Gene Symbol: foxo
Description: forkhead box, sub-group O
Alias: 3143, Afx, CG3143, DFOXO, Dfoxo, DmQ95V5, Dmel\CG3143, FKHR, FOXO, FOXO1, FoxO, Foxo, Q95V55, anon-WO0118547.374, cg3143, dFOXO, dFoxO, dFoxo, dfoxO, dfoxo, fd88A, foxO, foxo, dFOXO, forkhead box, sub-group O, CG3143-PB, CG3143-PC, CG3143-PF, CG3143-PG, CG3143-PH, forkhead Box O, forkhead bOX-containing protein, subfamily O, forkhead box, forkhead box sub-group O, forkhead box type O, forkhead box, subgroup O, forkhead box-containing protein, O subfamily, forkhead transcription factor, foxo-PB, foxo-PC, foxo-PF, foxo-PG, foxo-PH
Species: fruit fly
Products:     foxo

Top Publications

  1. Hsu H, LaFever L, Drummond Barbosa D. Diet controls normal and tumorous germline stem cells via insulin-dependent and -independent mechanisms in Drosophila. Dev Biol. 2008;313:700-12 pubmed that DILPs specifically control the G2 phase of the GSC cell cycle via phosphoinositide-3 kinase (PI3K) and dFOXO, and that a separate diet mediator regulates the G1 phase...
  2. Karpac J, Hull Thompson J, Falleur M, Jasper H. JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila. Aging Cell. 2009;8:288-95 pubmed publisher
    ..Endocrine control of IIS by JNK in IPCs is thus critical for systemic adaptation to stress. ..
  3. Xu K, Zheng X, Sehgal A. Regulation of feeding and metabolism by neuronal and peripheral clocks in Drosophila. Cell Metab. 2008;8:289-300 pubmed publisher
    ..We propose that the input of neuronal clocks and clocks in metabolic tissues is coordinated to provide effective energy homeostasis...
  4. Bülow M, Aebersold R, Pankratz M, Jünger M. The Drosophila FoxA ortholog Fork head regulates growth and gene expression downstream of Target of rapamycin. PLoS ONE. 2010;5:e15171 pubmed publisher
    ..Furthermore, TOR signaling levels and FKH impact on transcription of the dFOXO target gene d4E-BP, implying a point of crosstalk with the insulin pathway...
  5. Birse R, Choi J, Reardon K, Rodriguez J, Graham S, Diop S, et al. High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila. Cell Metab. 2010;12:533-44 pubmed publisher
    ..Moreover, reducing insulin-TOR activity (by expressing TSC1-2, 4EBP or FOXO), or increasing lipase expression-only within the myocardium-suffices to efficiently alleviate cardiac fat ..
  6. Alic N, Andrews T, Giannakou M, Papatheodorou I, Slack C, Hoddinott M, et al. Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling. Mol Syst Biol. 2011;7:502 pubmed publisher
    ..Using genomic tools, we uncover over 700 direct dFOXO targets in adult female Drosophila...
  7. Cognigni P, Bailey A, Miguel Aliaga I. Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis. Cell Metab. 2011;13:92-104 pubmed publisher
  8. Min K, Yamamoto R, Buch S, Pankratz M, Tatar M. Drosophila lifespan control by dietary restriction independent of insulin-like signaling. Aging Cell. 2008;7:199-206 pubmed publisher
    ..Here, we aim to understand this potential overlap. We found that over-expression of dFOXO in head fat body extends lifespan and reduces steady-state mRNA abundance of insulin-like peptide-2 under ..
  9. Xu X, Gopalacharyulu P, Seppanen Laakso T, Ruskeepää A, Aye C, Carson B, et al. Insulin signaling regulates fatty acid catabolism at the level of CoA activation. PLoS Genet. 2012;8:e1002478 pubmed publisher
    ..We identify pudgy as an ACS that is transcriptionally regulated by direct FOXO action in Drosophila...

More Information


  1. Griswold A, Chang K, Runko A, Knight M, MIN K. Sir2 mediates apoptosis through JNK-dependent pathways in Drosophila. Proc Natl Acad Sci U S A. 2008;105:8673-8 pubmed publisher
    ..of sir2 in Drosophila promotes caspase-dependent but p53-independent apoptosis that is mediated by the JNK and FOXO signaling pathways...
  2. Owusu Ansah E, Yavari A, Mandal S, Banerjee U. Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint. Nat Genet. 2008;40:356-61 pubmed publisher
    ..The mechanism involves a specific signaling cascade initiated by ROS and transduced by ASK-1, JNK, FOXO and the Drosophila p27 homolog, Dacapo...
  3. Owusu Ansah E, Banerjee U. Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation. Nature. 2009;461:537-41 pubmed publisher
    ..into all three mature blood cell types found in Drosophila, through a signalling pathway that involves JNK and FoxO activation as well as Polycomb downregulation...
  4. Demontis F, Perrimon N. FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell. 2010;143:813-25 pubmed publisher
    ..The transcription factor FOXO and its target 4E-BP remove damaged proteins at least in part via the autophagy/lysosome system, whereas foxo ..
  5. Lee G, Chung J. Discrete functions of rictor and raptor in cell growth regulation in Drosophila. Biochem Biophys Res Commun. 2007;357:1154-9 pubmed
    ..Furthermore, FOXO-dependent apoptosis, which is inhibited by Akt, was augmented in the rictor-null background, indicating that rictor ..
  6. Bai H, Kang P, Tatar M. Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain. Aging Cell. 2012;11:978-85 pubmed publisher
    ..these, reduced dilp2 expressed in the brain has been associated with longevity assurance when over-expression of dfoxo in fat bodies extends lifespan...
  7. DiAngelo J, Birnbaum M. Regulation of fat cell mass by insulin in Drosophila melanogaster. Mol Cell Biol. 2009;29:6341-52 pubmed publisher
    ..depends on its capacity to bring about phosphorylation and inhibition of the transcription factor Drosophila FOXO (dFOXO) and the serine/threonine protein kinase shaggy, the fly ortholog of glycogen synthase kinase 3 (GSK3)...
  8. Slack C, Giannakou M, Foley A, Goss M, Partridge L. dFOXO-independent effects of reduced insulin-like signaling in Drosophila. Aging Cell. 2011;10:735-48 pubmed publisher
    ..We have addressed this issue by examining the effects of reduced IIS in the absence of dFOXO in Drosophila, using a newly generated null allele of dfoxo...
  9. Karpac J, Biteau B, Jasper H. Misregulation of an adaptive metabolic response contributes to the age-related disruption of lipid homeostasis in Drosophila. Cell Rep. 2013;4:1250-61 pubmed publisher
    ..We find that activation of the insulin-responsive transcription factor Foxo in intestinal enterocytes is required to inhibit the expression of evolutionarily conserved lipases as part of a ..
  10. Kramer J, Davidge J, Lockyer J, Staveley B. Expression of Drosophila FOXO regulates growth and can phenocopy starvation. BMC Dev Biol. 2003;3:5 pubmed
    Components of the insulin signaling pathway are important regulators of growth. The FOXO (forkhead box, sub-group "O") transcription factors regulate cellular processes under conditions of low levels of insulin signaling...
  11. Buescher J, Musselman L, Wilson C, Lang T, Keleher M, Baranski T, et al. Evidence for transgenerational metabolic programming in Drosophila. Dis Model Mech. 2013;6:1123-32 pubmed publisher
    ..Our data indicate that nutritional programming mechanisms could be highly conserved and support the use of Drosophila as a model for evaluating the underlying genetic and epigenetic contributions to this phenomenon. ..
  12. Lavery W, Hall V, Yager J, Rottgers A, Wells M, Stern M. Phosphatidylinositol 3-kinase and Akt nonautonomously promote perineurial glial growth in Drosophila peripheral nerves. J Neurosci. 2007;27:279-88 pubmed
    ..growth-promoting effects of activated PI3K are suppressed by coexpression within the peripheral glia of FOXO+ (forkhead box O) a transcription factor inhibited by Akt-dependent phosphorylation...
  13. Banerjee K, Ayyub C, Ali S, Mandot V, Prasad N, Kolthur Seetharam U. dSir2 in the adult fat body, but not in muscles, regulates life span in a diet-dependent manner. Cell Rep. 2012;2:1485-91 pubmed publisher
    ..We also show that dSir2 knockdown abrogates fat-body dFOXO-dependent life span extension...
  14. Shen J, Tower J. Drosophila foxo acts in males to cause sexual-dimorphism in tissue-specific p53 life span effects. Exp Gerontol. 2010;45:97-105 pubmed publisher
    ..In a foxo null background, p53 life span effects in males were reversed, becoming similar to the effects in females...
  15. Howlett E, Lin C, Lavery W, Stern M. A PI3-kinase-mediated negative feedback regulates neuronal excitability. PLoS Genet. 2008;4:e1000277 pubmed publisher
    ..excitability by preventing PI3 kinase (PI3K) activation and consequently hyperactivating the transcription factor Foxo. Furthermore, glutamate application increases levels of phospho-Akt, a product of PI3K signaling, within motor ..
  16. Biteau B, Karpac J, Supoyo S, Degennaro M, Lehmann R, Jasper H. Lifespan extension by preserving proliferative homeostasis in Drosophila. PLoS Genet. 2010;6:e1001159 pubmed publisher
  17. Fridell Y, Hoh M, Kréneisz O, Hosier S, Chang C, Scantling D, et al. Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan. Aging (Albany NY). 2009;1:699-713 pubmed IPCs results in decreased steady state Ca(2+) levels in IPCs as well as decreased PI3K activity and increased FoxO nuclear localization in periphery...
  18. Zhao X, Campos A. Insulin signalling in mushroom body neurons regulates feeding behaviour in Drosophila larvae. J Exp Biol. 2012;215:2696-702 pubmed publisher
    ..Here, we show that impairment of insulin signalling in the mushroom body neurons, a structure involved in associative learning, impairs feeding behaviour in the Drosophila larva. ..
  19. Nielsen M, Luo X, Biteau B, Syverson K, Jasper H. 14-3-3 Epsilon antagonizes FoxO to control growth, apoptosis and longevity in Drosophila. Aging Cell. 2008;7:688-99 pubmed publisher
    ..We find that dFoxO and 14-3-3epsilon proteins interact in vivo and that this interaction is lost in response to oxidative stress...
  20. Giannakou M, Goss M, Partridge L. Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response. Aging Cell. 2008;7:187-98 pubmed publisher
    ..fruitfly Drosophila melanogaster to investigate the responses to DR of flies mutant for the transcription factor dFOXO, the main transcription factor target of IIS. We found that lifespan extension by DR does not require dFOXO...
  21. Rera M, Clark R, Walker D. Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila. Proc Natl Acad Sci U S A. 2012;109:21528-33 pubmed publisher
    ..insulin/insulin-like growth factor signaling, as evidenced by a reduction in Akt activation and up-regulation of dFOXO target genes...
  22. Shingleton A, Das J, Vinicius L, Stern D. The temporal requirements for insulin signaling during development in Drosophila. PLoS Biol. 2005;3:e289 pubmed
    ..We hypothesize that the insulin-signaling pathway controls such diverse effects as total developmental time, total body size and organ size through its effects on the rate of cell growth, and proliferation in different organs. ..
  23. Cheng L, Bailey A, Leevers S, Ragan T, Driscoll P, Gould A. Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila. Cell. 2011;146:435-47 pubmed publisher
    ..Together, these findings identify a brain-sparing mechanism that shares some regulatory features with the starvation-resistant growth programs of mammalian tumors. ..
  24. Marr M, D Alessio J, Puig O, Tjian R. IRES-mediated functional coupling of transcription and translation amplifies insulin receptor feedback. Genes Dev. 2007;21:175-83 pubmed
  25. Teleman A, Chen Y, Cohen S. 4E-BP functions as a metabolic brake used under stress conditions but not during normal growth. Genes Dev. 2005;19:1844-8 pubmed
    ..We suggest that 4E-BP works as a metabolic brake that is activated under conditions of environmental stress to control fat metabolism. 4E-BP mutants lack this regulation, reducing their ability to survive under unfavorable conditions. ..
  26. Gershman B, Puig O, Hang L, Peitzsch R, Tatar M, Garofalo R. High-resolution dynamics of the transcriptional response to nutrition in Drosophila: a key role for dFOXO. Physiol Genomics. 2007;29:24-34 pubmed
    ..feeding-induced expression changes were compared with those induced by the insulin-regulated transcription factor dFOXO in Drosophila S2 cells...
  27. Vihervaara T, Puig O. dFOXO regulates transcription of a Drosophila acid lipase. J Mol Biol. 2008;376:1215-23 pubmed publisher
    ..The transcription factor FOXO1 has a central role in the regulation of glucose levels by insulin: reduced insulin signaling causes FOXO1 ..
  28. Hong Y, Lee N, Lee M, Park M, Choi G, Suh Y, et al. dXNP/DATRX increases apoptosis via the JNK and dFOXO pathway in Drosophila neurons. Biochem Biophys Res Commun. 2009;384:160-6 pubmed publisher
    ..Furthermore, dXNP/DATRX-induced rough eye phenotype and apoptosis were suppressed by dFOXO deficiency...
  29. Hennig K, Colombani J, Neufeld T. TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth. J Cell Biol. 2006;173:963-74 pubmed
    ..Our data indicate that endocytosis acts both as an effector function downstream of TOR and as a physiologically relevant regulator of TOR signaling...
  30. Jünger M, Rintelen F, Stocker H, Wasserman J, Végh M, Radimerski T, et al. The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J Biol. 2003;2:20 pubmed
    ..In this study, we present a genetic characterization of dFOXO, the only Drosophila FOXO ortholog...
  31. Kramer J, Slade J, Staveley B. foxo is required for resistance to amino acid starvation in Drosophila. Genome. 2008;51:668-72 pubmed publisher
    ..During conditions of starvation the level of circulating insulin is low. Under conditions of low insulin, the foxo family of transcription factors are activated...
  32. Lee K, Kwon O, Lee J, Kwon K, Min K, Jung S, et al. Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling. Nat Cell Biol. 2008;10:468-75 pubmed publisher
    ..The fat body of sNPF mutant Drosophila had downregulated Akt, nuclear localized FOXO, upregulated translational inhibitor 4E-BP and reduced cell size...
  33. Lee K, Iijima Ando K, Iijima K, Lee W, Lee J, Yu K, et al. JNK/FOXO-mediated neuronal expression of fly homologue of peroxiredoxin II reduces oxidative stress and extends life span. J Biol Chem. 2009;284:29454-61 pubmed publisher
    ..N-terminal kinase (JNK) signaling in neurons increases stress resistance and extends life span, in part through FOXO-mediated transcription in Drosophila. However, the JNK/FOXO target genes are unknown...
  34. Luo X, Puig O, Hyun J, Bohmann D, Jasper H. Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation. EMBO J. 2007;26:380-90 pubmed
    ..Here, we show that the Forkhead Box O transcription factor Foxo and the AP-1 transcription factor DFos are required downstream of Jun-N-terminal ..
  35. Partridge L, Gems D, Withers D. Sex and death: what is the connection?. Cell. 2005;120:461-72 pubmed
    ..Understanding the molecular basis of the cost of reproduction will be informed by elucidation of the mechanisms by which DR and IIS affect these two traits. ..
  36. Buch S, Melcher C, Bauer M, Katzenberger J, Pankratz M. Opposing effects of dietary protein and sugar regulate a transcriptional target of Drosophila insulin-like peptide signaling. Cell Metab. 2008;7:321-32 pubmed publisher
    ..tobi is thus a target of the insulin- and glucagon-like signaling system that responds oppositely to dietary protein and sugar. ..
  37. Colombani J, Bianchini L, Layalle S, Pondeville E, Dauphin Villemant C, Antoniewski C, et al. Antagonistic actions of ecdysone and insulins determine final size in Drosophila. Science. 2005;310:667-70 pubmed
    ..animal growth rates by impeding general insulin signaling involving localization of the transcription factor dFOXO and transcription of the translation inhibitor 4E-BP...
  38. Broughton S, Alic N, Slack C, Bass T, Ikeya T, Vinti G, et al. Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs. PLoS ONE. 2008;3:e3721 pubmed publisher
    ..We observed a compensatory increase in dilp3 and 5 mRNA upon dilp2 knock down. By manipulation of dfoxo and dInR, we showed that the increase in dilp3 is regulated via autocrine insulin signaling in the mNSCs...
  39. Fuss B, Becker T, Zinke I, Hoch M. The cytohesin Steppke is essential for insulin signalling in Drosophila. Nature. 2006;444:945-8 pubmed
    ..step acts upstream of PI(3)K and is required for the proper regulation of Akt and the transcription factor FOXO. Temporally controlled interference with the GEF activity of the Step protein by feeding the chemical inhibitor ..
  40. Becker T, Loch G, Beyer M, Zinke I, Aschenbrenner A, Carrera P, et al. FOXO-dependent regulation of innate immune homeostasis. Nature. 2010;463:369-73 pubmed publisher
    ..that AMP activation can be achieved independently of these immunoregulatory pathways by the transcription factor FOXO, a key regulator of stress resistance, metabolism and ageing...
  41. Alic N, Hoddinott M, Vinti G, Partridge L. Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor. Aging Cell. 2011;10:137-47 pubmed publisher
    ..Our findings point to the possibility that an IGFBP or a related protein, such as IGFBP7, plays a role in mammalian aging. ..
  42. Puig O, Marr M, Ruhf M, Tjian R. Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev. 2003;17:2006-20 pubmed the identification and functional characterization of the Drosophila forkhead-related transcription factor dFOXO, a key component of the insulin signaling cascade...
  43. Kanao T, Venderova K, Park D, Unterman T, Lu B, Imai Y. Activation of FoxO by LRRK2 induces expression of proapoptotic proteins and alters survival of postmitotic dopaminergic neuron in Drosophila. Hum Mol Genet. 2010;19:3747-58 pubmed publisher
    ..In the current study, we report that the gene product LRRK2 directly phosphorylates the forkhead box transcription factor FoxO1 and enhances its transcriptional activity...
  44. Hyun S, Lee J, Jin H, Nam J, Namkoong B, Lee G, et al. Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K. Cell. 2009;139:1096-108 pubmed publisher
    ..Our study identifies two novel regulators of insulin signaling, miR-8/miR-200 and USH/FOG2, and suggests their roles in adolescent growth, aging, and cancer. ..
  45. Zid B, Rogers A, Katewa S, Vargas M, Kolipinski M, Lu T, et al. 4E-BP extends lifespan upon dietary restriction by enhancing mitochondrial activity in Drosophila. Cell. 2009;139:149-60 pubmed publisher
    ..For a video summary of this article, see the PaperFlick file with the Supplemental Data available online. ..
  46. Ikeya T, Broughton S, Alic N, Grandison R, Partridge L. The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila. Proc Biol Sci. 2009;276:3799-807 pubmed publisher
    ..This effect of Wolbachia infection on IIS could have an evolutionary explanation, and has some implications for studies of IIS in Drosophila and other organisms that harbour endosymbionts. ..
  47. Tiefenböck S, Baltzer C, Egli N, Frei C. The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling. EMBO J. 2010;29:171-83 pubmed publisher
    ..In this process, Spargel functioned in parallel to the insulin-responsive transcription factor, dFoxo, and provided a negative feedback loop to fine-tune insulin signalling...
  48. Wu Q, Brown M. Signaling and function of insulin-like peptides in insects. Annu Rev Entomol. 2006;51:1-24 pubmed
  49. Siegrist S, Haque N, Chen C, Hay B, Hariharan I. Inactivation of both Foxo and reaper promotes long-term adult neurogenesis in Drosophila. Curr Biol. 2010;20:643-8 pubmed publisher
    ..and proliferation slows because of decreased insulin/PI3 kinase signaling, resulting in nuclear localization of Foxo. These small neuroblasts are typically eliminated by caspase-dependent cell death, and not exclusively by terminal ..
  50. Demontis F, Piccirillo R, Goldberg A, Perrimon N. Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models. Dis Model Mech. 2013;6:1339-52 pubmed publisher
  51. Villa Cuesta E, Sage B, Tatar M. A role for Drosophila dFoxO and dFoxO 5'UTR internal ribosomal entry sites during fasting. PLoS ONE. 2010;5:e11521 pubmed publisher
    ..Here we show that the Drosophila melanogaster Forkhead box type O (dFoxO) transcription factor is required for adult survival during fasting, and that the 5'UTR of dfoxO has ..
  52. Slaidina M, Delanoue R, Gronke S, Partridge L, Leopold P. A Drosophila insulin-like peptide promotes growth during nonfeeding states. Dev Cell. 2009;17:874-84 pubmed publisher also induced upon starvation, and both its developmental and environmental expression require the Drosophila FoxO transcription factor...
  53. Wang M, Bohmann D, Jasper H. JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell. 2005;121:115-25 pubmed
    ..The transcription factor Foxo, which is inhibited by IIS, extends life span in conditions of low IIS activity...
  54. Luong N, Davies C, Wessells R, Graham S, King M, Veech R, et al. Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity. Cell Metab. 2006;4:133-42 pubmed
    ..metabolic syndrome phenotypes associated with increased activity of the insulin responsive transcription factor, dFOXO. Reduction in dTOR function also protects against age-dependent decline in heart function and increases longevity...
  55. Casas Tinto S, Marr M, Andreu P, Puig O. Characterization of the Drosophila insulin receptor promoter. Biochim Biophys Acta. 2007;1769:236-43 pubmed
    ..Our results indicate that dInR expression in Drosophila displays an intricate pattern of regulation that assures an adequate control of growth, development and metabolism. ..
  56. Giannakou M, Goss M, Jacobson J, Vinti G, Leevers S, Partridge L. Dynamics of the action of dFOXO on adult mortality in Drosophila. Aging Cell. 2007;6:429-38 pubmed
    ..Extension of lifespan by reduced IIS has been shown in C. elegans to require the key IIS target, forkhead box class O (FOXO) transcription factor, DAF-16...
  57. Hwangbo D, Gershman B, Gersham B, Tu M, Palmer M, Tatar M. Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature. 2004;429:562-6 pubmed
    ..signalling is inhibited in certain tissues, or when repressed in adult worms, and this requires the forkhead transcription factor (FOXO) encoded by daf-16 (ref. 6). The D...
  58. Wigby S, Slack C, Gronke S, Martinez P, Calboli F, Chapman T, et al. Insulin signalling regulates remating in female Drosophila. Proc Biol Sci. 2011;278:424-31 pubmed publisher
    ..However, overexpression of the IIS-regulated transcription factor dFOXO in the fat body-which extends lifespan-does not affect remating rate...
  59. LaFever L, Feoktistov A, Hsu H, Drummond Barbosa D. Specific roles of Target of rapamycin in the control of stem cells and their progeny in the Drosophila ovary. Development. 2010;137:2117-26 pubmed publisher
    ..These results uncover specific TOR functions in the control of stem cells versus their differentiating progeny, and reveal parallels between Drosophila and mammalian follicle growth. ..
  60. Wang B, Moya N, Niessen S, Hoover H, Mihaylova M, Shaw R, et al. A hormone-dependent module regulating energy balance. Cell. 2011;145:596-606 pubmed publisher
    ..In the fasted state, SIRT1 promotes catabolic gene expression by deacetylating the forkhead factor FOXO in response to stress and nutrient deprivation...
  61. Mojsilovic Petrovic J, Nedelsky N, Boccitto M, Mano I, Georgiades S, Zhou W, et al. FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases. J Neurosci. 2009;29:8236-47 pubmed publisher
    ..These results indicate that activation of the DAF-16/FOXO3a pathway, genetically or pharmacologically, confers protection against the known causes of motor neuron diseases. ..
  62. Wessells R, Fitzgerald E, Piazza N, Ocorr K, Morley S, Davies C, et al. d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila. Aging Cell. 2009;8:542-52 pubmed publisher
    dTOR (target of rapamycin) and dFoxo respond to changes in the nutritional environment to induce a broad range of responses in multiple tissue types...
  63. Alic N, Tullet J, Niccoli T, Broughton S, Hoddinott M, Slack C, et al. Cell-nonautonomous effects of dFOXO/DAF-16 in aging. Cell Rep. 2014;6:608-16 pubmed publisher
    Drosophila melanogaster and Caenorhabditis elegans each carry a single representative of the Forkhead box O (FoxO) family of transcription factors, dFOXO and DAF-16, respectively...
  64. Zhang W, Thompson B, Hietakangas V, Cohen S. MAPK/ERK signaling regulates insulin sensitivity to control glucose metabolism in Drosophila. PLoS Genet. 2011;7:e1002429 pubmed publisher
    ..The MAPK/ERK pathway acts via the ETS-1 transcription factor Pointed. This mechanism permits physiological adjustment of insulin sensitivity and subsequent maintenance of circulating glucose at appropriate levels. ..
  65. Nechipurenko I, Broihier H. FoxO limits microtubule stability and is itself negatively regulated by microtubule disruption. J Cell Biol. 2012;196:345-62 pubmed publisher
    ..In this paper, we identify a novel neuronal function for Drosophila melanogaster FoxO in limiting MT stability at the neuromuscular junction (NMJ)...
  66. Sun X, Komatsu T, Lim J, Laslo M, Yolitz J, Wang C, et al. Nutrient-dependent requirement for SOD1 in lifespan extension by protein restriction in Drosophila melanogaster. Aging Cell. 2012;11:783-93 pubmed publisher
    ..A low sugar-high protein diet had an opposite effect. Our genetic analysis indicated that SOD1 overexpression or dfoxo deletion did not alter lifespan patterns of flies responding to diets...
  67. Tettweiler G, Miron M, Jenkins M, Sonenberg N, Lasko P. Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP. Genes Dev. 2005;19:1840-3 pubmed
    ..The Drosophila forkhead transcription factor (dFOXO) activates d4E-BP transcription...
  68. Wittwer F, Jaquenoud M, Brogiolo W, Zarske M, Wüstemann P, Fernandez R, et al. Susi, a negative regulator of Drosophila PI3-kinase. Dev Cell. 2005;8:817-27 pubmed
    ..The fact that Susi is expressed in a circadian rhythm, with highest levels during the night, suggests that Susi attenuates insulin signaling during the fasting period. ..
  69. Delanoue R, Slaidina M, Leopold P. The steroid hormone ecdysone controls systemic growth by repressing dMyc function in Drosophila fat cells. Dev Cell. 2010;18:1012-21 pubmed publisher
    ..In conclusion, the present work reveals an unexpected function of dMyc in the systemic control of growth in response to steroid hormone signaling. ..
  70. Sousa Nunes R, Yee L, Gould A. Fat cells reactivate quiescent neuroblasts via TOR and glial insulin relays in Drosophila. Nature. 2011;471:508-12 pubmed publisher
    ..This mechanism indicates that dietary nutrients and remote organs, as well as local niches, are key regulators of transitions in stem-cell behaviour...
  71. Papatheodorou I, Ziehm M, Wieser D, Alic N, Partridge L, Thornton J. Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageing. PLoS ONE. 2012;7:e50881 pubmed publisher
    ..We apply our method to RNA expression data from Drosophila mutants in the insulin pathway that alter lifespan, in a foxo dependent fashion. We use this information to deduce how the pathway influences lifespan in the mutant animals...
  72. Balaban R, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell. 2005;120:483-95 pubmed
    ..Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging. ..