Research Topics
Genomes and Genes | fliISummaryGene Symbol: fliI Description: flightless I Alias: BcDNA:LD21753, CG1484, CT3691, DCA3-19, Dmel\CG1484, EN3, FLI-I, Fli-I, fli, fli I, fli-I, fltI, fltO, l(1)18-80, l(1)19Fd, l(1)ESHS53, lDCB2-19, sdby, CG1484-PA, Flightless-I, fliI-PA, flightless, gluful-2, lgluful-2, section 15, standby Species: fruit fly Top Publications
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Publications
The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humansH D Campbell
Research School of Biological Sciences, Australian National University, Canberra
Proc Natl Acad Sci U S A 90:11386-90. 1993Mutations at the flightless-I locus (fliI) of Drosophila melanogaster cause flightlessness or, when severe, incomplete cellularization during early embryogenesis, with subsequent abnormalities in mesoderm invagination and in gastrulation...
The flightless I protein localizes to actin-based structures during embryonic developmentD A Davy
Molecular Signalling Group, Division of Neuroscience, Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Ausralian National University, Canberra
Immunol Cell Biol 78:423-9. 2000The product of the flightless I gene is predicted to provide a link between molecules of an as yet unidentified signal transduction pathway and the actin cytoskeleton...- Isolation and characterization of flightless mutants in Drosophila melanogasterT Koana
J Embryol Exp Morphol 45:123-43. 1978..After mutagenesis with ethyl methanesulphonate (EMS), we screened for X-linked flightless mutants of Drosophila melanogaster by using column-type flight tester... - The sluggish-A gene of Drosophila melanogaster is expressed in the nervous system and encodes proline oxidase, a mitochondrial enzyme involved in glutamate biosynthesisD C Hayward
Research School of Biological Sciences, Australian National University, Canberra, ACT
Proc Natl Acad Sci U S A 90:2979-83. 1993..Significantly, it has previously been reported that a mouse mutant, PRO/Re, which has reduced proline oxidase activity and elevated free proline levels, also exhibits sluggish behavior... - The Drosophila melanogaster dodo (dod) gene, conserved in humans, is functionally interchangeable with the ESS1 cell division gene of Saccharomyces cerevisiaeR Maleszka
Visual Sciences Group, Research School of Biological Sciences, Australian National University, Canberra, Australia
Proc Natl Acad Sci U S A 93:447-51. 1996We have sequenced the region of DNA adjacent to and including the flightless (fli) gene of Drosophila melanogaster and molecularly characterized four transcription units within it, which we have named tweety (twe), flightless (fli), dodo (.. - Molecular and mutational analysis of a gelsolin-family member encoded by the flightless I gene of Drosophila melanogasterH G de Couet
Department of Zoology, University of Hawaii, Honolulu 96822, USA
Genetics 141:1049-59. 1995The flightless locus of Drosophila melanogaster has been analyzed at the genetic, molecular, ultrastructural and comparative crystallographic levels... - The gelsolin-related flightless I protein is required for actin distribution during cellularisation in DrosophilaK L Straub
Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
J Cell Sci 109:263-70. 1996..analysed the developmental defects in Drosophila embryos lacking a gelsolin-related protein encoded by the gene flightless I. Such embryos have previously been reported to gastrulate abnormally... - Data transferability from model organisms to human beings: insights from the functional genomics of the flightless region of DrosophilaR Maleszka
Research School of Biological Sciences, Australian National University, Canberra ACT 2600, Australia
Proc Natl Acad Sci U S A 95:3731-6. 1998.... - Promoter sequence and expression of the leucine-rich repeat gene LRR47: evidence for cytoplasmic and nuclear localization in Drosophila embryos and cellsS G Buchanan
Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1GA, UK
Gene 211:235-44. 1998..The protein is also constitutively present in growing SL2 culture cells and again is present in both cytoplasm and nuclei. These results suggest that LRR47 function may be modulated in the cell or nuclear division cycle... - Genes and chromomeres: A puzzle in three dimensionsB H Judd
411 Clayton Road, Chapel Hill, North Carolina 27514, USA
Genetics 150:1-9. 1998 - Molecular genetic approaches to understanding the actin cytoskeletonJ D Sutherland
European Molecular Biology Laboratory Mouse Biology Programme via Ramarini 32 00016 Monterotondo Italy
Curr Opin Cell Biol 11:142-51. 1999..Yeast, Dictyostelium, Caenorhabditis elegans, Drosophila, and mice have contributed much in recent years to a better understanding of both the numerous functions and modes of regulation of the actin cytoskeleton... - Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesisT Hsu
Laboratory of Cancer Genomics, Hollings Cancer Center, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, South Carolina 29425, USA
Nat Cell Biol 3:538-43. 2001..Its function is to facilitate the degradation of transcription factor CF2, which requires, a priori, activated epidermal growth factor receptor-MAPK signalling... - Calcineurin function is required for myofilament formation and troponin I isoform transition in Drosophila indirect flight muscleKathleen M Gajewski
Department of Biochemistry and Molecular Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Dev Biol 289:17-29. 2006..Together, these findings suggest a molecular basis for the indirect flight muscle hypercontractility phenotype observed in flies mutant for Drosophila calcineurin B2... - Interplay of Fli-I and FLAP1 for regulation of beta-catenin dependent transcriptionYoung Ho Lee
Department of Biochemistry and Molecular Biology, University of Southern California, 1333 San Pablo Avenue, MCA 51A, Los Angeles, CA 90089, USA
Nucleic Acids Res 34:5052-9. 2006..We previously demonstrated that a developmentally essential protein, Flightless-I (Fli-I), serves as a coactivator for nuclear receptor-mediated transcription... - Evolution of secretin family GPCR members in the metazoaJoão C R Cardoso
Centre of Marine Sciences, Universidade do Algarve, Campus de Gambelas, 8005 139 Faro, Portugal
BMC Evol Biol 6:108. 2006..In this study a comprehensive description of family 2 GPCR evolution is given based on in silico and expression analyses of the invertebrate receptor genes... - The novel flightless-I gene brings together two gene families, actin-binding proteins related to gelsolin and leucine-rich-repeat proteins involved in Ras signal transductionC Claudianos
Division of Botany and Zoology, Australian National University, Canberra
Mol Biol Evol 12:405-14. 1995The Drosophila melanogaster gene flightless-I, involved in gastrulation and muscle degeneration, has Caenorhabditis elegans and human homologues... - Mutations affecting the indirect flight muscles of Drosophila melanogasterI I Deak
J Embryol Exp Morphol 69:61-81. 1982..The absence of reduction of the 54 K protein was strongly correlated with aberrant Z-bands... - The role of X-linked lethal and viable male-sterile mutations in male gametogenesis of Drosophila melanogaster: genetic analysisE Lifschytz
Mol Gen Genet 161:275-84. 1978..It is further shown that about the same proportion of vital genes is operating in female gonads and that the two groups overlap by about 70%. The role of viable and lethal male gametogenesis is discussed in detail... - Molecular analysis of the lethal(1)B214 region at the base of the X chromosome of Drosophila melanogasterR J Russell
CSIRO Division of Entomology, Canberra, A C T, Australia
Chromosoma 101:456-66. 1992.... - Chromosome structure at interfaces between major chromatin types: alpha- and beta-heterochromatinG L Miklos
Molecular Neurobiology Group, Research School of Biological Sciences, Australian National University, Canberra
Bioessays 12:1-6. 1990..The recent microcloning of part of this region, the isolation of a monoclonal antibody to a beta-heterochromatin binding protein, and new in situ studies now shed a little more light on this chromosomal region... - The mutations previously designated as flightless-I3, flightless-O2 and standby are members of the W-2 lethal complementation group at the base of the X-chromosome of Drosophila melanogasterG L Miklos
Molecular Neurobiology Group, Research School of Biological Sciences, Australian National University, Canberra ACT
J Neurogenet 6:133-51. 1990..of chromosomal deficiencies, duplications and lethals, we have mapped three mutations causing flightlessness, flightless-I3, flightless-O2 and standby, to a single lethal complementation group (termed W-2) at the base of the X-.. - Developmental genetics of loci at the base of the X chromosome of Drosophila melanogasterN Perrimon
Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115
Genetics 121:313-31. 1989..Additionally, all lethal complementation groups, as well as a specific subset of deficiencies, have been studied histologically for defects in the development of the central and peripheral embryonic nervous systems... - Localization of the genes shaking-B, small optic lobes, sluggish-A, stoned and stress-sensitive-C to a well-defined region on the X-chromosome of Drosophila melanogasterG L Miklos
J Neurogenet 4:1-19. 1987.... - Functional interactions between unlinked muscle genes within haploinsufficient regions of the Drosophila genomeT Homyk
Department of Biology, University of Virginia, Charlottesville 22901
Genetics 119:105-21. 1988.... - Distribution of MR-induced sex-linked recessive lethal mutations in Drosophila melanogasterJ C Eeken
Mutat Res 150:261-75. 1985.... - The localization of "ordinary" sex-linked genes in section 20 of the polytene X chromosome of Drosophila melanogasterA Schalet
Chromosoma 44:183-202. 1973 - Fine structure analysis of a chromosome segment in Drosophila melanogaster: analysis of ethyl methanesulphonate-induced lethalsE Lifschytz
Mutat Res 8:147-55. 1969 - Studies on genetic organization in higher organisms. I. Analysis of a complex gene in Drosophila melanogasterA Chovnick
Genetics 62:145-60. 1969 - Effect of storage and dose on MMS-induced deletions. Complementation analysis of X-chromosomal recessive lethals in the zeste-white and maroon-like regions of Drosophila melanogasterE Paradi
Mutat Res 111:145-59. 1983..An interesting aspect for further analysis is the apparent infrequency in the zeste-white region of alkylation-induced chromosomal breakage, as observed by various investigators for MMS, EMS and MNNG... - Behavioral mutants of Drosophila melanogaster. III. Isolation and mapping of mutations by direct visual observations of behavioral phenotypesT Homyk
Mol Gen Genet 177:553-65. 1980.... - Flightless I: an actin-remodelling protein and an important negative regulator of wound repairZ Kopecki
Child Health Research Institute, North Adelaide, SA and Discipline of Paediatrics, University of Adelaide, Australia
Int J Biochem Cell Biol 40:1415-9. 2008b>Flightless I (FliI) is a member of the gelsolin family of actin-remodelling proteins, and has been identified as having two functional protein family domains: a leucine rich repeat (LRR) domain and a gelsolin-like domain...
Research Grants
- Vascular cell migration and VHL gene function in fliesTien Hsu; Fiscal Year: 2003..2) To assess the relevance of the potential D-VHL interacting proteins and complete the ongoing yeast 2-hybrid screen for D-VHL interacting proteins. (4) Generating genomic D-VHL mutant. ..