Gene Symbol: foi
Description: fear-of-intimacy
Alias: CG6817, Dmel\CG6817, FOI, Foi, cg6817, dFOI, dZIPfoi, dZipFOI, kas, l(3)j8E8, l(3)neo13, fear-of-intimacy, CG6817-PA, CG6817-PB, CG6817-PC, CG6817-PD, fear of intimacy, foi-PA, foi-PB, foi-PC, foi-PD, kastchen
Species: fruit fly

Top Publications

  1. Mathews W, Ong D, Milutinovich A, Van Doren M. Zinc transport activity of Fear of Intimacy is essential for proper gonad morphogenesis and DE-cadherin expression. Development. 2006;133:1143-53 pubmed Drosophila requires the homophilic cell-adhesion molecule Drosophila E-cadherin (DE-cadherin), and also Fear of Intimacy (FOI), which is required for stable accumulation of DE-cadherin protein in the gonad...
  2. Lye J, Richards C, Dechen K, Warr C, Burke R. In vivo zinc toxicity phenotypes provide a sensitized background that suggests zinc transport activities for most of the Drosophila Zip and ZnT genes. J Biol Inorg Chem. 2013;18:323-32 pubmed publisher
    ..Additionally, targeted suppression of each gene by RNA interference reveals several of the fly Zip and ZnT genes are required in the eye, indicating that numerous independent zinc transport genes are acting together in a single tissue. ..
  3. Lye J, Richards C, Dechen K, Paterson D, de Jonge M, Howard D, et al. Systematic functional characterization of putative zinc transport genes and identification of zinc toxicosis phenotypes in Drosophila melanogaster. J Exp Biol. 2012;215:3254-65 pubmed publisher
    ..Our findings show that a genetically based zinc toxicosis situation can be therapeutically treated or exacerbated by modifications to the diet, providing a sensitized background for future, more detailed studies of Zip/ZnT function. ..
  4. Mathews W, Wang F, Eide D, Van Doren M. Drosophila fear of intimacy encodes a Zrt/IRT-like protein (ZIP) family zinc transporter functionally related to mammalian ZIP proteins. J Biol Chem. 2005;280:787-95 pubmed
    ..Previously, we have shown that fear of intimacy (foi) encodes a putative member of the ZIP family that is essential for development in Drosophila...
  5. Saini N, Schaffner W. Zinc supplement greatly improves the condition of parkin mutant Drosophila. Biol Chem. 2010;391:513-8 pubmed publisher
  6. Starz Gaiano M, Lehmann R. Moving towards the next generation. Mech Dev. 2001;105:5-18 pubmed
    ..Here we review findings from Drosophila, zebrafish, and mouse; each organism provides unique insight into the mechanisms that determine germ cell fate and the cues that may guide their migration. ..
  7. Gutierrez L, Sabaratnam N, Aktar R, Bettedi L, Mandilaras K, Missirlis F. Zinc accumulation in heterozygous mutants of fumble, the pantothenate kinase homologue of Drosophila. FEBS Lett. 2010;584:2942-6 pubmed publisher
    ..Accordingly, zinc supplementation had an adverse impact on the development of fumble mutant larvae, but zinc chelation failed to protect. ..
  8. Dechen K, Richards C, Lye J, Hwang J, Burke R. Compartmentalized zinc deficiency and toxicities caused by ZnT and Zip gene over expression result in specific phenotypes in Drosophila. Int J Biochem Cell Biol. 2015;60:23-33 pubmed publisher
    ..This research highlights the differential effects that redistribution of zinc can have within a particular tissue and identifies the Golgi as being particularly sensitive to both excess and insufficient zinc. ..
  9. Carrasco Rando M, Atienza Manuel A, Martin P, Burke R, Ruiz Gomez M. Fear-of-intimacy-mediated zinc transport controls the function of zinc-finger transcription factors involved in myogenesis. Development. 2016;143:1948-57 pubmed publisher
    ..We show that the ZIP transporter Fear-of-intimacy (Foi) is necessary for the formation of Drosophila muscles...

More Information


  1. DeFalco T, Verney G, Jenkins A, McCaffery J, Russell S, Van Doren M. Sex-specific apoptosis regulates sexual dimorphism in the Drosophila embryonic gonad. Dev Cell. 2003;5:205-16 pubmed
    ..Our work furthers the hypotheses that a conserved pathway controls gonad sexual dimorphism in diverse species and that sex-specific cell recruitment and programmed cell death are common mechanisms for creating sexual dimorphism. ..
  2. Saini N, Georgiev O, Schaffner W. The parkin mutant phenotype in the fly is largely rescued by metal-responsive transcription factor (MTF-1). Mol Cell Biol. 2011;31:2151-61 pubmed publisher
    ..Our findings also raise the possibility that MTF-1 gene polymorphisms in humans could affect the severity of Parkinson's disease. ..
  3. Pielage J, Kippert A, Zhu M, Klämbt C. The Drosophila transmembrane protein Fear-of-intimacy controls glial cell migration. Dev Biol. 2004;275:245-57 pubmed
    ..controlling midline glia migration in the Drosophila nervous system, we have identified mutations in the gene kastchen. Here we show that during embryogenesis kastchen is also required for the normal migration of longitudinal and ..
  4. Taylor K, Nicholson R. Fear of intimacy--a close LIV-1 acquaintancy?. Development. 2006;133:3053 pubmed
  5. Rongo C, Broihier H, Moore L, Van Doren M, Forbes A, Lehmann R. Germ plasm assembly and germ cell migration in Drosophila. Cold Spring Harb Symp Quant Biol. 1997;62:1-11 pubmed
    ..Further genetic studies will reveal the extent to which molecular aspects of germ cell migration and gonad formation are conserved. ..
  6. Ryuda M, Shimada K, Koyanagi R, Azumi K, Tanimura T, Hayakawa Y. Analysis of hunger-driven gene expression in the Drosophila melanogaster larval central nervous system. Zoolog Sci. 2008;25:746-52 pubmed publisher
    ..Given that these genes contribute to mediating hunger-driven changes in food preference and intake in D. melanogaster larvae, the dysfunction of these key genes could cause the defect in food preference observed in GS1189-strain larvae. ..
  7. Van Doren M, Mathews W, Samuels M, Moore L, Broihier H, Lehmann R. fear of intimacy encodes a novel transmembrane protein required for gonad morphogenesis in Drosophila. Development. 2003;130:2355-64 pubmed
    ..We have identified mutations in the fear of intimacy (foi) gene that cause defects in the formation of the embryonic gonad in Drosophila...
  8. Hummel T, Schimmelpfeng K, Klämbt C. Commissure formation in the embryonic CNS of Drosophila. Development. 1999;126:771-9 pubmed
    ..The results lead to a detailed model relating different cellular functions to axonal patterning at the midline. ..
  9. Saja S, Buff H, Smith A, Williams T, Korey C. Identifying cellular pathways modulated by Drosophila palmitoyl-protein thioesterase 1 function. Neurobiol Dis. 2010;40:135-45 pubmed publisher
    ..This work lays the groundwork for further experimental exploration of these processes to better understand their contributions to the INCL disease process. ..
  10. Garcia Lopez A, Monferrer L, Garcia Alcover I, Vicente Crespo M, Alvarez Abril M, Artero R. Genetic and chemical modifiers of a CUG toxicity model in Drosophila. PLoS ONE. 2008;3:e1595 pubmed publisher
    ..These findings provide new insights into the DM1 phenotype, and suggest novel candidates for DM1 treatments. ..
  11. Le Bras S, Van Doren M. Development of the male germline stem cell niche in Drosophila. Dev Biol. 2006;294:92-103 pubmed
    ..This work establishes the Drosophila male GSC niche as a model for understanding the mechanisms controlling niche formation and initial stem cell recruitment, as well as the development of sexual dimorphism in the gonad. ..
  12. Godt D, Tepass U. Organogenesis: keeping in touch with the germ cells. Curr Biol. 2003;13:R683-5 pubmed
    DE-cadherin and its novel regulator, the transmembrane protein Fear of Intimacy, have been found to control the adhesive interactions between germline and somatic cells that lead to gonad formation in Drosophila.
  13. Qin Q, Wang X, Zhou B. Functional studies of Drosophila zinc transporters reveal the mechanism for dietary zinc absorption and regulation. BMC Biol. 2013;11:101 pubmed publisher
    ..The knowledge gained will act as a reference for future mammalian studies, and also enable an appreciation of this important process from an evolutionary perspective. ..
  14. Soriano S, Calap Quintana P, Llorens J, Al Ramahi I, Gutierrez L, Martínez Sebastián M, et al. Metal Homeostasis Regulators Suppress FRDA Phenotypes in a Drosophila Model of the Disease. PLoS ONE. 2016;11:e0159209 pubmed publisher
    ..Taken together, these results demonstrate that the metal dysregulation in FRDA includes other metals besides iron, therefore providing a new set of potential therapeutic targets. ..
  15. Richards C, Warr C, Burke R. A role for dZIP89B in Drosophila dietary zinc uptake reveals additional complexity in the zinc absorption process. Int J Biochem Cell Biol. 2015;69:11-9 pubmed publisher
    ..We postulate that dZIP89B works in concert with the closely related dZIP42C.1 and 2 to ensure optimal zinc absorption under a range of dietary conditions. ..
  16. Chen F, Woodfin A, Gardini A, Rickels R, Marshall S, Smith E, et al. PAF1, a Molecular Regulator of Promoter-Proximal Pausing by RNA Polymerase II. Cell. 2015;162:1003-15 pubmed publisher
  17. Jenkins A, McCaffery J, Van Doren M. Drosophila E-cadherin is essential for proper germ cell-soma interaction during gonad morphogenesis. Development. 2003;130:4417-26 pubmed
    ..In addition, we find that Fear of Intimacy, a novel transmembrane protein, is also required for both germ cell ensheathment and gonad compaction...
  18. Howard K. Organogenesis: Drosophila goes gonadal. Curr Biol. 1998;8:R415-7 pubmed
    ..Recent work in Drosophila has built a picture of the gene activities that specify the gonad and allow it to attract germ cells, and has led to the identification of a gene, columbus, that may encode the attractive factor. ..