Gene Symbol: Fsn
Description: F-box synaptic protein
Alias: BEST:GH20696, CG4643, DFsn, Dmel\CG4643, FBXO2, Wals, dFsn, fsn, F-box synaptic protein, CG4643-PA, CG4643-PB, Fsn-PA, Fsn-PB, wallenstein
Species: fruit fly

Top Publications

  1. Kugler J, Woo J, Oh B, Lasko P. Regulation of Drosophila vasa in vivo through paralogous cullin-RING E3 ligase specificity receptors. Mol Cell Biol. 2010;30:1769-82 pubmed publisher
    ..Here, we found that Gustavus (Gus) and Fsn, two ubiquitin Cullin-RING E3 ligase specificity receptors, bind to the same motif on Vasa through their paralogous ..
  2. Myster D, Bonnette P, Duronio R. A role for the DP subunit of the E2F transcription factor in axis determination during Drosophila oogenesis. Development. 2000;127:3249-61 pubmed
    ..Thus we have uncovered new functions for E2F transcription factors during development, including an unexpected role in pattern formation. ..
  3. Wu C, Daniels R, DiAntonio A. DFsn collaborates with Highwire to down-regulate the Wallenda/DLK kinase and restrain synaptic terminal growth. Neural Dev. 2007;2:16 pubmed
    ..To investigate the mechanism of Highwire action, we have identified DFsn as a binding partner of Highwire and characterized the roles of DFsn in synapse development, synaptic transmission, ..
  4. Skaar J, Pagan J, Pagano M. SnapShot: F box proteins I. Cell. 2009;137:1160-1160.e1 pubmed publisher
  5. Tian X, Li J, Valakh V, DiAntonio A, Wu C. Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons. Nat Neurosci. 2011;14:1267-75 pubmed publisher
    The evolutionarily conserved Highwire (Hiw)/Drosophila Fsn E3 ubiquitin ligase complex is required for normal synaptic morphology during development and axonal regeneration after injury...
  6. Kugler J, Chen Y, Weng R, Cohen S. Maternal loss of miRNAs leads to increased variance in primordial germ cell numbers in Drosophila melanogaster. G3 (Bethesda). 2013;3:1573-6 pubmed publisher
    ..Our observations are consistent with the hypothesis that miR-969 and miR-9c contribute to stabilizing the processes that control germ number, supporting phenotypic robustness. ..
  7. Brace E, Wu C, Valakh V, DiAntonio A. SkpA restrains synaptic terminal growth during development and promotes axonal degeneration following injury. J Neurosci. 2014;34:8398-410 pubmed publisher
    ..As in highwire mutants, this axonal protection requires Nmnat. Hence, SkpA is a novel negative regulator of the Wnd-Jnk pathway that functions with Hiw to regulate both synaptic development and axonal maintenance. ..