Gene Symbol: FLASH
Description: FLICE-associated huge protein
Alias: CG4616, Dmel\CG4616, dFLASH, FLICE-associated huge protein, CG4616-PA, CG4616-PB, FLASH ortholog, FLASH-PA, FLASH-PB
Species: fruit fly
Terzo E, Lyons S, Poulton J, Temple B, Marzluff W, Duronio R. Distinct self-interaction domains promote Multi Sex Combs accumulation in and formation of the Drosophila histone locus body. Mol Biol Cell. 2015;26:1559-74 pubmed publisher
..Finally, the C-terminal 195 amino acids of Mxc are required for recruiting FLASH, an essential histone mRNA-processing factor, to the HLB...
Sabath I, Skrajna A, Yang X, Dadlez M, Marzluff W, Dominski Z. 3'-End processing of histone pre-mRNAs in Drosophila: U7 snRNP is associated with FLASH and polyadenylation factors. RNA. 2013;19:1726-44 pubmed publisher
..Lsm11, the largest component of the U7-specific Sm ring, interacts with FLASH, and in mammalian nuclear extracts these two proteins form a platform that recruits the CPSF73 endonuclease and ..
Rajendra T, Praveen K, Matera A. Genetic analysis of nuclear bodies: from nondeterministic chaos to deterministic order. Cold Spring Harb Symp Quant Biol. 2010;75:365-74 pubmed publisher
Salzler H, Tatomer D, Malek P, McDaniel S, Orlando A, Marzluff W, et al
. A sequence in the Drosophila H3-H4 Promoter triggers histone locus body assembly and biosynthesis of replication-coupled histone mRNAs. Dev Cell. 2013;24:623-34 pubmed publisher
..We conclude that HLB assembly occurs through a stepwise process involving stochastic interactions of individual components that localize to a specific sequence in the H3-H4 promoter. ..
Yang X, Sabath I, Kunduru L, Van Wijnen A, Marzluff W, Dominski Z. A conserved interaction that is essential for the biogenesis of histone locus bodies. J Biol Chem. 2014;289:33767-82 pubmed publisher
Nuclear protein, ataxia-telangiectasia locus (NPAT) and FLICE-associated huge protein (FLASH) are two major components of discrete nuclear structures called histone locus bodies (HLBs)...
Tatomer D, Rizzardi L, Curry K, Witkowski A, Marzluff W, Duronio R. Drosophila Symplekin localizes dynamically to the histone locus body and tricellular junctions. Nucleus. 2014;5:613-25 pubmed publisher
..This localization depends on the RNA binding protein ypsilon schachtel. CPSF-73 and a number of mRNAs are localized at this same site, suggesting that Symplekin participates in cytoplasmic polyadenylation at tricellular junctions. ..
Yang X, Burch B, Yan Y, Marzluff W, Dominski Z. FLASH, a proapoptotic protein involved in activation of caspase-8, is essential for 3' end processing of histone pre-mRNAs. Mol Cell. 2009;36:267-78 pubmed publisher
..We also identified the FLASH ortholog in Drosophila and demonstrate that it interacts with Lsm11 in vitro and in vivo...
Burch B, Godfrey A, Gasdaska P, Salzler H, Duronio R, Marzluff W, et al
. Interaction between FLASH and Lsm11 is essential for histone pre-mRNA processing in vivo in Drosophila. RNA. 2011;17:1132-47 pubmed publisher
..Here, we identify sequences in Drosophila FLASH (dFLASH) that bind Drosophila Lsm11 (dLsm11), allow localization of dFLASH to the nucleus and histone locus body (HLB), ..