Gene Symbol: eya
Description: eyes absent
Alias: 24582246, BcDNA:LD16029, CG9554, CLI, CLIFT, Dmel\CG9554, EY2-1, EYA, Eya, cli, cli/eya, dEYA, del1, eay, ey-2, eyes absent, CG9554-PA, CG9554-PB, CG9554-PC, Eye absent, Eyes-absent, clift, delayed gonad formation 1, eya-PA, eya-PB, eya-PC, eyeless 2
Species: fruit fly
Products:     eya

Top Publications

  1. Xiong W, Dabbouseh N, Rebay I. Interactions with the Abelson tyrosine kinase reveal compartmentalization of eyes absent function between nucleus and cytoplasm. Dev Cell. 2009;16:271-9 pubmed publisher
    b>Eyes absent (Eya), named for its role in Drosophila eye development but broadly conserved in metazoa, possesses dual functions as a transcriptional coactivator and protein tyrosine phosphatase...
  2. Ostrin E, Li Y, Hoffman K, Liu J, Wang K, Zhang L, et al. Genome-wide identification of direct targets of the Drosophila retinal determination protein Eyeless. Genome Res. 2006;16:466-76 pubmed
    ..Initial analysis reveals three genes, eyes absent, shifted, and Optix, as novel direct targets of Ey...
  3. Curtiss J, Mlodzik M. Morphogenetic furrow initiation and progression during eye development in Drosophila: the roles of decapentaplegic, hedgehog and eyes absent. Development. 2000;127:1325-36 pubmed
    ..In the eye disc, the transcription factors eyeless (ey), eyes absent (eya), sine oculis (so) and dachshund (dac) participate with these signaling molecules in a complex regulatory ..
  4. DeFalco T, Le Bras S, Van Doren M. Abdominal-B is essential for proper sexually dimorphic development of the Drosophila gonad. Mech Dev. 2004;121:1323-33 pubmed
    ..Our results indicate that Abd-B acts at multiple levels to regulate gonad development and that Abd-B class homeotic genes are conserved factors in establishing gonad sexual dimorphism in diverse species. ..
  5. Sheng G, Thouvenot E, Schmucker D, Wilson D, Desplan C. Direct regulation of rhodopsin 1 by Pax-6/eyeless in Drosophila: evidence for a conserved function in photoreceptors. Genes Dev. 1997;11:1122-31 pubmed
    ..These results suggest that Pax-6/Ey directly regulates rhodopsin 1 gene expression by binding to the conserved P3/RCS1 element in the promoter. ..
  6. Pignoni F, Hu B, Zavitz K, Xiao J, Garrity P, Zipursky S. The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development. Cell. 1997;91:881-91 pubmed
    Sine oculis (so) and eyes absent (eya) are required for Drosophila eye development and are founding members of the mammalian Six and Eya gene families...
  7. Bessa J, Gebelein B, Pichaud F, Casares F, Mann R. Combinatorial control of Drosophila eye development by eyeless, homothorax, and teashirt. Genes Dev. 2002;16:2415-27 pubmed
    ..A key step in the transition from an immature proliferative state to a committed state in eye development is the repression of hth by the BMP-4 homolog Decapentaplegic (Dpp). ..
  8. Boyle M, DiNardo S. Specification, migration and assembly of the somatic cells of the Drosophila gonad. Development. 1995;121:1815-25 pubmed
    ..Mutations in iab-4 abolish expression of abd A within these cells, and as a result block the coalescence of the gonad. ..
  9. Anderson A, Weasner B, Weasner B, Kumar J. Dual transcriptional activities of SIX proteins define their roles in normal and ectopic eye development. Development. 2012;139:991-1000 pubmed publisher
    ..These activities are thought to occur through physical interactions with the Eyes absent (Eya) co-activator and the Groucho (Gro) co-repressor, but the relative contribution that each complex makes to ..

More Information


  1. Meignin C, Alvarez Garcia I, Davis I, Palacios I. The salvador-warts-hippo pathway is required for epithelial proliferation and axis specification in Drosophila. Curr Biol. 2007;17:1871-8 pubmed
    ..This work highlights a novel connection between cell proliferation, cell growth, and axis specification in egg chambers. ..
  2. Firth L, Baker N. Retinal determination genes as targets and possible effectors of extracellular signals. Dev Biol. 2009;327:366-75 pubmed publisher
    ..mosaic studies establish that expression of the retinal determination genes eyeless, teashirt, homothorax, eyes absent, sine oculis, and dachshund are each regulated by combinations of Dpp, Hh, N, Wg, and Ras signals in Drosophila...
  3. Silver S, Rebay I. Signaling circuitries in development: insights from the retinal determination gene network. Development. 2005;132:3-13 pubmed
    ..Further study of the RDGN may provide insights into how common cues can generate context-specific responses, a key aspect of developmental regulation that remains poorly understood. ..
  4. Wawersik M, Milutinovich A, Casper A, Matunis E, Williams B, Van Doren M. Somatic control of germline sexual development is mediated by the JAK/STAT pathway. Nature. 2005;436:563-7 pubmed
    ..Our findings provide direct evidence that the JAK/STAT pathway mediates a key signal from the somatic gonad that regulates male germline sexual development. ..
  5. Salzer C, Kumar J. Identification of retinal transformation hot spots in developing Drosophila epithelia. PLoS ONE. 2010;5:e8510 pubmed publisher
  6. Jin M, Jusiak B, Bai Z, Mardon G. Eyes absent tyrosine phosphatase activity is not required for Drosophila development or survival. PLoS ONE. 2013;8:e58818 pubmed publisher
    b>Eyes absent (Eya) is an evolutionarily conserved transcriptional coactivator and protein phosphatase that regulates multiple developmental processes throughout the metazoans...
  7. Kango Singh M, Singh A, Henry Sun Y. Eyeless collaborates with Hedgehog and Decapentaplegic signaling in Drosophila eye induction. Dev Biol. 2003;256:49-60 pubmed
    ..Ectopic expression of ey can induce the expression of several eye-specification genes (eya, so, and dac) and induce eye formation in multiple locations on the body...
  8. Salzer C, Kumar J. Position dependent responses to discontinuities in the retinal determination network. Dev Biol. 2009;326:121-30 pubmed publisher
    ..is comprised of three genes, two (sine oculis and dachshund) of which code for DNA binding proteins and one (eyes absent) that encodes a transcriptional co-activator...
  9. Koontz L, Liu Chittenden Y, Yin F, Zheng Y, Yu J, Huang B, et al. The Hippo effector Yorkie controls normal tissue growth by antagonizing scalloped-mediated default repression. Dev Cell. 2013;25:388-401 pubmed publisher
    ..These findings fill a major gap in Hippo-mediated transcriptional regulation and open up possibilities for modulating the YAP oncoprotein in cancer and regenerative medicine. ..
  10. Zimmerman J, Bui Q, Liu H, Bonini N. Molecular genetic analysis of Drosophila eyes absent mutants reveals an eye enhancer element. Genetics. 2000;154:237-46 pubmed
    The eyes absent (eya) gene is critical for normal eye development in Drosophila and is highly conserved to vertebrates. To define regions of the gene critical for eye function, we have defined the mutations in the four viable eya alleles...
  11. Chen R, Amoui M, Zhang Z, Mardon G. Dachshund and eyes absent proteins form a complex and function synergistically to induce ectopic eye development in Drosophila. Cell. 1997;91:893-903 pubmed
    The eyeless, dachshund, and eyes absent genes encode conserved, nuclear proteins that are essential for eye development in Drosophila...
  12. Okegbe T, Dinardo S. The endoderm specifies the mesodermal niche for the germline in Drosophila via Delta-Notch signaling. Development. 2011;138:1259-67 pubmed publisher
    ..Because in mammals primordial germ cells also track through endoderm on their way to the genital ridge, our work raises the possibility that conserved mechanisms are employed to regulate germline niche formation...
  13. Datta R, Lurye J, Kumar J. Restriction of ectopic eye formation by Drosophila teashirt and tiptop to the developing antenna. Dev Dyn. 2009;238:2202-10 pubmed publisher
    ..We also demonstrate that in addition to being expressed in coincident patterns within the developing eye, both paralogs are transcribed at very similar levels. ..
  14. Li Y, Jiang Y, Chen Y, Karandikar U, Hoffman K, Chattopadhyay A, et al. optix functions as a link between the retinal determination network and the dpp pathway to control morphogenetic furrow progression in Drosophila. Dev Biol. 2013;381:50-61 pubmed publisher
    ..In parallel, we find that optix is regulated by sine oculis and eyes absent, key members of the RD network...
  15. Bai J, Montell D. Eyes absent, a key repressor of polar cell fate during Drosophila oogenesis. Development. 2002;129:5377-88 pubmed
    ..Our studies reveal the gene eyes absent (eya) to be a key repressor of polar cell fate...
  16. Kenyon K, Ranade S, Curtiss J, Mlodzik M, Pignoni F. Coordinating proliferation and tissue specification to promote regional identity in the Drosophila head. Dev Cell. 2003;5:403-14 pubmed
    ..Drosophila eye-antennal epithelium by controlling the expression of selector genes for the eye (Eyeless/Pax6, Eyes absent) and/or antenna (Distal-less). Here, we investigate the function of these signaling pathways in this process...
  17. Koushika S, Lisbin M, White K. ELAV, a Drosophila neuron-specific protein, mediates the generation of an alternatively spliced neural protein isoform. Curr Biol. 1996;6:1634-41 pubmed
    ..The findings reported in this paper demonstrate that ELAV is necessary, and the ectopic expression of ELAV in imaginal disc cells is sufficient, to mediate neuron-specific alternative splicing. ..
  18. Weasner B, Salzer C, Kumar J. Sine oculis, a member of the SIX family of transcription factors, directs eye formation. Dev Biol. 2007;303:756-71 pubmed
    ..Taken together, these results shed new light on the role that so plays in eye specification. ..
  19. Baumgardt M, Karlsson D, Terriente J, Diaz Benjumea F, Thor S. Neuronal subtype specification within a lineage by opposing temporal feed-forward loops. Cell. 2009;139:969-82 pubmed publisher
    ..This mechanism of temporal and "subtemporal" genes acting in opposing feed-forward loops may be used by many stem cell lineages to generate diversity. ..
  20. Leatherman J, Dinardo S. Zfh-1 controls somatic stem cell self-renewal in the Drosophila testis and nonautonomously influences germline stem cell self-renewal. Cell Stem Cell. 2008;3:44-54 pubmed publisher
    ..In contrast, germline-intrinsic STAT activation was insufficient for GSC renewal. These data reveal unexpected complexity in cell interactions in the niche, implicating CPCs in GSC self-renewal. ..
  21. Liu X, Sano T, Guan Y, Nagata S, Hoffmann J, Fukuyama H. Drosophila EYA regulates the immune response against DNA through an evolutionarily conserved threonine phosphatase motif. PLoS ONE. 2012;7:e42725 pubmed publisher
    ..Here, we demonstrate that the unique Drosophila eya gene is also involved in the response specific to DNA...
  22. Kiger A, White Cooper H, Fuller M. Somatic support cells restrict germline stem cell self-renewal and promote differentiation. Nature. 2000;407:750-4 pubmed
  23. Lopes C, Casares F. hth maintains the pool of eye progenitors and its downregulation by Dpp and Hh couples retinal fate acquisition with cell cycle exit. Dev Biol. 2010;339:78-88 pubmed publisher
    ..We integrate these results in a model of the early steps of eye development that links proliferation control and differential gene expression with patterning signals. ..
  24. Abdelhak S, Kalatzis V, Heilig R, Compain S, Samson D, Vincent C, et al. A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family. Nat Genet. 1997;15:157-64 pubmed
    ..3 by positional cloning and shown to underlie the disease. This gene is a human homologue of the Drosophila eyes absent gene (eya), and was therefore called EYA1...
  25. Polesello C, Tapon N. Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch. Curr Biol. 2007;17:1864-70 pubmed
    ..The PCP members of the SWH network are not involved in this process, indicating that signaling upstream of Hpo varies according to developmental context. ..
  26. Brockmann A, Domínguez Cejudo M, Amore G, Casares F. Regulation of ocellar specification and size by twin of eyeless and homothorax. Dev Dyn. 2011;240:75-85 pubmed publisher
    ..of simple eyes located on the fly's dorsal head, by studying the expression, regulation, and function of toy, hth, eya, and so, members of the Pax6, Meis, Eya, and Six gene families...
  27. Clark I, Boyd J, Hamilton G, Finnegan D, Jarman A. D-six4 plays a key role in patterning cell identities deriving from the Drosophila mesoderm. Dev Biol. 2006;294:220-31 pubmed
    ..Misexpression analysis suggests that D-Six4 and its likely cofactor, Eyes absent, are sufficient to impose these fates on other mesodermal cells...
  28. Halder G, Callaerts P, Gehring W. Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science. 1995;267:1788-92 pubmed
    ..Because homologous genes are present in vertebrates, ascidians, insects, cephalopods, and nemerteans, ey may function as a master control gene throughout the metazoa. ..
  29. Morillo S, Braid L, Verheyen E, Rebay I. Nemo phosphorylates Eyes absent and enhances output from the Eya-Sine oculis transcriptional complex during Drosophila retinal determination. Dev Biol. 2012;365:267-76 pubmed publisher
    ..Here, we report that the Nemo kinase positively and directly regulates Eyes absent (Eya)...
  30. DeFalco T, Verney G, Jenkins A, McCaffery J, Russell S, Van Doren M. Sex-specific apoptosis regulates sexual dimorphism in the Drosophila embryonic gonad. Dev Cell. 2003;5:205-16 pubmed
    ..Our work furthers the hypotheses that a conserved pathway controls gonad sexual dimorphism in diverse species and that sex-specific cell recruitment and programmed cell death are common mechanisms for creating sexual dimorphism. ..
  31. Kirby R, Hamilton G, Finnegan D, Johnson K, Jarman A. Drosophila homolog of the myotonic dystrophy-associated gene, SIX5, is required for muscle and gonad development. Curr Biol. 2001;11:1044-9 pubmed
  32. Hsiao F, Williams A, Davies E, Rebay I. Eyes absent mediates cross-talk between retinal determination genes and the receptor tyrosine kinase signaling pathway. Dev Cell. 2001;1:51-61 pubmed
    b>Eyes absent (eya) encodes a member of a network of nuclear transcription factors that promotes eye development in both vertebrates and invertebrates...
  33. Moore L, Broihier H, Van Doren M, Lehmann R. Gonadal mesoderm and fat body initially follow a common developmental path in Drosophila. Development. 1998;125:837-44 pubmed
    ..10 of embryogenesis, gonadal mesoderm and the fat body have not yet been specified as different cell types, but exist as a common pool of precursor cells requiring the functions of the tin, zfh-1 and cli genes for their development.
  34. Leiserson W, Benzer S, Bonini N. Dual functions of the Drosophila eyes absent gene in the eye and embryo. Mech Dev. 1998;73:193-202 pubmed
    In eyes absent (eya) mutants, eye progenitor cells undergo cell death early in development. Whereas the phenotype of eya1 is limited to the eye, other mutations are lethal...
  35. Braid L, Verheyen E. Drosophila nemo promotes eye specification directed by the retinal determination gene network. Genetics. 2008;180:283-99 pubmed publisher
    ..nmo genetically interacts with the retinal determination factors Eyeless (Ey), Eyes Absent (Eya), and Dachshund (Dac)...
  36. Punzo C, Seimiya M, Flister S, Gehring W, Plaza S. Differential interactions of eyeless and twin of eyeless with the sine oculis enhancer. Development. 2002;129:625-34 pubmed
    ..development is under the control of early eye specifying genes including eyeless (ey), twin of eyeless (toy), eyes absent (eya), dachshund (dac) and sine oculis (so)...
  37. Sprecher S, Reichert H, Hartenstein V. Gene expression patterns in primary neuronal clusters of the Drosophila embryonic brain. Gene Expr Patterns. 2007;7:584-95 pubmed
  38. Bonini N, Bui Q, Gray Board G, Warrick J. The Drosophila eyes absent gene directs ectopic eye formation in a pathway conserved between flies and vertebrates. Development. 1997;124:4819-26 pubmed
    The fly eyes absent (eya) gene which is essential for compound eye development in Drosophila, was shown to be functionally replaceable in eye development by a vertebrate Eya homolog...
  39. Seimiya M, Gehring W. The Drosophila homeobox gene optix is capable of inducing ectopic eyes by an eyeless-independent mechanism. Development. 2000;127:1879-86 pubmed
    ..of eyeless, whereas optix is expressed independently of eyeless; (3) sine oculis functions synergistically with eyes absent in eye development whereas optix does not; (4) ectopic expression of optix alone, but not of sine oculis can ..
  40. Van Doren M, Mathews W, Samuels M, Moore L, Broihier H, Lehmann R. fear of intimacy encodes a novel transmembrane protein required for gonad morphogenesis in Drosophila. Development. 2003;130:2355-64 pubmed
    ..Our findings that FOI is a cell-surface protein required in the mesoderm for gonad morphogenesis shed light on the function of this new family of proteins and on the molecular mechanisms of organogenesis. ..
  41. Jusiak B, Abulimiti A, Haelterman N, Chen R, Mardon G. MAPK target sites of eyes absent are not required for eye development or survival in Drosophila. PLoS ONE. 2012;7:e50776 pubmed publisher
    b>Eyes absent (Eya) is a highly conserved transcription cofactor and protein phosphatase that plays an essential role in eye development and survival in Drosophila...
  42. Weasner B, Weasner B, Deyoung S, Michaels S, Kumar J. Transcriptional activities of the Pax6 gene eyeless regulate tissue specificity of ectopic eye formation in Drosophila. Dev Biol. 2009;334:492-502 pubmed publisher
    ..The identification of both transcriptional activator and repressor activity within the Pax6 protein furthers our understanding of how this gene family regulates tissue determination. ..
  43. Karlsson D, Baumgardt M, Thor S. Segment-specific neuronal subtype specification by the integration of anteroposterior and temporal cues. PLoS Biol. 2010;8:e1000368 pubmed publisher
    ..This study reveals a surprisingly restricted, yet multifaceted, function of both anteroposterior and temporal cues with respect to lineage control and cell fate specification...
  44. Assa Kunik E, Torres I, Schejter E, Johnston D, Shilo B. Drosophila follicle cells are patterned by multiple levels of Notch signaling and antagonism between the Notch and JAK/STAT pathways. Development. 2007;134:1161-9 pubmed
  45. Baumgardt M, Miguel Aliaga I, Karlsson D, Ekman H, Thor S. Specification of neuronal identities by feedforward combinatorial coding. PLoS Biol. 2007;5:e37 pubmed
    ..These results indicate that a limited number of regulators may constitute a potent combinatorial code that dictates unique neuronal cell fate, and that such codes show a surprising disregard for many global instructive cues. ..
  46. Gómez J, Wang Y, Riechmann V. Tao controls epithelial morphogenesis by promoting Fasciclin 2 endocytosis. J Cell Biol. 2012;199:1131-43 pubmed publisher
    ..In wild-type cells, Tao initiated morphogenesis by promoting Fasciclin 2 endocytosis at the lateral membrane. Thus, we identify here a mechanism controlling the morphogenesis of a squamous epithelium. ..
  47. Pignoni F, Zipursky S. Induction of Drosophila eye development by decapentaplegic. Development. 1997;124:271-8 pubmed
    ..In addition, Dpp positively controls its own expression and suppresses wingless transcription. In contrast to the wing disc, Dpp does not appear to be the principal mediator of Hedgehog function in the eye. ..
  48. Halder G, Callaerts P, Flister S, Walldorf U, Kloter U, Gehring W. Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development. Development. 1998;125:2181-91 pubmed
    ..Here we identify sine oculis and eyes absent as two mediators of the eye-inducing activity of eyeless...
  49. Torres I, Lopez Schier H, St Johnston D. A Notch/Delta-dependent relay mechanism establishes anterior-posterior polarity in Drosophila. Dev Cell. 2003;5:547-58 pubmed
    ..The anterior-posterior axis is therefore established by a relay mechanism, which propagates polarity from one cyst to the next. ..
  50. Chang T, Mazotta J, Dumstrei K, Dumitrescu A, Hartenstein V. Dpp and Hh signaling in the Drosophila embryonic eye field. Development. 2001;128:4691-704 pubmed
    ..Regulatory genes that are required for eye/optic lobe fate, including sine oculis (so) and eyes absent (eya), are turned on in their respective domains by Dpp...
  51. Pappu K, Ostrin E, Middlebrooks B, Sili B, Chen R, Atkins M, et al. Dual regulation and redundant function of two eye-specific enhancers of the Drosophila retinal determination gene dachshund. Development. 2005;132:2895-905 pubmed
    ..and gain-of-function analyses suggest that the 3' eye enhancer is synergistically activated by a combination of eya, so and dpp signaling, and only indirectly activated by ey, whereas the 5' eye enhancer is primarily regulated by ..
  52. Zhang T, Ranade S, Cai C, Clouser C, Pignoni F. Direct control of neurogenesis by selector factors in the fly eye: regulation of atonal by Ey and So. Development. 2006;133:4881-9 pubmed
    ..The subordination of neurogenesis to the RD pathway in the eye provides a direct mechanism for the coordination of neurogenesis and tissue specification during sensory organ formation. ..
  53. Bui Q, Zimmerman J, Liu H, Bonini N. Molecular analysis of Drosophila eyes absent mutants reveals features of the conserved Eya domain. Genetics. 2000;155:709-20 pubmed
    The eyes absent (eya) gene is critical to eye formation in Drosophila; upon loss of eya function, eye progenitor cells die by programmed cell death...
  54. Bui Q, Zimmerman J, Liu H, Gray Board G, Bonini N. Functional analysis of an eye enhancer of the Drosophila eyes absent gene: differential regulation by eye specification genes. Dev Biol. 2000;221:355-64 pubmed
    ..We have focused on defining regulatory elements critical for Drosophila eyes absent (eya) expression...
  55. Mutsuddi M, Chaffee B, Cassidy J, Silver S, Tootle T, Rebay I. Using Drosophila to decipher how mutations associated with human branchio-oto-renal syndrome and optical defects compromise the protein tyrosine phosphatase and transcriptional functions of eyes absent. Genetics. 2005;170:687-95 pubmed
    b>Eyes absent (EYA) proteins are defined by a conserved C-terminal EYA domain (ED) that both contributes to its function as a transcriptional coactivator by mediating protein-protein interactions and possesses intrinsic protein tyrosine ..
  56. Pappu K, Chen R, Middlebrooks B, Woo C, Heberlein U, Mardon G. Mechanism of hedgehog signaling during Drosophila eye development. Development. 2003;130:3053-62 pubmed
    ..In this report, we demonstrate that the retinal determination gene eyes absent (eya) is the crucial link between the Hedgehog signaling pathway and photoreceptor differentiation...
  57. Bessa J, Casares F. Restricted teashirt expression confers eye-specific responsiveness to Dpp and Wg signals during eye specification in Drosophila. Development. 2005;132:5011-20 pubmed
    ..Under these conditions, though, terminal eye differentiation proceeds only if tsh expression is transient. ..
  58. Silver S, Davies E, Doyon L, Rebay I. Functional dissection of eyes absent reveals new modes of regulation within the retinal determination gene network. Mol Cell Biol. 2003;23:5989-99 pubmed
    ..Here we present the results of structure-function analyses that reveal novel aspects of Eyes absent (EYA) function and regulation...
  59. Grammont M. Adherens junction remodeling by the Notch pathway in Drosophila melanogaster oogenesis. J Cell Biol. 2007;177:139-50 pubmed
    ..This provides new evidence that Notch, besides playing a key role in cell differentiation, also controls cell morphogenesis. ..
  60. Blanco J, Seimiya M, Pauli T, Reichert H, Gehring W. Wingless and Hedgehog signaling pathways regulate orthodenticle and eyes absent during ocelli development in Drosophila. Dev Biol. 2009;329:104-15 pubmed publisher
    ..primordium development and determined its involvement in the expression of the retinal determination gene eyes absent (eya)...
  61. Yeh P, Yang W, Chiang P, Wang S, Chang M, Chang C. Drosophila eyes absent is a novel mRNA target of the tristetraprolin (TTP) protein DTIS11. Int J Biol Sci. 2012;8:606-19 pubmed publisher
    ..of mouse TIS11b or DTIS11 in the Drosophila retina dramatically reduced eye size, similar to the phenotype of eyes absent (eya) mutants. The eya transcript is one of many ARE-containing mRNAs in Drosophila...
  62. Kawakami K, Sato S, Ozaki H, Ikeda K. Six family genes--structure and function as transcription factors and their roles in development. Bioessays. 2000;22:616-26 pubmed
    ..Six-type homeodomain, both of which are essential for specific DNA binding and for cooperative interactions with Eya proteins...
  63. Singh S, Zheng Z, Wang H, Oh S, Chen X, Hou S. Competitiveness for the niche and mutual dependence of the germline and somatic stem cells in the Drosophila testis are regulated by the JAK/STAT signaling. J Cell Physiol. 2010;223:500-10 pubmed publisher
    ..These data suggest that a single JAK/STAT signal from the niche orchestrate the competitive and dependent co-existence of GSCs and CPCs in the Drosophila testis niche. ..
  64. Hazelett D, Bourouis M, Walldorf U, Treisman J. decapentaplegic and wingless are regulated by eyes absent and eyegone and interact to direct the pattern of retinal differentiation in the eye disc. Development. 1998;125:3741-51 pubmed
    ..The eyes absent and eyegone genes encode members of a group of nuclear proteins required to specify the fate of the eye ..
  65. Hayashi T, Xu C, Carthew R. Cell-type-specific transcription of prospero is controlled by combinatorial signaling in the Drosophila eye. Development. 2008;135:2787-96 pubmed publisher
    ..The activity level, therefore, is dictated by the proper combination of highly cooperative selector and pre-pattern factors present in the cell...
  66. Atkins M, Jiang Y, Sansores Garcia L, Jusiak B, Halder G, Mardon G. Dynamic rewiring of the Drosophila retinal determination network switches its function from selector to differentiation. PLoS Genet. 2013;9:e1003731 pubmed publisher
    ..20 factors, whose core comprises twin of eyeless (toy), eyeless (ey), sine oculis (so), dachshund (dac), and eyes absent (eya)...
  67. Nanda S, DeFalco T, Loh S, Phochanukul N, Camara N, Van Doren M, et al. Sox100B, a Drosophila group E Sox-domain gene, is required for somatic testis differentiation. Sex Dev. 2009;3:26-37 pubmed publisher
  68. Starz Gaiano M, Melani M, Meinhardt H, Montell D. Interpretation of the UPD/JAK/STAT morphogen gradient in Drosophila follicle cells. Cell Cycle. 2009;8:2917-25 pubmed
    ..By combining biological experiments and mathematical modeling, we can achieve a more sophisticated understanding of how cells interpret molecular gradients. ..
  69. Datta R, Weasner B, Kumar J. A dissection of the teashirt and tiptop genes reveals a novel mechanism for regulating transcription factor activity. Dev Biol. 2011;360:391-402 pubmed publisher
    ..And finally we report that the physical interaction that has been described for Tsh and Homothorax (Hth) do not occur through the zinc finger domains. ..
  70. Erclik T, Hartenstein V, Lipshitz H, McInnes R. Conserved role of the Vsx genes supports a monophyletic origin for bilaterian visual systems. Curr Biol. 2008;18:1278-87 pubmed publisher
  71. Wang S, Tulina N, Carlin D, Rulifson E. The origin of islet-like cells in Drosophila identifies parallels to the vertebrate endocrine axis. Proc Natl Acad Sci U S A. 2007;104:19873-8 pubmed
    ..This ontogenic-molecular concordance suggests that a rudimentary brain endocrine axis was present in the common ancestor of humans and flies, where it orchestrated the islet-like endocrine functions of insulin and glucagon biology. ..
  72. Kenyon K, Li D, Clouser C, Tran S, Pignoni F. Fly SIX-type homeodomain proteins Sine oculis and Optix partner with different cofactors during eye development. Dev Dyn. 2005;234:497-504 pubmed publisher
  73. Miguel Aliaga I, Allan D, Thor S. Independent roles of the dachshund and eyes absent genes in BMP signaling, axon pathfinding and neuronal specification. Development. 2004;131:5837-48 pubmed
    ..We have found that the Dachshund (Dac) and Eyes Absent (Eya) transcription co-factors participate in this combinatorial code...
  74. Rayapureddi J, Kattamuri C, Steinmetz B, Frankfort B, Ostrin E, Mardon G, et al. Eyes absent represents a class of protein tyrosine phosphatases. Nature. 2003;426:295-8 pubmed
    The Eyes absent proteins are members of a conserved regulatory network implicated in the development of the eye, muscle, kidney and ear...
  75. Chen R, Halder G, Zhang Z, Mardon G. Signaling by the TGF-beta homolog decapentaplegic functions reiteratively within the network of genes controlling retinal cell fate determination in Drosophila. Development. 1999;126:935-43 pubmed
    ..cell fate determination in Drosophila is controlled by an interactive network of genes, including eyeless, eyes absent, sine oculis and dachshund...
  76. Jenkins A, McCaffery J, Van Doren M. Drosophila E-cadherin is essential for proper germ cell-soma interaction during gonad morphogenesis. Development. 2003;130:4417-26 pubmed
    ..E-cadherin expression in the gonad is dramatically decreased in fear of intimacy mutants, indicating that Fear of Intimacy may be a regulator of E-cadherin expression or function. ..
  77. Bonini N, Leiserson W, Benzer S. Multiple roles of the eyes absent gene in Drosophila. Dev Biol. 1998;196:42-57 pubmed
    The eyes absent (eya) gene plays an essential role in the events that lead to formation of the Drosophila eye; without expression of eya in retinal progenitor cells, they undergo programmed cell death just prior to the morphogenetic ..
  78. Baonza A, Freeman M. Control of Drosophila eye specification by Wingless signalling. Development. 2002;129:5313-22 pubmed
    ..between the retina and adjacent head structures by inhibiting the expression of the eye specification genes eyes absent, sine oculis and dachshund...