Gene Symbol: Fer3HCH
Description: Ferritin 3 heavy chain homologue
Alias: CG4349, Dmel\CG4349, Fer3, Fer3 HCH, ferritin 3 heavy chain homologue, CG4349-PA, Fer3HCH-PA, mitoch. ferritin
Species: fruit fly
Missirlis F, Holmberg S, Georgieva T, Dunkov B, Rouault T, Law J. Characterization of mitochondrial ferritin in Drosophila. Proc Natl Acad Sci U S A. 2006;103:5893-8 pubmed
..The conservation of mitochondrial ferritin in an insect species underscores the importance of this iron-storage molecule. ..
Greenspan L, Clark A. Associations between Variation in X Chromosome Male Reproductive Genes and Sperm Competitive Ability in Drosophila melanogaster. Int J Evol Biol. 2011;2011:214280 pubmed publisher
..This suggests that much of the male reproductive variation lies outside of genes that encode seminal proteins. ..
Metzendorf C, Lind M. Drosophila mitoferrin is essential for male fertility: evidence for a role of mitochondrial iron metabolism during spermatogenesis. BMC Dev Biol. 2010;10:68 pubmed publisher
..Furthermore, due to the similar expression patterns of some mitochondrial iron metabolism genes in Drosophila and mammals, it is likely that our results are applicable for mammals as well. ..
Shi Z, Shi F, Wang Y, Sheftel A, Nie G, Zhao Y, et al
. Mitochondrial ferritin, a new target for inhibiting neuronal tumor cell proliferation. Cell Mol Life Sci. 2015;72:983-97 pubmed publisher
..We thus propose FtMt as a new candidate target for inhibiting neuronal tumor cell proliferation. Appropriate regulation of FtMt expression may prevent tumor cell growth. Our study may provide a new strategy for neuronal cancer therapy. ..
Navarro J, Botella J, Metzendorf C, Lind M, Schneuwly S. Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich's ataxia. Free Radic Biol Med. 2015;85:71-82 pubmed publisher
Dunkov B, Georgieva T. Insect iron binding proteins: insights from the genomes. Insect Biochem Mol Biol. 2006;36:300-9 pubmed
Esposito G, Vos M, Vilain S, Swerts J, De Sousa Valadas J, Van Meensel S, et al
. Aconitase causes iron toxicity in Drosophila pink1 mutants. PLoS Genet. 2013;9:e1003478 pubmed publisher
..Thus our data indicate that superoxide-dependent [4Fe-4S] inactivation defines a potential pathogenic cascade that acts independent of mitophagy and links iron toxicity to mitochondrial failure in a PD-relevant model. ..
Chen K, Lin G, Haelterman N, Ho T, Li T, Li Z, et al
. Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration. elife. 2016;5: pubmed publisher
..Our results indicate that an iron/sphingolipid/Pdk1/Mef2 pathway may play a role in FRDA. ..