Gene Symbol: fs(1)M3
Description: female sterile (1) M3
Alias: CG4790, Dmel\CG4790, Fs(1)K646, fs(1)K646, fs(1)ph, fs(1)phl, fs(1)pole hole, fs(1)polehole, female sterile (1) M3, CG4790-PA, fs(1)M3-PA, fs(1)polehole, polehole
Species: fruit fly

Top Publications

  1. Stevens L, Beuchle D, Jurcsak J, Tong X, Stein D. The Drosophila embryonic patterning determinant torsolike is a component of the eggshell. Curr Biol. 2003;13:1058-63 pubmed
    ..To our knowledge, Tsl represents the first example of an embryonic patterning determinant that is a component of the eggshell. ..
  2. Degelmann A, Hardy P, Mahowald A. Genetic analysis of two female-sterile loci affecting eggshell integrity and embryonic pattern formation in Drosophila melanogaster. Genetics. 1990;126:427-34 pubmed
    ..Possible mechanisms to account for the association of these two functions are discussed. ..
  3. Ventura G, Furriols M, Martin N, Barbosa V, Casanova J. closca, a new gene required for both Torso RTK activation and vitelline membrane integrity. Germline proteins contribute to Drosophila eggshell composition. Dev Biol. 2010;344:224-32 pubmed publisher
    ..This observation also provides a new scenario that accounts for the long known contribution of germline products to vitelline membrane biogenesis and to the follicle cell-dependent activation of the Torso receptor...
  4. Jiménez G, González Reyes A, Casanova J. Cell surface proteins Nasrat and Polehole stabilize the Torso-like extracellular determinant in Drosophila oogenesis. Genes Dev. 2002;16:913-8 pubmed
    ..Here we identify a novel family of Drosophila proteins, Nasrat and Polehole, that coat the oocyte surface and play two roles: They mediate assembly of the eggshell, and act in the Torso RTK ..
  5. Casali A, Casanova J. The spatial control of Torso RTK activation: a C-terminal fragment of the Trunk protein acts as a signal for Torso receptor in the Drosophila embryo. Development. 2001;128:1709-15 pubmed
    ..We therefore propose that the restricted activation of the torso receptor is defined by the spatial control of the proteolytic processing of the trunk protein. ..
  6. Furriols M, Casali A, Casanova J. Dissecting the mechanism of torso receptor activation. Mech Dev. 1998;70:111-8 pubmed
  7. Furriols M, Casanova J. In and out of Torso RTK signalling. EMBO J. 2003;22:1947-52 pubmed
  8. Airoldi S, McLean P, Shimada Y, Cooley L. Intercellular protein movement in syncytial Drosophila follicle cells. J Cell Sci. 2011;124:4077-86 pubmed publisher
    ..These results provide insight into the composition and function of ring canals in somatic cells, implying a broader functional significance for syncytial organization of cells outside the germline. ..
  9. Grillo M, Furriols M, Casanova J, Luschnig S. Control of germline torso expression by the BTB/POZ domain protein pipsqueak is required for embryonic terminal patterning in Drosophila. Genetics. 2011;187:513-21 pubmed publisher

More Information


  1. Lim Y, Nishizawa K, Nishi Y, Tsuda L, Inoue Y, Nishida Y. Genetic analysis of rolled, which encodes a Drosophila mitogen-activated protein kinase. Genetics. 1999;153:763-71 pubmed
    ..Involvement of rl in cell proliferation was also demonstrated by clonal analysis. Branching and integration of signals in the MAP kinase cascade is discussed. ..
  2. LeMosy E. Pattern formation: the eggshell holds the cue. Curr Biol. 2003;13:R508-10 pubmed
  3. Tsuda L, Inoue Y, Yoo M, Mizuno M, Hata M, Lim Y, et al. A protein kinase similar to MAP kinase activator acts downstream of the raf kinase in Drosophila. Cell. 1993;72:407-14 pubmed
    ..Our genetic results demonstrate the connection between raf and the highly conserved protein kinase cascade involving MAP kinase in vivo. ..
  4. Perrimon N, Desplan C. Signal transduction in the early Drosophila embryo: when genetics meets biochemistry. Trends Biochem Sci. 1994;19:509-13 pubmed
    ..This pathway involves a membrane-bound receptor tyrosine kinase (RTK) that is similar to other Drosophila RTKs, such as sevenless, and the mammalian RTKs, such as the epidermal growth factor or platelet-derived growth factor receptors. ..
  5. Ambrosio L, Mahowald A, Perrimon N. l(1)pole hole is required maternally for pattern formation in the terminal regions of the embryo. Development. 1989;106:145-58 pubmed
    ..Thus, the maternal l(1)ph+ gene product is required for the establishment of cell identities at the anterior and posterior poles of the Drosophila embryo. ..
  6. Furriols M, Casanova J. Germline and somatic vitelline proteins colocalize in aggregates in the follicular epithelium of Drosophila ovaries. Fly (Austin). 2014;8:113-9 pubmed publisher
    Nasrat and Polehole, two Drosophila proteins related functionally and by sequence, are secreted from the oocyte and incorporated into the vitelline membrane, where they play a role in the integrity of the same and in the activation of ..
  7. Komitopoulou K, Gans M, Margaritis L, Kafatos F, Masson M. Isolation and Characterization of Sex-Linked Female-Sterile Mutants in DROSOPHILA MELANOGASTER with Special Attention to Eggshell Mutants. Genetics. 1983;105:897-920 pubmed
    ..At least six groups with clear-cut effects were found at loci not previously identified with known chorion structural genes. ..
  8. Grillo M, Furriols M, de Miguel C, Franch Marro X, Casanova J. Conserved and divergent elements in Torso RTK activation in Drosophila development. Sci Rep. 2012;2:762 pubmed publisher
    ..A combination of these mechanisms is likely to allow the repeated activation of a single receptor in different contexts. ..
  9. Wagner C, Mahowald A, Miller K. One of the two cytoplasmic actin isoforms in Drosophila is essential. Proc Natl Acad Sci U S A. 2002;99:8037-42 pubmed
    ..Instead, our results suggest that regulated expression of Act5C is essential to the fly. ..
  10. Casanova J, Struhl G. Localized surface activity of torso, a receptor tyrosine kinase, specifies terminal body pattern in Drosophila. Genes Dev. 1989;3:2025-38 pubmed
  11. Stein D, Stevens L. Establishment of dorsal-ventral and terminal pattern in the Drosophila embryo. Curr Opin Genet Dev. 1991;1:247-54 pubmed
  12. Manseau L, Schupbach T. The egg came first, of course! Anterior-posterior pattern formation in Drosophila embryogenesis and oogenesis. Trends Genet. 1989;5:400-5 pubmed
    ..The initial spatial localizations of the maternal organizing activities are established during oogenesis. After fertilization these activities regulate zygotic gene activity along the anterior-posterior axis of the egg. ..
  13. Grossniklaus U, Bellen H, Wilson C, Gehring W. P-element-mediated enhancer detection applied to the study of oogenesis in Drosophila. Development. 1989;107:189-200 pubmed
    ..On the basis of our results, we suggest new strategies, which are not primarily based on the generation of mutants, to screen for and isolated female sterile genes. ..
  14. Gao Q, Wang Y, Finkelstein R. Orthodenticle regulation during embryonic head development in Drosophila. Mech Dev. 1996;56:3-15 pubmed
    ..Finally, we identify a novel pathway mediated by the gap gene huckebein through which three maternal systems cooperate to repress otd expression at the anterior terminus of the embryo. ..
  15. Lu X, Perkins L, Perrimon N. The torso pathway in Drosophila: a model system to study receptor tyrosine kinase signal transduction. Dev Suppl. 1993;:47-56 pubmed
    ..Also involved in tor signaling is the non-receptor protein tyrosine phosphatase corkscrew (csw). Here, we review the current model and discuss future research directions in this field. ..
  16. Perrimon N, Gans M. Clonal analysis of the tissue specificity of recessive female-sterile mutations of Drosophila melanogaster using a dominant female-sterile mutation Fs(1)K1237. Dev Biol. 1983;100:365-73 pubmed
    ..These results are discussed in terms of a coincident production of clones in the follicle cells. ..
  17. Nishida Y. [Oncogene research using Drosophila as a model system]. Jpn J Genet. 1990;65:121-34 pubmed
  18. Pignoni F, Steingrimsson E, Lengyel J. bicoid and the terminal system activate tailless expression in the early Drosophila embryo. Development. 1992;115:239-51 pubmed
    ..This is the first described example of how, by jointly controlling expression of the same gene, two systems of positional information function together to set unique positional values. ..
  19. Cernilogar F, Fabbri F, Andrenacci D, Taddei C, Gargiulo G. Drosophila vitelline membrane cross-linking requires the fs(1)Nasrat, fs(1)polehole and chorion genes activities. Dev Genes Evol. 2001;211:573-80 pubmed
    ..In the fs(1)Nasrat and fs(1)polehole mutant alleles conferring defects in vitelline membrane formation, disruption of vitelline membrane cross-linking ..
  20. Remolina S, Chang P, Leips J, Nuzhdin S, Hughes K. Genomic basis of aging and life-history evolution in Drosophila melanogaster. Evolution. 2012;66:3390-403 pubmed publisher
    ..More generally, we argue that hitchhiking mapping can be a powerful tool for uncovering the molecular bases of quantitative genetic variation. ..