused by mutations of the dco gene in Drosophila
    V A Jursnich
    Developmental Biology Center, University of California, Irvine 92717
    Dev Biol 140:413-29. 1990
    ..The results suggest that gap-junctional cell communication may be involved in the cell interactions that limit cell proliferation in vivo...
  14. ncbi Cell behaviour of Drosophila fat cadherin mutations in wing development
    F Garoia
    Dipartimento di Biologia Evoluzionistica Sperimentale, Universita di Bologna, Italy
    Mech Dev 94:95-109. 2000
    We have studied several cell behaviour parameters of mutant alleles of fat (ft) in Drosophila imaginal wing disc development...
  15. ncbi Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye
    Chung Hui Yang
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Cell 108:675-88. 2002
    ..We show that two cadherin superfamily members, Fat and Dachsous, and the transmembrane/secreted protein Four-jointed play important roles in this process...
  16. ncbi Planar polarity: photoreceptors on a high fat diet
    Helen Strutt
    Centre for Developmental Genetics, School of Medicine and Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Curr Biol 12:R384-5. 2002
    Differential activity of Frizzled in the R3/R4 photo-receptors of Drosophila regulates the orientation of ommatidia. New evidence suggests that the cadherins Dachsous and Fat act upstream of Frizzled in this process.
  17. ncbi The cadherins fat and dachsous regulate dorsal/ventral signaling in the Drosophila eye
    Amy S Rawls
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Biol 12:1021-6. 2002
    ..We report the role of two cadherins, Fat (Ft) and Dachsous (Ds), in conveying the polarizing signal from the D/V midline in the Drosophila eye...
  18. ncbi Developmental compartments and planar polarity in Drosophila
    José Casal
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Curr Biol 12:1189-98. 2002
    ....
  19. ncbi The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor
    Manolis Fanto
    Cancer Research UK ICRF, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 130:763-74. 2003
    b>Fat is an atypical cadherin that controls both cell growth and planar polarity...
  20. ncbi Fidelity in planar cell polarity signalling
    Dali Ma
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Nature 421:543-7. 2003
    ..The first tier, mediated by the cadherin Fat, dictates global orientation by transducing a directional signal to individual cells...
  21. ncbi Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling
    Eunjoo Cho
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 131:4489-500. 2004
    ..Here, we show that three genes that act together during the establishment of tissue polarity, fat, four-jointed and dachsous, also influence the expression of Wingless in the proximal wing...
  22. ncbi Planar cell polarity in the Drosophila eye is directed by graded Four-jointed and Dachsous expression
    Michael A Simon
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Development 131:6175-84. 2004
    ..gradients were proposed to specify the direction of polarization by producing an activity gradient of the cadherin Fat within each ommatidium...
  23. ncbi Mathematical modeling of planar cell polarity to understand domineering nonautonomy
    Keith Amonlirdviman
    Department of Aeronautics and Astronautics, Stanford University, Stanford, CA 94305 4035, USA
    Science 307:423-6. 2005
    ..The sufficiency of this model and the experimental validation of model predictions reveal how specific protein-protein interactions produce autonomy or domineering nonautonomy...
  24. ncbi Control of planar cell polarity by interaction of DWnt4 and four-jointed
    Janghoo Lim
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Genesis 42:150-61. 2005
    ..Our results suggest that DWnt4 is involved in ommatidial polarity signaling in the ventral region of the eye and its function is mediated by interacting with Fj...
  25. ncbi The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling
    Sushmita Maitra
    Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637, USA
    Curr Biol 16:702-9. 2006
    ..We propose that these proteins control proliferation by regulating the abundance, localization, and turnover of cell-surface receptors and that misregulation of these processes may be a key component of tumorigenesis...
  26. ncbi Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins
    Hitoshi Matakatsu
    Department of Zoology, University of Wisconsin, 250 North Mills Street, Madison, WI 53706, USA
    Development 133:2315-24. 2006
    The protocadherins Fat (Ft) and Dachsous (Ds) are required for several processes in the development of Drosophila, including controlling growth of imaginal discs, planar cell polarity (PCP) and the proximodistal patterning of appendages...
  27. ncbi Delineation of a Fat tumor suppressor pathway
    Eunjoo Cho
    Howard Hughes Medical Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Nat Genet 38:1142-50. 2006
    Recent studies in Drosophila melanogaster of the protocadherins Dachsous and Fat suggest that they act as ligand and receptor, respectively, for an intercellular signaling pathway that influences tissue polarity, growth and gene ..
  28. ncbi The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size
    Maria Willecke
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Curr Biol 16:2090-100. 2006
    ..However, components acting upstream of Expanded and Merlin, such as transmembrane receptors, have not yet been identified...
  29. ncbi The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway
    Elizabeth Silva
    Samuel Lunenfeld Research Institute and Department of Medical Genetics and Microbiology, University of Toronto, Toronto M5G 1X5, Canada
    Curr Biol 16:2081-9. 2006
    ..The cytoskeletal proteins Merlin and Expanded colocalize at apical junctions and function redundantly upstream of Hippo. It is not clear how they regulate growth or how they are localized to apical junctions...
  30. ncbi Growth regulation: a beginning for the hippo pathway
    Iswar K Hariharan
    Department of Molecular and Cell Biology, 361 LSA, University of California Berkeley, Berkeley, California 94720, USA
    Curr Biol 16:R1037-9. 2006
    A signaling pathway involving two protein kinases, Hippo and Warts, restricts the growth of imaginal discs in Drosophila. Four recent studies taken together show that the protocadherin Fat can regulate Warts in two different ways.
  31. pmc Expanded and fat regulate growth and differentiation in the Drosophila eye through multiple signaling pathways
    David M Tyler
    Department of Molecular Genetics, Albert Einstein College of Medicine 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Dev Biol 305:187-201. 2007
    ..Mutations in ft show effects on proliferation, Wg signaling and sterols very similar to those of ex mutations...
  32. doi SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila
    Youlian Goulev
    Department of Developmental Biology, Unite Mixte de Recherche 7592, Universite Paris 7 Denis Diderot, Tour 43 2, place Jussieu, F 75251 Paris Cedex 05, France
    Curr Biol 18:435-41. 2008
    ..induces vg and dE2F1 expression and that proliferation induced by YKI or by a dominant-negative form of FAT in wing disc is significantly reduced in a sd hypomorphic mutant context...
  33. pmc The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating dally and dally-like
    Luis Alberto Baena-Lopez
    Developmental Neurobiology, National Institute of Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Proc Natl Acad Sci U S A 105:9645-50. 2008
    ..The Drosophila tumor suppressor genes dachsous (ds) and fat (ft) modulate organ size and pattern formation during imaginal disc development...
  34. pmc The DHHC palmitoyltransferase approximated regulates Fat signaling and Dachs localization and activity
    Hitoshi Matakatsu
    Department of Zoology, University of Wisconsin, 250 North Mills Street, Madison, Wisconsin 53706, USA
    Curr Biol 18:1390-5. 2008
    Signaling via the large protocadherin Fat (Ft), regulated in part by its binding partner Dachsous (Ds) and the Golgi-resident kinase Four-jointed (Fj), is required for a variety of developmental functions in Drosophila...
  35. pmc Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation
    Maria Willecke
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:14897-902. 2008
    ..To date a signal transduction cascade from the Cadherin Fat at the plasma membrane into the nucleus has been discovered...
  36. doi Is anisotropic propagation of polarized molecular distribution the common mechanism of swirling patterns of planar cell polarization?
    Hao Zhu
    Division of Applied Mathematics, School of Mathematical Sciences, University of Nottingham, Nottingham NG7 2RD, UK
    J Theor Biol 256:315-25. 2009
    ..Damaged global directional cue caused by mutations in four-jointed, fat, and dachsous, impaired cellular hexagonal packing caused by mutations in frizzled, or weakened intracellular ..
  37. pmc Cell packing influences planar cell polarity signaling
    Dali Ma
    Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305 5324, USA
    Proc Natl Acad Sci U S A 105:18800-5. 2008
    ..A Frizzled-mediated feedback loop coordinates PCP between neighboring cells, and the cadherin Fat transduces a global directional cue that orients PCP with respect to the tissue axes...
  38. pmc The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth
    Fisun Hamaratoglu
    Program in Developmental Biology, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Sci 122:2351-9. 2009
    ..The Hippo pathway includes the Fat cadherin, a transmembrane protein, which acts upstream of several other components that form a kinase cascade that ..
  39. pmc Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown
    Richelle Sopko
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Curr Biol 19:1112-7. 2009
    The Drosophila tumor suppressor gene fat encodes a large cadherin that regulates growth and a form of tissue organization known as planar cell polarity (PCP)...
  40. pmc Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling
    Hyangyee Oh
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Dev Biol 335:188-97. 2009
    The Fat-Hippo signaling pathway plays an important role in the regulation of normal organ growth during development, and in pathological growth during cancer...
  41. doi Echinoid regulates Flamingo endocytosis to control ommatidial rotation in the Drosophila eye
    Yu Huei Ho
    Institute of Molecular Medicine, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan 30034, Republic of China
    Development 137:745-54. 2010
    ..Thus, co-endocytosis of Ed and Fmi provides a link between apicobasal polarity and PCP...
  42. pmc Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded
    Brian S Robinson
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Biol 20:582-90. 2010
    ....
  43. pmc Modulation of fat:dachsous binding by the cadherin domain kinase four-jointed
    Michael A Simon
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    Curr Biol 20:811-7. 2010
    ..The cadherin Fat plays a central role in this process...
  44. pmc Four-jointed modulates growth and planar polarity by reducing the affinity of dachsous for fat
    Amy L Brittle
    Medical Research Council MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Curr Biol 20:803-10. 2010
    The Drosophila genes fat (ft) and dachsous (ds) encode large atypical cadherins that collaborate to coordinately polarize cells in the plane of the epithelium (planar cell polarity) and to affect growth via the Warts/Hippo pathway...
  45. pmc The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded
    Chen Ling
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 107:10532-7. 2010
    ..Furthermore, our studies implicate Crb as a putative cell surface receptor for Hippo signaling by uncovering a transmembrane protein that directly binds to an apical component of the Hippo pathway...
  46. pmc A feed-forward circuit linking wingless, fat-dachsous signaling, and the warts-hippo pathway to Drosophila wing growth
    Myriam Zecca
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York, USA
    PLoS Biol 8:e1000386. 2010
    ..Here, we identify the protocadherins Fat (Ft) and Dachsous (Ds), the Warts-Hippo tumor suppressor pathway, and the transcriptional co-activator Yorkie (Yki, ..
  47. pmc The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila
    Chiao Lin Chen
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Proc Natl Acad Sci U S A 107:15810-5. 2010
    ..mislocalized in both crb mutant cells and Crb overexpressing tissues, whereas the other Hippo pathway components, Fat and Merlin, are unaffected...
  48. pmc Planar cell polarity: the orientation of larval denticles in Drosophila appears to depend on gradients of Dachsous and Fat
    Ada Repiso
    Department of Zoology, Downing Street, Cambridge, UK
    Development 137:3411-5. 2010
    ..We present evidence that denticle orientation is determined almost entirely by Dachsous and Fat, one of two planar cell polarity systems...
  49. pmc Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways
    Fangfang Ren
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 107:21064-9. 2010
    ..Finally, we show that the Hpo pathway mediator Yorkie (Yki) is also required in precursor cells for injury-induced ISC proliferation in response to tissue-damaging reagent DSS...
  50. pmc The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration
    Phillip Karpowicz
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Development 137:4135-45. 2010
    ..further show that prior to injury, Yki activity is constitutively repressed by the upstream Hippo pathway members Fat and Dachsous (Ds)...
  51. pmc Two frizzled planar cell polarity signals in the Drosophila wing are differentially organized by the Fat/Dachsous pathway
    Justin Hogan
    Department of Biological Sciences, Marshall University, Huntington, West Virginia, United States of America
    PLoS Genet 7:e1001305. 2011
    ..Normal wing PCP requires both the Frizzled (Fz) PCP pathway and the Fat/Dachsous (Ft/Ds) pathway, although the functional relationship between these pathways remains under debate...
  52. pmc Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway
    Julian C Boggiano
    Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA
    Dev Cell 21:888-95. 2011
    ..These results demonstrate that one family of Ste20 kinases can activate another and identify Tao-1 as a component of the regulatory network controlling HSW pathway signaling, and therefore tissue growth, during development...
  53. doi The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway
    Carole L C Poon
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne, Victoria 3002, Australia
    Dev Cell 21:896-906. 2011
    ..Given that SWH pathway activity is subverted in many human cancers, our findings identify human TAO kinases as potential tumor suppressor genes...
  54. pmc Separating planar cell polarity and Hippo pathway activities of the protocadherins Fat and Dachsous
    Hitoshi Matakatsu
    Department of Zoology, University of Wisconsin Madison, 250 North Mills Street, Madison, WI 53706, USA
    Development 139:1498-508. 2012
    The giant Drosophila protocadherin Fat (Ft) affects planar cell polarity (PCP). Ft also inhibits the overgrowth of imaginal discs via the Hippo pathway, repressing the activity of the transcription co-factor Yorkie (Yki)...
  55. pmc Planar polarity specification through asymmetric subcellular localization of Fat and Dachsous
    Amy Brittle
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Western Bank, Sheffield, UK
    Curr Biol 22:907-14. 2012
    Two pathways regulate planar polarity: the core proteins and the Fat-Dachsous-Four-jointed (Ft-Ds-Fj) system. Morphogens specify complementary expression patterns of Ds and Fj that potentially act as polarizing cues...
  56. pmc Differences in levels of the transmembrane protein Crumbs can influence cell survival at clonal boundaries
    Yassi Hafezi
    Department of Molecular and Cell Biology, University of California, Berkeley, 361 LSA, Berkeley, CA 94720 3200, USA
    Dev Biol 368:358-69. 2012
    ..Thus, Crb may be part of a "surveillance mechanism" that is responsible for the cell death that is observed at the boundaries of mutant clones in these cases...
  57. pmc Propagation of Dachsous-Fat planar cell polarity
    Abhijit A Ambegaonkar
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Curr Biol 22:1302-8. 2012
    The Fat pathway controls both planar cell polarity (PCP) and organ growth. Fat signaling is regulated by the graded expression of the Fat ligand Dachsous (Ds) and the cadherin-domain kinase Four-jointed (Fj)...
  58. doi Establishment of global patterns of planar polarity during growth of the Drosophila wing epithelium
    Andreas Sagner
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    Curr Biol 22:1296-301. 2012
    ..Thus, PCP may be guided by morphogenesis rather than morphogen gradients...
  59. pmc Regulation of cytoskeletal organization and junctional remodeling by the atypical cadherin Fat
    Emily Marcinkevicius
    Howard Hughes Medical Institute and Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA
    Development 140:433-43. 2013
    The atypical cadherin Fat is a conserved regulator of planar cell polarity, but the mechanisms by which Fat controls cell shape and tissue structure are not well understood...
  60. pmc Signal transduction by the Fat cytoplasmic domain
    Guohui Pan
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 140:831-42. 2013
    The large atypical cadherin Fat is a receptor for both Hippo and planar cell polarity (PCP) pathways...
  61. pmc An evolutionary shift in the regulation of the Hippo pathway between mice and flies
    W Bossuyt
    1 Vlaams Instituut voor Biotechnologie VIB Center for the Biology of Disease, Leuven, Belgium 2 Kuleuven, Center for Human Genetics, Leuven, Belgium 3 The University of Texas, MD Anderson Cancer Center, Houston, TX, USA
    Oncogene 33:1218-28. 2014
    ..Here we show that the mouse Fat4 cadherin, the ortholog of the Hippo pathway regulator Fat in Drosophila, does not apparently regulate the Hippo pathway in the murine liver...
  62. pmc The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains
    Xuesong Zhao
    Department of Biology, Stanford University, Stanford, California, United States of America
    PLoS ONE 8:e62998. 2013
    The Drosophila Cadherin Fat (Ft) has been identified as a crucial regulator of tissue size and Planar Cell Polarity (PCP). However, the precise mechanism by which Ft regulates these processes remains unclear...
  63. pmc Functional modelling of planar cell polarity: an approach for identifying molecular function
    Lee D Hazelwood
    Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
    BMC Dev Biol 13:20. 2013
    ..This polarisation is commonly known as planar cell polarity and has been found to be important in developmental processes, as planar polarity is required to define the in-plane tissue coordinate system at the cellular level...
  64. doi Dachsous-dependent asymmetric localization of spiny-legs determines planar cell polarity orientation in Drosophila
    Tomonori Ayukawa
    Research Center for Biosignal, Akita University, Akita 010 8543, Japan Department of Cell Biology and Morphology, Akita University Graduate School of Medicine, Akita 010 8543, Japan Global COE Program, Gunma University and Akita University, Akita 010 8543, Japan
    Cell Rep 8:610-21. 2014
    ..When the amount of Sple is increased in the wing, Sple induces a reversal of PCP using the Ds-Ft system. A mathematical model demonstrates that Sple is the key regulator connecting Ds and the core proteins...
  65. ncbi Organ shape: controlling oriented cell division
    David Strutt
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Curr Biol 15:R758-9. 2005
    ..One mechanism by which organisms control the shape of growing organs is by regulating the orientation of cell divisions. This occurs in the Drosophila wing under the control of genes previously implicated in regulating cell polarity...
  66. ncbi Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway
    F Christian Bennett
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    Curr Biol 16:2101-10. 2006
    The atypical Fat cadherin has long been known to control cell proliferation and organ size in Drosophila, but the mechanism by which Fat controls these processes has remained elusive...
  67. pmc The salvador-warts-hippo pathway is required for epithelial proliferation and axis specification in Drosophila
    Carine Meignin
    Wellcome Trust Centre for Cell Biology, Kings Buildings, University of Edinburgh, Edinburgh EH9 3JR, United Kingdom
    Curr Biol 17:1871-8. 2007
    ..This work highlights a novel connection between cell proliferation, cell growth, and axis specification in egg chambers...
  68. pmc In vivo regulation of Yorkie phosphorylation and localization
    Hyangyee Oh
    Howard Hughes Medical Institute, Waksman Institute, Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 135:1081-8. 2008
    Yorkie (Yki), a transcription factor of the Fat and Hippo signaling pathways, is negatively regulated by the Warts kinase...
  69. pmc Morphogen control of wing growth through the Fat signaling pathway
    Dragana Rogulja
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Dev Cell 15:309-21. 2008
    ..We show that the Dpp morphogen gradient in the Drosophila wing influences growth by modulating the activity of the Fat signaling pathway...
  70. doi The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster
    Felix A Grusche
    Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria, Australia
    Dev Biol 350:255-66. 2011
    ..Several proteins serve as upstream modulators of this pathway including the atypical cadherins, Dachsous and Fat, whilst the atypical myosin, Dachs, functions downstream of Fat to activate Yorkie...
  71. ncbi The fat tumor suppressor gene in Drosophila encodes a novel member of the cadherin gene superfamily
    P A Mahoney
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Cell 67:853-68. 1991
    Recessive lethal mutations in the fat locus of Drosophila cause hyperplastic, tumor-like overgrowth of larval imaginal discs, defects in differentiation and morphogenesis, and death during the pupal stage...
  72. ncbi Cleavage and secretion is not required for Four-jointed function in Drosophila patterning
    Helen Strutt
    Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Development 131:881-90. 2004
    ..fj has similar phenotypes to those caused by mutations in the cadherin-encoding genes fat (ft) and dachsous (ds)...
  73. ncbi The orientation of cell divisions determines the shape of Drosophila organs
    Luis Alberto Baena-Lopez
    Centro de Biologia Molecular Severo Ochoa, Edificio Ciencias, Universidad Autonoma de Madrid, CX 504, 28049 Madrid, Spain
    Curr Biol 15:1640-4. 2005
    ..In addition, we find that a subset of planar cell polarity genes is required for the proper orientation of cell division during organ development...
  74. ncbi Dachsous encodes a member of the cadherin superfamily that controls imaginal disc morphogenesis in Drosophila
    H F Clark
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Genes Dev 9:1530-42. 1995
    ..and shown to encode a huge transmembrane protein that is a member of the cadherin superfamily, similar to the fat gene reported previously...
  75. ncbi Identification and characterization of the expression of the translation initiation factor 4A (eIF4A) from Drosophila melanogaster
    Greco Hernández
    Centro de Biologia Molecular Severo Ochoa, Universidad Autónoma de Madrid and C S I C, Madrid, Spain
    Proteomics 4:316-26. 2004
    ..We observed ubiquitous expression of eIF4A mRNA and protein during Drosophila embryogenesis. Yeast two-hybrid analysis demonstrated the in vivo interaction of Drosophila eIF4G with the N-terminal third of eIF4A...
  76. pmc Su(dx) E3 ubiquitin ligase-dependent and -independent functions of polychaetoid, the Drosophila ZO-1 homologue
    Alexandre Djiane
    Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge, England, UK
    J Cell Biol 192:189-200. 2011
    ..As both Su(dx) and Expanded regulate trafficking, we propose that a conserved role of ZO proteins is to coordinate receptor trafficking and signaling with junctional organization...
  77. pmc Planar polarization of the atypical myosin Dachs orients cell divisions in Drosophila
    Yanlan Mao
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, United Kingdom
    Genes Dev 25:131-6. 2011
    ..Planar polarization of Dachs is ultimately oriented by long-range gradients emanating from compartment boundaries, and is therefore a mechanism linking these gradients with the control of tissue shape...
  78. pmc Requirement for cell-proliferation control genes in Drosophila oogenesis
    J Szabad
    Howard Hughes Medical Institute, Department of Biology, University of Utah, Salt Lake City 84112
    Genetics 127:525-33. 1991
    ..were produced in which developing oocytes and nurse cells were mutant at one of five imaginal disc overgrowth loci (fat, lgd, lgl, c43 and dco) while the enveloping follicle cells were normal...
  79. ncbi The genetic control of cell proliferation in Drosophila imaginal discs
    P J Bryant
    Developmental Biology Center, University of California, Irvine 92717
    J Cell Sci Suppl 13:169-89. 1990
    ..In some of these mutants (fat, lgd, c43, dco) the overgrowing tissue is hyperplastic; it retains its single-layered epithelial structure and is ..
  80. ncbi The fruit fly Drosophila and the fish Xiphophorus as model systems for cancer studies
    B Mechler
    Department of Development Genetics, Deutsches Krebsforschungszentrum, German Cancer Research Center, Heidelberg
    Cancer Surv 9:505-27. 1990
    ..This gene encodes a receptor tyrosine kinase related to the EGF-receptor, and its activation and overexpression are thought to play a critical part in melanoma formation...
  81. ncbi Not just glue: cell-cell junctions as cellular signaling centers
    C Kirkpatrick
    Department of Biology, University of North Carolina, Chapel Hill 27599 3280, USA
    Curr Opin Genet Dev 5:56-65. 1995
    ....
  82. ncbi Epithelial hyperplasia of imaginal discs induced by mutations in Drosophila tumor suppressor genes: growth and pattern formation in genetic mosaics
    N Agrawal
    Drosophila Stock Center, School of Life Sciences, Devi Ahilya Vishwavidyalaya, Indore, India
    Dev Biol 169:387-98. 1995
    Lethal mutations in the giant discs (lgd) and fat (ft) tumor suppressor genes of Drosophila cause epithelial hyperplasia in all imaginal discs...
  83. ncbi Control of epithelial cell polarity in Drosophila
    E Knust
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Germany
    Trends Genet 10:275-80. 1994
    ....
  84. ncbi Tumor suppressor genes encoding proteins required for cell interactions and signal transduction in Drosophila
    P J Bryant
    Developmental Biology Center, University of California, Irvine 92717
    Dev Suppl . 1993
    ..Mutations in the fat gene cause hyperplastic imaginal disc overgrowth, in which the overgrowing disc tissue retains its epithelial ..
  85. ncbi Motifs of cadherin- and fibronectin type III-related sequences and evolution of the receptor-type-protein tyrosine kinases: sequence similarity between proto-oncogene ret and cadherin family
    K Kuma
    Department of Biology, Kyushu University, Japan
    Mol Biol Evol 10:539-51. 1993
    ....
  86. pmc Needs and targets for the multi sex combs gene product in Drosophila melanogaster
    O Saget
    Centre de Genetique Moleculaire du Centre National de la Recherche Scientifique, 91198 Gif sur Yvette Cedex, France
    Genetics 149:1823-38. 1998
    ..We discuss these data in view of the numerous functions of PcG genes during development...
  87. pmc Quantitative trait loci affecting components of wing shape in Drosophila melanogaster
    E Zimmerman
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695 7614, USA
    Genetics 155:671-83. 2000
    ....
  88. ncbi Microsatellite variability differs between dinucleotide repeat motifs-evidence from Drosophila melanogaster
    D Bachtrog
    Institut fur Tierzucht und Genetik, Vienna, Austria
    Mol Biol Evol 17:1277-85. 2000
    ..Similar differences in mutation rates were obtained by an alternative method which estimates microsatellite mutation rates from their genomic length distribution...
  89. pmc Precocious expression of the Glide/Gcm glial-promoting factor in Drosophila induces neurogenesis
    Veronique Van de Bor
    Institut de Génétique et Biologie Moléculaire et Cellulaire IGBMC CNRS ULP INSERM BP 163 67404 Illkirch, C U de Strasbourg, France
    Genetics 160:1095-106. 2002
    ..These findings also emphasize the requirement for both spatial and temporal glide/gcm regulation to achieve proper cell specification within the nervous system...
  90. ncbi Microsatellite analysis of Drosophila melanogaster populations along a microclimatic contrast at lower Nahel Oren canyon, Mount Carmel, Israel
    Christian Schlotterer
    Institut fur Tierzucht und Genetik, Vienna University of Veterinary Medicine, Josef Baumann Gasse 1, 1210 Vienna, Austria
    Mol Biol Evol 19:563-8. 2002
    ..melanogaster populations was low (F(ST) = 0.0012). Also a tree of individuals based on the proportion of shared alleles and a model-based clustering method provided no evidence for population substructuring...
  91. ncbi Similarities between the Hedgehog and Wnt signaling pathways
    Daniel Kalderon
    Department of Biological Sciences, Columbia University, New York NY 10027, USA
    Trends Cell Biol 12:523-31. 2002
    ..This review compares the two pathways to explore whether our more extensive knowledge of Wnt pathways can be of predictive value for investigating Hedgehog signaling...
  92. ncbi Bonsaï, a ribosomal protein S15 homolog, involved in gut mitochondrial activity and systemic growth
    Mireille Galloni
    INSERM UM2 E343, Universite Montpellier 2, C C 103, Place Eugene Bataillon, 34095 Montpellier, France
    Dev Biol 264:482-94. 2003
    ..Altogether, these observations suggest that mitochondrial activity is regulated at the tissue-specific level and that this regulation has profound implications for growth and development...
  93. ncbi The environmental and genetic regulation of obake expressivity: morphogenetic fields as evolvable systems
    Joel Atallah
    Department of Zoology, University of Toronto, 25 Harbord Street, Toronto, Ontario M5S 3G5, Canada
    Evol Dev 6:114-22. 2004
    ....
  94. ncbi Fat and Wingless signaling oppositely regulate epithelial cell-cell adhesion and distal wing development in Drosophila
    Manish Jaiswal
    Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 20 80 16, India
    Development 133:925-35. 2006
    ..The Fat (Ft) tumor suppressor, by contrast, represses DE-Cad expression...
  95. ncbi Genes of Hippo signaling network act unconventionally in the control of germline proliferation in Drosophila
    Shuguo Sun
    Key Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, P R China
    Dev Dyn 237:270-5. 2008
    ..Surprisingly, when we generated germline mutant clones of Hippo-network genes such as fat, expanded, hippo, salvador, and warts, we did not observe any overgrowth of these mutant cells...
  96. pmc Basolateral junctions utilize warts signaling to control epithelial-mesenchymal transition and proliferation crucial for migration and invasion of Drosophila ovarian epithelial cells
    Min Zhao
    Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genetics 178:1947-71. 2008
    ..Apicolateral junction proteins Fat (Ft), Expanded (Ex), and Merlin (Mer) either are not involved in these processes, or have highly spatio-temporally ..
  97. pmc Expression patterns of cadherin genes in Drosophila oogenesis
    Jeremiah J Zartman
    Lewis Sigler Institute, Department of Chemical Engineering, Princeton University, Princeton, NJ 08544, USA
    Gene Expr Patterns 9:31-6. 2009
    ..Of particular note is the complex patterning of the region of the follicular epithelium that gives rise to the dorsal appendages, which are tubular structures that serve as respiratory organs for the developing embryo...
  98. doi Antagonistic growth regulation by Dpp and Fat drives uniform cell proliferation
    Gerald Schwank
    Institute of Molecular Life Sciences, Winterthurerstr 190, 8057 Zurich, Switzerland
    Dev Cell 20:123-30. 2011
    ..We first show that proper expression and subcellular localization of components in the Fat tumor-suppressor pathway, which have been argued to depend on Dpp activity differences, are not reliant on the Dpp ..
  99. pmc Zyxin links fat signaling to the hippo pathway
    Cordelia Rauskolb
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America
    PLoS Biol 9:e1000624. 2011
    ..Through epistasis tests, we position the requirement for Zyx within the Fat branch of Hippo signaling, downstream of Fat and Dco, and upstream of the Yorkie kinase Warts, and we find that Zyx ..
  100. ncbi Tumor-suppressor genes of Drosophila melanogaster
    E Gateff
    Institute of Genetics, Johannes Gutenberg University, Mainz, West Germany
    Crit Rev Oncog 1:221-45. 1989
  101. ncbi Drosophila warts--tumor suppressor and member of the myotonic dystrophy protein kinase family
    K L Watson
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Bioessays 17:673-6. 1995
    ..These genes encode members of a cyclic AMP-dependent protein kinase subfamily that includes other plant and animal orthologues...

Research Grants11

  1. MOLECULAR GENETIC OF TYROSINE KINASE AND RAS FUNCTION
    Michael Simon; Fiscal Year: 2001
    ....
  2. CYTOSKELETAL REGULATION BY SRC64/TEC29 KINASES
    Michael Simon; Fiscal Year: 2004
    ..abstract_text> ..
  3. Cadherin regulation of tissue polarity and growth
    Michael Simon; Fiscal Year: 2007
    ..In a recent study of PCP in the Drosophila eye, we demonstrated that Fat, a protocadherin protein, is essential for establishing the Frizzled activity gradient that directs PCP...
  4. CONFOCAL MICROSCOPE FOR LIVE CELL & MULTIWAVELENGTH WORK
    Mark Peifer; Fiscal Year: 2001
    ..Our proposal seeks to meet these new needs, by the creation of a multi-user facility that will provide a state-of-the art confocal microscope to a large group of NIH funded investigators. ..
  5. Analysis of fringe-dependent cell-signaling
    Kenneth Irvine; Fiscal Year: 2004
    ....
  6. Transcriptional Repression and Cofactor Recruitment
    Susan Parkhurst; Fiscal Year: 2008
    ..Results obtained from these projects are expected to have wide implications as HES family proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..
  7. Mechanisms of Wound Healing in Drosphila
    Susan Parkhurst; Fiscal Year: 2009
    ..Controlling repair and inflammation will also be a fundamental consideration in tissue engineering where artificial and/or cell based constructs are implanted to reconstruct tissues. ..
  8. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    Susan Parkhurst; Fiscal Year: 2002
    ..Results obtained from these projects are expected to have wide implications as Hairy/E(spl) proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..
  9. Mechanisms governing polarity in Drosophila oogenesis
    Daniel Kalderon; Fiscal Year: 2004
    ....
  10. Mechanisms of Rho GTPase Function in Drosophila
    Susan Parkhurst; Fiscal Year: 2006
    ..Our results are expected to have wide implications as Rho GTPases and the diverse cellular mechanisms they mediate are conserved across a wide range of organisms. ..