Fbp1

Summary

Gene Symbol: Fbp1
Description: Fat body protein 1
Alias: CG17285, DmeFBP1, Dmel\CG17285, FBP-1, FBP1, Fbp-1, LP07910p, fbp-1, fbp1, CG17285-PA, CG17285-PB, CG17285-PD, Fbp1-PA, Fbp1-PB, Fbp1-PD, Protein-1, fat body protein 1, fat body protein-1, fat body protein1
Species: fruit fly

Top Publications

  1. ncbi Nucleosomal core histones mediate dynamic regulation of poly(ADP-ribose) polymerase 1 protein binding to chromatin and induction of its enzymatic activity
    Aaron Pinnola
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 282:32511-9. 2007
  2. ncbi Ecdysone-regulation of synthesis and processing of fat body protein 1, the larval serum protein receptor of Drosophila melanogaster
    T Burmester
    Institut Jacques Monod, Biologie du Développement, CNRS et Université Paris 6 et Paris 7, France
    Eur J Biochem 262:49-55. 1999
  3. pmc Tropomyosin is an interaction partner of the Drosophila coiled coil protein yuri gagarin
    Michael J Texada
    Department of Biochemistry and Cell Biology, Rice University, MS 140, 6100 Main Street, Houston TX 77005, USA
    Exp Cell Res 317:474-87. 2011
  4. ncbi Proteomic identification of PKC-mediated expression of 20E-induced protein in Drosophila melanogaster
    Yaning Sun
    Division of Plant Sciences, 1 31 Agriculture Building, University of Missouri, Columbia, Missouri 65211, USA
    J Proteome Res 6:4478-88. 2007
  5. pmc Helicase89B is a Mot1p/BTAF1 homologue that mediates an antimicrobial response in Drosophila
    Yoshimasa Yagi
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, Massachusetts 01605, USA
    EMBO Rep 6:1088-94. 2005
  6. pmc Quantitative proteomics of a presymptomatic A53T alpha-synuclein Drosophila model of Parkinson disease
    Zhiyin Xun
    Department of Chemistry, Indiana University, Bloomington, Indiana 47405 7102, USA
    Mol Cell Proteomics 7:1191-203. 2008
  7. pmc Proteome response to the panneural expression of human wild-type alpha-synuclein: a Drosophila model of Parkinson's disease
    Zhiyin Xun
    Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA
    J Proteome Res 7:3911-21. 2008
  8. pmc Stable isotope labeling and label-free proteomics of Drosophila parkin null mutants
    Zhiyin Xun
    Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA
    J Proteome Res 8:4500-10. 2009
  9. pmc The Drosophila nuclear receptors DHR3 and betaFTZ-F1 control overlapping developmental responses in late embryos
    Anne Françoise Ruaud
    Department of Human Genetics, University of Utah School of Medicine, 15 N 2030 E Room 2100, Salt Lake City, UT 84112 5330, USA
    Development 137:123-31. 2010
  10. pmc Lineage tracing of lamellocytes demonstrates Drosophila macrophage plasticity
    Martin Stofanko
    Institute of Biomedical Research, University of Birmingham, Edgbaston, England
    PLoS ONE 5:e14051. 2010

Detail Information

Publications38

  1. ncbi Nucleosomal core histones mediate dynamic regulation of poly(ADP-ribose) polymerase 1 protein binding to chromatin and induction of its enzymatic activity
    Aaron Pinnola
    Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    J Biol Chem 282:32511-9. 2007
    ..Therefore, our data collectively suggests a model in which both the regulation of PARP1 protein binding to chromatin and the enzymatic activation of PARP1 protein depend on the dynamics of nucleosomal core histone mediation...
  2. ncbi Ecdysone-regulation of synthesis and processing of fat body protein 1, the larval serum protein receptor of Drosophila melanogaster
    T Burmester
    Institut Jacques Monod, Biologie du Développement, CNRS et Université Paris 6 et Paris 7, France
    Eur J Biochem 262:49-55. 1999
    ..Here, we show that the product of the ecdysteroid-inducible gene Fbp-1 (Fat Body Protein 1) is the receptor that binds LSP-1...
  3. pmc Tropomyosin is an interaction partner of the Drosophila coiled coil protein yuri gagarin
    Michael J Texada
    Department of Biochemistry and Cell Biology, Rice University, MS 140, 6100 Main Street, Houston TX 77005, USA
    Exp Cell Res 317:474-87. 2011
    ..Tropomyosin has been implicated in actin-mediated membrane trafficking activity in other systems. Our findings suggest that Yuri-Tm1 complexes participate in related functions...
  4. ncbi Proteomic identification of PKC-mediated expression of 20E-induced protein in Drosophila melanogaster
    Yaning Sun
    Division of Plant Sciences, 1 31 Agriculture Building, University of Missouri, Columbia, Missouri 65211, USA
    J Proteome Res 6:4478-88. 2007
    ..The data further indicate that PKC-mediated phosphorylation is also required for genes regulated indirectly by 20E-induced changes in the larval salivary gland...
  5. pmc Helicase89B is a Mot1p/BTAF1 homologue that mediates an antimicrobial response in Drosophila
    Yoshimasa Yagi
    Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, Massachusetts 01605, USA
    EMBO Rep 6:1088-94. 2005
    ..Thus, Helicase89B positively regulates gene expression during innate immune response and may act as a link between NF-kappaB-related transcription factors and the basal transcription machinery...
  6. pmc Quantitative proteomics of a presymptomatic A53T alpha-synuclein Drosophila model of Parkinson disease
    Zhiyin Xun
    Department of Chemistry, Indiana University, Bloomington, Indiana 47405 7102, USA
    Mol Cell Proteomics 7:1191-203. 2008
    ..expressed in A53T alpha-synuclein Drosophila; up-regulation of troponin T and down-regulation of fat body protein 1 were confirmed by Western blot analysis...
  7. pmc Proteome response to the panneural expression of human wild-type alpha-synuclein: a Drosophila model of Parkinson's disease
    Zhiyin Xun
    Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA
    J Proteome Res 7:3911-21. 2008
    ..in response to the expression of human WT alpha-synuclein; down-regulations of larval serum protein 2 and fat body protein 1 levels were confirmed by Western blot analysis...
  8. pmc Stable isotope labeling and label-free proteomics of Drosophila parkin null mutants
    Zhiyin Xun
    Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA
    J Proteome Res 8:4500-10. 2009
    ..levels, of which larval serum protein 1alpha, larval serum protein 1beta, larval serum protein 1gamma, and fat body protein 1 showed >10-fold up-regulation and substantially higher level of fat body protein 1 was confirmed by ..
  9. pmc The Drosophila nuclear receptors DHR3 and betaFTZ-F1 control overlapping developmental responses in late embryos
    Anne Françoise Ruaud
    Department of Human Genetics, University of Utah School of Medicine, 15 N 2030 E Room 2100, Salt Lake City, UT 84112 5330, USA
    Development 137:123-31. 2010
    ..Taken together, these studies define the lethal phenotypes of DHR3 and betaFTZ-F1 mutants, and provide evidence for functional bifurcation in the 20E-responsive transcriptional cascade...
  10. pmc Lineage tracing of lamellocytes demonstrates Drosophila macrophage plasticity
    Martin Stofanko
    Institute of Biomedical Research, University of Birmingham, Edgbaston, England
    PLoS ONE 5:e14051. 2010
    ..Taken together, our data suggest that lamellocytes arise from plasmatocytes and that plasmatocytes may be inherently plastic, possessing the ability to differentiate further into lamellocytes upon appropriate challenge...
  11. ncbi Study of tauopathies by comparing Drosophila and human tau in Drosophila
    Xinping Chen
    State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Cell Tissue Res 329:169-78. 2007
    ..These results suggest that the two tau genes differ significantly. This comparison between species-specific isoforms may help to clarify whether the homologous tau genes are conserved...
  12. ncbi Loss of the ecdysteroid-inducible E75A orphan nuclear receptor uncouples molting from metamorphosis in Drosophila
    Michael Bialecki
    Howard Hughes Medical Institute, Department of Human Genetics, 15 North 2030 East, University of Utah, Salt Lake City 84112, USA
    Dev Cell 3:209-20. 2002
    ..We propose that ecdysteroid-induced E75A expression defines a feed-forward pathway that amplifies or maintains the ecdysteroid titer during larval development, ensuring proper temporal progression through the life cycle...
  13. ncbi Isolation and characterization of hemolymph clotting factors in Drosophila melanogaster by a pullout method
    Christoph Scherfer
    Department of Molecular Biology and Functional Genomics, University of Stockholm, 10691 Stockholm, Sweden
    Curr Biol 14:625-9. 2004
    ..The most abundant clot protein is Hemolectin, and we confirm that hemolectin mutant larvae show clotting defects...
  14. pmc microRNA miR-14 acts to modulate a positive autoregulatory loop controlling steroid hormone signaling in Drosophila
    Jishy Varghese
    European Molecular Biology Laboratory, 69117, Heidelberg, Germany
    Genes Dev 21:2277-82. 2007
    ..Failure to limit EcR levels is responsible for the many of the defects observed in miR-14 mutants. miR-14 plays a key role in modulating the positive autoregulatory loop by which Ecdysone sensitizes its own signaling pathway...
  15. pmc Prothoracicotropic hormone regulates developmental timing and body size in Drosophila
    Zofeyah McBrayer
    The Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Cell 13:857-71. 2007
    ..These results indicate that final body size in insects is determined by a balance between growth-rate regulators such as insulin and developmental timing cues such as PTTH that set the duration of the feeding interval...
  16. doi Functional and bioinformatics analyses reveal conservation of cis-regulatory elements between sciaridae and drosophilidae
    Matheus S Lecci
    Departamento de Analises Clinicas, Toxicológicas e Bromatológicas DACTB, Faculdade de Ciências Farmacêuticas de Ribeirão Preto FCFRP, Universidade de Sao Paulo USP, Ribeirao Preto, SP, Brazil
    Genesis 46:43-51. 2008
    ....
  17. pmc Drosophila DHR38 nuclear receptor is required for adult cuticle integrity at eclosion
    Tatiana Kozlova
    Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah 84112 5330, USA
    Dev Dyn 238:701-7. 2009
    ..In contrast, cuticle gene expression is significantly reduced in DHR38(Y214) mutant pupae. These studies define the essential functions of DHR38 and provide a genetic context for further characterization of its roles during development...
  18. ncbi Hormonal regulation of the E75 gene in Drosophila: identifying functional regulatory elements through computational and biological analysis
    Travis J Bernardo
    Department of Biology, Fordham University, Bronx, NY 10458, USA
    J Mol Biol 387:794-808. 2009
    ..We propose that the presence of multiple EcREs with distinct features provides flexibility to the rapid and powerful response of E75A to ecdysone during Drosophila development...
  19. pmc Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila
    Petros Ligoxygakis
    Institut de Biologie Moléculaire and Cellulaire, Strasbourg Cedex, France
    EMBO Rep 3:666-73. 2002
    ..18-Wheeler does not qualify as a pattern recognition receptor of Gram-negative bacteria...
  20. ncbi Genetic and molecular analysis in the 70CD region of the third chromosome of Drosophila melanogaster
    T Burmester
    Department of Genetics, Attila Jozsef University, H 6726, Szeged, Hungary
    Gene 246:157-67. 2000
    ..The genomic sequence of the l(3)70Ca/b gene reveals a novel heat shock protein (hsc70Cb). l(3)70Da was identified as a member of the CDC48/PEX1 ATPase family and its coding sequence was determined...
  21. pmc Dual requirement for the EcR/USP nuclear receptor and the dGATAb factor in an ecdysone response in Drosophila melanogaster
    V Brodu
    Institut Jacques Monod, Laboratoire de Biologie du Developpement, CNRS UMR 7592, Universite Paris 7 Denis Diderot, Université Paris 6 P et M Curie, 75251 Paris Cedex 05, France
    Mol Cell Biol 19:5732-42. 1999
    ..b>Fbp1 is a good model of primary ecdysone response gene expressed in the fat body for addressing this question...
  22. ncbi Hormones, puffs and flies: the molecular control of metamorphosis by ecdysone
    A J Andres
    Howard Hughes Medical Institute, Eccles Institute of Human Genetics, University of Utah, Salt Lake City 84112
    Trends Genet 8:132-8. 1992
    ..Molecular characterization of some of these genes has provided valuable clues to regulatory mechanisms by which the ecdysone signal is transduced and amplified...
  23. ncbi Structure of the ecdysone-inducible P1 gene of Drosophila melanogaster
    F Maschat
    Institut Jacques Monod CNRS et Université Paris 7, France
    J Mol Biol 214:359-72. 1990
    ..Short stretches of nucleotide sequences similar to sequences located in the 5' regions of other genes expressed in the D. melanogaster fat body were found in the proximal promoter and transcribed region of the P1 gene...
  24. pmc Transformation mapping of the regulatory elements of the ecdysone-inducible P1 gene of Drosophila melanogaster
    F Maschat
    Institut Jacques Monod, Centre National de la Recherche Scientifique, Paris, France
    Mol Cell Biol 11:2913-7. 1991
    ..Sequences from -138 to -68 are essential for this expression...
  25. ncbi Larval fat body-specific gene expression in D. melanogaster
    J Deutsch
    Institut Jacques Monod, CNRS Université Paris, France
    Dev Genet 10:220-31. 1989
    ..This region includes an element that behaves as a fat-body transcriptional enhancer and element(s) required for ecdysone inducibility of transcription of the P1 gene...
  26. ncbi Histochemical analysis of the ecdysterone-regulated expression of the Drosophila genes P1 and LSP-2
    M L Paco-Larson
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511
    Dev Genet 7:197-203. 1986
    ....
  27. ncbi Developmentally regulated gene expression in Drosophila larval fat bodies
    J A Lepesant
    J Mol Appl Genet 1:371-83. 1982
    ..Ecdysterone increases the level of the P1 transcript, but not of the P6 transcript, in ecdysterone-deficient ecd1 larvae...
  28. ncbi Insect nuclear receptors: a developmental and comparative perspective
    V C Henrich
    Department of Biology, University of North Carolina Greensboro 27412 5001, USA
    Insect Biochem Mol Biol 25:881-97. 1995
    ..As receptor homologues have been identified in other insects, several general ideas concerning insect hormonal regulation have begun to emerge and these will be examined from a comparative point of view...
  29. pmc The ecdysone response enhancer of the Fbp1 gene of Drosophila melanogaster is a direct target for the EcR/USP nuclear receptor
    C Antoniewski
    Institut Jacques Monod, Centre National de la Recherche Scientifique, Paris, France
    Mol Cell Biol 14:4465-74. 1994
    The transcription of the Drosophila melanogaster Fbp1 gene is induced by the steroid hormone 20-hydroxyecdysone and restricted to the late-third-instar fat body tissue...
  30. ncbi In vivo functional characterization of an ecdysone response enhancer in the proximal upstream region of the Fbp1 gene of D. melanogaster
    M Laval
    Institut Jacques Monod, CNRS et Université Paris, France
    Mech Dev 44:123-38. 1993
    Transcription of the D. melanogaster Fat-body-protein-1 (Fbp1) gene is induced by the steroid hormone 20-hydroxyecdysone and is restricted to the fat body tissue at the end of the third larval instar...
  31. pmc Deletion scanning of the regulatory sequences of the Fbp1 gene of Drosophila melanogaster using P transposase-induced deficiencies
    P Lapie
    Laboratoire de Biologie du Developpement, Institut Jacques Monod, CNRS, Paris, France
    Genetics 135:801-16. 1993
    ..remains fixed was applied to the study of the upstream sequences of the ecdysteroid-inducible Fat-body-protein-1 (Fbp1) gene. Deficiencies were induced in a Fbp1:Adh fusion transgene by means of a secondary P transposase mutagenesis...
  32. ncbi Structural features critical to the activity of an ecdysone receptor binding site
    C Antoniewski
    Institut Jacques Monod, CNRS, Paris, France
    Insect Biochem Mol Biol 23:105-14. 1993
    Two ecdysone-response elements from the hsp27 (hsp27 EcRE) and the Fbp1 (D EcRE) genes of Drosophila melanogaster were used as probes in a gel shift assay to investigate the interactions of the ecdysone receptor (EcR) with its cognate DNA ..
  33. ncbi Characterization of an EcR/USP heterodimer target site that mediates ecdysone responsiveness of the Drosophila Lsp-2 gene
    C Antoniewski
    Institut Jacques Monod, Centre National de la Recherche Scientifique and Université de Paris 7, France
    Mol Gen Genet 249:545-56. 1995
    ..complex is comparable to that of the canonical EcRE of the hsp27 gene and is at least 4-fold greater than that of Fbp1, another fat body-specific Drosophila gene...
  34. ncbi Drosophila Sgs genes: stage and tissue specificity of hormone responsiveness
    M Lehmann
    Institut für Genetik Freie Universität Berlin, Germany
    Bioessays 18:47-54. 1996
    ..g. secretion enhancer binding proteins, which act together in a synergistic manner with the 20E receptor and early gene products to establish a stage- and tissue-specific expression pattern...
  35. pmc Direct repeats bind the EcR/USP receptor and mediate ecdysteroid responses in Drosophila melanogaster
    C Antoniewski
    Institut Jacques Monod, CNRS et Université Paris, France
    Mol Cell Biol 16:2977-86. 1996
    ..elements (EcREs) such as those present in the promoter of the hsp27 gene or the fat body-specific enhancer of the Fbp1 gene...
  36. ncbi crooked legs encodes a family of zinc finger proteins required for leg morphogenesis and ecdysone-regulated gene expression during Drosophila metamorphosis
    P P D'Avino
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112 5331, USA
    Development 125:1733-45. 1998
    ..The genetic criteria described here provide a new direction for identifying regulators of adult tissue development during insect metamorphosis...
  37. ncbi The DHR78 nuclear receptor is required for ecdysteroid signaling during the onset of Drosophila metamorphosis
    G J Fisk
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah, Salt Lake City 84112 5331, USA
    Cell 93:543-55. 1998
    ..We propose that DHR78 is a ligand-activated receptor that plays a central role in directing the onset of Drosophila metamorphosis...
  38. pmc Ecdysone-inducible functions of larval fat bodies in Drosophila
    J A Lepesant
    Proc Natl Acad Sci U S A 75:5570-4. 1978
    ....