Gene Symbol: ERO1 L
Description: Endoplasmic reticulum oxidoreductin-1-like
Alias: CG1333, Dmel\CG1333, ERO1-L, Ero1l, ero1L, kiga, l(3)64Ag, l(3)SH22, endoplasmic reticulum oxidoreductin-1-like, CG1333-PB, Ero1L-PB, endoplasmic reticulum oxidoreductin-1L, lethal (3) 64Ag
Species: fruit fly

Top Publications

  1. Harrison S, Solomon N, Rubin G. A genetic analysis of the 63E-64A genomic region of Drosophila melanogaster: identification of mutations in a replication factor C subunit. Genetics. 1995;139:1701-9 pubmed
    ..In addition we have isolated 11 new mutant alleles of the disembodied gene. ..
  2. Cabibbo A, Pagani M, Fabbri M, Rocchi M, Farmery M, Bulleid N, et al. ERO1-L, a human protein that favors disulfide bond formation in the endoplasmic reticulum. J Biol Chem. 2000;275:4827-33 pubmed
    ..ERO1-L is no longer functional when either one of the highly conserved Cys-394 or Cys-397 is mutated. These results strongly suggest that ERO1-L is involved in oxidative ER protein folding in mammalian cells. ..
  3. Wang L, Ryoo H, Qi Y, Jasper H. PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress. PLoS Genet. 2015;11:e1005220 pubmed publisher
    ..Our studies highlight the significance of the PERK branch of the unfolded protein response of the ER (UPRER) in intestinal homeostasis and provide a viable strategy to improve organismal health- and lifespan. ..
  4. Kulkarni S, Newby L, Jackson F. Drosophila GABAergic systems. II. Mutational analysis of chromosomal segment 64AB, a region containing the glutamic acid decarboxylase gene. Mol Gen Genet. 1994;243:555-64 pubmed
    ..Both of these rearrangements are associated with embryonic lethality and decreased GAD enzymatic activity. ..
  5. Ryoo H. Drosophila as a model for unfolded protein response research. BMB Rep. 2015;48:445-53 pubmed
    ..The fact that the basic UPR pathways are conserved, together with the availability of many human disease models in this organism, makes Drosophila a powerful tool for studying human disease mechanisms. ..
  6. Clements M, Duncan D, Milbrandt J. Drosophila NAB (dNAB) is an orphan transcriptional co-repressor required for correct CNS and eye development. Dev Dyn. 2003;226:67-81 pubmed
    ..Similarly, dNAB overexpression in the eye causes eyes to be very small with few ommatidia. These dramatic eye-specific phenotypes will prove useful for enhancer/suppressor screens to identify dnab-interacting genes. ..
  7. Tien A, Rajan A, Schulze K, Ryoo H, Acar M, Steller H, et al. Ero1L, a thiol oxidase, is required for Notch signaling through cysteine bridge formation of the Lin12-Notch repeats in Drosophila melanogaster. J Cell Biol. 2008;182:1113-25 pubmed publisher
    ..a role in Notch signaling for a conserved thiol oxidase, endoplasmic reticulum (ER) oxidoreductin 1-like (Ero1L)...
  8. Malzer E, Szajewska Skuta M, Dalton L, Thomas S, Hu N, Skaer H, et al. Coordinate regulation of eIF2α phosphorylation by PPP1R15 and GCN2 is required during Drosophila development. J Cell Sci. 2013;126:1406-15 pubmed publisher
    ..Moreover, we show that its expression is necessary for embryonic and larval development and that this is to oppose the inhibitory effects of GCN2 on anabolic growth. ..