Gene Symbol: Fer1HCH
Description: Ferritin 1 heavy chain homologue
Alias: 1HCH, BEST:LD36673, CG2216, Dmel\CG2216, FER1, FER1HCH, Fe1HCH, Fer-L, Fer1, Fer1HC, FerHCH, HCH, T21, fer1, fer1hch, l(3)00451, l(3)j10B4, ferritin 1 heavy chain homologue, CG2216-PA, CG2216-PB, CG2216-PC, CG2216-PD, CG2216-PE, CG2216-PF, CG2216-PG, CG2216-PI, CG2216-PJ, Fer1HCH-PA, Fer1HCH-PB, Fer1HCH-PC, Fer1HCH-PD, Fer1HCH-PE, Fer1HCH-PF, Fer1HCH-PG, Fer1HCH-PI, Fer1HCH-PJ, Ferritin-Heavy, Ferritin-Light, ferritin, ferritin 1 heavy chain, ferritin 1 heavy chain homolog, ferritin 1HCH, ferritin H, ferritin HCH, ferritin heavy chain, ferritin subunit 1
Species: fruit fly
Products:     Fer1HCH

Top Publications

  1. Mandilaras K, Missirlis F. Genes for iron metabolism influence circadian rhythms in Drosophila melanogaster. Metallomics. 2012;4:928-36 pubmed publisher
    ..The results indicate that Ferritin 2 Light Chain Homologue (Fer2LCH) is required for the circadian activity of flies kept in constant darkness...
  2. Anderson P, Kirby K, Hilliker A, Phillips J. RNAi-mediated suppression of the mitochondrial iron chaperone, frataxin, in Drosophila. Hum Mol Genet. 2005;14:3397-405 pubmed
    ..the differential larval and adult phenotypes, our results indicate that dfh silencing differentially dysregulates ferritin expression in adults but not in larvae...
  3. Metzendorf C, Wu W, Lind M. Overexpression of Drosophila mitoferrin in l(2)mbn cells results in dysregulation of Fer1HCH expression. Biochem J. 2009;421:463-71 pubmed publisher
    ..Compared with control cell lines, mbn-dmfrn cells had higher Fer1HCH (ferritin 1 heavy chain homologue) transcript and protein levels...
  4. Mehta A, Deshpande A, Bettedi L, Missirlis F. Ferritin accumulation under iron scarcity in Drosophila iron cells. Biochimie. 2009;91:1331-4 pubmed publisher
    ..are highly stable, multi-subunit protein complexes with iron-binding capacities that reach 4500 iron atoms per ferritin molecule...
  5. Dunkov B, Georgieva T. Organization of the ferritin genes in Drosophila melanogaster. DNA Cell Biol. 1999;18:937-44 pubmed
    ..comparisons of ferritin genes from invertebrates, vertebrates, and plants, suggest that the specialization of ferritin H and L type chains, the complex exon-intron organization of plant and vertebrate genes, and the use of the IRE/..
  6. Surdej P, Richman L, Kühn L. Differential translational regulation of IRE-containing mRNAs in Drosophila melanogaster by endogenous IRP and a constitutive human IRP1 mutant. Insect Biochem Mol Biol. 2008;38:891-4 pubmed publisher
    ..Two mRNAs, an unspliced form of ferritin H mRNA and succinate dehydrogenase subunit b (SDHb) mRNA, are known to comprise an iron responsive element (IRE) ..
  7. Missirlis F, Kosmidis S, Brody T, Mavrakis M, Holmberg S, Odenwald W, et al. Homeostatic mechanisms for iron storage revealed by genetic manipulations and live imaging of Drosophila ferritin. Genetics. 2007;177:89-100 pubmed
    ..We showed that ferritin H and L transcripts are coexpressed during embryogenesis and that both subunits are essential for embryonic ..
  8. Lind M, Ekengren S, Melefors O, Soderhall K. Drosophila ferritin mRNA: alternative RNA splicing regulates the presence of the iron-responsive element. FEBS Lett. 1998;436:476-82 pubmed
    Several mRNAs encoding the same ferritin subunit of Drosophila melanogaster were identified. Alternative RNA splicing and utilisation of different polyadenylation sites were found to generate the transcripts...
  9. Wang X, Wu Y, Zhou B. Dietary zinc absorption is mediated by ZnT1 in Drosophila melanogaster. FASEB J. 2009;23:2650-61 pubmed publisher
    ..This study will be helpful in understanding the fundamental process of acquiring dietary zinc in higher eukaryotes. ..

More Information


  1. Dunkov B, Georgieva T. Insect iron binding proteins: insights from the genomes. Insect Biochem Mol Biol. 2006;36:300-9 pubmed
    ..Analysis of genes encoding new members of the Tsf family and non-secreted ferritin subunits allows making preliminary hypotheses about their possible functions and opens possibilities to study ..
  2. Kosmidis S, Botella J, Mandilaras K, Schneuwly S, Skoulakis E, Rouault T, et al. Ferritin overexpression in Drosophila glia leads to iron deposition in the optic lobes and late-onset behavioral defects. Neurobiol Dis. 2011;43:213-9 pubmed publisher
    Cellular and organismal iron storage depends on the function of the ferritin protein complex in insects and mammals alike...
  3. Missirlis F, Holmberg S, Georgieva T, Dunkov B, Rouault T, Law J. Characterization of mitochondrial ferritin in Drosophila. Proc Natl Acad Sci U S A. 2006;103:5893-8 pubmed
    ..is known about how mitochondrial iron homeostasis is maintained, although the recent discovery of a mitochondrial ferritin in mammals and plants has uncovered a potential key player in the process...
  4. Lind M, Missirlis F, Melefors O, Uhrigshardt H, Kirby K, Phillips J, et al. Of two cytosolic aconitases expressed in Drosophila, only one functions as an iron-regulatory protein. J Biol Chem. 2006;281:18707-14 pubmed
    ..Our data suggest that as a first step during the evolution of the IRP/IRE system, the ancient cytosolic aconitase was duplicated in insects with one variant acquiring IRE-specific binding. ..
  5. Tang X, Zhou B. Ferritin is the key to dietary iron absorption and tissue iron detoxification in Drosophila melanogaster. FASEB J. 2013;27:288-98 pubmed publisher
    Mammalian ferritin is predominantly in the cytosol, with a minor portion found in plasma. In most insects, including Drosophila melanogaster, ferritin belongs to the secretory type...
  6. Gutierrez L, Sabaratnam N, Aktar R, Bettedi L, Mandilaras K, Missirlis F. Zinc accumulation in heterozygous mutants of fumble, the pantothenate kinase homologue of Drosophila. FEBS Lett. 2010;584:2942-6 pubmed publisher
    ..Accordingly, zinc supplementation had an adverse impact on the development of fumble mutant larvae, but zinc chelation failed to protect. ..
  7. Georgieva T, Dunkov B, Harizanova N, Ralchev K, Law J. Iron availability dramatically alters the distribution of ferritin subunit messages in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1999;96:2716-21 pubmed
    ..Iron significantly increases the amount of ferritin HCH messages and dramatically shifts the balance toward those messages that lack an IRE and/or have a short 3' UTR...
  8. Vierstraete E, Verleyen P, Baggerman G, D Hertog W, Van den Bergh G, Arckens L, et al. A proteomic approach for the analysis of instantly released wound and immune proteins in Drosophila melanogaster hemolymph. Proc Natl Acad Sci U S A. 2004;101:470-5 pubmed
    ..Determining the function of all of these immune-induced proteins represents an exciting challenge for increasing our knowledge of insect immunity. ..
  9. Sadraie M, Missirlis F. Evidence for evolutionary constraints in Drosophila metal biology. Biometals. 2011;24:679-86 pubmed publisher
    ..The changes in total body iron content correlated with altered iron storage in intestinal ferritin stores of these species...
  10. Vichas A, Laurie M, Zallen J. The Ski2-family helicase Obelus regulates Crumbs alternative splicing and cell polarity. J Cell Biol. 2015;211:1011-24 pubmed publisher
    ..These results indicate that regulation of Crumbs alternative splicing by the Obelus helicase modulates epithelial polarity during development. ..
  11. Shibata T, Ariki S, Shinzawa N, Miyaji R, Suyama H, Sako M, et al. Protein crosslinking by transglutaminase controls cuticle morphogenesis in Drosophila. PLoS ONE. 2010;5:e13477 pubmed publisher
    ..RNAi of their corresponding genes caused a lethal phenotype or cuticle abnormality. Our results indicate that TG-dependent protein crosslinking in Drosophila plays a key role in cuticle morphogenesis and sclerotization. ..
  12. Uhrigshardt H, Rouault T, Missirlis F. Insertion mutants in Drosophila melanogaster Hsc20 halt larval growth and lead to reduced iron-sulfur cluster enzyme activities and impaired iron homeostasis. J Biol Inorg Chem. 2013;18:441-9 pubmed publisher
    ..of iron homeostasis in the mutant flies was evidenced by an apparent reduction in induction of intestinal ferritin with ferric iron accumulating in a subcellular pattern reminiscent of mitochondria...
  13. Llorens J, Metzendorf C, Missirlis F, Lind M. Mitochondrial iron supply is required for the developmental pulse of ecdysone biosynthesis that initiates metamorphosis in Drosophila melanogaster. J Biol Inorg Chem. 2015;20:1229-38 pubmed publisher
    ..in mitochondrial iron import, fail to grow and initiate metamorphosis under dietary iron depletion or when ferritin function is partially compromised...
  14. Lighthouse D, Buszczak M, Spradling A. New components of the Drosophila fusome suggest it plays novel roles in signaling and transport. Dev Biol. 2008;317:59-71 pubmed publisher
    ..A significant number of fusome components are dispensable, because genetic disruption of tropomodulin, ferritin-1 heavy chain, or scribble, does not alter fusome structure or female fertility...
  15. Mehta A, Deshpande A, Missirlis F. Genetic screening for novel Drosophila mutants with discrepancies in iron metabolism. Biochem Soc Trans. 2008;36:1313-6 pubmed publisher
    ..the model organism Drosophila melanogaster which expresses a GFP (green fluorescent protein)-tagged ferritin 1 heavy chain homologue from its native chromosomal locus and incorporated it into endogenous functional ferritin, enabling ..
  16. Metzendorf C, Lind M. Drosophila mitoferrin is essential for male fertility: evidence for a role of mitochondrial iron metabolism during spermatogenesis. BMC Dev Biol. 2010;10:68 pubmed publisher
    ..Furthermore, due to the similar expression patterns of some mitochondrial iron metabolism genes in Drosophila and mammals, it is likely that our results are applicable for mammals as well. ..
  17. Gutierrez L, Zubow K, Nield J, Gambis A, Mollereau B, Lazaro F, et al. Biophysical and genetic analysis of iron partitioning and ferritin function in Drosophila melanogaster. Metallomics. 2013;5:997-1005 pubmed publisher
    ..The primary function of ferritin is to store bioavailable iron in the form of ferrihydrite...
  18. Georgieva T, Dunkov B, Dimov S, Ralchev K, Law J. Drosophila melanogaster ferritin: cDNA encoding a light chain homologue, temporal and tissue specific expression of both subunit types. Insect Biochem Mol Biol. 2002;32:295-302 pubmed
    Drosophila melanogaster secreted ferritin like the cytosolic ferritins of other organisms is composed of two subunits, a heavy chain homologue (HCH) and a light chain homologue (LCH)...
  19. Rival T, Page R, Chandraratna D, Sendall T, Ryder E, Liu B, et al. Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease. Eur J Neurosci. 2009;29:1335-47 pubmed publisher
    ..The effect of iron appears to be mediated by oxidative stress as ferritin heavy chain co-expression reduced carbonyl levels in Abeta(1-42) flies by 65% and restored the survival and locomotion ..
  20. González Morales N, Mendoza Ortíz M, Blowes L, Missirlis F, Riesgo Escovar J. Ferritin Is Required in Multiple Tissues during Drosophila melanogaster Development. PLoS ONE. 2015;10:e0133499 pubmed publisher
    In Drosophila melanogaster, iron is stored in the cellular endomembrane system inside a protein cage formed by 24 ferritin subunits of two types (Fer1HCH and Fer2LCH) in a 1:1 stoichiometry...
  21. Navarro J, Botella J, Metzendorf C, Lind M, Schneuwly S. Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich's ataxia. Free Radic Biol Med. 2015;85:71-82 pubmed publisher
    ..In the fly model exhibiting only partial frataxin loss, we demonstrated that the inability to activate ferritin translation and the enhancement of mitochondrial iron uptake via mitoferrin upregulation were likely the key ..
  22. Zhan M, Yamaza H, Sun Y, Sinclair J, Li H, Zou S. Temporal and spatial transcriptional profiles of aging in Drosophila melanogaster. Genome Res. 2007;17:1236-43 pubmed
    ..The spatial and temporal transcriptome data presented in this study provide a basis and a valuable resource for further genetic and genomic investigation of tissue-specific regulation of aging. ..
  23. Wang M, Bohmann D, Jasper H. JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. Dev Cell. 2003;5:811-6 pubmed
    ..Our work thus identifies the evolutionarily conserved JNK signaling pathway as a major genetic factor in the control of longevity. ..
  24. Liu B, Moloney A, Meehan S, Morris K, Thomas S, Serpell L, et al. Iron promotes the toxicity of amyloid beta peptide by impeding its ordered aggregation. J Biol Chem. 2011;286:4248-56 pubmed publisher
    We have previously shown that overexpressing subunits of the iron-binding protein ferritin can rescue the toxicity of the amyloid β (Aβ) peptide in our Drosophila model system...
  25. Zeng Q, Smith D, Shippy S. Proteomic analysis of individual fruit fly hemolymph. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;981-982:33-9 pubmed publisher
    ..This nano-scale analysis method will facilitate future study of Drosophila and lead to a more complete understanding of the physiology of the fly model system. ..
  26. Rosas Arellano A, Vásquez Procopio J, Gambis A, Blowes L, Steller H, Mollereau B, et al. Ferritin Assembly in Enterocytes of Drosophila melanogaster. Int J Mol Sci. 2016;17:27 pubmed publisher
    ..eukaryotic ferritin subunits are present in secreted ferritins from insects, but here dimers between Ferritin 1 Heavy Chain Homolog (Fer1HCH) and Ferritin 2 Light Chain Homolog (Fer2LCH) are further stabilized by disulfide-bridge in ..
  27. Pavesi G, Mauri G, Stefani M, Pesole G. RNAProfile: an algorithm for finding conserved secondary structure motifs in unaligned RNA sequences. Nucleic Acids Res. 2004;32:3258-69 pubmed publisher
    ..We also show how it can be applied to corrupted datasets in which a motif does not appear in all the input sequences, as well as to the discovery of more complex motifs in the non-coding RNA...
  28. Li S. Identification of iron-loaded ferritin as an essential mitogen for cell proliferation and postembryonic development in Drosophila. Cell Res. 2010;20:1148-57 pubmed publisher
    ..Here I report the biochemical purification of iron-loaded ferritin as an active ingredient of fly extract that is required for promoting the growth of clone 8 imaginal disc cells...
  29. Sun X, Seeberger J, Alberico T, Wang C, Wheeler C, Schauss A, et al. Açai palm fruit (Euterpe oleracea Mart.) pulp improves survival of flies on a high fat diet. Exp Gerontol. 2010;45:243-51 pubmed publisher
    ..Açai has the potential to antagonize the detrimental effect of fat in the diet and alleviate oxidative stress in aging. ..
  30. Kremer N, Voronin D, Charif D, Mavingui P, Mollereau B, Vavre F. Wolbachia interferes with ferritin expression and iron metabolism in insects. PLoS Pathog. 2009;5:e1000630 pubmed publisher
    ..transcriptomics between symbiotic and aposymbiotic individuals, we observed a differential expression of ferritin, which forms a complex involved in iron storage...
  31. Xiao G, Wan Z, Fan Q, Tang X, Zhou B. The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster. elife. 2014;3:e03191 pubmed publisher
    ..defect, simultaneous iron increase in the cytosol and decrease in the secretory compartments, failure of ferritin iron loading, and abnormal collagen secretion. dZIP13 expression in E...
  32. Kosmidis S, Missirlis F, Botella J, Schneuwly S, Rouault T, Skoulakis E. Behavioral decline and premature lethality upon pan-neuronal ferritin overexpression in Drosophila infected with a virulent form of Wolbachia. Front Pharmacol. 2014;5:66 pubmed publisher
    ..One way the host can transiently reduce iron bioavailability is by ferritin overexpression...
  33. Biteau B, Hochmuth C, Jasper H. JNK activity in somatic stem cells causes loss of tissue homeostasis in the aging Drosophila gut. Cell Stem Cell. 2008;3:442-55 pubmed publisher
    ..Our findings suggest that this balance is lost in old animals, increasing the potential for neoplastic transformation. ..
  34. Wang C, Yolitz J, Alberico T, Laslo M, Sun Y, Wheeler C, et al. Cranberry interacts with dietary macronutrients to promote healthy aging in Drosophila. J Gerontol A Biol Sci Med Sci. 2014;69:945-54 pubmed publisher
    ..Our study reveals an interaction of cranberry with dietary macronutrients and stresses the importance of considering diet composition in designing interventions for promoting healthy aging. ..
  35. Tiklová K, Senti K, Wang S, Gräslund A, Samakovlis C. Epithelial septate junction assembly relies on melanotransferrin iron binding and endocytosis in Drosophila. Nat Cell Biol. 2010;12:1071-7 pubmed publisher
    ..Mouse MTf complements the defects of Drosophila MTf mutants. Drosophila provides the first genetic model for the functional dissection of MTf in epithelial junction assembly and morphogenesis. ..
  36. Charlesworth A, Georgieva T, Gospodov I, Law J, Dunkov B, Ralcheva N, et al. Isolation and properties of Drosophila melanogaster ferritin--molecular cloning of a cDNA that encodes one subunit, and localization of the gene on the third chromosome. Eur J Biochem. 1997;247:470-5 pubmed
    b>Ferritin was purified from iron-fed Drosophila melanogaster extracts by centrifugation in a gradient of potassium bromide...
  37. Mendes C, Levet C, Chatelain G, Dourlen P, Fouillet A, Dichtel Danjoy M, et al. ER stress protects from retinal degeneration. EMBO J. 2009;28:1296-307 pubmed publisher
    ..We propose that an immediate consequence of the UPR not only limits the accumulation of misfolded proteins but also protects tissues from harmful exogenous stresses. ..
  38. Vierstraete E, Verleyen P, Sas F, Van den Bergh G, De Loof A, Arckens L, et al. The instantly released Drosophila immune proteome is infection-specific. Biochem Biophys Res Commun. 2004;317:1052-60 pubmed
    ..Next to known immune proteins, unannotated proteins were identified such as CG4306 protein, which has homologues with unknown function in all metazoan genome databases available today. ..
  39. Chen K, Lin G, Haelterman N, Ho T, Li T, Li Z, et al. Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration. elife. 2016;5: pubmed publisher
    ..Our results indicate that an iron/sphingolipid/Pdk1/Mef2 pathway may play a role in FRDA. ..