Gene Symbol: Epac
Description: Exchange protein directly activated by cAMP
Alias: CG15235, CG3427, CG34392, D-EPAC, D-Epac, Dm_2R:10367, Dmel\CG34392, Dmel_CG15235, Dmel_CG3427, epac, exchange protein directly activated by cAMP, CG34392-PD, CG34392-PE, CG34392-PF, CG34392-PG, Epac-PD, Epac-PE, Epac-PF, Epac-PG, epac guanine nucleotide exchange factor, exchange protein directly activated by cAMP ortholog
Species: fruit fly

Top Publications

  1. Schneider C, Will C, BROSIUS J, Frilander M, Luhrmann R. Identification of an evolutionarily divergent U11 small nuclear ribonucleoprotein particle in Drosophila. Proc Natl Acad Sci U S A. 2004;101:9584-9 pubmed
    ..A comparison of U11 snRNAs that we have identified from vertebrates, plants, and insects, suggests that an evolutionarily divergent U11 snRNA may be unique to Drosophila and not characteristic of insects in general. ..
  2. Dupuy A, L Hoste S, Cherfils J, Camonis J, Gaudriault G, de Gunzburg J. Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac. Oncogene. 2005;24:4509-20 pubmed
    ..In cellular models where Rap1 is activated via endogenous GEFs, the Rap1[S17A] mutant inhibits both the cAMP-Epac and EGF-C3G pathways, whereas Rap1[G15D] selectively interferes with the latter...
  3. Boyle M, French R, Cosand K, Dorman J, Kiehart D, Berg C. Division of labor: subsets of dorsal-appendage-forming cells control the shape of the entire tube. Dev Biol. 2010;346:68-79 pubmed publisher
    ..Gbeta mutant floor cells are unable to control the width of the appendage while Gbeta mutant leading roof cells fail to direct the elongation of the appendage and the convergent-extension of the roof-cell population. ..
  4. Praveen K, Wen Y, Matera A. A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects. Cell Rep. 2012;1:624-31 pubmed publisher
    ..These findings have major implications for SMA etiology because they show that SMN's role in snRNP biogenesis can be uncoupled from the organismal viability and locomotor defects. ..
  5. Efetova M, Petereit L, Rosiewicz K, Overend G, Haußig F, Hovemann B, et al. Separate roles of PKA and EPAC in renal function unraveled by the optogenetic control of cAMP levels in vivo. J Cell Sci. 2013;126:778-88 pubmed publisher
    ..via cAMP-dependent effectors such as protein kinase A (PKA) and/or exchange proteins directly activated by cAMP (EPAC)...
  6. Wang J, Lindholm J, Willis D, Orth A, Goodman W. Juvenile hormone regulation of Drosophila Epac--a guanine nucleotide exchange factor. Mol Cell Endocrinol. 2009;305:30-7 pubmed publisher
    ..transcription polymerase chain reaction (qRT-PCR) was used to characterize the effects of juvenile hormone (JH) on Epac (Exchange Protein directly Activated by Cyclic AMP; NM_001103732), a guanine nucleotide exchange factor for Rap1 in ..
  7. van Dam T, Rehmann H, Bos J, Snel B. Phylogeny of the CDC25 homology domain reveals rapid differentiation of Ras pathways between early animals and fungi. Cell Signal. 2009;21:1579-85 pubmed publisher
    ..Finally, a comparison of the domain composition of the Ras guanine nucleotide exchange factors shows that domain addition and diversification occurred both prior to and after the fungal-animal split. ..
  8. Lin C, Mount S, Jarmołowski A, Makałowski W. Evolutionary dynamics of U12-type spliceosomal introns. BMC Evol Biol. 2010;10:47 pubmed publisher
    ..Loss of U12 introns or the genes containing them is more common than conversion to the U2-type. The degeneracy of U12-type terminal dinucleotides among natural U12-type introns is higher than previously thought. ..
  9. Reid D, Muyskens J, Neal J, Gaddini G, Cho L, Wandler A, et al. Identification of genetic modifiers of CagA-induced epithelial disruption in Drosophila. Front Cell Infect Microbiol. 2012;2:24 pubmed publisher
    ..Collectively, these results point to new cellular pathways whose disruption by CagA are likely to contribute to H. pylori-associated disease pathology. ..

More Information


  1. Shakiryanova D, Zettel G, Gu T, Hewes R, Levitan E. Synaptic neuropeptide release induced by octopamine without Ca2+ entry into the nerve terminal. Proc Natl Acad Sci U S A. 2011;108:4477-81 pubmed publisher
    ..requires cAMP-dependent protein kinase, with only a minor contribution of exchange protein activated by cAMP (epac)...
  2. Roberts O, Dart C. cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP). Biochem Soc Trans. 2014;42:89-97 pubmed publisher
    ..In the present paper, we review what is currently known about the role of Epac within blood vessels, particularly with regard to the regulation of vascular tone, endothelial barrier function and ..
  3. Richlitzki A, Latour P, Schwärzel M. Null EPAC mutants reveal a sequential order of versatile cAMP effects during Drosophila aversive odor learning. Learn Mem. 2017;24:210-215 pubmed publisher
    Here, we define a role of the cAMP intermediate EPAC in Drosophila aversive odor learning by means of null epac mutants...