Gene Symbol: fray
Description: frayed
Alias: 4624, CG7693, Dmel\CG7693, Dosr1, Fray, STE20-like/SPAK, dOSR1, dSTRAD, l(3)07551, lag, frayed, CG7693-PA, CG7693-PB, CG7693-PC, CG7693-PE, CG7693-PF, CG7693-PG, CG7693-PH, CG7693-PI, Ste20-like, Ste20-like protein kinase, fray-PA, fray-PB, fray-PC, fray-PE, fray-PF, fray-PG, fray-PH, fray-PI, laggard, oxidative-stress-responsive kinase 1
Species: fruit fly

Top Publications

  1. Leiserson W, Harkins E, Keshishian H. Fray, a Drosophila serine/threonine kinase homologous to mammalian PASK, is required for axonal ensheathment. Neuron. 2000;28:793-806 pubmed
    b>Fray is a serine/threonine kinase expressed by the peripheral glia of Drosophila, whose function is required for normal axonal ensheathment...
  2. Delpire E. The mammalian family of sterile 20p-like protein kinases. Pflugers Arch. 2009;458:953-67 pubmed publisher
    ..A number of molecular details involved in the activation of the kinases are discussed including autophosphorylation, substrate recognition, autoinhibition, dimerization, and substrate binding. ..
  3. Leiserson W, Forbush B, Keshishian H. Drosophila glia use a conserved cotransporter mechanism to regulate extracellular volume. Glia. 2011;59:320-32 pubmed publisher
    ..barrier have a conserved molecular mechanism that regulates extracellular volume: the Serine/Threonine kinase Fray, which we previously showed is an ortholog of mammalian PASK/SPAK; and the Na-K-Cl cotransporter Ncc69, which we ..
  4. Zheng Y, Wang W, Liu B, Deng H, Uster E, Pan D. Identification of Happyhour/MAP4K as Alternative Hpo/Mst-like Kinases in the Hippo Kinase Cascade. Dev Cell. 2015;34:642-55 pubmed publisher
    ..These Hpo/Mst-like kinases provide an expanded view of the Hippo kinase cascade in development and physiology. ..
  5. Pueyo J, Magny E, Sampson C, Amin U, Evans I, Bishop S, et al. Hemotin, a Regulator of Phagocytosis Encoded by a Small ORF and Conserved across Metazoans. PLoS Biol. 2016;14:e1002395 pubmed publisher
  6. Einheber S, Salzer J. A glial investment of axons defrayed. Neuron. 2000;28:627-8 pubmed
  7. Jones B. Glial cell development in the Drosophila embryo. Bioessays. 2001;23:877-87 pubmed
    ..Other roles of glia are being explored, including their requirement for axon guidance, neuronal survival, and signaling. ..
  8. Yamamoto Y, Izumi Y, Matsuzaki F. The GC kinase Fray and Mo25 regulate Drosophila asymmetric divisions. Biochem Biophys Res Commun. 2008;366:212-8 pubmed
    ..Mechanisms underlying this process, however, remain elusive. We found that Mo25 and the GC kinase Fray act in this regulation. mo25 and fray mutants show an indistinguishable defect in Miranda localization...
  9. Hirata T, Czapar A, Brin L, Haritonova A, Bondeson D, LINSER P, et al. Ion and solute transport by Prestin in Drosophila and Anopheles. J Insect Physiol. 2012;58:563-9 pubmed publisher
    ..Finally, we present and discuss Drosophila genetic models that integrate these processes. ..

More Information


  1. Sato A, Shibuya H. WNK signaling is involved in neural development via Lhx8/Awh expression. PLoS ONE. 2013;8:e55301 pubmed publisher
    ..Drosophila WNK mutant caused defects in axon guidance during embryogenesis. These results suggest that WNK signaling is involved in the morphological and neural development via Lhx8/Arrowhead...
  2. Russell M, Ostafichuk L, Scanga S. Lethal P-lacZ insertion lines expressed during pattern respecification in the imaginal discs of Drosophila. Genome. 1998;41:7-13 pubmed
    ..One is an allele of schnurri, a gene that encodes a component of the decapentaplegic (dpp) signal transduction pathway used for positional signalling in the embryo and in imaginal discs. ..
  3. Chen W, Yazicioglu M, Cobb M. Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily. J Biol Chem. 2004;279:11129-36 pubmed
    ..Here we have extended that analysis to the possible MAPK kinase kinase kinases (MAP4Ks) in the JNK pathway. Fray, a putative Drosophila MAP4K, provided a major contribution to JNK activation by sorbitol...
  4. Chotard C, Salecker I. Neurons and glia: team players in axon guidance. Trends Neurosci. 2004;27:655-61 pubmed
    ..Equally, neurons provide crucial information to glia, supporting their migration and correct positioning. ..
  5. Serysheva E, Berhane H, Grumolato L, Demir K, Balmer S, Bodak M, et al. Wnk kinases are positive regulators of canonical Wnt/?-catenin signalling. EMBO Rep. 2013;14:718-25 pubmed publisher
    ..Importantly, knockdown of human WNK1 and WNK2 also results in decreased Wnt signalling in mammalian cell culture, suggesting that Wnk kinases have a conserved function in ensuring peak levels of canonical Wnt signalling. ..
  6. Wu Y, Schellinger J, Huang C, Rodan A. Hypotonicity stimulates potassium flux through the WNK-SPAK/OSR1 kinase cascade and the Ncc69 sodium-potassium-2-chloride cotransporter in the Drosophila renal tubule. J Biol Chem. 2014;289:26131-42 pubmed publisher
    ..Similarly, knocking down the SPAK/OSR1 homolog fray also decreases K(+) flux...
  7. Li X, Chatterjee N, Spirohn K, Boutros M, Bohmann D. Cdk12 Is A Gene-Selective RNA Polymerase II Kinase That Regulates a Subset of the Transcriptome, Including Nrf2 Target Genes. Sci Rep. 2016;6:21455 pubmed publisher
    ..We suggest that Cdk12 acts as a gene-selective Pol II kinase that engages a global shift in gene expression to switch cells from a metabolically active state to "stress-defence mode" when challenged by external stress. ..