Eno

Summary

Gene Symbol: Eno
Description: Enolase
Alias: BEST:LD15491, CG17654, CT32526, Dmel\CG17654, ENOA, Eno2, T18, anon-WO0153538.76, eno, enolase, CG17654-PA, CG17654-PB, CG17654-PC, CG17654-PD, CG17654-PE, CG17654-PF, Eno-PA, Eno-PB, Eno-PC, Eno-PD, Eno-PE, Eno-PF, phosphopyruvate hydratase
Species: fruit fly

Top Publications

  1. de la Cova C, Senoo Matsuda N, Ziosi M, Wu D, Bellosta P, Quinzii C, et al. Supercompetitor status of Drosophila Myc cells requires p53 as a fitness sensor to reprogram metabolism and promote viability. Cell Metab. 2014;19:470-83 pubmed publisher
    ..Our findings suggest that the initial confrontation between precancerous and WT cells could enhance cancer cell fitness and promote tumor progression. ..
  2. Lindsay H, Baines R, ffrench Constant R, Lilley K, Jacobs H, O Dell K. The dominant cold-sensitive Out-cold mutants of Drosophila melanogaster have novel missense mutations in the voltage-gated sodium channel gene paralytic. Genetics. 2008;180:873-84 pubmed publisher
    ..Therefore, in the absence of suitable vertebrate models, Ocd provides a system in which genetic, molecular, physiological, and behavioral tools can be exploited to determine mechanisms underlying sodium channel periodic paralyses...
  3. Nakahara K, Kim K, Sciulli C, Dowd S, Minden J, Carthew R. Targets of microRNA regulation in the Drosophila oocyte proteome. Proc Natl Acad Sci U S A. 2005;102:12023-8 pubmed
    ..The preponderance of genes that control global protein abundance suggests this process is under tight control by miRNAs at the onset of fertilization. ..
  4. Bishop J, Corces V. The nucleotide sequence of a Drosophila melanogaster enolase gene. Nucleic Acids Res. 1990;18:191 pubmed
  5. Harr B, Schlotterer C. Long microsatellite alleles in Drosophila melanogaster have a downward mutation bias and short persistence times, which cause their genome-wide underrepresentation. Genetics. 2000;155:1213-20 pubmed
    ..We propose that species-specific, size-dependent mutation spectra of microsatellite alleles may provide a general mechanism to account for the observed differences in microsatellite length between species. ..
  6. Schlotterer C, Agis M. Microsatellite analysis of Drosophila melanogaster populations along a microclimatic contrast at lower Nahel Oren canyon, Mount Carmel, Israel. Mol Biol Evol. 2002;19:563-8 pubmed
    ..melanogaster populations was low (F(ST) = 0.0012). Also a tree of individuals based on the proportion of shared alleles and a model-based clustering method provided no evidence for population substructuring. ..
  7. Terhzaz S, Southall T, Lilley K, Kean L, Allan A, Davies S, et al. Differential gel electrophoresis and transgenic mitochondrial calcium reporters demonstrate spatiotemporal filtering in calcium control of mitochondria. J Biol Chem. 2006;281:18849-58 pubmed
    ..The results highlight the dynamic nature and both spatial and temporal heterogeneity of calcium signaling possible in differentiated, organotypic cells and provide a new model for neuroendocrine control of V-ATPase. ..
  8. Sezgin E, Duvernell D, Matzkin L, Duan Y, Zhu C, Verrelli B, et al. Single-locus latitudinal clines and their relationship to temperate adaptation in metabolic genes and derived alleles in Drosophila melanogaster. Genetics. 2004;168:923-31 pubmed
    ..melanogaster of latitudinal clines for 23 SNPs embedded in 13 genes (Pgi, Gapdh1, UGPase, Pglym78, Pglym87, Eno, Men, Gdh, Sod, Pgk, Mdh1, TreS, Treh) representing various metabolic enzymes...
  9. Santaren J, Van Damme J, Puype M, Vandekerckhove J, Garcia Bellido A. Identification of Drosophila wing imaginal disc proteins by two-dimensional gel analysis and microsequencing. Exp Cell Res. 1993;206:220-6 pubmed
    ..As an illustration we present 12 of them: 8 corresponding to proteins already known in Drosophila and the 4 showing homologies with proteins of other organisms. ..

More Information

Publications23

  1. Paludo G, Lorenzatto K, Bonatto D, Ferreira H. Systems biology approach reveals possible evolutionarily conserved moonlighting functions for enolase. Comput Biol Chem. 2015;58:1-8 pubmed publisher
    Glycolytic enzymes, such as enolase, have been described as multifunctional complex proteins that also display non-glycolytic activities, termed moonlighting functions...
  2. Vinayagam A, ZIRIN J, Roesel C, Hu Y, Yilmazel B, Samsonova A, et al. Integrating protein-protein interaction networks with phenotypes reveals signs of interactions. Nat Methods. 2014;11:94-9 pubmed publisher
    ..We identified an unexpected role for the metabolic enzymes enolase and aldo-keto reductase as positive and negative regulators of proteolysis, respectively...
  3. Collier S, Lee H, Burgess R, Adler P. The WD40 repeat protein fritz links cytoskeletal planar polarity to frizzled subcellular localization in the Drosophila epidermis. Genetics. 2005;169:2035-45 pubmed
    ..We show that the fritz gene product functions cell-autonomously downstream of the core PCP proteins to regulate both the location and the number of wing cell prehair initiation sites. ..
  4. Bartolomé C, Maside X, Yi S, Grant A, Charlesworth B. Patterns of selection on synonymous and nonsynonymous variants in Drosophila miranda. Genetics. 2005;169:1495-507 pubmed
    ..The joint intensity of selection and biased gene conversion, in terms of the product of effective population size and the sum of the selection and conversion coefficients, was estimated to be approximately 0.65. ..
  5. Vierstraete E, Verleyen P, Sas F, Van den Bergh G, De Loof A, Arckens L, et al. The instantly released Drosophila immune proteome is infection-specific. Biochem Biophys Res Commun. 2004;317:1052-60 pubmed
    ..Next to known immune proteins, unannotated proteins were identified such as CG4306 protein, which has homologues with unknown function in all metazoan genome databases available today. ..
  6. Vierstraete E, Verleyen P, Baggerman G, D Hertog W, Van den Bergh G, Arckens L, et al. A proteomic approach for the analysis of instantly released wound and immune proteins in Drosophila melanogaster hemolymph. Proc Natl Acad Sci U S A. 2004;101:470-5 pubmed
    ..Determining the function of all of these immune-induced proteins represents an exciting challenge for increasing our knowledge of insect immunity. ..
  7. Hausdorf B. Early evolution of the bilateria. Syst Biol. 2000;49:130-42 pubmed
    ..Estimations of the divergence times show that the major bilaterian phyla did not originate in an explosive radiation during the Cambrian but rather that the Bilateria have a several hundred million years long Precambrian history. ..
  8. Buescher J, Musselman L, Wilson C, Lang T, Keleher M, Baranski T, et al. Evidence for transgenerational metabolic programming in Drosophila. Dis Model Mech. 2013;6:1123-32 pubmed publisher
    ..Our data indicate that nutritional programming mechanisms could be highly conserved and support the use of Drosophila as a model for evaluating the underlying genetic and epigenetic contributions to this phenomenon. ..
  9. Schriner S, Lee K, Truong S, Salvadora K, Maler S, Nam A, et al. Extension of Drosophila lifespan by Rhodiola rosea through a mechanism independent from dietary restriction. PLoS ONE. 2013;8:e63886 pubmed publisher
    ..The latter conclusion is especially relevant given the limited potential for DR to improve human health and lifespan, and presents R. rosea as a potential viable candidate to treat aging and age-related diseases in humans. ..
  10. Xie T, Ding D. Investigating 42 candidate orthologous protein groups by molecular evolutionary analysis on genome scale. Gene. 2000;261:305-10 pubmed
    ..The result could imply that the classical one-to-one orthology might be not as common as typically accepted and automated similarity-based methods should be used with caution when accurate orthology/paralogy discrimination is required. ..
  11. Gao M, Thomson T, Creed T, Tu S, Loganathan S, Jackson C, et al. Glycolytic enzymes localize to ribonucleoprotein granules in Drosophila germ cells, bind Tudor and protect from transposable elements. EMBO Rep. 2015;16:379-86 pubmed publisher
    ..Our data indicate that germ cells, similarly to stem cells and tumor cells, might prefer to produce energy through the glycolytic pathway, thus linking a particular metabolism to pluripotency. ..
  12. Bachtrog D, Agis M, Imhof M, Schlotterer C. Microsatellite variability differs between dinucleotide repeat motifs-evidence from Drosophila melanogaster. Mol Biol Evol. 2000;17:1277-85 pubmed
    ..Similar differences in mutation rates were obtained by an alternative method which estimates microsatellite mutation rates from their genomic length distribution. ..
  13. Sun C, Xu B, Liu X, Zhang Z, Su Z. Crystal structure of enolase from Drosophila melanogaster. Acta Crystallogr F Struct Biol Commun. 2017;73:228-234 pubmed publisher
    b>Enolase is an important enzyme in glycolysis and various biological processes. Its dysfunction is closely associated with diseases. Here, the enolase from Drosophila melanogaster (DmENO) was purified and crystallized...
  14. Flowers J, Sezgin E, Kumagai S, Duvernell D, Matzkin L, Schmidt P, et al. Adaptive evolution of metabolic pathways in Drosophila. Mol Biol Evol. 2007;24:1347-54 pubmed
    ..The data suggest that adaptive evolution of G6P branch point enzymes may have special significance in metabolic adaptation. ..