Genomes and Genes
Gene Symbol: Eno
Alias: BEST:LD15491, CG17654, CT32526, Dmel\CG17654, ENOA, Eno2, T18, anon-WO0153538.76, eno, enolase, CG17654-PA, CG17654-PB, CG17654-PC, CG17654-PD, CG17654-PE, CG17654-PF, Eno-PA, Eno-PB, Eno-PC, Eno-PD, Eno-PE, Eno-PF, phosphopyruvate hydratase
Species: fruit fly
- Paludo G, Lorenzatto K, Bonatto D, Ferreira H. Systems biology approach reveals possible evolutionarily conserved moonlighting functions for enolase. Comput Biol Chem. 2015;58:1-8 pubmed publisherGlycolytic enzymes, such as enolase, have been described as multifunctional complex proteins that also display non-glycolytic activities, termed moonlighting functions...
- Vinayagam A, ZIRIN J, Roesel C, Hu Y, Yilmazel B, Samsonova A, et al. Integrating protein-protein interaction networks with phenotypes reveals signs of interactions. Nat Methods. 2014;11:94-9 pubmed publisher..We identified an unexpected role for the metabolic enzymes enolase and aldo-keto reductase as positive and negative regulators of proteolysis, respectively...
- Collier S, Lee H, Burgess R, Adler P. The WD40 repeat protein fritz links cytoskeletal planar polarity to frizzled subcellular localization in the Drosophila epidermis. Genetics. 2005;169:2035-45 pubmed..We show that the fritz gene product functions cell-autonomously downstream of the core PCP proteins to regulate both the location and the number of wing cell prehair initiation sites. ..
- Bartolomé C, Maside X, Yi S, Grant A, Charlesworth B. Patterns of selection on synonymous and nonsynonymous variants in Drosophila miranda. Genetics. 2005;169:1495-507 pubmed..The joint intensity of selection and biased gene conversion, in terms of the product of effective population size and the sum of the selection and conversion coefficients, was estimated to be approximately 0.65. ..
- Vierstraete E, Verleyen P, Sas F, Van den Bergh G, De Loof A, Arckens L, et al. The instantly released Drosophila immune proteome is infection-specific. Biochem Biophys Res Commun. 2004;317:1052-60 pubmed..Next to known immune proteins, unannotated proteins were identified such as CG4306 protein, which has homologues with unknown function in all metazoan genome databases available today. ..
- Vierstraete E, Verleyen P, Baggerman G, D Hertog W, Van den Bergh G, Arckens L, et al. A proteomic approach for the analysis of instantly released wound and immune proteins in Drosophila melanogaster hemolymph. Proc Natl Acad Sci U S A. 2004;101:470-5 pubmed..Determining the function of all of these immune-induced proteins represents an exciting challenge for increasing our knowledge of insect immunity. ..
- Hausdorf B. Early evolution of the bilateria. Syst Biol. 2000;49:130-42 pubmed..Estimations of the divergence times show that the major bilaterian phyla did not originate in an explosive radiation during the Cambrian but rather that the Bilateria have a several hundred million years long Precambrian history. ..
- Buescher J, Musselman L, Wilson C, Lang T, Keleher M, Baranski T, et al. Evidence for transgenerational metabolic programming in Drosophila. Dis Model Mech. 2013;6:1123-32 pubmed publisher..Our data indicate that nutritional programming mechanisms could be highly conserved and support the use of Drosophila as a model for evaluating the underlying genetic and epigenetic contributions to this phenomenon. ..
- Schriner S, Lee K, Truong S, Salvadora K, Maler S, Nam A, et al. Extension of Drosophila lifespan by Rhodiola rosea through a mechanism independent from dietary restriction. PLoS ONE. 2013;8:e63886 pubmed publisher..The latter conclusion is especially relevant given the limited potential for DR to improve human health and lifespan, and presents R. rosea as a potential viable candidate to treat aging and age-related diseases in humans. ..
- Xie T, Ding D. Investigating 42 candidate orthologous protein groups by molecular evolutionary analysis on genome scale. Gene. 2000;261:305-10 pubmed..The result could imply that the classical one-to-one orthology might be not as common as typically accepted and automated similarity-based methods should be used with caution when accurate orthology/paralogy discrimination is required. ..
- Gao M, Thomson T, Creed T, Tu S, Loganathan S, Jackson C, et al. Glycolytic enzymes localize to ribonucleoprotein granules in Drosophila germ cells, bind Tudor and protect from transposable elements. EMBO Rep. 2015;16:379-86 pubmed publisher..Our data indicate that germ cells, similarly to stem cells and tumor cells, might prefer to produce energy through the glycolytic pathway, thus linking a particular metabolism to pluripotency. ..
- Bachtrog D, Agis M, Imhof M, Schlotterer C. Microsatellite variability differs between dinucleotide repeat motifs-evidence from Drosophila melanogaster. Mol Biol Evol. 2000;17:1277-85 pubmed..Similar differences in mutation rates were obtained by an alternative method which estimates microsatellite mutation rates from their genomic length distribution. ..
- Sun C, Xu B, Liu X, Zhang Z, Su Z. Crystal structure of enolase from Drosophila melanogaster. Acta Crystallogr F Struct Biol Commun. 2017;73:228-234 pubmed publisherb>Enolase is an important enzyme in glycolysis and various biological processes. Its dysfunction is closely associated with diseases. Here, the enolase from Drosophila melanogaster (DmENO) was purified and crystallized...
- Flowers J, Sezgin E, Kumagai S, Duvernell D, Matzkin L, Schmidt P, et al. Adaptive evolution of metabolic pathways in Drosophila. Mol Biol Evol. 2007;24:1347-54 pubmed..The data suggest that adaptive evolution of G6P branch point enzymes may have special significance in metabolic adaptation. ..