Gene Symbol: Fer2LCH
Description: Ferritin 2 light chain homologue
Alias: 2LCH, CG1469, Dmel\CG1469, Fe2LCH, Fer-H, Fer2, Fer2LC, FerLCH, LCH, anon-EST:ParkEST264, fer2, fer2lch, l(3)00035, l(3)07016, l(3)j2A3, l(3)neo60, l(3)neo63, l(3)s2083, ferritin 2 light chain homologue, CG1469-PA, CG1469-PB, CG1469-PC, CG1469-PD, CG1469-PE, Fer2LCH-PA, Fer2LCH-PB, Fer2LCH-PC, Fer2LCH-PD, Fer2LCH-PE, Ferritin-Heavy, Ferritin-Light, ferritin, ferritin 2 light chain, ferritin 2 light chain homolog, ferritin L, ferritin LCH, ferritin light chain
Species: fruit fly

Top Publications

  1. Carrera P, Abrell S, Kerber B, Walldorf U, Preiss A, Hoch M, et al. A modifier screen in the eye reveals control genes for Krüppel activity in the Drosophila embryo. Proc Natl Acad Sci U S A. 1998;95:10779-84 pubmed
    ..The results indicate that the Kr gain-of-function mutation If provides a tool to identify genes that are active during eye development and that a number of them function also in the control of Kr-dependent developmental processes. ..
  2. Georgieva T, Dunkov B, Harizanova N, Ralchev K, Law J. Iron availability dramatically alters the distribution of ferritin subunit messages in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1999;96:2716-21 pubmed
    ..Cloning and sequence of the heavy chain homologue (HCH) of Drosophila melanogaster ferritin subunit have been reported earlier. When Northern blots of D...
  3. Dunkov B, Georgieva T. Insect iron binding proteins: insights from the genomes. Insect Biochem Mol Biol. 2006;36:300-9 pubmed
    ..Analysis of genes encoding new members of the Tsf family and non-secreted ferritin subunits allows making preliminary hypotheses about their possible functions and opens possibilities to study ..
  4. Missirlis F, Holmberg S, Georgieva T, Dunkov B, Rouault T, Law J. Characterization of mitochondrial ferritin in Drosophila. Proc Natl Acad Sci U S A. 2006;103:5893-8 pubmed
    ..is known about how mitochondrial iron homeostasis is maintained, although the recent discovery of a mitochondrial ferritin in mammals and plants has uncovered a potential key player in the process...
  5. Dunkov B, Georgieva T. Organization of the ferritin genes in Drosophila melanogaster. DNA Cell Biol. 1999;18:937-44 pubmed
    ..encoding the heavy-chain homolog (HCH) and the light-chain homolog (LCH) subunits of Drosophila melanogaster ferritin are reported here...
  6. Missirlis F, Kosmidis S, Brody T, Mavrakis M, Holmberg S, Odenwald W, et al. Homeostatic mechanisms for iron storage revealed by genetic manipulations and live imaging of Drosophila ferritin. Genetics. 2007;177:89-100 pubmed
    b>Ferritin is a symmetric, 24-subunit iron-storage complex assembled of H and L chains...
  7. Metzendorf C, Wu W, Lind M. Overexpression of Drosophila mitoferrin in l(2)mbn cells results in dysregulation of Fer1HCH expression. Biochem J. 2009;421:463-71 pubmed publisher
    ..Compared with control cell lines, mbn-dmfrn cells had higher Fer1HCH (ferritin 1 heavy chain homologue) transcript and protein levels...
  8. Mendes C, Levet C, Chatelain G, Dourlen P, Fouillet A, Dichtel Danjoy M, et al. ER stress protects from retinal degeneration. EMBO J. 2009;28:1296-307 pubmed publisher
    ..We propose that an immediate consequence of the UPR not only limits the accumulation of misfolded proteins but also protects tissues from harmful exogenous stresses. ..
  9. Tiklová K, Senti K, Wang S, Gräslund A, Samakovlis C. Epithelial septate junction assembly relies on melanotransferrin iron binding and endocytosis in Drosophila. Nat Cell Biol. 2010;12:1071-7 pubmed publisher
    ..Mouse MTf complements the defects of Drosophila MTf mutants. Drosophila provides the first genetic model for the functional dissection of MTf in epithelial junction assembly and morphogenesis. ..

More Information


  1. Chen K, Lin G, Haelterman N, Ho T, Li T, Li Z, et al. Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration. elife. 2016;5: pubmed publisher
    ..Our results indicate that an iron/sphingolipid/Pdk1/Mef2 pathway may play a role in FRDA. ..
  2. González Morales N, Mendoza Ortíz M, Blowes L, Missirlis F, Riesgo Escovar J. Ferritin Is Required in Multiple Tissues during Drosophila melanogaster Development. PLoS ONE. 2015;10:e0133499 pubmed publisher
    In Drosophila melanogaster, iron is stored in the cellular endomembrane system inside a protein cage formed by 24 ferritin subunits of two types (Fer1HCH and Fer2LCH) in a 1:1 stoichiometry...
  3. Zeng Q, Smith D, Shippy S. Proteomic analysis of individual fruit fly hemolymph. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;981-982:33-9 pubmed publisher
    ..This nano-scale analysis method will facilitate future study of Drosophila and lead to a more complete understanding of the physiology of the fly model system. ..
  4. Kosmidis S, Botella J, Mandilaras K, Schneuwly S, Skoulakis E, Rouault T, et al. Ferritin overexpression in Drosophila glia leads to iron deposition in the optic lobes and late-onset behavioral defects. Neurobiol Dis. 2011;43:213-9 pubmed publisher
    Cellular and organismal iron storage depends on the function of the ferritin protein complex in insects and mammals alike...
  5. Xun Z, Kaufman T, Clemmer D. Proteome response to the panneural expression of human wild-type alpha-synuclein: a Drosophila model of Parkinson's disease. J Proteome Res. 2008;7:3911-21 pubmed publisher
    ..An increased level of the iron (III)-binding protein, ferritin, typically found in the brains of PD patients, is also observed in presymptomatic WT alpha-synuclein expressing ..
  6. Metzendorf C, Lind M. Drosophila mitoferrin is essential for male fertility: evidence for a role of mitochondrial iron metabolism during spermatogenesis. BMC Dev Biol. 2010;10:68 pubmed publisher
    ..Furthermore, due to the similar expression patterns of some mitochondrial iron metabolism genes in Drosophila and mammals, it is likely that our results are applicable for mammals as well. ..
  7. Tang X, Zhou B. Ferritin is the key to dietary iron absorption and tissue iron detoxification in Drosophila melanogaster. FASEB J. 2013;27:288-98 pubmed publisher
    Mammalian ferritin is predominantly in the cytosol, with a minor portion found in plasma. In most insects, including Drosophila melanogaster, ferritin belongs to the secretory type...
  8. Kremer N, Voronin D, Charif D, Mavingui P, Mollereau B, Vavre F. Wolbachia interferes with ferritin expression and iron metabolism in insects. PLoS Pathog. 2009;5:e1000630 pubmed publisher
    ..transcriptomics between symbiotic and aposymbiotic individuals, we observed a differential expression of ferritin, which forms a complex involved in iron storage...
  9. Rival T, Page R, Chandraratna D, Sendall T, Ryder E, Liu B, et al. Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease. Eur J Neurosci. 2009;29:1335-47 pubmed publisher
    ..The effect of iron appears to be mediated by oxidative stress as ferritin heavy chain co-expression reduced carbonyl levels in Abeta(1-42) flies by 65% and restored the survival and ..
  10. Navarro J, Botella J, Metzendorf C, Lind M, Schneuwly S. Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich's ataxia. Free Radic Biol Med. 2015;85:71-82 pubmed publisher
    ..In the fly model exhibiting only partial frataxin loss, we demonstrated that the inability to activate ferritin translation and the enhancement of mitochondrial iron uptake via mitoferrin upregulation were likely the key ..
  11. Charlesworth A, Georgieva T, Gospodov I, Law J, Dunkov B, Ralcheva N, et al. Isolation and properties of Drosophila melanogaster ferritin--molecular cloning of a cDNA that encodes one subunit, and localization of the gene on the third chromosome. Eur J Biochem. 1997;247:470-5 pubmed
    b>Ferritin was purified from iron-fed Drosophila melanogaster extracts by centrifugation in a gradient of potassium bromide...
  12. Shibata T, Ariki S, Shinzawa N, Miyaji R, Suyama H, Sako M, et al. Protein crosslinking by transglutaminase controls cuticle morphogenesis in Drosophila. PLoS ONE. 2010;5:e13477 pubmed publisher
    ..RNAi of their corresponding genes caused a lethal phenotype or cuticle abnormality. Our results indicate that TG-dependent protein crosslinking in Drosophila plays a key role in cuticle morphogenesis and sclerotization. ..
  13. Gutierrez L, Zubow K, Nield J, Gambis A, Mollereau B, Lazaro F, et al. Biophysical and genetic analysis of iron partitioning and ferritin function in Drosophila melanogaster. Metallomics. 2013;5:997-1005 pubmed publisher
    ..The primary function of ferritin is to store bioavailable iron in the form of ferrihydrite...
  14. Kosmidis S, Missirlis F, Botella J, Schneuwly S, Rouault T, Skoulakis E. Behavioral decline and premature lethality upon pan-neuronal ferritin overexpression in Drosophila infected with a virulent form of Wolbachia. Front Pharmacol. 2014;5:66 pubmed publisher
    ..One way the host can transiently reduce iron bioavailability is by ferritin overexpression...
  15. Liu J, Lee D, Yu C, Angers S, Harris T. Stepping stone: a cytohesin adaptor for membrane cytoskeleton restraint in the syncytial Drosophila embryo. Mol Biol Cell. 2015;26:711-25 pubmed publisher
    ..Overall we propose that Sstn acts as a cytohesin adaptor that promotes Steppke activity for localized membrane cytoskeleton restraint in the syncytial Drosophila embryo. ..
  16. Georgieva T, Dunkov B, Dimov S, Ralchev K, Law J. Drosophila melanogaster ferritin: cDNA encoding a light chain homologue, temporal and tissue specific expression of both subunit types. Insect Biochem Mol Biol. 2002;32:295-302 pubmed
    ..We report the cloning of a cDNA encoding the ferritin LCH of this insect. As predicted from the gene sequence, it contains no iron responsive element (IRE)...
  17. Rosas Arellano A, Vásquez Procopio J, Gambis A, Blowes L, Steller H, Mollereau B, et al. Ferritin Assembly in Enterocytes of Drosophila melanogaster. Int J Mol Sci. 2016;17:27 pubmed publisher
    ..secreted ferritins from insects, but here dimers between Ferritin 1 Heavy Chain Homolog (Fer1HCH) and Ferritin 2 Light Chain Homolog (Fer2LCH) are further stabilized by disulfide-bridge in the 24-subunit complex...
  18. Sadraie M, Missirlis F. Evidence for evolutionary constraints in Drosophila metal biology. Biometals. 2011;24:679-86 pubmed publisher
    ..The changes in total body iron content correlated with altered iron storage in intestinal ferritin stores of these species...
  19. Li S. Identification of iron-loaded ferritin as an essential mitogen for cell proliferation and postembryonic development in Drosophila. Cell Res. 2010;20:1148-57 pubmed publisher
    ..Here I report the biochemical purification of iron-loaded ferritin as an active ingredient of fly extract that is required for promoting the growth of clone 8 imaginal disc cells...
  20. Mandilaras K, Missirlis F. Genes for iron metabolism influence circadian rhythms in Drosophila melanogaster. Metallomics. 2012;4:928-36 pubmed publisher
    ..The results indicate that Ferritin 2 Light Chain Homologue (Fer2LCH) is required for the circadian activity of flies kept in constant darkness...
  21. Zeng Q, Avilov V, Shippy S. Prefractionation methods for individual adult fruit fly hemolymph proteomic analysis. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1015-1016:74-81 pubmed publisher
    ..The demonstration of this method establishes a means to deepen proteomic analysis to this commonly used, important biological model system. ..
  22. Liu B, Moloney A, Meehan S, Morris K, Thomas S, Serpell L, et al. Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation. J Biol Chem. 2011;286:4248-56 pubmed publisher
    We have previously shown that overexpressing subunits of the iron-binding protein ferritin can rescue the toxicity of the amyloid β (Aβ) peptide in our Drosophila model system...