eve

Summary

Gene Symbol: eve
Description: even skipped
Alias: 10.5, 10.9, 14.10, 20.35, CG2328, Dmel\CG2328, E(eve), EVE, Eve, eve2, even, l(2)46CFg, l(2)46CFh, l(2)46CFj, l(2)46CFp, l(2)46Ce, l(2)46Cg, CG2328-PA, EVEN-SKIPPED, complementation group F, eve-PA, even-skiped, evenskip, evenskipped, group V, group VI, lethal(2)46Ce
Species: fruit fly

Top Publications

  1. ncbi Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    A H Brand
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Development 118:401-15. 1993
  2. doi Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila
    Katarzyna Oktaba
    EMBL, Gene Expression Programme, Heidelberg, Germany
    Dev Cell 15:877-89. 2008
  3. ncbi Mutations affecting segment number and polarity in Drosophila
    C Nusslein-Volhard
    Nature 287:795-801. 1980
  4. ncbi Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors
    M S Halfon
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Cell 103:63-74. 2000
  5. ncbi Altered electrical properties in Drosophila neurons developing without synaptic transmission
    R A Baines
    Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ United Kingdom
    J Neurosci 21:1523-31. 2001
  6. ncbi Regulation of the twist target gene tinman by modular cis-regulatory elements during early mesoderm development
    Z Yin
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Development 124:4971-82. 1997
  7. pmc Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservation
    Emily E Hare
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
    PLoS Genet 4:e1000106. 2008
  8. pmc Early even-skipped stripes act as morphogenetic gradients at the single cell level to establish engrailed expression
    M Fujioka
    Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Development 121:4371-82. 1995
  9. ncbi Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS
    J B Skeath
    Department of Cell and Structural Biology, Howard Hughes Medical Institute, University of Illinois, Urbana, Illinois 61801, USA
    Development 125:1857-65. 1998
  10. ncbi Evolutionary dynamics of the enhancer region of even-skipped in Drosophila
    M Z Ludwig
    Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA
    Mol Biol Evol 12:1002-11. 1995

Research Grants

  1. Pancreas-specific primary regulatory targets of Nkx2.2
    DERVLA MELLERICK DRESSLER; Fiscal Year: 2004
  2. HOW DOES VND INTEGRATE POSITIONAL INFORMATION?
    DERVLA MELLERICK DRESSLER; Fiscal Year: 2003
  3. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
  4. Mechanisms of Polycomb Silencing
    Yi Zhang; Fiscal Year: 2007
  5. REGULATORY CASCADES IN GASTROINTESTINAL PROLIFERATION
    KLAUS KAESTNER; Fiscal Year: 2006
  6. GENETIC AND MOLECULAR STUDIES OF NEUROGENESIS
    Chris Q Doe; Fiscal Year: 2010
  7. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2006
  8. Molecular and genetic analysis of sanpodo
    JAMES SKEATH; Fiscal Year: 2006
  9. Mechanisms Regulating Myoblast Fusion in Drosophila
    Mary Baylies; Fiscal Year: 2007
  10. Genetic Control of the Heart by Tinman, Pannier and Neuromancer
    Rolf Bodmer; Fiscal Year: 2011

Detail Information

Publications153 found, 100 shown here

  1. ncbi Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    A H Brand
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115
    Development 118:401-15. 1993
    ..We have used GAL4-directed transcription to expand the domain of embryonic expression of the homeobox protein even-skipped...
  2. doi Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila
    Katarzyna Oktaba
    EMBL, Gene Expression Programme, Heidelberg, Germany
    Dev Cell 15:877-89. 2008
    ..Analysis of cell cycle regulators indicates that the PcG system also dynamically modulates the expression levels of certain genes, providing a possible explanation for the tumor phenotype of PcG mutants...
  3. ncbi Mutations affecting segment number and polarity in Drosophila
    C Nusslein-Volhard
    Nature 287:795-801. 1980
    ....
  4. ncbi Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors
    M S Halfon
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Cell 103:63-74. 2000
    ..The integration of Pointed with the combinatorial effects of dTCF, Mad, Twist, and Tinman determines inductive Ras signaling specificity in muscle and heart development...
  5. ncbi Altered electrical properties in Drosophila neurons developing without synaptic transmission
    R A Baines
    Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ United Kingdom
    J Neurosci 21:1523-31. 2001
    ....
  6. ncbi Regulation of the twist target gene tinman by modular cis-regulatory elements during early mesoderm development
    Z Yin
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Development 124:4971-82. 1997
    ..We further show that the 180 bp enhancer also includes negatively acting sequences. Binding of Even-skipped to these sequences appears to reduce twist-dependent activation in a periodic fashion, thus producing a ..
  7. pmc Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservation
    Emily E Hare
    Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, California, United States of America
    PLoS Genet 4:e1000106. 2008
    ..We sequenced the even-skipped locus from six species of scavenger flies (Sepsidae) that are highly diverged from the model species ..
  8. pmc Early even-skipped stripes act as morphogenetic gradients at the single cell level to establish engrailed expression
    M Fujioka
    Jefferson Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Development 121:4371-82. 1995
    b>even-skipped (eve) has been proposed to set up parasegment borders at the anterior edge of each of its seven stripes by providing a sharp expression boundary, where engrailed is activated on one side and wingless on the other...
  9. ncbi Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS
    J B Skeath
    Department of Cell and Structural Biology, Howard Hughes Medical Institute, University of Illinois, Urbana, Illinois 61801, USA
    Development 125:1857-65. 1998
    ..Taken together, these results show that interactions between sanpodo, the Notch signaling pathway and numb enable CNS sibling neurons to acquire different fates...
  10. ncbi Evolutionary dynamics of the enhancer region of even-skipped in Drosophila
    M Z Ludwig
    Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA
    Mol Biol Evol 12:1002-11. 1995
    We report findings on naturally occurring variation in the regulatory region of even-skipped in Drosophila...
  11. pmc STAT is an essential activator of the zygotic genome in the early Drosophila embryo
    Amy Tsurumi
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York, United States of America
    PLoS Genet 7:e1002086. 2011
    ..We further show that STAT92E and Zelda synergistically regulate transcription. We conclude that STAT92E, in conjunction with Zelda, plays an important role in transcription of the zygotic genome at the onset of embryonic development...
  12. ncbi Developmental function of Elf-1: an essential transcription factor during embryogenesis in Drosophila
    S J Bray
    Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138
    Genes Dev 5:1672-83. 1991
    ..The results highlight the importance of genetic analysis in the study of proteins required for developmental regulation of gene expression...
  13. ncbi Requirements of DFR1/Heartless, a mesoderm-specific Drosophila FGF-receptor, for the formation of heart, visceral and somatic muscles, and ensheathing of longitudinal axon tracts in CNS
    E Shishido
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Bunkyo ku, Japan
    Development 124:2119-28. 1997
    ..DFR1 mutant phenotypes were partially mimicked by the targeted expression of activated Yan, thus demonstrating the MAP kinase pathway to be involved in differentiation of mesoderm...
  14. pmc Transcriptional integration of competence modulated by mutual repression generates cell-type specificity within the cardiogenic mesoderm
    Zhe Han
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Dev Biol 252:225-40. 2002
    ..of activating and repressing transcription factors work together to confine the expression of the homeobox gene even-skipped (eve) to a small region of the dorsal mesoderm...
  15. ncbi Complex regulation of early paired expression: initial activation by gap genes and pattern modulation by pair-rule genes
    T Gutjahr
    Institute of Molecular Biology II, University of Zurich, Switzerland
    Development 117:609-23. 1993
    ..Analysis of the initial paired expression in the primary pair-rule mutants even-skipped, runt and hairy, and in all gap mutants suggests that the products of the gap genes hunchback, Krüppel, ..
  16. pmc Differential and overlapping functions of two closely related Drosophila FGF8-like growth factors in mesoderm development
    Anna Klingseisen
    Division of Cell and Developmental Biology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Development 136:2393-402. 2009
    ..Furthermore, Pyr is essential for the specification of even-skipped-positive mesodermal precursors and Pyr and Ths are both required for the specification of a subset of ..
  17. ncbi Drosophila embryonic pattern repair: how embryos respond to bicoid dosage alteration
    R Namba
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Development 124:1393-403. 1997
    ..We also show that compression of the fate map does not appear to be repaired by the induction of new cell divisions. In addition, some tissues are more sensitive to fate map compression than others...
  18. ncbi Homeobox genes and axial patterning
    W McGinnis
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06511
    Cell 68:283-302. 1992
  19. pmc The Drosophila homolog of vertebrate Islet1 is a key component in early cardiogenesis
    Tabea Mann
    Institute for Biochemistry and Molecular Biology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    Development 136:317-26. 2009
    ..analyses for tup and pnr suggest that a proper balance of these factors is also required for the specification of Eve-expressing pericardial cells...
  20. doi A quantitative spatiotemporal atlas of gene expression in the Drosophila blastoderm
    Charless C Fowlkes
    Berkeley Drosophila Transcription Network Project, University of California, Irvine, CA 92697, USA
    Cell 133:364-74. 2008
    ..We present a VirtualEmbryo containing data for 95 genes at six time cohorts. We show that known gene-regulatory interactions can be automatically recovered from this data set and predict hundreds of new interactions...
  21. pmc Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution I: data acquisition pipeline
    Cris L Luengo Hendriks
    Berkeley Drosophila Transcription Network Project, Life Sciences Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720, USA
    Genome Biol 7:R123. 2006
    ..To model and thoroughly understand animal transcription networks, it is essential to derive accurate spatial and temporal descriptions of developing gene expression patterns with cellular resolution...
  22. ncbi Drosophila mef2 expression during mesoderm development is controlled by a complex array of cis-acting regulatory modules
    H T Nguyen
    Department of Medicine, Division of Cardiology, Forchheimer G42, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461, USA
    Dev Biol 204:550-66. 1998
    ....
  23. ncbi Individual stripe regulatory elements in the Drosophila hairy promoter respond to maternal, gap, and pair-rule genes
    G Riddihough
    Imperial Cancer Research Fund, Department of Zoology, University of Oxford, UK
    Genes Dev 5:840-54. 1991
    ..Our results suggest that different but overlapping subsets of gap genes regulate each stripe and that activation and repression are both important in generating the stripe pattern...
  24. ncbi Sequence-specific DNA-binding activities of the gap proteins encoded by hunchback and Krüppel in Drosophila
    D Stanojevic
    Department of Biological Sciences, Fairchild Center, Columbia University, New York, New York 10027
    Nature 341:331-5. 1989
    ..We also provide evidence that the on/off periodicity of the pair-rule gene even-skipped (eve) involves the interaction of the hb and Kr proteins with defined eve promoter elements.
  25. ncbi The even-skipped locus is contained in a 16-kb chromatin domain
    C Sackerson
    Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, Pennsylvania, 19107, USA
    Dev Biol 211:39-52. 1999
    The even-skipped (eve) gene of Drosophila melanogaster is a crucial member of the pair-rule class of segmentation genes...
  26. ncbi Wingless effects mesoderm patterning and ectoderm segmentation events via induction of its downstream target sloppy paired
    H H Lee
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Development 127:5497-508. 2000
    ..We also propose that in wg-expressing ectodermal cells, slp is an integral component in an autocrine feedback loop of Wg signaling...
  27. ncbi Dose-dependent regulation of pair-rule stripes by gap proteins and the initiation of segment polarity
    R Warrior
    Department of Biological Sciences, Fairchild Center, Columbia University, New York, NY 10027
    Development 110:759-67. 1990
    ..By the end of the fourteenth nuclear division cycle, the stripes of the pair-rule gene even-skipped (eve) sharpen and polarize, a process that is essential for the precisely localized expression of segment ..
  28. ncbi Early and late periodic patterns of even skipped expression are controlled by distinct regulatory elements that respond to different spatial cues
    T Goto
    Department of Biochemistry, Harvard University, Cambridge, Massachusetts 02138
    Cell 57:413-22. 1989
    ..We have identified the regulatory sequences required for the periodic expression of the Drosophila pair rule gene even skipped (eve)...
  29. ncbi even-skipped determines the dorsal growth of motor axons in Drosophila
    M Landgraf
    Department of Zoology, University of Cambridge, United Kingdom
    Neuron 22:43-52. 1999
    ..show that in the Drosophila embryo, motorneurons with targets in the dorsal muscle field express the homeobox gene even-skipped and that this expression is necessary and sufficient to direct motor axons into the dorsal muscle field...
  30. ncbi Autonomous determination of anterior structures in the early Drosophila embryo by the bicoid morphogen
    W Driever
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, FRG
    Development 109:811-20. 1990
    ..Our findings further support the notion that the concentration gradient of bcd protein, and not the existence of different forms of bcd protein, is responsible for specifying subregions of the embryo...
  31. pmc FlyEx, the quantitative atlas on segmentation gene expression at cellular resolution
    Andrei Pisarev
    Department of Computational Biology, St Petersburg State Polytechnical University, St Petersburg 195251, Russia
    Nucleic Acids Res 37:D560-6. 2009
    ..5 h of development. FlyEx supports the data downloads and construction of personal reference datasets, that makes it possible to more effectively use and analyze data...
  32. ncbi Dual functions of the heartless fibroblast growth factor receptor in development of the Drosophila embryonic mesoderm
    A M Michelson
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Genet 22:212-29. 1998
    ..Finally, parallels between requirements for FGFR signaling in Drosophila and vertebrate mesoderm development are considered...
  33. pmc Accessibility of transcriptionally inactive genes is specifically reduced at homeoprotein-DNA binding sites in Drosophila
    A Carr
    Department of Molecular Biophysics and Biochemistry, Yale University, PO Box 208114, 260 Whitney Avenue, New Haven, CT 06520 8114, USA
    Nucleic Acids Res 28:2839-46. 2000
    ....
  34. pmc Pre-steady-state decoding of the Bicoid morphogen gradient
    Sven Bergmann
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
    PLoS Biol 5:e46. 2007
    ..This can explain the surprisingly small shifts in gap and pair-rule gene expression domains observed in response to alterations in bcd dosage...
  35. ncbi The co-activator CREB-binding protein participates in enhancer-dependent activities of bicoid
    Dechen Fu
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Graduate Program in Molecular and Developmental Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    J Biol Chem 279:48725-33. 2004
    ..Together, these experiments suggest that dCBP is an enhancer-dependent co-activator of Bcd, facilitating its activation through multiple mechanisms...
  36. ncbi Motor neuron specification in worms, flies and mice: conserved and 'lost' mechanisms
    Stefan Thor
    Department of Neurobiology, Harvard Medical School, 220 Longwood Ave, Boston, Massachusetts 02115, USA
    Curr Opin Genet Dev 12:558-64. 2002
    ..By comparing findings from Caenorhabditis elegans, Drosophila and vertebrate model systems, it is apparent that both evolutionarily conserved and non-conserved mechanisms are used...
  37. ncbi Parcas, a regulator of non-receptor tyrosine kinase signaling, acts during anterior-posterior patterning and somatic muscle development in Drosophila melanogaster
    Karen Beckett
    Program in Developmental Biology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Weill Graduate School of Medical Science at Cornell University, New York, NY 10021, USA
    Dev Biol 299:176-92. 2006
    ..We propose that Pcs fulfils its distinct roles during development by the regulation of multiple NRTKs...
  38. ncbi Molecular integration of inductive and mesoderm-intrinsic inputs governs even-skipped enhancer activity in a subset of pericardial and dorsal muscle progenitors
    S Knirr
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Dev Biol 238:13-26. 2001
    ..The expression of the homeobox gene even-skipped (eve) identifies one specific subset of cells in the dorsal mesoderm, which give rise to particular ..
  39. ncbi huckebein is required for glial development and axon pathfinding in the neuroblast 1-1 and neuroblast 2-2 lineages in the Drosophila central nervous system
    T Bossing
    Institut fur Genetik, Universitat Mainz, Germany
    Mech Dev 55:53-64. 1996
    ....
  40. ncbi Par-1 regulates bicoid mRNA localisation by phosphorylating Exuperantia
    Veit Riechmann
    European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Development 131:5897-907. 2004
    ..Furthermore, our analysis reveals two phases of Exu-dependent bicoid mRNA localisation: an early phase that is strictly dependent on Exu phosphorylation and a late phase that is less phosphorylation dependent...
  41. ncbi Muscle patterning and specification in Drosophila
    M Ruiz-Gomez
    Department of Zoology, University of Cambridge, United Kingdom
    Int J Dev Biol 42:283-90. 1998
    ....
  42. ncbi Two new roles for the Drosophila AP patterning system in early morphogenesis
    J T Blankenship
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Development 128:5129-38. 2001
    ..Our results therefore suggest a link between cytoskeletal organization during cellularization and subsequent morphogenetic processes of gastrulation...
  43. ncbi Drosophila homeodomain protein dHb9 directs neuronal fate via crossrepressive and cell-nonautonomous mechanisms
    Heather T Broihier
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 35:39-50. 2002
    ..We show that dHb9 regulates neuronal fate by restricting expression of Lim3 and Even-skipped (Eve), two homeodomain (HD) proteins required for development of distinct neuronal classes...
  44. ncbi Control of neuronal fate by the Drosophila segmentation gene even-skipped
    C Q Doe
    Department of Biological Sciences, Stanford University, California 94305
    Nature 333:376-8. 1988
    ..Here we show that another segmentation gene, even-skipped (eve), is expressed in a different but overlapping subset of neurons...
  45. pmc Transcription factors bind thousands of active and inactive regions in the Drosophila blastoderm
    Xiao Yong Li
    Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America
    PLoS Biol 6:e27. 2008
    ..their recognition sites are not unambiguously more constrained evolutionarily than the immediate flanking DNA, even in more highly bound and presumably functional regions, indicating that comparative DNA sequence analysis is ..
  46. pmc Developmental roles of 21 Drosophila transcription factors are determined by quantitative differences in binding to an overlapping set of thousands of genomic regions
    Stewart MacArthur
    Genomics Division, Lawrence Berkeley National Laboratory, Cyclotron Road MS 84 181, Berkeley, CA 94720, USA
    Genome Biol 10:R80. 2009
    ....
  47. ncbi Imaging neuronal subsets and other cell types in whole-mount Drosophila embryos and larvae using antibody probes
    N H Patel
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210
    Methods Cell Biol 44:445-87. 1994
  48. doi Mind bomb 2, a founder myoblast-specific protein, regulates myoblast fusion and muscle stability
    Marta Carrasco-Rando
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and UAM, Universidad Autonoma de Madrid, Madrid, Spain
    Development 135:849-57. 2008
    ..We suggest that Mib2 acts sequentially in myoblast fusion and sarcomeric stability by two separable processes involving distinct functions of Mib2...
  49. ncbi Concentration-dependent activities of the even-skipped protein in Drosophila embryos
    A S Manoukian
    Banting and Best Department of Medical Research, University of Toronto, C H Best Institute, Ontario, Canada
    Genes Dev 6:1740-51. 1992
    The Drosophila pair-rule gene even-skipped (eve) encodes a homeo-domain-containing protein (Eve) that is required for the development of both odd- and even-numbered parasegments...
  50. pmc The repressor activity of Even-skipped is highly conserved, and is sufficient to activate engrailed and to regulate both the spacing and stability of parasegment boundaries
    Miki Fujioka
    Department of Microbiology and Immunology, Thomas Jefferson University, JAH490, Philadelphia, PA 19107, USA
    Development 129:4411-21. 2002
    During segmentation of the Drosophila embryo, even skipped is required to activate engrailed stripes and to organize odd-numbered parasegments...
  51. pmc A genetic and molecular analysis of the 46C chromosomal region surrounding the FMRFamide neuropeptide gene in Drosophila melanogaster
    M A O'Brien
    Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, Missouri 63110
    Genetics 137:121-37. 1994
    ..One of these groups corresponds to even-skipped, the other 12 are previously unidentified...
  52. pmc Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells
    M Buescher
    Institute of Molecular and Cell Biology, National University of Singapore, Singapore
    Genes Dev 12:1858-70. 1998
    ..Moreover, our data suggest that the fate of some sibling neurons may be regulated by signals that do not require lateral interaction between the sibling cells...
  53. ncbi Regulation of a segmentation stripe by overlapping activators and repressors in the Drosophila embryo
    D Stanojevic
    Department of Biological Sciences, Fairchild Center, Columbia University, New York, NY 10027
    Science 254:1385-7. 1991
    ..Genetic studies suggested that even-skipped (eve) stripe 2 is controlled by three gap genes, hunchback (hb), Kruppel (Kr), and giant (gt), and by the ..
  54. ncbi Embryonic enhancers in the dpp disk region regulate a second round of Dpp signaling from the dorsal ectoderm to the mesoderm that represses Zfh-1 expression in a subset of pericardial cells
    A N Johnson
    Department of Biology, Arizona State University, Tempe, AZ 85287 1501, USA
    Dev Biol 262:137-51. 2003
    ....
  55. pmc Autoregulatory and gap gene response elements of the even-skipped promoter of Drosophila
    K Harding
    Department of Biological Sciences, Fairchild Center, Columbia University, New York, NY 10027
    EMBO J 8:1205-12. 1989
    The pair-rule gene even-skipped (eve) plays a key role in the regulatory hierarchy governing segmentation in Drosophila...
  56. ncbi Segregation of myogenic lineages in Drosophila requires numb
    M Ruiz Gomez
    Department of Zoology, Cambridge, UK
    Development 124:4857-66. 1997
    ..Numb acts to block Notch-mediated repression of genes expressed in muscle progenitor cells. Thus asymmetric cell divisions are essential determinants of muscle fates during myogenesis in Drosophila..
  57. ncbi Changing role of even-skipped during the evolution of insect pattern formation
    N H Patel
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Nature 357:339-42. 1992
    ..initially in alternate segments in a pair-rule pattern that reflects its known control by pair-rule genes such as even-skipped...
  58. ncbi Mechanism of eve stripe formation
    J Reinitz
    Brookdale Center for Molecular Biology, Mt Sinai School of Medicine, New York, NY 10029, USA
    Mech Dev 49:133-58. 1995
    In this paper we analyze the formation of stripes of expression of the pair-rule gene eve. We identify detailed mechanisms which control the formation of stripes 2-5...
  59. ncbi Rapid evolution of cis-regulatory sequences via local point mutations
    J R Stone
    Department of Ecology and Evolution, State University of New York at Stony Brook, USA
    Mol Biol Evol 18:1764-70. 2001
    ..b>Even combinations of two new binding sites evolve very quickly...
  60. pmc Even-skipped, acting as a repressor, regulates axonal projections in Drosophila
    Miki Fujioka
    Department of Microbiology and Immunology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA
    Development 130:5385-400. 2003
    Nervous system-specific eve mutants were created by removing regulatory elements from a 16 kb transgene capable of complete rescue of normal eve function...
  61. pmc Characterization of the Drosophila segment determination morphome
    Svetlana Surkova
    Department of Computational Biology, Center for Advanced Studies, St Petersburg State Polytechnical University, 29 Polytehnicheskaya Street, St Petersburg, 195251, Russia
    Dev Biol 313:844-62. 2008
    ..As the first quantitatively characterized morphogenetic field, this system and its behavior constitute an extraordinarily rich set of materials for the study of canalization and embryonic regulation at the molecular level...
  62. pmc Characterization and localization of the even-skipped protein of Drosophila
    M Frasch
    EMBO J 6:749-59. 1987
    On the basis of homeo box cross-homology we have isolated the pair-rule gene even-skipped (eve) of Drosophila. The eve transcription unit appears to be less than 1.5 kb in length, and encodes a single mRNA of approximately 1.4 kb...
  63. pmc Three-dimensional morphology and gene expression in the Drosophila blastoderm at cellular resolution II: dynamics
    Soile V E Keränen
    Berkeley Drosophila Transcription Network Project, Genomics Division, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, California 94720, USA
    Genome Biol 7:R124. 2006
    ..To accurately describe gene expression and computationally model animal transcriptional networks, it is essential to determine the changing locations of cells in developing embryos...
  64. pmc eyelid antagonizes wingless signaling during Drosophila development and has homology to the Bright family of DNA-binding proteins
    J E Treisman
    Skirball Institute of Biomolecular Medicine, NYU Medical Center, New York, New York 10016, USA
    Genes Dev 11:1949-62. 1997
    ..Based on this homology and on the phenotypic analysis, we suggest that Eld could act as a transcription factor antagonistic to the Wg pathway...
  65. ncbi Spacing ensures autonomous expression of different stripe enhancers in the even-skipped promoter
    S Small
    Department of Biology, UCSD, La Jolla 92093 0322
    Development 119:762-72. 1993
    The even-skipped (eve) promoter contains a series of enhancers that control the expression of different segmentation stripes in the Drosophila embryo. The stripe 3 enhancer is located 1.7 kb upstream of the stripe 2 enhancer...
  66. pmc A precise Bicoid gradient is nonessential during cycles 11-13 for precise patterning in the Drosophila blastoderm
    Elena M Lucchetta
    Department of Chemistry and Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois, USA
    PLoS ONE 3:e3651. 2008
    ..Therefore, it has not been tested explicitly whether a temporally stable Bicoid gradient prior to cellularization is required for precise patterning...
  67. ncbi A purified Drosophila homeodomain protein represses transcription in vitro
    M D Biggin
    Howard Hughes Medical Institute, Department of Biochemistry, University of California, Berkeley 94720
    Cell 58:433-40. 1989
    b>even-skipped (eve) is a homeodomain-encoding gene that is a genetically defined repressor of Ultrabithorax (Ubx), fushi-tarazu (ftz), and wingless (wg)...
  68. ncbi Partner of Numb colocalizes with Numb during mitosis and directs Numb asymmetric localization in Drosophila neural and muscle progenitors
    B Lu
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143 0725, USA
    Cell 95:225-35. 1998
    ..We propose that PON is one component of a multimolecular machinery that localizes Numb by responding to polarity cues conserved in neural precursors and epithelial cells...
  69. ncbi Integration of the head and trunk segmentation systems controls cephalic furrow formation in Drosophila
    A Vincent
    Department of Molecular Biology, Princeton University, New Jersey 08540, USA
    Development 124:3747-54. 1997
    ..may be defined by the overlapping expression of the head gap gene buttonhead (btd) and the primary pair-rule gene even-skipped (eve)...
  70. doi MulteeSum: a tool for comparative spatial and temporal gene expression data
    Miriah Meyer
    Harvard University, USA
    IEEE Trans Vis Comput Graph 16:908-17. 2010
    ..We justify our design decisions based on specific descriptions of the analysis needs of our collaborators, and provide anecdotal evidence of the efficacy of MulteeSum through a series of case studies...
  71. ncbi Glia maintain follower neuron survival during Drosophila CNS development
    G E Booth
    NeuroDevelopment Group, Department of Genetics, University of Cambridge, Cambridge, UK
    Development 127:237-44. 2000
    ..This differential requirement of neurons for glia is instructive in patterning and links control of cell number with axon guidance during CNS development...
  72. ncbi Sloppy paired acts as the downstream target of wingless in the Drosophila CNS and interaction between sloppy paired and gooseberry inhibits sloppy paired during neurogenesis
    K M Bhat
    Department of Cell Biology, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA
    Development 127:655-65. 2000
    ..This mechanism appears to be responsible for specifying NB5-3 identity to a row 5 neuroblast and preventing Wg from specifying NB4-2 identity to that cell...
  73. ncbi Evidence for stabilizing selection in a eukaryotic enhancer element
    M Z Ludwig
    Department of Ecology and Evolution, University of Chicago, Illinois 60637, USA
    Nature 403:564-7. 2000
    ..The even-skipped stripe 2 element controls the expression of the second transverse stripe of even-skipped messenger RNA in ..
  74. ncbi Segmentation: painting stripes from flies to vertebrates
    L Pick
    Brookdale Center for Developmental and Molecular Biology, Mt Sinai School of Medicine, New York, NY 10029, USA
    Dev Genet 23:1-10. 1998
  75. ncbi rolling pebbles (rols) is required in Drosophila muscle precursors for recruitment of myoblasts for fusion
    A Rau
    Developmental Biology, Philipps Universitat Marburg, 35032 Marburg, Germany
    Development 128:5061-73. 2001
    ..Transplantation assays of rols mutant mesodermal cells into wild-type embryos show that Rols is required in muscle precursor cells and is essential to recruit fusion-competent myoblasts for myotube formation...
  76. pmc Drosophila SNS, a member of the immunoglobulin superfamily that is essential for myoblast fusion
    B A Bour
    Department of Biochemistry and Molecular Biology, Penn State University, University Park, PA 16802 USA
    Genes Dev 14:1498-511. 2000
    ..To these ends, we demonstrate that the presence of SNS-expressing cells is absolutely dependent on Notch, and that expression of SNS does not require the myogenic regulatory protein MEF2...
  77. pmc Extraction of functional binding sites from unique regulatory regions: the Drosophila early developmental enhancers
    Dmitri A Papatsenko
    Department of Biology, New York University, New York, NY 10003 6688, USA
    Genome Res 12:470-81. 2002
    ..We also discuss the definition of true binding sites and the possible biological principles that govern patterning of regulatory regions and the distribution of transcriptional signals...
  78. pmc Bicoid cooperative DNA binding is critical for embryonic patterning in Drosophila
    Danielle Lebrecht
    Wadsworth Center, New York State Department of Health, 120 New Scotland Avenue, Albany, NY 12208, USA
    Proc Natl Acad Sci U S A 102:13176-81. 2005
    ..These failures in precise transcriptional control demonstrate the importance of cooperative DNA binding for embryonic patterning in vivo...
  79. pmc Formation of the BMP activity gradient in the Drosophila embryo
    Claudia Mieko Mizutani
    Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, California 92093, USA
    Dev Cell 8:915-24. 2005
    ....
  80. ncbi A high-throughput method for quantifying gene expression data from early Drosophila embryos
    Hilde Janssens
    Department of Applied Mathematics and Statistics, and Center for Developmental Genetics, Stony Brook University, Stony Brook, NY 11794 3600, USA
    Dev Genes Evol 215:374-81. 2005
    ..This method provides high-throughput quantification at cellular resolution...
  81. ncbi Drosophila homeodomain protein Nkx6 coordinates motoneuron subtype identity and axonogenesis
    Heather T Broihier
    Department of Genetics, Washington University School of Medicine, 4566 Scott Avenue, St Louis, MO 63110, USA
    Development 131:5233-42. 2004
    ..Thus, this work demonstrates that Nkx6 acts in a specific neuronal population to link neuronal subtype identity to neuronal morphology and connectivity...
  82. pmc Dynamical analysis of regulatory interactions in the gap gene system of Drosophila melanogaster
    Johannes Jaeger
    Department of Applied Mathematics and Statistics, Stony Brook University, Stony Brook, New York 11794 3600, USA
    Genetics 167:1721-37. 2004
    ..Finally, our models suggest a correlation between timing of gap domain boundary formation and regulatory contributions from the terminal maternal system...
  83. ncbi Charting the Drosophila neuropile: a strategy for the standardised characterisation of genetically amenable neurites
    Matthias Landgraf
    Department of Zoology, Downing Street, CB2 3EJ, Cambridge, UK
    Dev Biol 260:207-25. 2003
    ..Using the Fasciclin2-based mapping procedure as a standard (e.g., in a common database) would facilitate studies on the functional architecture of the neuropile and the identification of candiate circuit elements...
  84. ncbi Molecular markers for identified neuroblasts and ganglion mother cells in the Drosophila central nervous system
    C Q Doe
    Department of Cell and Structural Biology, University of Illinois, Urbana 61801
    Development 116:855-63. 1992
    ..These results set the stage for investigating neuroblast specification and the mechanisms controlling neuroblast cell lineages...
  85. pmc Regulation of even-skipped stripe 2 in the Drosophila embryo
    S Small
    Biology Department, UCSD, La Jolla 92093 0322
    EMBO J 11:4047-57. 1992
    ..and repressors specify sharp stripes of gene expression in the early embryo, we have conducted a detailed study of even-skipped (eve) stripe 2...
  86. ncbi Arthropod segmentation: beyond the Drosophila paradigm
    Andrew D Peel
    University Museum of Zoology, Department of Zoology, Downing Street, Cambridge CB2 3EJ, UK
    Nat Rev Genet 6:905-16. 2005
    ..A model is emerging, although slowly, for the way that arthropod segmentation mechanisms have evolved...
  87. pmc Postsynaptic expression of tetanus toxin light chain blocks synaptogenesis in Drosophila
    R A Baines
    Department of Zoology, University of Cambridge, Cambridge, CB2 3EJ, UK
    Curr Biol 9:1267-70. 1999
    ..Unexpectedly, we found that the cells that expressed TeTxLC, which were themselves incapable of evoked release, showed a dramatic reduction in synaptic input. We detected this reduction both electrophysiologically and ultrastructurally...
  88. ncbi The Drosophila EGF receptor controls the formation and specification of neuroblasts along the dorsal-ventral axis of the Drosophila embryo
    J B Skeath
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 125:3301-12. 1998
    ..that the concomitant loss of rhomboid and vein yield CNS phenotypes indistinguishable from DER mutant embryos, even though loss of either gene alone yields minor CNS phenotypes...
  89. ncbi Autoregulation of a segmentation gene in Drosophila: combinatorial interaction of the even-skipped homeo box protein with a distal enhancer element
    J Jiang
    Department of Biological Sciences, Fairchild Center, Columbia University, New York, New York 10027
    Genes Dev 5:265-77. 1991
    ..In the case of the segmentation gene even-skipped (eve), autoregulation is important for the specification of sharp stripes of gene expression at the onset ..
  90. ncbi Zebra patterns in fly embryos: activation of stripes or repression of interstripes?
    S B Carroll
    Laboratory of Molecular Biology, University of Wisconsin, Madison 53706
    Cell 60:9-16. 1990
    ..proximal upstream elements by the striped expression of other pair-rule genes, while others, such as hairy and eve, are largely regulated through distal upstream elements by the aperiodic gap genes (Figure 7)...
  91. ncbi Gap gene properties of the pair-rule gene runt during Drosophila segmentation
    C Tsai
    Department of Biochemistry and Cell Biology, State University of New York at Stony Brook 11794 5215
    Development 120:1671-83. 1994
    ..heat-shock promoter caused stripe-specific defects in the expression patterns of the pair-rule genes hairy and even-skipped but had a more uniform effect on the secondary pair-rule gene fushi tarazu...
  92. pmc Inscuteable and numb mediate asymmetric muscle progenitor cell divisions during Drosophila myogenesis
    A Carmena
    Centro de Biologia Molecular Severo Ochoa, C S I C Universidad Autonoma, 28049 Madrid, Spain
    Genes Dev 12:304-15. 1998
    ....
  93. ncbi Regulation of two pair-rule stripes by a single enhancer in the Drosophila embryo
    S Small
    Department of Biology, New York University, New York 10003, USA
    Dev Biol 175:314-24. 1996
    Previous studies on the regulation of the segmentation gene even-skipped (eve) have centered on the transcription of stripe 2...
  94. ncbi The eve stripe 2 enhancer employs multiple modes of transcriptional synergy
    D N Arnosti
    Department of Biology, UCSD, La Jolla 92093 0347, USA
    Development 122:205-14. 1996
    Previous studies have provided a detailed model for the regulation of even-skipped (eve) stripe 2 expression in the Drosophila embryo...
  95. ncbi Transcriptional repression in development
    S Gray
    Department of Biology, University of California, San Diego, La Jolla 92093 0347, USA
    Curr Opin Cell Biol 8:358-64. 1996
    ..The former permit enhancer autonomy in modular promoters, whereas the latter function in a dominant fashion to silence multiple enhancers...
  96. ncbi The Drosophila schnurri gene acts in the Dpp/TGF beta signaling pathway and encodes a transcription factor homologous to the human MBP family
    K Arora
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92717, USA
    Cell 81:781-90. 1995
    ..Genetic interactions and the strikingly similar phenotypes of mutations in shn and the dpp receptors encoded by thick veins and punt suggest that shn plays a downstream role in dpp signaling...
  97. ncbi The Drosophila toll gene functions zygotically and is necessary for proper motoneuron and muscle development
    M S Halfon
    Department of Biology, Yale University, New Haven, Connecticut 06520, USA
    Dev Biol 169:151-67. 1995
    ..The limited expressivity observed suggests that Toll is only one of several genes required for proper motoneuron and muscle specification...
  98. ncbi Rapid preparation of a panel of polyclonal antibodies to Drosophila segmentation proteins
    D Kosman
    Brookdale Center for Molecular Biology, Box 1126, Mt Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Dev Genes Evol 208:290-4. 1998
    ..Antigenicity of the purified recombinant proteins may be increased by precipitation in double-distilled water. The results of using the serums obtained for fluorescent staining of Drosophila embryos are shown...
  99. ncbi The Drosophila ATM homologue Mei-41 has an essential checkpoint function at the midblastula transition
    O C Sibon
    Department of Biochemistry and Cell Biology, Institute for Cell and Developmental Biology, State University of New York at Stony Brook, Stony Brook, New York, USA
    Curr Biol 9:302-12. 1999
    ....
  100. ncbi Non-periodic cues generate seven ftz stripes in the Drosophila embryo
    Y Yu
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mech Dev 50:163-75. 1995
    ..Furthermore, the seven ftz stripes are correctly established in embryos carrying mutations in h, eve or runt, with normal expression patterns decaying only after cellularization...
  101. ncbi The Drosophila homeobox genes zfh-1 and even-skipped are required for cardiac-specific differentiation of a numb-dependent lineage decision
    M T Su
    Department of Biology, University of Michigan, Ann Arbor, MI 48109 1048, USA
    Development 126:3241-51. 1999
    ..Here, we show that zfh-1 is specifically required for formation of the even-skipped (eve)-expressing subset of pericardial cells (EPCs), without affecting the formation of their siblings, the ..

Research Grants70

  1. Pancreas-specific primary regulatory targets of Nkx2.2
    DERVLA MELLERICK DRESSLER; Fiscal Year: 2004
    ..2 target genes. This knowledge may be highly instructive in defining those regulatory networks required for beta islet specification. ..
  2. HOW DOES VND INTEGRATE POSITIONAL INFORMATION?
    DERVLA MELLERICK DRESSLER; Fiscal Year: 2003
    ..These studies address the structure and function of vnd, a critical regulator of early neuronal development, and may serve as a prototype for vertebrate vnd-like genes. ..
  3. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ..129 ES lines maintain self-renewal under a wide range of conditions even in absence of mouse embryonic fibroblast (MEF) feeders if supplied with Bone Morphogenetic Protein (BMP) and ..
  4. Mechanisms of Polycomb Silencing
    Yi Zhang; Fiscal Year: 2007
    ..5. .Determine the transcriptional effect and understand the mechanism of H3K27 methylation and H2A ubiquitylation using a reconstituted chromatin transcription system. More description in proposal. ..
  5. REGULATORY CASCADES IN GASTROINTESTINAL PROLIFERATION
    KLAUS KAESTNER; Fiscal Year: 2006
    ..Together, these studies will further our understanding of the regulatory circuits that control gastrointestinal proliferation in normal development and carcinogenesis. ..
  6. GENETIC AND MOLECULAR STUDIES OF NEUROGENESIS
    Chris Q Doe; Fiscal Year: 2010
    ..Thus, we propose to continue our investigation of temporal patterning in the Drosophila CMS,with the goal of providing insight into the mechanisms regulating temporal patterning during mammalian neurogenesis. ..
  7. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2006
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  8. Molecular and genetic analysis of sanpodo
    JAMES SKEATH; Fiscal Year: 2006
    ....
  9. Mechanisms Regulating Myoblast Fusion in Drosophila
    Mary Baylies; Fiscal Year: 2007
    ....
  10. Genetic Control of the Heart by Tinman, Pannier and Neuromancer
    Rolf Bodmer; Fiscal Year: 2011
    ..Our goal is to elucidate the genetic basis of these diseases using the genetic model system Drosophila. Polygenic interactive genes identified in this project will directly provide new candidates for human heart disease genes. ..
  11. Molecular and genetic analysis of sanpodo
    JAMES SKEATH; Fiscal Year: 2009
    ..Such insight should help us understand the etiology of diseases in which this process is de-regulated and design new methods to treat these diseases. ..
  12. Mechanisms of Polycomb Silencing
    Yi Zhang; Fiscal Year: 2010
    ..5. .Determine the transcriptional effect and understand the mechanism of H3K27 methylation and H2A ubiquitylation using a reconstituted chromatin transcription system. More description in proposal. ..
  13. DEVELOPMENT OF IDENTIFIED MOTONEURONS
    Judith Eisen; Fiscal Year: 2009
    ..Our proposed studies will help reveal mechanisms that regulate motoneuron differentiation and survival, thus providing insights that should facilitate new therapies for treatment of motoneuron diseases and injury. ..
  14. Molecular and genetic analysis of sanpodo
    James B Skeath; Fiscal Year: 2010
    ..Such insight should help us understand the etiology of diseases in which this process is de-regulated and design new methods to treat these diseases. ..
  15. Polygenic basis of cardiac function in Drosophila melanogaster
    Rolf Bodmer; Fiscal Year: 2010
    ....
  16. Patterning of Drosphila Embryos by the Dorsal-dependent Gene Network
    ANGELIKE M STATHOPOULOS; Fiscal Year: 2010
    ....
  17. GENETIC AND MOLECULAR STUDIES OF NEUROGENESIS
    Chris Doe; Fiscal Year: 2009
    ..Thus, we propose to continue our investigation of temporal patterning in the Drosophila CNS, with the goal of providing insight into the mechanisms regulating temporal patterning during mammalian neurogenesis. ..
  18. DEVELOPMENT OF IDENTIFIED MOTONEURONS
    Judith Eisen; Fiscal Year: 2007
    ..Our proposed studies will provide insights that should facilitate new therapies for treatment of motoneuron diseases and injury. ..
  19. E1A-CtBP interactions in oncogenic transformations
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2007
    ..Our proposed studies will harness the knowledge gained from the study of the viral oncoprotein E1A to unravel potential new mechanisms governing oncogenesis and suggest strategies to inhibit the process in humans. ..
  20. DEVELOPMENT OF IDENTIFIED MOTONEURONS
    Judith Eisen; Fiscal Year: 2000
    ....
  21. GENETIC CONTROL OF CARDIAC CELL TYPES AND LINEAGES
    Rolf Bodmer; Fiscal Year: 2000
    ..the cytoplasmic factors encoded by numb and sanpodo and the nuclear transcription factors encoded by zfh-1 and evenskipped, (3) to determine if a recently isolated mouse zfh-1 gene is part of a new conserved gene family that plays a ..
  22. DEVELOPMENT OF IDENTIFIED MOTONEURONS
    Judith Eisen; Fiscal Year: 1993
    ..We will learn whether death of a specific motoneuron can be prevented, and we will learn its fate when it survives. We will learn whether motoneurons that do not typically behave as an equivalence pair can be induced to do so...
  23. ADENOVIRUS LP LOCUS: ROLE IN ONCOGENIC TRANSFORMATION
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 1990
    ..Since 175R T antigen is also localized on the nuclear envelope, we will investigate whether this protein could play a role in the nucleocytoplasmic transport of RNA via enhanced nucleoside triphophatase activity...
  24. MOLECULAR GENETIC ANALYSIS OF ASYMMETRIC CELL DIVISIONS
    Chris Doe; Fiscal Year: 2002
    ..We will do RNA and protein localization studies; our collaborator, Dr. G. Oliver will generate and assay the gene knock-out mice. ..
  25. REGULATORY CASCADES IN GASTROINTESTINAL PROLIFERATION
    KLAUS KAESTNER; Fiscal Year: 2001
    ..Together, these studies will further our understanding of the regulatory circuits that control gastrointestinal proliferation in normal development and carcinogenesis. ..
  26. Patterning of Drosphila Embryos by the Dorsal-dependent Gene Network
    Angelike Stathopoulos; Fiscal Year: 2009
    ....
  27. A Novel Mutagenesis Technology for Drosophila
    Charles Dearolf; Fiscal Year: 2003
    ..It will also allow the recovery of mutations without any selection based upon phenotype. Finally, this technology should ultimately be applicable to other model genetic organisms as well as to Drosophila. ..
  28. Mechanisms Regulating Myoblast Fusion in Drosophila
    Mary K Baylies; Fiscal Year: 2010
    ....
  29. REGULATORY CASCADES IN GASTROINTESTINAL PROLIFERATION
    Klaus H Kaestner; Fiscal Year: 2010
    ..Together, this proposal will further our understanding of GI development and cancer, and allow for the development of novel diagnostic and possibly therapeutic tools in the future. ..
  30. BH3-only protein BNIP3 in tumor progression
    GOVINDASWAMY CHINNADURAI; Fiscal Year: 2006
    ..Our results may also provide the experimental support to suggest that BNIP3 may be a new prognostic marker for human cancer. ..