fj

Summary

Gene Symbol: fj
Description: four-jointed
Alias: CG10917, Dmel\CG10917, CG10917 gene product from transcript CG10917-RA, CG10917-PA, fj-PA, four jointed
Species: fruit fly

Top Publications

  1. pmc A modifier screen for Bazooka/PAR-3 interacting genes in the Drosophila embryo epithelium
    Wei Shao
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 5:e9938. 2010
  2. pmc Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown
    Richelle Sopko
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Curr Biol 19:1112-7. 2009
  3. ncbi Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling
    Eunjoo Cho
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 131:4489-500. 2004
  4. ncbi Planar cell polarity in the Drosophila eye is directed by graded Four-jointed and Dachsous expression
    Michael A Simon
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Development 131:6175-84. 2004
  5. ncbi Mathematical modeling of planar cell polarity to understand domineering nonautonomy
    Keith Amonlirdviman
    Department of Aeronautics and Astronautics, Stanford University, Stanford, CA 94305 4035, USA
    Science 307:423-6. 2005
  6. ncbi Organ shape: controlling oriented cell division
    David Strutt
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Curr Biol 15:R758-9. 2005
  7. ncbi Long-range coordination of planar polarity in Drosophila
    Helen Strutt
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield, UK
    Bioessays 27:1218-27. 2005
  8. ncbi Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila
    Yaopan Mao
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 133:2539-51. 2006
  9. ncbi Delineation of a Fat tumor suppressor pathway
    Eunjoo Cho
    Howard Hughes Medical Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Nat Genet 38:1142-50. 2006
  10. ncbi The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size
    Maria Willecke
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Curr Biol 16:2090-100. 2006

Research Grants

Scientific Experts

  • David I Strutt
  • Michael Simon
  • Peter A Lawrence
  • Lee D Hazelwood
  • Danelle Devenport
  • S J Bray
  • Hong Luo
  • MARK A PEIFER
  • J P Couso
  • Susan Parkhurst
  • Michel Kerszberg
  • Kenneth D Irvine
  • Hitoshi Matakatsu
  • Helen Strutt
  • José Casal
  • Yongqiang Feng
  • Eunjoo Cho
  • Gary Struhl
  • Maria Willecke
  • Chung Hui Yang
  • M P Zeidler
  • Jeffrey D Axelrod
  • Misako Okumura
  • Milos Galic
  • Cordelia Rauskolb
  • Joseph Parker
  • Jose Maria Carvajal-Gonzalez
  • Yun Qing
  • W Bossuyt
  • Xuesong Zhao
  • Kynan T Lawlor
  • Helen McNeill
  • Aloma B Rodrigues
  • Stephen Dinardo
  • Floris Bosveld
  • Amy Brittle
  • Verónica Muñoz-Soriano
  • Abhijit A Ambegaonkar
  • Laura A Johnston
  • Gerald Schwank
  • Seth Donoughe
  • Justin Hogan
  • Julian C Boggiano
  • Ricardo M Neto-Silva
  • Amy L Brittle
  • Hans Martin Herz
  • Wei Shao
  • Myriam Zecca
  • Nicola A Grzeschik
  • Xinghua Li
  • David R P Tree
  • Richelle Sopko
  • Francisco Jose Gutierrez-Aviño
  • Dali Ma
  • Stein Aerts
  • Dragana Rogulja
  • Javier Terriente
  • Hiroyuki O Ishikawa
  • Seth S Blair
  • Jean François Le Garrec
  • Zhihong Chen
  • Fisun Hamaratoglu
  • Georg Halder
  • Chunyao Tao
  • Yaopan Mao
  • Lesley Clayton
  • Keith Amonlirdviman
  • Janghoo Lim
  • C Rauskolb
  • N Perrimon
  • Haeryun Lee
  • Yu Chen Tsai
  • Y Henry Sun
  • Stefan Kölzer
  • Manolis Fanto
  • Maja Matis
  • Masayuki Miura
  • Chisako Sakuma
  • Takahiro Chihara
  • G Halder
  • Feng Yin
  • M Sudol
  • Chiou Yang Tang
  • Duojia Pan
  • A Kopp
  • Frederick Schozer
  • Pengfei Guo
  • H McNeill
  • Wei Wang
  • Q Chen

Detail Information

Publications78

  1. pmc A modifier screen for Bazooka/PAR-3 interacting genes in the Drosophila embryo epithelium
    Wei Shao
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    PLoS ONE 5:e9938. 2010
    ..We sought to identify additional proteins that function with Baz to regulate epithelial structure in the Drosophila embryo...
  2. pmc Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown
    Richelle Sopko
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Curr Biol 19:1112-7. 2009
    ..We propose that Ds regulates Dco-dependent phosphorylation of Fat and Fat-associated proteins to control Fat signaling in growth and PCP...
  3. ncbi Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling
    Eunjoo Cho
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 131:4489-500. 2004
    ....
  4. ncbi Planar cell polarity in the Drosophila eye is directed by graded Four-jointed and Dachsous expression
    Michael A Simon
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Development 131:6175-84. 2004
    ..the establishment of graded expression of the cadherin Dachsous (Ds) and the Golgi-associated protein Four-jointed (Fj)...
  5. ncbi Mathematical modeling of planar cell polarity to understand domineering nonautonomy
    Keith Amonlirdviman
    Department of Aeronautics and Astronautics, Stanford University, Stanford, CA 94305 4035, USA
    Science 307:423-6. 2005
    ..The sufficiency of this model and the experimental validation of model predictions reveal how specific protein-protein interactions produce autonomy or domineering nonautonomy...
  6. ncbi Organ shape: controlling oriented cell division
    David Strutt
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Curr Biol 15:R758-9. 2005
    ..One mechanism by which organisms control the shape of growing organs is by regulating the orientation of cell divisions. This occurs in the Drosophila wing under the control of genes previously implicated in regulating cell polarity...
  7. ncbi Long-range coordination of planar polarity in Drosophila
    Helen Strutt
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield, UK
    Bioessays 27:1218-27. 2005
    ..Subsequently, this long-range polarity signal is refined by local cell-cell interactions involving the transmembrane molecules Frizzled, Strabismus and Flamingo. The role of these factors in coordinating polarity will be discussed...
  8. ncbi Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila
    Yaopan Mao
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 133:2539-51. 2006
    ..Our results implicate Dachs as a crucial downstream component of a Fat signaling pathway that influences growth, affinity and gene expression during development...
  9. ncbi Delineation of a Fat tumor suppressor pathway
    Eunjoo Cho
    Howard Hughes Medical Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Nat Genet 38:1142-50. 2006
    ..melanogaster tumor suppressors, establish a basic framework for Fat signaling from receptor to transcription factor and implicate Warts as an integrator of multiple growth control signals...
  10. ncbi The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size
    Maria Willecke
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Curr Biol 16:2090-100. 2006
    ..However, components acting upstream of Expanded and Merlin, such as transmembrane receptors, have not yet been identified...
  11. pmc Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity
    José Casal
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 133:4561-72. 2006
    ..We consider how polarity may be propagated by Ds-Ft heterodimers acting as bridges between cells...
  12. pmc Planar cell polarity: one or two pathways?
    Peter A Lawrence
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Nat Rev Genet 8:555-63. 2007
    ..We argue that the prevailing opinion that planar polarity depends on a single genetic pathway is wrong and conclude that there are (at least) two independently acting processes. This conclusion has major consequences for the PCP field...
  13. pmc Four-jointed is a Golgi kinase that phosphorylates a subset of cadherin domains
    Hiroyuki O Ishikawa
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Science 321:401-4. 2008
    ..Our results indicate that Four-jointed regulates Fat signaling by phosphorylating cadherin domains of Fat and Dachsous as they transit through the Golgi...
  14. pmc Morphogen control of wing growth through the Fat signaling pathway
    Dragana Rogulja
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Dev Cell 15:309-21. 2008
    ..These observations identify Fat as a signaling pathway that links the morphogen-mediated establishment of gradients of positional values across developing organs to the regulation of organ growth...
  15. pmc Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation
    Maria Willecke
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:14897-902. 2008
    ..growth but also planar cell polarity, for which it interacts with the Dachsous (Ds) Cadherin, and Four-jointed (Fj), a transmembrane kinase that modulates the interaction between Ds and Fat...
  16. ncbi four-jointed is required for intermediate growth in the proximal-distal axis in Drosophila
    J L Villano
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235 9038, USA
    Development 121:2767-77. 1995
    ..Mutants in the Drosophila four-jointed (fj) gene show reduced growth and altered differentiation only within restricted sectors of the proximal-distal (PD) ..
  17. pmc Processing and phosphorylation of the Fat receptor
    Yongqiang Feng
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway NJ 08854, USA
    Proc Natl Acad Sci U S A 106:11989-94. 2009
    ....
  18. doi Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms
    Nicola A Grzeschik
    Cell Cycle and Development, Peter MacCallum Cancer Centre, Victoria, Australia
    Curr Biol 20:573-81. 2010
    ..Here we investigate how these cell polarity regulators control proliferation and survival...
  19. pmc Modulation of fat:dachsous binding by the cadherin domain kinase four-jointed
    Michael A Simon
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    Curr Biol 20:811-7. 2010
    ..Fat is regulated by the cadherin Dachsous (Ds) and the protein kinase Four-jointed (Fj), which are expressed in gradients in many tissues...
  20. pmc Four-jointed modulates growth and planar polarity by reducing the affinity of dachsous for fat
    Amy L Brittle
    Medical Research Council MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Curr Biol 20:803-10. 2010
    ..Ft and Ds form heterodimeric bridges that convey polarity information from cell to cell. four-jointed (fj) is a modulator of Ft/Ds activity that acts in a graded fashion in the abdomen, eye, and wing...
  21. pmc A feed-forward circuit linking wingless, fat-dachsous signaling, and the warts-hippo pathway to Drosophila wing growth
    Myriam Zecca
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York, USA
    PLoS Biol 8:e1000386. 2010
    ..We posit that Wg propels wing growth at least in part by fueling a wave front of Ft-Ds signaling that propagates vg expression from one cell to the next...
  22. pmc Evidence for a growth-stabilizing regulatory feedback mechanism between Myc and Yorkie, the Drosophila homolog of Yap
    Ricardo M Neto-Silva
    Gulbenkian PhD Program in Biomedicine, P 2780 156 Oeiras, Portugal
    Dev Cell 19:507-20. 2010
    ..We propose that the codependent regulatory relationship functionally coordinates the cellular activities of Yki and Myc and provides a mechanism of growth control that regulates organ size and has broad implications for cancer...
  23. pmc Two frizzled planar cell polarity signals in the Drosophila wing are differentially organized by the Fat/Dachsous pathway
    Justin Hogan
    Department of Biological Sciences, Marshall University, Huntington, West Virginia, United States of America
    PLoS Genet 7:e1001305. 2011
    ..6) Altering the timing of ds knockdown during wing development can separate the role of the Ft/Ds pathway in wing morphogenesis from its role in Early Fz PCP signaling...
  24. pmc Separating planar cell polarity and Hippo pathway activities of the protocadherins Fat and Dachsous
    Hitoshi Matakatsu
    Department of Zoology, University of Wisconsin Madison, 250 North Mills Street, Madison, WI 53706, USA
    Development 139:1498-508. 2012
    ..We also found that the extracellular domain of Ft can act independently of the Ft ICD in PCP and can trigger dominant-negative and boundary effects on Hippo activity, probably via binding to the protocadherin Dachsous...
  25. doi Mechanical control of morphogenesis by Fat/Dachsous/Four-jointed planar cell polarity pathway
    Floris Bosveld
    Polarity, Division and Morphogenesis Team, Institut Curie, CNRS UMR 3215, INSERM U934, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Science 336:724-7. 2012
    ..Our results establish how tissue planar polarization coordinates the local changes of cell mechanical properties to control tissue morphogenesis...
  26. pmc Planar polarity specification through asymmetric subcellular localization of Fat and Dachsous
    Amy Brittle
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Western Bank, Sheffield, UK
    Curr Biol 22:907-14. 2012
    Two pathways regulate planar polarity: the core proteins and the Fat-Dachsous-Four-jointed (Ft-Ds-Fj) system. Morphogens specify complementary expression patterns of Ds and Fj that potentially act as polarizing cues...
  27. pmc Propagation of Dachsous-Fat planar cell polarity
    Abhijit A Ambegaonkar
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Curr Biol 22:1302-8. 2012
    ..is regulated by the graded expression of the Fat ligand Dachsous (Ds) and the cadherin-domain kinase Four-jointed (Fj). The vectors of these gradients influence PCP, whereas their slope can influence growth...
  28. pmc Functional modelling of planar cell polarity: an approach for identifying molecular function
    Lee D Hazelwood
    Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
    BMC Dev Biol 13:20. 2013
    ..This polarisation is commonly known as planar cell polarity and has been found to be important in developmental processes, as planar polarity is required to define the in-plane tissue coordinate system at the cellular level...
  29. ncbi Use of mini-white as a reporter gene to screen for GAL4 insertions with spatially restricted expression pattern in the developing eye in drosophila
    Chiou Yang Tang
    Institute of Molecular Biology, Academia Sinica, Nankang, Taipei, Taiwan, Republic of China
    Genesis 34:39-45. 2002
  30. ncbi Four-jointed interacts with dachs, abelson and enabled and feeds back onto the Notch pathway to affect growth and segmentation in the Drosophila leg
    G R Buckles
    Department of Biology, Texas A and M University, College Station, TX 77843 3258, USA
    Development 128:3533-42. 2001
    ..Thus, four-jointed may bridge the gap between the signals that direct morphogenesis and those that carry it out...
  31. ncbi Multiple roles for four-jointed in planar polarity and limb patterning
    M P Zeidler
    Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA
    Dev Biol 228:181-96. 2000
    ..The subtle phenotypes of mutant flies, and the diverse patterning processes in which it is involved, suggest that four-jointed may act as a modifier of the activity of multiple other signalling factors...
  32. ncbi Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye
    Chung Hui Yang
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Cell 108:675-88. 2002
    ....
  33. ncbi Planar polarity: out of joint?
    S Bray
    Department of Anatomy, University of Cambridge, Cambridge, CB2 3DY, UK
    Curr Biol 10:R155-8. 2000
    ..This planar polarity requires the transmembrane receptor Frizzled. Recent studies have shed new light on mechanisms that could be involved in generating or transducing the polarity signal...
  34. ncbi The four-jointed gene is required in the Drosophila eye for ommatidial polarity specification
    M P Zeidler
    Department of Genetics, Harvard Medical School, Boston, 02115, USA
    Curr Biol 9:1363-72. 1999
    ..These three pathways are thought to act by setting up a gradient of a signalling molecule (or molecules) often referred to as the 'second signal'. Thus far, no candidate for a second signal has been identified...
  35. ncbi Planar polarity: photoreceptors on a high fat diet
    Helen Strutt
    Centre for Developmental Genetics, School of Medicine and Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Curr Biol 12:R384-5. 2002
    ..Differential activity of Frizzled in the R3/R4 photo-receptors of Drosophila regulates the orientation of ommatidia. New evidence suggests that the cadherins Dachsous and Fat act upstream of Frizzled in this process...
  36. ncbi Developmental compartments and planar polarity in Drosophila
    José Casal
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Curr Biol 12:1189-98. 2002
    ....
  37. ncbi The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor
    Manolis Fanto
    Cancer Research UK ICRF, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 130:763-74. 2003
    ....
  38. ncbi Fidelity in planar cell polarity signalling
    Dali Ma
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Nature 421:543-7. 2003
    ..Subsequent action of the Frizzled feedback loop is sufficient to align all the cells cooperatively. This economical system is therefore highly robust, and produces virtually error-free arrays...
  39. ncbi Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing
    Hitoshi Matakatsu
    Department of Zoology, University of Wisconsin, 250 North Mills Street, Madison, WI 53706, USA
    Development 131:3785-94. 2004
    ..Nor are distal PCP defects increased by the loss of spatial information from the distally expressed four-jointed (fj) gene, which encodes putative modulator of Ft-Ds signaling...
  40. ncbi Cleavage and secretion is not required for Four-jointed function in Drosophila patterning
    Helen Strutt
    Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Development 131:881-90. 2004
    Four-jointed (fj) is required for proximodistal growth and planar polarity in Drosophila tissues...
  41. pmc Drosophila Dachsous and Fat polarize actin-based protrusions over a restricted domain of the embryonic denticle field
    Kynan T Lawlor
    Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6058, United States
    Dev Biol 383:285-94. 2013
    ..Ectopic Ds signaling provides evidence for a model whereby Ds acts to asymmetrically enrich Fat in a neighboring cell, in turn polarizing the cell to specify the position of the actin-based protrusions at the cell cortex. ..
  42. pmc Scaling the Drosophila Wing: TOR-Dependent Target Gene Access by the Hippo Pathway Transducer Yorkie
    Joseph Parker
    Department of Genetics and Development, Columbia University, New York, New York, United States of America Division of Biology, Imperial College London, London, United Kingdom
    PLoS Biol 13:e1002274. 2015
    ....
  43. pmc Planar cell polarity signaling in collective cell movements during morphogenesis and disease
    Verónica Muñoz-Soriano
    Departamento de Genetica, Facultad de CC Biológicas, Universidad de Valencia, Burjassot 46100, Valencia, Spain
    Curr Genomics 13:609-22. 2012
    ..Therefore, new discoveries about the contribution of this pathway to collective cell movements could provide new potential diagnostic and therapeutic targets for these disorders...
  44. pmc The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains
    Xuesong Zhao
    Department of Biology, Stanford University, Stanford, California, United States of America
    PLoS ONE 8:e62998. 2013
    ..Surprisingly, the crucial regions of Ft identified in our structure-function study do not overlap with the previously reported interaction regions with Atrophin, Dco, or Lowfat...
  45. pmc The Hippo effector Yorkie activates transcription by interacting with a histone methyltransferase complex through Ncoa6
    Yun Qing
    Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, United States
    elife 3:. 2014
    ..These findings shed light on Yki-mediated transcriptional regulation and uncover a potential link between chromatin modification and tissue growth. ..
  46. pmc An evolutionary shift in the regulation of the Hippo pathway between mice and flies
    W Bossuyt
    1 Vlaams Instituut voor Biotechnologie VIB Center for the Biology of Disease, Leuven, Belgium 2 Kuleuven, Center for Human Genetics, Leuven, Belgium 3 The University of Texas, MD Anderson Cancer Center, Houston, TX, USA
    Oncogene 33:1218-28. 2014
    ..We conclude that fundamental differences exist in the upstream regulatory mechanisms of Hippo signaling between Drosophila and vertebrates. ..
  47. pmc Activated STAT regulates growth and induces competitive interactions independently of Myc, Yorkie, Wingless and ribosome biogenesis
    Aloma B Rodrigues
    Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA
    Development 139:4051-61. 2012
    ..As hyper-activated STATs are causal to tumorigenesis and stem cell niche occupancy, our results have therapeutic implications for cancer and regenerative medicine...
  48. pmc The cell biology of planar cell polarity
    Danelle Devenport
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544
    J Cell Biol 207:171-9. 2014
    ..Together, these findings are shedding light on how global cues integrate with local cell interactions to organize cellular polarity at the tissue level. ..
  49. pmc Mechanisms of planar cell polarity establishment in Drosophila
    Jose Maria Carvajal-Gonzalez
    Department of Developmental and Regenerative Biology and Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai One Gustave L Levy Place, Box 1020, New York, NY 10029 USA
    F1000Prime Rep 6:98. 2014
    ..Here, we discuss the current models based on Drosophila studies and incorporate recent insights into this long-standing cell and developmental biology problem. ..
  50. doi Linking cell surface receptors to microtubules: tubulin folding cofactor D mediates Dscam functions during neuronal morphogenesis
    Misako Okumura
    Department of Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113 0033, Japan, and
    J Neurosci 35:1979-90. 2015
    ..Genetic analyses revealed that TBCD cooperates with Dscam in vivo. Our study may offer new insights into the molecular mechanism underlying the altered neural networks in cognitive disabilities of Down syndrome. ..
  51. doi Polarized trafficking provides spatial cues for planar cell polarization within a tissue
    Milos Galic
    Cells In Motion Cluster of Excellence EXC1003 CiM, University of Munster, Germany
    Bioessays 37:678-86. 2015
    ..In this review, we discuss recent findings on the molecular mechanism that links "global" directional signals with local coordinated polarity. ..
  52. pmc dachsous and frizzled contribute separately to planar polarity in the Drosophila ventral epidermis
    Seth Donoughe
    University of Pennsylvania Medical School, Department of Cell and Developmental Biology, 421 Curie Blvd, Philadelphia, PA 19104 6048, USA
    Development 138:2751-9. 2011
    ..Furthermore, we find that the requirement for the Ds system changes as field size increases. Lastly, we find that Ds and its putative receptor Fat (Ft) are enriched in distinct patterns in the epithelium during embryonic development...
  53. doi Antagonistic growth regulation by Dpp and Fat drives uniform cell proliferation
    Gerald Schwank
    Institute of Molecular Life Sciences, Winterthurerstr 190, 8057 Zurich, Switzerland
    Dev Cell 20:123-30. 2011
    ..Together, our results indicate that the activities of both signaling pathways are regulated in a parallel rather than sequential manner and that uniform proliferation is achieved by their complementary action on growth...
  54. pmc Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway
    Julian C Boggiano
    Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, IL 60637, USA
    Dev Cell 21:888-95. 2011
    ..These results demonstrate that one family of Ste20 kinases can activate another and identify Tao-1 as a component of the regulatory network controlling HSW pathway signaling, and therefore tissue growth, during development...
  55. doi Modeling polarity buildup and cell fate decision in the fly eye: insight into the connection between the PCP and Notch pathways
    Jean François Le Garrec
    Modélisation dynamique des systèmes intégrés, Universite Pierre et Marie Curie Paris 6, 75005, Paris, France
    Dev Genes Evol 218:413-26. 2008
    ..The model provides insight into the crosstalk between the PCP and Notch modules in development and illustrates the ability of signaling modules to robustly maintain vital phenotypes in a noisy environment...
  56. ncbi Proximo-distal development in the legs of Drosophila
    J P Couso
    School of Biological Sciences, Royal Holloway College, University of London, Surrey, United Kingdom
    Int J Dev Biol 42:345-52. 1998
    ..The data suggest a process of regionalization and progressive subdivision of an anlage similar to both insect embryonic segmentation and vertebrate somitogenesis...
  57. ncbi Long-range effect of upd, a ligand for Jak/STAT pathway, on cell cycle in Drosophila eye development
    Yu Chen Tsai
    Institute of Genetics, National Yang Ming University, Taipei, Taiwan, Republic of China
    Genesis 39:141-53. 2004
    ..Consistent with the long-range effect, we found that the extracellular Upd protein can be detected over a comparable long range, suggesting that Upd acts directly over a long distance as a signaling molecule...
  58. ncbi Mathematical modeling of planar polarity
    David Strutt
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Dev Cell 8:134-6. 2005
    ..A recent paper by presents a mathematical model of a feedback loop-based mechanism for propagation of polarity between cells that can account for the known functions of Frizzled...
  59. ncbi Control of planar cell polarity by interaction of DWnt4 and four-jointed
    Janghoo Lim
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Genesis 42:150-61. 2005
    ..margins is insufficient to induce ommatidial polarity but becomes inductive when coexpressed with Four-jointed (Fj)...
  60. ncbi Frizzled signalling and cell polarisation in Drosophila and vertebrates
    David Strutt
    Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Development 130:4501-13. 2003
    ..This review discusses recent findings regarding non-canonical Frizzled signalling and cell polarisation...
  61. ncbi Defective proventriculus is required for pattern formation along the proximodistal axis, cell proliferation and formation of veins in the Drosophila wing
    Stefan Kölzer
    Institut fur Genetik, Universitat zu Koln, Weyertal 121, 50931 Koln, Germany
    Development 130:4135-47. 2003
    ..The study of the regulation of dve expression provides information about the strategies employed to subdivide and pattern the PD axis, and reveals the importance of vg during this process...
  62. ncbi Fly developments: an introspective
    Susan Parkhurst
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle WA 98109, USA
    Bioessays 25:87-9. 2003
  63. ncbi Specifying positional information in the embryo: looking beyond morphogens
    Michel Kerszberg
    Universite Pierre et Marie Curie Paris 6, UMR7138 CNRS, 75005 Paris, France
    Cell 130:205-9. 2007
    ..It is now becoming clear that additional or alternative mechanisms involving interactions among cells are also crucial for positional specification...
  64. ncbi Developmental genetics of Drosophila imaginal discs
    J H Postlethwait
    Annu Rev Genet 7:381-433. 1973
  65. doi The Drosophila gene zfh2 is required to establish proximal-distal domains in the wing disc
    Javier Terriente
    Centro de Biologia Molecular Severo Ochoa, Universidad Autónoma C S I C, Madrid, Spain
    Dev Biol 320:102-12. 2008
    ..The results we present here indicate that Zfh2 plays a critical role in both processes...
  66. ncbi Positional information along the dorsal-ventral axis of the Drosophila eye: graded expression of the four-jointed gene
    M H Brodsky
    Howard Hughes Medical Institute, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA
    Dev Biol 173:428-46. 1996
    ..Several insertions with an equatorial-to-polar gradient of lacZ expression disrupt the four-jointed (fj) gene which is required for proper leg, wing, and eye development...
  67. ncbi Limb development: getting down to the ground state
    B Starling Emerald
    European Molecular Biology Laboratory, Meyerhofstr 1, 69117, Heidelberg, Germany
    Curr Biol 11:R1025-7. 2001
    ..Recent genetic studies on the Antennapedia and Homothorax genes of Drosophila raise questions about the nature of this ground state appendage...
  68. ncbi Notch-mediated segmentation and growth control of the Drosophila leg
    C Rauskolb
    Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University, Piscataway, New Jersey, 08854, USA
    Dev Biol 210:339-50. 1999
    ..The Notch pathway is also deployed for segmentation during vertebrate somitogenesis, which raises the possibility of a common origin for the segmentation of these distinct tissues...
  69. pmc Integrating computational biology and forward genetics in Drosophila
    Stein Aerts
    Department of Molecular and Developmental Genetics, Laboratory of Neurogenetics, Vlaams Instituut voor Biotechnologie, Leuven, Belgium
    PLoS Genet 5:e1000351. 2009
    ..A systems genetics approach that combines the power of computational predictions with in vivo genetic screens strongly enhances the process of gene function and gene-gene association discovery...
  70. ncbi The ballet of morphogenesis: unveiling the hidden choreographers
    Mark Peifer
    Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 27599, USA
    Cell 109:271-4. 2002
    ..Several recent papers reveal new insights into the mechanisms by which cells turn their perceptions about fate into action, focusing on the role of Wnt signal transduction in cell polarization and migration...
  71. ncbi The roles of the Drosophila JAK/STAT pathway
    M P Zeidler
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, MA 02115, USA
    Oncogene 19:2598-606. 2000
    ..even skipped and the establishment of polarity within the adult compound eye via a mechanism that includes the four jointed gene...
  72. pmc The position and function of the Notch-mediated eye growth organizer: the roles of JAK/STAT and four-jointed
    Francisco Jose Gutierrez-Aviño
    Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas, Universidad Miguel Hernandez, Campus de Sant Joan, Avd Santiago Ramon y Cajal s n Crta Alicante Valencia km 87, Alicante, Apartado 18, E 03550, San Juan de Alicante, Spain
    EMBO Rep 10:1051-8. 2009
    ..These findings redefine the process of organizer formation and function, and they identify four-jointed as a regulatory node, integrating multiple growth-control pathways...
  73. pmc Polycomb group genes Psc and Su(z)2 restrict follicle stem cell self-renewal and extrusion by controlling canonical and noncanonical Wnt signaling
    Xinghua Li
    National Institute of Biological Sciences, Beijing 102206, People s Republic of China
    Genes Dev 24:933-46. 2010
    ..Given evolutionary conservation of PcG genes from Drosophila to mammals, they could have similar functions in mammalian stem cells and cancer...
  74. ncbi Advantages of a P-element construct containing MtnA sequences for the identification of patterning and cell determination genes in Drosophila melanogaster
    M Faucheux
    Laboratoire d Embryologie Moleculaire et Experimentale, CNRS UPRES A 8080, Universite Paris XI, Orsay, France
    Mol Genet Genomics 265:14-22. 2001
    ..Taken together, these results indicate that P[MTW] allows the tagging of patterning and cell determination genes, and thus provides a useful tool for identifying new developmental functions...
  75. pmc The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila
    Hans Martin Herz
    M D Anderson Cancer Center, Department of Biochemistry and Molecular Biology, Graduate Program in Genes and Development, 1515 Holcombe Boulevard, Unit 1000, Houston, TX 77030, USA
    Mol Cell Biol 30:2485-97. 2010
    ..In summary, these data suggest that dUTX is a suppressor of Notch- and Rbf-dependent tumors in Drosophila melanogaster and may provide a model for UTX-dependent tumorigenesis in humans...
  76. ncbi The JAK/STAT pathway and Drosophila development
    H Luo
    The Cardiovascular Research Institute, Division of Molecular Cardiology, The Texas A and M University System Health Science Center, College of Medicine, Temple, Texas 76504, USA
    Bioessays 23:1138-47. 2001
    ..Hence, the JAK/STAT pathway in Drosophila serves as an attractive model for in vivo functional analyses of JAK/STAT signaling...
  77. ncbi A three-tiered mechanism for regulation of planar cell polarity
    David R P Tree
    Department of Pathology, L235, Stanford University School of Medicine, Stanford, CA 94305, USA
    Semin Cell Dev Biol 13:217-24. 2002
    ..The third modules are tissue specific, acting to translate subcellular asymmetry into the appropriate morphological manifestations in the different cell types...
  78. ncbi The grainy head transcription factor is essential for the function of the frizzled pathway in the Drosophila wing
    Haeryun Lee
    Department of Biology and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
    Mech Dev 121:37-49. 2004
    ..In addition, we found that grh has frizzled pathway independent functions during the development of the adult cuticle...

Research Grants9

  1. MOLECULAR GENETIC OF TYROSINE KINASE AND RAS FUNCTION
    Michael Simon; Fiscal Year: 2001
    ....
  2. CYTOSKELETAL REGULATION BY SRC64/TEC29 KINASES
    Michael Simon; Fiscal Year: 2004
    ..abstract_text> ..
  3. Cadherin regulation of tissue polarity and growth
    Michael Simon; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  4. Signaling Mechanisms of the Drosophila JAK/STAT Pathway
    Hong Luo; Fiscal Year: 2003
    ..abstract_text> ..
  5. Transcriptional Repression and Cofactor Recruitment
    Susan Parkhurst; Fiscal Year: 2008
    ..Results obtained from these projects are expected to have wide implications as HES family proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..
  6. CONFOCAL MICROSCOPE FOR LIVE CELL & MULTIWAVELENGTH WORK
    Mark Peifer; Fiscal Year: 2001
    ..Our proposal seeks to meet these new needs, by the creation of a multi-user facility that will provide a state-of-the art confocal microscope to a large group of NIH funded investigators. ..
  7. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    Susan Parkhurst; Fiscal Year: 2002
    ..Results obtained from these projects are expected to have wide implications as Hairy/E(spl) proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..
  8. Mechanisms of Rho GTPase Function in Drosophila
    Susan Parkhurst; Fiscal Year: 2006
    ..Our results are expected to have wide implications as Rho GTPases and the diverse cellular mechanisms they mediate are conserved across a wide range of organisms. ..
  9. Mechanisms of Wound Healing in Drosphila
    Susan Parkhurst; Fiscal Year: 2009
    ..Controlling repair and inflammation will also be a fundamental consideration in tissue engineering where artificial and/or cell based constructs are implanted to reconstruct tissues. ..