Gene Symbol: Fatp
Description: Fatty acid (long chain) transport protein
Alias: CG45083, CG46149, CG7400, Dmel\CG46149, Dmel_CG45083, Dmel_CG7400, Dromel_CG7400_FBtr0080133_fatp_mORF, Dromel_CG7400_FBtr0080133_fatp_uORF, FATP, anon-WO0121795.74, dFATP, dFatp, fatp, l(2)k10307, fatty acid (long chain) transport protein, CG46149-PA, CG46149-PB, CG46149-PE, CG46149-PF, Fatp-PA, Fatp-PB, Fatp-PE, Fatp-PF, fatty acid transport protein
Species: fruit fly

Top Publications

  1. Gambis A, Dourlen P, Steller H, Mollereau B. Two-color in vivo imaging of photoreceptor apoptosis and development in Drosophila. Dev Biol. 2011;351:128-34 pubmed publisher
    ..The "Tomato/GFP-FLP/FRT" method allows high-throughput, rapid and precise identification of survival and developmental pathways in living adult PRs at single-cell resolution. ..
  2. Shi W, Stampas A, Zapata C, Baker N. The pineapple eye gene is required for survival of Drosophila imaginal disc cells. Genetics. 2003;165:1869-79 pubmed
    ..The pineapple eye gene was identified and predicted to encode a novel 582-amino-acid protein. The protein contains a novel, cysteine-rich domain of 270 amino acids also found in predicted proteins of unknown function from other animals. ..
  3. Dourlen P, Levet C, Mejat A, Gambis A, Mollereau B. The Tomato/GFP-FLP/FRT method for live imaging of mosaic adult Drosophila photoreceptor cells. J Vis Exp. 2013;:e50610 pubmed publisher
    ..This method is also useful for addressing cell autonomy issues in developmental mutants, such as those in which the establishment of planar cell polarity is affected. ..
  4. Dourlen P, Sujkowski A, Wessells R, Mollereau B. Fatty acid transport proteins in disease: New insights from invertebrate models. Prog Lipid Res. 2015;60:30-40 pubmed publisher
    ..Recent studies have characterized fatty acid transport protein (fatp) mutants in Drosophila and C...
  5. Chiang Y, Tan K, Chung H, Lavrynenko O, Shevchenko A, Yew J. Steroid Hormone Signaling Is Essential for Pheromone Production and Oenocyte Survival. PLoS Genet. 2016;12:e1006126 pubmed publisher
    ..Taken together, these results identify a novel regulator of pheromone synthesis and reveal that ecdysteroid signaling is essential for the maintenance of cuticular lipids and oenocytes throughout adulthood. ..
  6. Mesilaty Gross S, Reich A, Motro B, Wides R. The Drosophila STAM gene homolog is in a tight gene cluster, and its expression correlates to that of the adjacent gene ial. Gene. 1999;231:173-86 pubmed
    ..Developmental Northern data and embryonic and ovariole expression data show that STAM and ial expression are correlated. The other two genes in the cluster appear to be expressed at constitutive levels throughout development. ..
  7. Oba Y, Ojika M, Inouye S. Characterization of CG6178 gene product with high sequence similarity to firefly luciferase in Drosophila melanogaster. Gene. 2004;329:137-45 pubmed
    ..Further, phylogenic analyses strongly suggest that the firefly luciferase gene may have evolved from a fatty acyl-CoA synthetase gene as a common ancestral gene. ..
  8. Yang M, Nelson D, Funakoshi Y, Padgett R. Genome-wide microarray analysis of TGFbeta signaling in the Drosophila brain. BMC Dev Biol. 2004;4:14 pubmed
    ..Many of these genes are novel and several genes are implicated in growth control. Among the genes regulated by both pathways is ultraspiracle, which further connects TGFbeta with neuronal remodeling. ..
  9. Oba Y, Sato M, Ojika M, Inouye S. Enzymatic and genetic characterization of firefly luciferase and Drosophila CG6178 as a fatty acyl-CoA synthetase. Biosci Biotechnol Biochem. 2005;69:819-28 pubmed
    ..These results suggest that insects have a novel type of fatty acyl-CoA synthetase. ..

More Information


  1. Zhao X, Feng D, Wang Q, Abdulla A, Xie X, Zhou J, et al. Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. J Clin Invest. 2012;122:2417-27 pubmed publisher
    ..Taken together, these results demonstrate that CDK8 and CycC function as evolutionarily conserved components of the insulin signaling pathway in regulating lipid homeostasis. ..
  2. Sujkowski A, Saunders S, Tinkerhess M, Piazza N, Jennens J, Healy L, et al. dFatp regulates nutrient distribution and long-term physiology in Drosophila. Aging Cell. 2012;11:921-32 pubmed publisher
    ..Here, we describe a heterozygous mutation in Drosophila (dFatp) that alters nutrient distribution and multiple aspects of physiology...
  3. Dourlen P, Bertin B, Chatelain G, Robin M, Napoletano F, Roux M, et al. Drosophila fatty acid transport protein regulates rhodopsin-1 metabolism and is required for photoreceptor neuron survival. PLoS Genet. 2012;8:e1002833 pubmed publisher
    ..In this study, we investigated a fatty acid transport protein (fatp) null mutation that caused adult-onset and progressive photoreceptor cell death...
  4. Coelho D, Domingos P. Physiological roles of regulated Ire1 dependent decay. Front Genet. 2014;5:76 pubmed publisher
    ..These studies demonstrate the importance of RIDD in tissues undergoing intense secretory function and highlight the physiologic role of RIDD during UPR activation in cells and organisms. ..
  5. Kory N, Thiam A, Farese R, Walther T. Protein Crowding Is a Determinant of Lipid Droplet Protein Composition. Dev Cell. 2015;34:351-63 pubmed publisher
    ..Moreover, the LD binding affinity determines protein localization during lipolysis. Our findings identify protein crowding as an important principle in determining LD protein composition. ..
  6. Speder P, Adam G, Noselli S. Type ID unconventional myosin controls left-right asymmetry in Drosophila. Nature. 2006;440:803-7 pubmed
    ..Like mouse inversin, Myo31DF interacts and colocalizes with beta-catenin, suggesting that situs inversus genes can direct left-right development through the adherens junction. ..