Grm5

Summary

Gene Symbol: Grm5
Description: glutamate receptor, metabotropic 5
Alias: mGluR5, mGlur5, metabotropic glutamate receptor (mGluR5), metabotropic glutamate receptor 5, metabotropic glutamate receptor 5b
Species: rat

Top Publications

  1. pmc Mechanisms and physiological role of enhancement of mGlu5 receptor function by group II mGlu receptor activation in rat perirhinal cortex
    K Cho
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 540:895-906. 2002
  2. pmc Group I metabotropic glutamate receptors activate a calcium-sensitive transient receptor potential-like conductance in rat hippocampus
    Christine E Gee
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Physiol 546:655-64. 2003
  3. ncbi Metabotropic glutamate receptor 5-regulated Elk-1 phosphorylation and immediate early gene expression in striatal neurons
    Limin Mao
    Department of Pharmacology, School of Pharmacy, University of Missouri Kansas City, 2411 Holmes Street, Rm M3 C225, Kansas City, MO 64108, USA
    J Neurochem 85:1006-17. 2003
  4. ncbi Co-stimulation of mGluR5 and N-methyl-D-aspartate receptors is required for potentiation of excitatory synaptic transmission in hippocampal neurons
    Suhas A Kotecha
    Department of Physiology, Faculty of Medicine, University of Toronto, Mt Sinai Hospital, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 278:27742-9. 2003
  5. ncbi Long-term enhancement of neuronal excitability and temporal fidelity mediated by metabotropic glutamate receptor subtype 5
    Valérie Sourdet
    Neurobiologie des Canaux Ioniques, Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche 464, Universitéde la Méditerranée, F 13916 Marseille Cedex 20, France
    J Neurosci 23:10238-48. 2003
  6. ncbi Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors
    J C Tu
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 21:717-26. 1998
  7. ncbi Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins
    B Xiao
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 21:707-16. 1998
  8. pmc Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors
    Paul J Kammermeier
    Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 711, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 104:6055-60. 2007
  9. pmc Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein
    Vikas Kumar
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 287:5412-25. 2012
  10. pmc Successful cognitive aging in rats: a role for mGluR5 glutamate receptors, homer 1 proteins and downstream signaling pathways
    Caroline Menard
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Canada
    PLoS ONE 7:e28666. 2012

Research Grants

  1. Metabotropic Receptors: Structure/Function/Regulation
    KAREN O MALLEY; Fiscal Year: 2006
  2. MODULATION OF DOPAMINE AUTORECEPTOR FUNCTION BY COCAINE
    KAREN O MALLEY; Fiscal Year: 2001
  3. Involvement of mGluR5 in inhibitory avoidance and aging
    Agnes Simonyi; Fiscal Year: 2004
  4. Signaling By Nuclear G-Protein Coupled Receptors
    KAREN O MALLEY; Fiscal Year: 2005
  5. Prefrontal Glutamate and Working Memory
    Mary Gregory; Fiscal Year: 2006
  6. Glutamate Signaling and Drug Abuse
    MOHAMMADHOSSEIN GHASEMZADEH; Fiscal Year: 2007
  7. TRANSCRIPTIONAL CONTROL OF NEUROENDOCRINE GENES
    KAREN O MALLEY; Fiscal Year: 2007
  8. Functional Consequences of Nuclear mGlu5 Receptor Activation
    KAREN O MALLEY; Fiscal Year: 2008
  9. MECHANISMS OF NEURONAL DEATH IN PARKINSON'S DISEASE
    KAREN O MALLEY; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications101 found, 100 shown here

  1. pmc Mechanisms and physiological role of enhancement of mGlu5 receptor function by group II mGlu receptor activation in rat perirhinal cortex
    K Cho
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol BS8 1TD, UK
    J Physiol 540:895-906. 2002
    ..Similar mechanisms of synergistic interaction may also be important in other physiological processes dependent on mGlu receptors...
  2. pmc Group I metabotropic glutamate receptors activate a calcium-sensitive transient receptor potential-like conductance in rat hippocampus
    Christine E Gee
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    J Physiol 546:655-64. 2003
    ..Stimulation of mGluR1 and mGluR5 converged to activate the TRP-like conductance in a synergistic manner, and activation of either subtype alone ..
  3. ncbi Metabotropic glutamate receptor 5-regulated Elk-1 phosphorylation and immediate early gene expression in striatal neurons
    Limin Mao
    Department of Pharmacology, School of Pharmacy, University of Missouri Kansas City, 2411 Holmes Street, Rm M3 C225, Kansas City, MO 64108, USA
    J Neurochem 85:1006-17. 2003
    The Galphaq protein-coupled metabotropic glutamate receptor subtype-5 (mGluR5) is densely expressed in medium spiny projection neurons of striatum...
  4. ncbi Co-stimulation of mGluR5 and N-methyl-D-aspartate receptors is required for potentiation of excitatory synaptic transmission in hippocampal neurons
    Suhas A Kotecha
    Department of Physiology, Faculty of Medicine, University of Toronto, Mt Sinai Hospital, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 278:27742-9. 2003
    ..Here we report that co-activation of mGluR5, a member of the group I mGluR family, and N-methyl-d-aspartate receptors (NMDARs) potentiates NMDAR currents and ..
  5. ncbi Long-term enhancement of neuronal excitability and temporal fidelity mediated by metabotropic glutamate receptor subtype 5
    Valérie Sourdet
    Neurobiologie des Canaux Ioniques, Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche 464, Universitéde la Méditerranée, F 13916 Marseille Cedex 20, France
    J Neurosci 23:10238-48. 2003
    ..We report here that synaptic or pharmacological activation of the metabotropic glutamate receptor subtype 5 (mGluR5) induces long-term potentiation of intrinsic excitability (LTP-IE) in layer V pyramidal neurons...
  6. ncbi Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors
    J C Tu
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 21:717-26. 1998
    ..These studies identify a novel mechanism in calcium signaling and provide evidence that an IEG, whose expression is driven by synaptic activity, can directly modify a specific synaptic function...
  7. ncbi Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins
    B Xiao
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 21:707-16. 1998
    ..These observations support a model in which the dynamic expression of Homer 1a competes with constitutively expressed CC-Homers to modify synaptic mGluR properties...
  8. pmc Homer 1a uncouples metabotropic glutamate receptor 5 from postsynaptic effectors
    Paul J Kammermeier
    Department of Pharmacology and Physiology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 711, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 104:6055-60. 2007
    ..This modulation occurred postsynaptically, was mediated primarily by mGluR5, and was inositol triphosphate receptor-dependent...
  9. pmc Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein
    Vikas Kumar
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 287:5412-25. 2012
    The G-protein coupled receptor, metabotropic glutamate receptor 5 (mGluR5), is expressed on both cell surface and intracellular membranes in striatal neurons...
  10. pmc Successful cognitive aging in rats: a role for mGluR5 glutamate receptors, homer 1 proteins and downstream signaling pathways
    Caroline Menard
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Canada
    PLoS ONE 7:e28666. 2012
    ..At the molecular level, an increase in metabotropic glutamate receptors 5 (mGluR5) was observed in post-synaptic densities (PSD) in the hippocampus of AU rats after training...
  11. pmc Neuroadaptations in the cellular and postsynaptic group 1 metabotropic glutamate receptor mGluR5 and Homer proteins following extinction of cocaine self-administration
    M Behnam Ghasemzadeh
    Department of Biomedical Sciences, Integrative Neuroscience Research Center, Marquette University, Milwaukee, WI 53201, United States
    Neurosci Lett 452:167-71. 2009
    This study examined the role of group1 metabotropic glutamate receptor mGluR5 and associated postsynaptic scaffolding protein Homer1b/c in behavioral plasticity after three withdrawal treatments from cocaine self-administration...
  12. ncbi Competitive interaction of seven in absentia homolog-1A and Ca2+/calmodulin with the cytoplasmic tail of group 1 metabotropic glutamate receptors
    K Ishikawa
    Department of Biological Sciences, Kyoto University Faculty of Medicine, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
    Genes Cells 4:381-90. 1999
    Group 1 metabotropic glutamate receptors (mGluR1 and mGluR5) are coupled to inositol trisphosphate/Ca2+ signaling via G proteins and play an important role in excitatory synaptic transmission...
  13. ncbi Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins
    J C Tu
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 23:583-92. 1999
    ..Moreover, Shank clusters mGluR5 in heterologous cells in the presence of Homer and mediates the coclustering of Homer with PSD-95/GKAP...
  14. pmc Differential roles of hippocampal metabotropic glutamate receptors 1 and 5 in inhibitory avoidance learning
    A Simonyi
    Department of Biochemistry, University of Missouri Columbia, M743 Medical Sciences Building, Columbia, MO 65212, USA
    Neurobiol Learn Mem 88:305-11. 2007
    ..These findings indicate a selective participation of hippocampal group I mGlu receptors in memory processing in this task...
  15. ncbi Long-term depression of NMDA receptor-mediated synaptic transmission is dependent on activation of metabotropic glutamate receptors and is altered to long-term potentiation by low intracellular calcium buffering
    Sarah C Harney
    Department of Physiology, Trinity College, Dublin 2, Ireland
    J Neurosci 26:1128-32. 2006
    ..We also identified a role for metabotropic glutamate receptor 5 (mGluR5) in NMDAR plasticity...
  16. pmc The Homer-1 protein Ania-3 interacts with the plasma membrane calcium pump
    Véronique Sgambato-Faure
    Molecular Plasticity Section, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA
    Biochem Biophys Res Commun 343:630-7. 2006
    ..The interaction between Ania-3/Homer and PMCAs may represent a novel mechanism by which local calcium signaling and hence synaptic function can be modulated in neurons...
  17. ncbi Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction
    T Abe
    Institute for Immunology, Kyoto University Faculty of Medicine, Japan
    J Biol Chem 267:13361-8. 1992
    A cDNA clone for a new metabotropic glutamate receptor, mGluR5, was isolated through polymerase chain reaction-mediated DNA amplification by using primer sequences conserved among the metabotropic glutamate receptor (mGluR) family and by ..
  18. ncbi Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins
    Jun Kitano
    Department of Biological Sciences, Faculty of Medicine, Graduate School of Biostudies, Kyoto University, Kyoto, 606 8501, Japan
    J Neurosci 22:1280-9. 2002
    ..of tamalin and dominant-negative tamalin facilitated and reduced the neuritic distribution of endogenous mGluR5 in cultured hippocampal neurons, respectively...
  19. ncbi Synaptic plasticity in the amygdala in a model of arthritic pain: differential roles of metabotropic glutamate receptors 1 and 5
    Volker Neugebauer
    Department of Anatomy and Neurosciences and Marine Biomedical Institute, The University of Texas Medical Branch, Galveston, Texas 77555 1069, USA
    J Neurosci 23:52-63. 2003
    ..condition induced in vivo on synaptic transmission and group I metabotropic glutamate receptor (mGluR1 and mGluR5) function was examined in vitro using whole-cell voltage-clamp recordings of neurons in the central nucleus of the ..
  20. pmc Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 (mGluR7) interactions with calmodulin and regulation of mGluR7 function
    Scott D Sorensen
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, USA
    Mol Pharmacol 61:1303-12. 2002
    ..Furthermore, our studies suggest that CaM binding is not required for mGluR7-mediated activation of GIRK current...
  21. ncbi Regulation of neurotransmitter release by metabotropic glutamate receptors
    J Cartmell
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    J Neurochem 75:889-907. 2000
    ..This review addresses the neurochemical evidence for mGlu receptor-mediated regulation of neurotransmitters, such as excitatory and inhibitory amino acids, monoamines, and neuropeptides...
  22. doi Metabotropic glutamate mGlu5 receptor-mediated serine phosphorylation of NMDA receptor subunit NR1 in hippocampal CA1 region after transient global ischemia in rats
    Norio Takagi
    Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Eur J Pharmacol 644:96-100. 2010
    ....
  23. ncbi [Expression of group I mGluRs in rat flocculus after unilateral labyrinthectomy]
    Yamin Zhang
    Department of Otorhinolaryngology, First Hospital of Zhengzhou University, Zhengzhou 450052, China
    Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 23:604-6. 2009
    ..Studies revealed that cerebellar flocculus-paraflocculus complex plays an important in vestibular compensation. To observe the expression change of Group I mGluRs in flocculus following left unilateral labyrinthectomy (UL)...
  24. doi Counteracting roles of metabotropic glutamate receptor subtypes 1 and 5 in regulation of pain-related spatial and temporal synaptic plasticity in rat entorhinal-hippocampal pathways
    Ming Gang Liu
    Institute for Biomedical Sciences of Pain, Capital Medical University, Beijing 100069, China
    Neurosci Lett 507:38-42. 2012
    ..However, inhibition of mGluR5 by a selective antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) produced no spatial change from either of the ..
  25. doi Effects of metabotropic glutamate mGlu5 receptor antagonist on tyrosine phosphorylation of NMDA receptor subunits and cell death in the hippocampus after brain ischemia in rats
    Norio Takagi
    Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Neurosci Lett 530:91-6. 2012
    ....
  26. pmc Defining protein kinase/phosphatase isoenzymic regulation of mGlu₅ receptor-stimulated phospholipase C and Ca²⁺ responses in astrocytes
    S J Bradley
    Department of Cell Physiology and Pharmacology, University of Leicester, Leicester, UK
    Br J Pharmacol 164:755-71. 2011
    ..Here, we have attempted to better define the kinase and phosphatase enzymes involved in this modulation...
  27. doi Hippocampal mGluR5 predicts an occurrence of helplessness behavior after repetitive exposure to uncontrollable stress
    Yeong Shin Yim
    Department of Pharmacology, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea
    Neurosci Lett 519:62-6. 2012
    ..In this study, we examined the relationship between the hippocampal mGluR5 expression and coping strategies to stress...
  28. doi The PDZ domain protein CAL interacts with mGluR5a and modulates receptor expression
    Shan Cheng
    Department of Biochemistry and Molecular Biology, Capital Medical University, Beijing 100069, China
    J Neurochem 112:588-98. 2010
    ..These results also suggest a molecular mechanism by which mGluR5a protein expression may be regulated at the post-translational level by the CAL protein, possibly by blocking ubiquitination-dependent receptor degradation...
  29. doi Examination of a role for metabotropic glutamate receptor 5 in the medial prefrontal cortex in cocaine sensitization in rats
    Kristin M Timmer
    Department of Pharmacology, University of Tennessee Health Science Center, 874 Union Ave, Rm 115 Crowe, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 221:91-100. 2012
    ..Evidence suggests that Group I metabotropic glutamate receptor 5 (mGluR5) is necessary for cocaine sensitization, and stimulation of this receptor in the mPFC ..
  30. doi mGluR5 is involved in proliferation of rat neural progenitor cells exposed to hypoxia with activation of mitogen-activated protein kinase signaling pathway
    Lingyu Zhao
    Institute of Neurobiology, Environment and Genes Related to Diseases Key Laboratory of Education Ministry, Xi an Jiaotong University College of Medicine, Xi an, China
    J Neurosci Res 90:447-60. 2012
    ..We investigated the effects of metabotropic glutamate receptor 5 (mGluR5) on NPC proliferation under hypoxia, the expression of cyclin D1, and the activation of the ..
  31. doi Modulation of intracellular calcium mobilization and GABAergic currents through subtype-specific metabotropic glutamate receptors in neonatal rat hippocampus
    M Taketo
    Department of Physiology 1, Faculty of Medicine, Kansai Medical University, 10 15 Fumizono cho Moriguchi, Osaka 570 8506, Japan
    Brain Res Bull 81:73-80. 2010
    ..In hippocampal interneurons, several subclasses of mGluRs including mGluR1 and mGluR5 have been immunohistochemically identified...
  32. doi Effects of glutamate and alpha2-noradrenergic receptor antagonists on the development of neurotoxicity produced by chronic rotenone in rats
    Mesbah Alam
    Zoological Institute, Department of Neuropharmacology, University of Tubingen, Auf der Morgenstelle 28E, D 72076 Tubingen, Germany
    Toxicol Appl Pharmacol 240:198-207. 2009
    ..idazoxan (alpha2-adrenoceptor antagonist) or 2-methyl-6-(phenyl-ethyl)-pyrimidine (MPEP, metabotropic glutamate receptor 5 antagonist) prevents rotenone-induced parkinsonian-like behaviours and neurochemical changes in rats...
  33. doi CB1 receptor knockout mice are hyporesponsive to the behavior-stimulating actions of d-amphetamine: role of mGlu5 receptors
    Eleni T Tzavara
    Eli Lilly and Company, Lilly Corporate Center, Neuroscience Discovery Research, Indianapolis, IN 46285 0510, USA
    Eur Neuropsychopharmacol 19:196-204. 2009
    ..Blockade of metabotropic-glutamate-receptors-5 (mGluR5)with MPEP, but not blockade of N-methyl-D-aspartate-receptors (NMDA) with MK-801,restored to a great extent the ..
  34. ncbi Metabotropic glutamate receptors subtype 5 are necessary for the enhancement of auditory evoked potentials in the lateral nucleus of the amygdala by tetanic stimulation of the auditory thalamus
    J Zheng
    Department of Psychology, Speech and Hearing Research Center, State Key Laboratory on Machine Perception, Peking University, 5 Yiheyuan Road, Beijing, China 100871
    Neuroscience 152:254-64. 2008
    ..whether the artificially-induced AEP potentiation is mediated by the metabotropic glutamate receptors subtype 5 (mGluR5)...
  35. doi A role for mGluR5 receptors in intravenous methamphetamine self-administration
    Megan P H Osborne
    Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, USA
    Ann N Y Acad Sci 1139:206-11. 2008
    Selective antagonists of the mGluR5 receptor attenuate rewarding and reinforcing effects of various drugs of abuse, including alcohol, nicotine, and cocaine...
  36. pmc Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity
    Kimberly R Byrnes
    Department of Neuroscience, Georgetown University Medical Center, 3970 Reservoir Road N W, Washington, DC 20057, USA
    Glia 57:550-60. 2009
    The Group I metabotropic glutamate receptor 5 (mGluR5) can modulate addiction, pain, and neuronal cell death. Expression of some mGluRs, such as Group II and III mGluRs, has been reported in microglia and may affect their activation...
  37. doi Endogenous homer proteins regulate metabotropic glutamate receptor signaling in neurons
    Paul J Kammermeier
    Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 28:8560-7. 2008
    Group I metabotropic glutamate receptors (mGluR1 and mGluR5) are important neuronal mediators of postsynaptic signaling that influence synaptic strength, plasticity, and other factors...
  38. pmc Calmodulin dynamically regulates the trafficking of the metabotropic glutamate receptor mGluR5
    Jeong Ho Lee
    Department of Pharmacology, Brain Research Institute, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120 752, Korea
    Proc Natl Acad Sci U S A 105:12575-80. 2008
    ..We have now identified calmodulin (CaM) as a dynamic regulator of mGluR5 trafficking...
  39. pmc Activation of metabotropic glutamate 5 (mGlu5) receptors induces spontaneous excitatory synaptic currents in layer V pyramidal cells of the rat prefrontal cortex
    Gerard J Marek
    Lilly Research Laboratories, Psychiatric Disorders Discovery Biology, Lilly Corporate Center, Mail Drop 0510, Eli Lilly and Company, Indianapolis, IN 46285, United States
    Neurosci Lett 442:239-43. 2008
    ..These findings further suggest that monoamines, neuropeptides and glutamate itself all enhance the excitability of prefrontal cortical output cells indirectly via modulation of glutamate release...
  40. doi Involvement of group I metabotropic glutamate receptors and glutamate transporters in the slow excitatory synaptic transmission in the spinal cord dorsal horn
    J Galik
    Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA
    Neuroscience 154:1372-87. 2008
    ..The results shown here suggest that the activation of both mGluR1 and mGluR5 along with NK1 receptors, may be involved in the generation of the slow EPSC in the spinal cord DH...
  41. pmc Interaction of N-methyl-D-aspartate and group 5 metabotropic glutamate receptors on behavioral flexibility using a novel operant set-shift paradigm
    Justin M Darrah
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Behav Pharmacol 19:225-34. 2008
    ..These results suggest an interaction between NMDA and mGlu5 receptors in cognitive flexibility and may provide a novel therapeutic approach for treating disorders associated with aberrant NMDA function...
  42. doi Impoverished rearing impairs working memory and metabotropic glutamate receptor 5 expression
    Mary L Gregory
    Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Neuroreport 19:239-43. 2008
    ..Thus, impoverished rearing conditions produce protracted deficits in spatial working memory, in association with reduced prefrontal mGluR 5 function that may be relevant to the etiology of several neuropsychiatric disorders...
  43. pmc Co-localization of caldesmon and calponin with cortical afferents, metabotropic glutamate and neurotrophic receptors in the lateral and central nuclei of the amygdala
    Khristofor Agassandian
    Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA 52242, USA
    Brain Res 1226:39-55. 2008
    ..TrkB IR in the central nucleus was associated with Cd and Cp-immunoreactive spines whereas mGluR1 alpha IR and mGluR5 IR were almost exclusively associated with the PSDs of asymmetric synapses, in most cases apposed by cortical ..
  44. pmc Molecular reconstruction of mGluR5a-mediated endocannabinoid signaling cascade in single rat sympathetic neurons
    Yu Jin Won
    Section on Transmitter Signaling, Laboratory of Molecular Physiology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 9411, USA
    J Neurosci 29:13603-12. 2009
    ..The system provides a platform for testing candidate molecules underlying facilitation of eCB transport across the plasma membrane...
  45. pmc Importance of Shank3 protein in regulating metabotropic glutamate receptor 5 (mGluR5) expression and signaling at synapses
    Chiara Verpelli
    Department of Pharmacology, CNR Institute of Neuroscience, University of Milan, Milan 20129, Italy
    J Biol Chem 286:34839-50. 2011
    ..neuronal cultures and showed that this treatment specifically reduced the synaptic expression of the metabotropic glutamate receptor 5 (mGluR5), but did not affect the expression of other major synaptic proteins...
  46. pmc Structural plasticity of perisynaptic astrocyte processes involves ezrin and metabotropic glutamate receptors
    Monique Lavialle
    Institut National de la Recherche Agronomique, Unité de Nutrition et Régulation Lipidique des Fonctions Cérébrales 909, 78352 Jouy en Josas, France
    Proc Natl Acad Sci U S A 108:12915-9. 2011
    ..The data suggest that (i) ezrin is required for the structural plasticity of PAPs and (ii) mGluRs can stimulate PAP plasticity...
  47. pmc Metabotropic glutamate receptor mGluR5 is not involved in the early hemodynamic response
    Novella Calcinaghi
    Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland
    J Cereb Blood Flow Metab 31:e1-10. 2011
    Activation of astrocytic metabotropic glutamate receptor 5 (mGluR5) is postulated to elicit calcium transients, triggering a chain of events that ultimately regulates cerebral blood flow by changing the tone of smooth muscle cells of ..
  48. pmc mGluR5 positive allosteric modulation enhances extinction learning following cocaine self-administration
    Richard M Cleva
    Center for Drug and Alcohol Programs, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, SC, USA
    Behav Neurosci 125:10-9. 2011
    ..In this study, the authors investigated the effects of the Type-5 metabotropic glutamate receptors (mGluR5) positive allosteric modulator 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB) on the extinction of ..
  49. pmc Potential therapeutic interventions for fragile X syndrome
    Josien Levenga
    CBG Department of Clinical Genetics, Erasmus MC, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Trends Mol Med 16:516-27. 2010
    ....
  50. pmc Protective effect of metabotropic glutamate mGluR5 receptor elimination in a 6-hydroxydopamine model of Parkinson's disease
    Yolanda D Black
    Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Neurosci Lett 486:161-5. 2010
    Pharmacologic or genetic blockade of metabotropic glutamate mGlu5 receptors (mGluR5) has been shown to attenuate parkinsonian motor deficits and protect nigrostriatal neurons from damage in the acute MPTP model of Parkinson's disease (PD),..
  51. pmc Memory for fear extinction requires mGluR5-mediated activation of infralimbic neurons
    DARAH E FONTANEZ-NUIN
    Department of Physiology and Pharmacology, Ponce School of Medicine, Ponce, Puerto Rico 00732 7004
    Cereb Cortex 21:727-35. 2011
    ..Previous studies have shown that systemic blockade of metabotropic glutamate receptor type 5 (mGluR5) reduces bursting in the mPFC and mGluR5 agonists enhance NMDA receptor currents in vitro, suggesting that mGluR5 ..
  52. pmc Chronic corticosterone administration down-regulates metabotropic glutamate receptor 5 protein expression in the rat hippocampus
    A H Iyo
    Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Neuroscience 169:1567-74. 2010
    ..Recently, we reported reduced levels of metabotropic glutamate receptor subtype 5 (mGluR5) in postmortem brains in MDD, however the neurobiological mechanisms that induce these abnormalities are unclear...
  53. pmc Regulation of group I metabotropic glutamate receptor expression in the rat striatum and prefrontal cortex in response to amphetamine in vivo
    Christopher Shaffer
    Department of Anesthesiology, School of Medicine, University of Missouri Kansas City, Kansas City, MO 64108, USA
    Brain Res 1326:184-92. 2010
    ..Group I mGluRs (mGluR1 and mGluR5 subtypes) are expressed in striatal medium spiny output neurons and are believed to play an important role in the ..
  54. pmc Activation of mGluR5 induces rapid and long-lasting protein kinase D phosphorylation in hippocampal neurons
    Dilja D Krueger
    Howard Hughes Medical Institute, Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 43 Vassar St, 46 3301, Cambridge, MA 02139, USA
    J Mol Neurosci 42:1-8. 2010
    Metabotropic glutamate receptors (mGluRs), including mGluR5, play a central role in regulating the strength and plasticity of synaptic connections in the brain...
  55. pmc Ultrastructural relationships between cortical, thalamic, and amygdala glutamatergic inputs and group I metabotropic glutamate receptors in the rat accumbens
    D A Mitrano
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 518:1315-29. 2010
    ..to study the ultrastructural relationships between specific glutamatergic afferents and mGluR1a- or mGluR5-containing neurons in the rat nucleus accumbens...
  56. doi Metabotropic glutamate receptor 5, but not 1, modulates NMDA receptor-mediated activation of neuronal nitric oxide synthase
    Marta Llansola
    Laboratory of Neurobiology, Centro de Investigacion Principe Felipe, 46012 Valencia, Spain
    Neurochem Int 56:535-45. 2010
    ..The aims of this work were to assess: (a) whether activation of group I mGluRs (mGluR1 or mGluR5) impairs NMDA-induced activation of the glutamate-nitric oxide-cGMP pathway; (b) which mGluR (1 or 5) is ..
  57. pmc Loss of object recognition memory produced by extended access to methamphetamine self-administration is reversed by positive allosteric modulation of metabotropic glutamate receptor 5
    Carmela M Reichel
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuropsychopharmacology 36:782-92. 2011
    ..metabotropic glutamate receptor (mGluR) expression, and the possible reversal of cognitive impairments with the mGluR5 allosteric modulator, 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl) benzamide (CDPPB)...
  58. ncbi Radiolabeling and in vitro and in vivo evaluation of [18F]-FE-DABP688 as a PET radioligand for the metabotropic glutamate receptor subtype 5
    Michael Honer
    Animal Imaging Center PET, Center for Radiopharmaceutical Science of ETH, PSI and USZ, ETH Hoenggerberg, CH 8093 Zurich, Switzerland
    Nucl Med Biol 34:973-80. 2007
    ..FE-DABP688 was radiolabeled with fluorine-18 and characterized as a PET imaging agent for the metabotropic glutamate receptor subtype 5 (mGluR5).
  59. ncbi Regional expression and regulation of alternative forms of mRNAs derived from two distinct transcription initiation sites of the rat mGluR5 gene
    S Yamaguchi
    Department of Biological Sciences, Kyoto University Faculty of Medicine, Japan
    J Neurochem 71:60-8. 1998
    ..To investigate the mechanism underlying the regulation of mGluR5 expression, we isolated and characterized genomic clones containing the 5'-upstream exons and their flanking ..
  60. ncbi The mGlu5 metabotropic glutamate receptor is expressed in zones of active neurogenesis of the embryonic and postnatal brain
    V D Di Giorgi Gerevini
    Department of Human Physiology, University of Rome La Sapienza, Piazzale Aldo Moro 5, 00195 Rome, Italy
    Brain Res Dev Brain Res 150:17-22. 2004
    ..These data suggest a role for mGlu5 receptors in the early brain development and in basic cellular processes such as proliferation and/or differentiation...
  61. ncbi Metabotropic glutamate receptor 5 (mGluR5)-mediated phosphoinositide hydrolysis and NMDA-potentiating effects are blunted in the striatum of aged rats: a possible additional mechanism in striatal senescence
    Maria Rosaria Domenici
    Department of Pharmacology, Istituto Superiore di Sanita, Viale Regina Elena, 299 00161 Rome, Italy
    Eur J Neurosci 17:2047-55. 2003
    ....
  62. ncbi mGluR5-dependent increases in immediate early gene expression in the rat striatum following acute administration of amphetamine
    Nikhil K Parelkar
    Division of Pharmacy, School of Pharmacology, University of Missouri Kansas City, 2411 Holmes Street, Room M3 225, Kansas City, MO, USA
    Brain Res Mol Brain Res 122:151-7. 2004
    b>Metabotropic glutamate receptor 5 (mGluR5) is densely expressed in medium-sized spiny projection neurons of the rat striatum. Activation of mGluR5 increases intracellular Ca2+, resulting in Ca(2+)-dependent cellular responses...
  63. pmc Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors
    Cyril Goudet
    Department of Molecular Pharmacology, Centre National de la Recherche Scientifique, Unite Propre de Recherche 2580, CCIPE, 34094 Montpellier Cedex 5, France
    Proc Natl Acad Sci U S A 101:378-83. 2004
    ..Here, we show that the HD of metabotropic glutamate receptor 5 (mGlu(5)) displays the same agonist-independent constitutive activity as the wild-type receptor...
  64. ncbi Activation of metabotropic glutamate receptor mGlu5 on nuclear membranes mediates intranuclear Ca2+ changes in heterologous cell types and neurons
    KAREN L O'MALLEY
    Department of Anatomy, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:28210-9. 2003
    ..Similarly, activation of mGlu5 receptors expressed on neuronal nuclei led to sustained Ca2+ oscillatory responses. These results suggest mGlu5 may mediate intranuclear signaling pathways...
  65. ncbi The mGluR5 selective antagonist 6-methyl-2-(phenylethynyl)-pyridine reduces the spinal neuron pain-related activity in mononeuropathic rats
    Maria Luisa Sotgiu
    Istituto di Bioimmagini e Fisiologia Molecolare, CNR, Via Fratelli Cervi 93, 20090 Mi, Segrate, Italy
    Neurosci Lett 342:85-8. 2003
    ..CCI rats), showing behavioural signs of neuropathic pain, 6-methyl-2-(phenylethynyl)-pyridine (MPEP), a selective mGluR5 antagonist, was intraperitoneally administered at 0.75, 1.0 and 1...
  66. ncbi A variant of metabotropic glutamate receptor subtype 5: an evolutionally conserved insertion with no termination codon
    R Minakami
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 194:622-7. 1993
    We herein report the presence of a variant of the rat metabotropic glutamate receptor subtype 5 (mGluR5) cDNA. In this variant, named mGluR5b, an extra 96 bp sequence is inserted into the originally reported mGluR5 cDNA...
  67. ncbi Distinct functional roles of the metabotropic glutamate receptors 1 and 5 in the rat globus pallidus
    Olga V Poisik
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 23:122-30. 2003
    ..Here, we report that group I mGluR1 and mGluR5 have distinct functional roles in type II neurons of the rat globus pallidus (GP)...
  68. ncbi The group I metabotropic glutamate receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdala
    Sarina M Rodrigues
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 22:5219-29. 2002
    The group I metabotropic glutamate receptor subtype mGluR5 has been shown to play a key role in the modulation of synaptic plasticity...
  69. ncbi Role of protein phosphatase 2A in mGluR5-regulated MEK/ERK phosphorylation in neurons
    Limin Mao
    Department of Basic Medical Science, University of Missouri Kansas City, School of Medicine, Kansas City, Missouri 64108, USA
    J Biol Chem 280:12602-10. 2005
    ..However, signaling mechanisms linking mGluR5 to ERK are poorly understood...
  70. ncbi Blockade of metabotropic glutamate receptor 5 activation inhibits mechanical hypersensitivity following abdominal surgery
    Sharron Dolan
    Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Cowcaddens Road, Glasgow, UK
    Eur J Pain 11:644-51. 2007
    ..01 vs. vehicle treatment). MPEP had no effect on acute nociceptive thresholds in naïve animals. These data suggest that activity at mGlu5 receptors contributes to development of pain and hypersensitivity following surgery...
  71. ncbi Behavioral expression of cocaine sensitization in rats is accompanied by a distinct pattern of modifications in the PKA/DARPP-32 signaling pathway
    Simona Scheggi
    Department of Neuroscience, Pharmacology Unit, University of Siena, Siena, Italy
    J Neurochem 103:1168-83. 2007
    ..and modifications in the DARPP-32 phosphorylation pattern, cAMP-dependent protein kinase (PKA) activity, and mGluR5 tone in the medial prefrontal cortex and nucleus accumbens...
  72. pmc Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors
    Mika Nakamoto
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Whitehead Biomedical Research Building, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 104:15537-42. 2007
    ..synaptic stimulation by an exogenous agonist and was rescued by 2-methyl-6-phenylethynyl-pyridine (MPEP), an mGluR5-specific inverse agonist...
  73. ncbi Low-frequency stimulation induces a new form of LTP, metabotropic glutamate (mGlu5) receptor- and PKA-dependent, in the CA1 area of the rat hippocampus
    Fabien Lanté
    Laboratoire Plasticité Cérébrale, FRE 2693 CNRS, Universite Montpellier II, 34095 Montpellier Cedex 05, France
    Hippocampus 16:345-60. 2006
    ..This new form of LTP could represent the mnesic engram of mild and repetitive stimulation involved in latent learning...
  74. ncbi Co-localization and functional interaction between adenosine A(2A) and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum
    Ricardo J Rodrigues
    Centre for Neuroscience of Coimbra, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    J Neurochem 92:433-41. 2005
    The anti-Parkinsonian effect of glutamate metabotropic group 5 (mGluR5) and adenosine A(2A) receptor antagonists is believed to result from their ability to postsynaptically control the responsiveness of the indirect pathway that is ..
  75. ncbi [Expression changes of metabotropic glutamate receptor 5 in neuropathic pain]
    Hong Yan Yan
    Department of Anesthesiology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 29:111-6. 2007
    To investigate the expression changes of metabotropic glutamate receptor 5 (mGluR5) in neuropathic pain.
  76. ncbi Global ischemia downregulates the function of metabotropic glutamate receptor subtype 5 in hippocampal CA1 pyramidal neurons
    Tu Hsueh Yeh
    Department of Neurology, Chang Gung Memorial Hospital, Kwei San, Tao Yuan, Taiwan, ROC
    Mol Cell Neurosci 29:484-92. 2005
    ..electrophysiological and immunohistochemical studies showed that metabotropic glutamate receptor subtype 5 (mGluR5) is the major postsynaptic mGluR expressed in CA1 pyramidal neurons...
  77. ncbi Prolonged blockade of NMDA or mGluR5 glutamate receptors reduces nigrostriatal degeneration while inducing selective metabolic changes in the basal ganglia circuitry in a rodent model of Parkinson's disease
    Marie Therese Armentero
    Laboratory of Functional Neurochemistry, IRCCS Neurological Institute C Mondino, Via Mondino, 2, 27100 Pavia, Italy
    Neurobiol Dis 22:1-9. 2006
    ..of SNc neurons was also observed following treatment with the metabotropic glutamate receptor (mGluR5) antagonist 2-methyl-6-(phenylehtynyl)-pyridine (MPEP)...
  78. ncbi Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents
    Gene G Kinney
    Department of Neuroscience, Merck, West Point, PA 19486, USA
    J Pharmacol Exp Ther 306:116-23. 2003
    ..Activation of the metabotropic glutamate receptor subtype 5 (mGluR5) enhances NMDAR-mediated currents in vitro...
  79. pmc Neurotensin inhibition of GABAergic transmission via mGluR-induced endocannabinoid signalling in rat periaqueductal grey
    V A Mitchell
    Pain Management Research Institute, Northern Clinical School, University of Sydney at Royal North Shore Hospital, St Leonards, NSW, Australia
    J Physiol 587:2511-20. 2009
    ..The neurotensin induced inhibition of evoked IPSCs was reduced by the mGluR5 antagonist MPEP (5microM) and abolished by the cannabinoid CB(1) receptor antagonist AM251 (3 microM)...
  80. ncbi Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway
    Joan Marc Servitja
    Departament de Bioquimica i Biologia Molecular, Facultat de Medicina, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Neuropharmacology 44:171-80. 2003
    ..Taken together, these results indicate that PLD activation by mGluRs in astrocytes is dependent on PKC and small G proteins of the ARF family, but does not require Rho proteins...
  81. pmc Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function
    Sergi Ferre
    Behavioral Neuroscience Branch, National Institute on Drug Abuse, National Institutes of Health, Intramural Research Program, Baltimore, MD 21224, U SA
    Proc Natl Acad Sci U S A 99:11940-5. 2002
    ..and in vivo evidence for a synergism between adenosine and glutamate based on subtype 5 metabotropic glutamate (mGluR5) and adenosine A2A (A2AR) receptor/receptor interactions...
  82. ncbi Involvement of metabotropic glutamate 5 receptor in visceral pain
    Erik Lindstrom
    AstraZeneca R and D, Molndal, Sweden
    Pain 137:295-305. 2008
    Metabotropic glutamate 5 receptor (mGluR5) antagonists are effective in animal models of inflammatory and neuropathic pain. The involvement of mGluR5 in visceral pain pathways from the gastrointestinal tract is as yet unknown...
  83. ncbi The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7
    Ralf Enz
    Institut fur Biochemie, Friedrich Alexander Universitat Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    FEBS Lett 514:184-8. 2002
    ..Finally, co-expression of Filamin-A and mGluR7 splice variants was shown in brain regions. These findings suggest that Filamin-A may physically link metabotropic glutamate receptors to the actin cytoskeleton...
  84. ncbi Expression of metabotropic glutamate receptors in rat meningeal and brain microvasculature and choroid plexus
    Samantha E Gillard
    Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Comp Neurol 461:317-32. 2003
    ..mGluR2/3, mGluR4a, mGluR5, and mGluR7 were also expressed in meningeal microvasculature...
  85. ncbi Membrane topology of a metabotropic glutamate receptor
    Gautam Bhave
    Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 278:30294-301. 2003
    ..In the present study, we set out to test whether mGluR5 has seven true transmembrane domains...
  86. pmc Activation of metabotropic glutamate receptor 5 modulates microglial reactivity and neurotoxicity by inhibiting NADPH oxidase
    David J Loane
    Department of Neuroscience, Georgetown University Medical Center, Washington, D C 20057, USA
    J Biol Chem 284:15629-39. 2009
    ..We demonstrate that the group I receptor member mGluR5 is highly expressed in primary microglial cultures and the BV2 microglial cell line...
  87. ncbi Localization of kainate receptor subunit GluR5-immunoreactive cells in the rat hypothalamus
    Ozhan Eyigor
    Department of Histology and Embryology, Uludag University, Faculty of Medicine, Gorukle Kampusu, 16059, Bursa, Turkey
    Brain Res Mol Brain Res 136:38-44. 2005
    ....
  88. ncbi Species differences in mGluR5 binding sites in mammalian central nervous system determined using in vitro binding with [18F]F-PEB
    Shil Patel
    Department of Research Imaging, Merck Research Laboratories, West Point, PA 19486, USA
    Nucl Med Biol 34:1009-17. 2007
    ..1-0.15 nM, n> or =3) to a saturable site previously shown to be metabotropic glutamate receptor 5 (mGluR5; Patel S, Ndubizu O, Hamill T, Chaudhary A, Burns HD, Hargreaves RJ, Gibson RE...
  89. ncbi Rap1-induced p38 mitogen-activated protein kinase activation facilitates AMPA receptor trafficking via the GDI.Rab5 complex. Potential role in (S)-3,5-dihydroxyphenylglycene-induced long term depression
    Chiung Chun Huang
    Department of Pharmacology, College of Medicine, National Cheng Kung University, No 1 University Road, Tainan City 701, Taiwan
    J Biol Chem 279:12286-92. 2004
    ..p38 MAPK through G protein betagamma-subunit, small GTPase Rap1, and MAPK kinase 3/6 (MKK3/6), thus resulting in mGluR5-dependent LTD...
  90. ncbi The role of group I metabotropic glutamate receptors in acquisition and expression of contextual and auditory fear conditioning in rats - a comparison
    A Gravius
    Preclinical R and D, Merz Pharmaceuticals GmbH, Eckenheimer Landstrasse 100, 60318 Frankfurt am Main, Germany
    Neuropharmacology 51:1146-55. 2006
    ..The purpose of the present study was to evaluate the contribution of mGluR1 and mGluR5 to both acquisition and expression of behaviours in contextual and auditory fear conditioning models...
  91. pmc Glutamate (mGluR-5) gene expression in brain regions of streptozotocin induced diabetic rats as a function of age: role in regulation of calcium release from the pancreatic islets in vitro
    Savitha Balakrishnan
    Molecular Neurobiology and Cell Biology Unit, Centre for Neuroscience, Department of Biotechnology, Cochin University of Science and Technology, Cochin 682 022, Kerala, India
    J Biomed Sci 16:99. 2009
    ..Also, the regulatory role of glutamate receptors in calcium release has immense therapeutic application in insulin secretion and function...
  92. ncbi Cell surface expression of GluR5 kainate receptors is regulated by an endoplasmic reticulum retention signal
    Zhao Ren
    Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    J Biol Chem 278:52700-9. 2003
    ..Taken together, our results identify novel trafficking signals in the C-terminal domain of GluR5-2b and demonstrate that alternative splicing is an important mechanism regulating KAR function...
  93. ncbi Group I metabotropic glutamate receptors bind to protein phosphatase 1C. Mapping and modeling of interacting sequences
    Cristina Croci
    Emil Fischer Zentrum, Institut fur Biochemie, Friedrich Alexander Universitat Erlangen Nurnberg, Fahrstr 17, Erlangen 91054, Germany
    J Biol Chem 278:50682-90. 2003
    ..In summary, these results provide a molecular description of the interaction between protein phosphatase 1C and metabotropic glutamate receptors and thereby increase our understanding of glutamatergic signal transduction...
  94. ncbi Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neurons
    Divina S Gryder
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 4457, USA
    J Neurosci 23:7069-74. 2003
    ..Moreover, these results support the concept that GluR5 kainate receptors represent a novel target for antiepileptic drug development...
  95. doi The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function
    Laia Canela
    IDIBAPS, CIBERNED and Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    J Neurochem 111:555-67. 2009
    ..Overall, these findings indicate that NECAB2 by its physical interaction with mGlu(5b) receptor modulates receptor function...
  96. ncbi Metabotropic glutamate 5 receptor blockade alleviates akinesia by normalizing activity of selective basal-ganglia structures in parkinsonian rats
    Nathalie Breysse
    Laboratoire de Neurobiologie de la Cognition, Centre National de la Recherche Scientifique, 13402 Marseille, France
    J Neurosci 23:8302-9. 2003
    ..Furthermore, chronic treatment with the mGluR5 antagonist 2-methyl-6-(phenylethylnyl)-pyridine alleviated the akinesia and was associated with a normalization of ..
  97. ncbi Cellular localization of metabotropic glutamate receptors mGluR1, 2/3, 5 and 7 in the main and accessory olfactory bulb of the rat
    Y Sahara
    Department of Maxillofacial Biology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Neurosci Lett 312:59-62. 2001
    ..These differences in the distribution of mGluRs in the MOB and AOB may reflect differences in synaptic transmission and sensitivity to neuromodulation in the two systems...
  98. ncbi Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition
    J Beneken
    Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 26:143-54. 2000
    ..Site-directed mutagenesis confirms the importance of specific Homer residues for ligand binding. These results establish a molecular basis for understanding the biological properties of Homer-ligand complexes...
  99. ncbi Antagonism of metabotropic glutamate receptor type 5 attenuates l-DOPA-induced dyskinesia and its molecular and neurochemical correlates in a rat model of Parkinson's disease
    Flora Mela
    Basal Ganglia Pathophysiology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden
    J Neurochem 101:483-97. 2007
    Metabotropic glutamate receptor type 5 (mGluR5) modulates dopamine and glutamate neurotransmission at central synapses...
  100. ncbi Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer
    Noah W Gray
    Molecular Neuroscience Program and Graduate School, Mayo Clinic, 200 First Street, S W, Rochester, MN 55905, USA
    Curr Biol 13:510-5. 2003
    ..These data suggest that Dyn3 is a postsynaptic dynamin and, like its binding partner Homer, plays a significant role in dendritic spine morphogenesis and remodeling...

Research Grants9

  1. Metabotropic Receptors: Structure/Function/Regulation
    KAREN O MALLEY; Fiscal Year: 2006
    ..We anticipate that these investigations of mGluR dimerization will deepen our understanding of neural communication and signal transduction, processes that underlie brain function and dysfunction. ..
  2. MODULATION OF DOPAMINE AUTORECEPTOR FUNCTION BY COCAINE
    KAREN O MALLEY; Fiscal Year: 2001
    ..Taken together these studies will significantly extend our ongoing efforts to understand the complex receptor/presynaptic effector interactions involved in the reinforcing and behavioral sensitization effects of cocaine. ..
  3. Involvement of mGluR5 in inhibitory avoidance and aging
    Agnes Simonyi; Fiscal Year: 2004
    ..It is predicted that among the mGluR ligands proposed to be studied, only the mGluR5 antagonist will cause a memory deficit...
  4. Signaling By Nuclear G-Protein Coupled Receptors
    KAREN O MALLEY; Fiscal Year: 2005
    ..Because preliminary results indicate that mGluR5 receptors are expressed on both nuclear and plasma membranes in striatal cultures, these preparations will be used ..
  5. Prefrontal Glutamate and Working Memory
    Mary Gregory; Fiscal Year: 2006
    ..This study proposes to investigate the effects of differential housing on glutamatergic transmission within the PFC and the relationship of these changes to working memory. ..
  6. Glutamate Signaling and Drug Abuse
    MOHAMMADHOSSEIN GHASEMZADEH; Fiscal Year: 2007
    ....
  7. TRANSCRIPTIONAL CONTROL OF NEUROENDOCRINE GENES
    KAREN O MALLEY; Fiscal Year: 2007
    ..Knowledge gained from these studies may offer new routes for therapeutic intervention. ..
  8. Functional Consequences of Nuclear mGlu5 Receptor Activation
    KAREN O MALLEY; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  9. MECHANISMS OF NEURONAL DEATH IN PARKINSON'S DISEASE
    KAREN O MALLEY; Fiscal Year: 2008
    ..If so, novel therapies can be targeted to the elucidated control points in order to stop or slow disease progression. ..