eIF-4E

Summary

Gene Symbol: eIF-4E
Description: Eukaryotic initiation factor 4E
Alias: 0260/09, 0587/11, 0589/11, 0919/12, 1004/13, 7238, CBP, CG4035, CT13384, CT39424, CT39426, D-eIF4E, Dmel\CG4035, EIF4E, Eif4E, Eif4e, IF4E, dEif4e, deIF-4E, deIF4E, eIF 4E, eIF-4E1, eIF-4E2, eIF-4EII, eIF-4e, eIF4E, eIF4E-1, eIF4E-1/2, eIF4E-2, eIF4E1, eIF4EI, eIF4e, eif-4E, eif-4e, eif4e, elF4E, l(3)07238, l(3)67Af, l(3)S025007, l(3)S026009, l(3)S058711, l(3)S091912, eukaryotic initiation factor 4E, CG4035-PA, CG4035-PB, CG4035-PC, CG4035-PD, CG4035-PE, CG4035-PF, CG4035-PG, CG4035-PH, CG4035-PI, cap binding protein, eIF-4E-PA, eIF-4E-PB, eIF-4E-PC, eIF-4E-PD, eIF-4E-PE, eIF-4E-PF, eIF-4E-PG, eIF-4E-PH, eIF-4E-PI, eukaryotic translation initiation factor 4E, lethal(3)67Af
Species: fruit fly
Products:     eIF-4E

Top Publications

  1. Zekri L, Kuzuoğlu Öztürk D, Izaurralde E. GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation. EMBO J. 2013;32:1052-65 pubmed publisher
    ..Here, we demonstrate that GW182 proteins decrease the association of eIF4E, eIF4G and PABP with miRNA targets...
  2. Nelson M, Leidal A, Smibert C. Drosophila Cup is an eIF4E-binding protein that functions in Smaug-mediated translational repression. EMBO J. 2004;23:150-9 pubmed
    ..Here we demonstrate that Smaug interacts with the Cup protein and that Cup is an eIF4E-binding protein that blocks the binding of eIF4G to eIF4E...
  3. Iwasaki S, Kawamata T, Tomari Y. Drosophila argonaute1 and argonaute2 employ distinct mechanisms for translational repression. Mol Cell. 2009;34:58-67 pubmed publisher
    ..In contrast, Ago2-RISC competitively blocks the interaction of eIF4E with eIF4G and inhibits the cap function...
  4. Kinkelin K, Veith K, Grünwald M, Bono F. Crystal structure of a minimal eIF4E-Cup complex reveals a general mechanism of eIF4E regulation in translational repression. RNA. 2012;18:1624-34 pubmed publisher
    Cup is an eIF4E-binding protein (4E-BP) that plays a central role in translational regulation of localized mRNAs during early Drosophila development...
  5. Wilhelm J, Hilton M, Amos Q, Henzel W. Cup is an eIF4E binding protein required for both the translational repression of oskar and the recruitment of Barentsz. J Cell Biol. 2003;163:1197-204 pubmed
    ..Surprisingly, Cup is also required to repress the translation of oskar. Furthermore, eukaryotic initiation factor 4E (eIF4E) is localized within the oocyte in a cup-dependent manner and binds directly to Cup in vitro...
  6. Cho P, Poulin F, Cho Park Y, Cho Park I, Chicoine J, Lasko P, et al. A new paradigm for translational control: inhibition via 5'-3' mRNA tethering by Bicoid and the eIF4E cognate 4EHP. Cell. 2005;121:411-23 pubmed
    ..Here, we show that d4EHP, an eIF4E-related cap binding protein, specifically interacts with Bcd to suppress cad translation...
  7. Lachance P, Miron M, Raught B, Sonenberg N, Lasko P. Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth. Mol Cell Biol. 2002;22:1656-63 pubmed
    b>Eukaryotic translation initiation factor 4E (eIF4E) binds to the cap structure at the 5' end of mRNAs and is a critical target for the control of protein synthesis...
  8. Hernández G, Vazquez Pianzola P, Sierra J, Rivera Pomar R. Internal ribosome entry site drives cap-independent translation of reaper and heat shock protein 70 mRNAs in Drosophila embryos. RNA. 2004;10:1783-97 pubmed
    ..In Drosophila mutant embryos devoid of the eukaryotic initiation factor 4E (eIF4E), reaper transcription is induced and apoptosis proceeds...
  9. Lee S, Lee J, Shin K, Yoo S. Translation initiation factor 4E (eIF4E) is regulated by cell death inhibitor, Diap1. Mol Cells. 2007;24:445-51 pubmed
    Translation initiation factor 4E (eIF4E) is a key regulator of protein synthesis. Abnormal regulation of eIF4E is closely linked to oncogenic transformation...

More Information

Publications81

  1. Hernández G, Altmann M, Sierra J, Urlaub H, Diez del Corral R, Schwartz P, et al. Functional analysis of seven genes encoding eight translation initiation factor 4E (eIF4E) isoforms in Drosophila. Mech Dev. 2005;122:529-43 pubmed
    The Drosophila genome-sequencing project has revealed a total of seven genes encoding eight eukaryotic initiation factor 4E (eIF4E) isoforms...
  2. Miron M, Verdu J, Lachance P, Birnbaum M, Lasko P, Sonenberg N. The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila. Nat Cell Biol. 2001;3:596-601 pubmed
    The initiation factor 4E for eukaryotic translation (eIF4E) binds the messenger RNA 5'-cap structure and is important in the regulation of protein synthesis...
  3. Zappavigna V, Piccioni F, Villaescusa J, Verrotti A. Cup is a nucleocytoplasmic shuttling protein that interacts with the eukaryotic translation initiation factor 4E to modulate Drosophila ovary development. Proc Natl Acad Sci U S A. 2004;101:14800-5 pubmed
    ..Cup was found to directly associate with eukaryotic translation initiation factor 4E (eIF4E)...
  4. Menon K, Sanyal S, Habara Y, Sanchez R, Wharton R, Ramaswami M, et al. The translational repressor Pumilio regulates presynaptic morphology and controls postsynaptic accumulation of translation factor eIF-4E. Neuron. 2004;44:663-76 pubmed
    ..The GluRIIa glutamate receptor is upregulated in pum mutants. These results, together with genetic epistasis studies, suggest that postsynaptic Pum modulates synaptic function via direct control of eIF-4E expression. ..
  5. Sigrist S, Thiel P, Reiff D, Lachance P, Lasko P, Schuster C. Postsynaptic translation affects the efficacy and morphology of neuromuscular junctions. Nature. 2000;405:1062-5 pubmed
    ..Genetic models of junctional plasticity and genetic manipulations using the translation initiation factors eIF4E and poly(A)-binding protein showed an increased occurrence of subsynaptic translation aggregates...
  6. Hernandez G, Sierra J. Translation initiation factor eIF-4E from Drosophila: cDNA sequence and expression of the gene. Biochim Biophys Acta. 1995;1261:427-31 pubmed
    ..Three transcripts of the eIF-4E gene were detected throughout Drosophila development. ..
  7. Maroto F, Sierra J. Purification and characterization of mRNA cap-binding protein from Drosophila melanogaster embryos. Mol Cell Biol. 1989;9:2181-90 pubmed
    ..Drosophila 35-kDa cap-binding protein (CBP) could also be isolated from the ribosomal high-salt wash as part of a salt-stable protein complex consisting of ..
  8. Nakamura A, Sato K, Hanyu Nakamura K. Drosophila cup is an eIF4E binding protein that associates with Bruno and regulates oskar mRNA translation in oogenesis. Dev Cell. 2004;6:69-78 pubmed
    ..Cup binds the 5'-cap binding translation initiation factor eIF4E through a sequence conserved among eIF4E binding proteins...
  9. Farny N, Kedersha N, Silver P. Metazoan stress granule assembly is mediated by P-eIF2alpha-dependent and -independent mechanisms. RNA. 2009;15:1814-21 pubmed publisher
    ..These results suggest that mammals evolved alternative mechanisms for dealing with thermal stress. ..
  10. Lavoie C, Lachance P, Sonenberg N, Lasko P. Alternatively spliced transcripts from the Drosophila eIF4E gene produce two different Cap-binding proteins. J Biol Chem. 1996;271:16393-8 pubmed
    b>Eukaryotic initiation factor 4E (eIF4E) is the subunit of eIF4F that binds to the cap structure at the 5' end of messenger RNA and is a critical component for the regulation of translation initiation...
  11. Shen R, Weng C, Yu J, Xie T. eIF4A controls germline stem cell self-renewal by directly inhibiting BAM function in the Drosophila ovary. Proc Natl Acad Sci U S A. 2009;106:11623-8 pubmed publisher
    ..Therefore, we propose that BAM functions as a translation repressor by interfering with translation initiation and eIF4A maintains self-renewal by inhibiting BAM function and promoting E-cadherin expression. ..
  12. Jäger E, Dorner S. The decapping activator HPat a novel factor co-purifying with GW182 from Drosophila cells. RNA Biol. 2010;7:381-5 pubmed
    ..Our findings implicate a potential interaction of the miRNA effector component GW182 with the decapping machinery. ..
  13. Imai Y, Gehrke S, Wang H, Takahashi R, Hasegawa K, Oota E, et al. Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J. 2008;27:2432-43 pubmed publisher
    ..Here, we show that both human LRRK2 and the Drosophila orthologue of LRRK2 phosphorylate eukaryotic initiation factor 4E (eIF4E)-binding protein (4E-BP), a negative regulator of eIF4E-mediated protein translation and a key ..
  14. McNeill H, Craig G, Bateman J. Regulation of neurogenesis and epidermal growth factor receptor signaling by the insulin receptor/target of rapamycin pathway in Drosophila. Genetics. 2008;179:843-53 pubmed publisher
    ..TOR regulates growth by controlling the activity of S6 kinase (S6K) and eIF4E. Loss of s6k delays differentiation, and is epistatic to the loss of tsc2, indicating that S6K acts downstream or ..
  15. Oldham S, Montagne J, Radimerski T, Thomas G, Hafen E. Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin. Genes Dev. 2000;14:2689-94 pubmed
    ..These results are consistent with dTOR residing on a parallel amino acid sensing pathway. ..
  16. Hernandez G, Diez Del Corral R, Santoyo J, Campuzano S, Sierra J. Localization, structure and expression of the gene for translation initiation factor eIF-4E from Drosophila melanogaster. Mol Gen Genet. 1997;253:624-33 pubmed
    ..It is ubiquitously expressed during embryogenesis but transcripts preferentially accumulate in certain tissues, particularly in the pole cells, at different developmental stages. ..
  17. Yarunin A, Harris R, Ashe M, Ashe H. Patterning of the Drosophila oocyte by a sequential translation repression program involving the d4EHP and Belle translational repressors. RNA Biol. 2011;8:904-12 pubmed publisher
    ..A critical step in translation initiation is the binding of the eukaryotic translation initiation factor 4E (eIF4E) to the mRNA cap structure, which ultimately leads to recruitment of the ribosome...
  18. Igreja C, Izaurralde E. CUP promotes deadenylation and inhibits decapping of mRNA targets. Genes Dev. 2011;25:1955-67 pubmed publisher
    CUP is an eIF4E-binding protein (4E-BP) that represses the expression of specific maternal mRNAs prior to their posterior localization. Here, we show that CUP employs multiple mechanisms to repress the expression of target mRNAs...
  19. Majzoub K, Hafirassou M, Meignin C, Goto A, Marzi S, Fedorova A, et al. RACK1 controls IRES-mediated translation of viruses. Cell. 2014;159:1086-1095 pubmed publisher
    ..Our findings demonstrate a specific function for RACK1 in selective mRNA translation and uncover a target for the development of broad antiviral intervention. ..
  20. Ferrero P, Layana C, Paulucci E, Gutierrez P, Hernández G, Rivera Pomar R. Cap binding-independent recruitment of eIF4E to cytoplasmic foci. Biochim Biophys Acta. 2012;1823:1217-24 pubmed publisher
    b>Eukaryotic translation initiation factor 4E (eIF4E) is required for cap-dependent initiation. In addition, eIF4E occurs in cytoplasmic foci such as processing bodies (PB) and stress granules (SG)...
  21. Fukaya T, Tomari Y. MicroRNAs mediate gene silencing via multiple different pathways in drosophila. Mol Cell. 2012;48:825-36 pubmed publisher
    ..Differential contribution from these multiple pathways may explain previous, apparently contradictory observations of how microRNAs inhibit protein synthesis. ..
  22. Tsokanos F, Albert M, Demetriades C, Spirohn K, Boutros M, Teleman A. eIF4A inactivates TORC1 in response to amino acid starvation. EMBO J. 2016;35:1058-76 pubmed publisher
    ..This effect is specific for eIF4F and not a general consequence of blocked translation. This study identifies specific components of the translation machinery as important mediators of TORC1 inactivation upon amino acid removal. ..
  23. Delanoue R, Slaidina M, Leopold P. The steroid hormone ecdysone controls systemic growth by repressing dMyc function in Drosophila fat cells. Dev Cell. 2010;18:1012-21 pubmed publisher
    ..In conclusion, the present work reveals an unexpected function of dMyc in the systemic control of growth in response to steroid hormone signaling. ..
  24. Khurana V, Lu Y, Steinhilb M, Oldham S, Shulman J, Feany M. TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model. Curr Biol. 2006;16:230-41 pubmed
    ..TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model, identifying TOR and the cell cycle as potential therapeutic targets in tauopathies and AD. ..
  25. Van Buskirk C, Schupbach T. Half pint regulates alternative splice site selection in Drosophila. Dev Cell. 2002;2:343-53 pubmed
    ..In particular, hfp mutants display striking defects in the developmentally regulated splicing of ovarian tumor (otu). Furthermore, transgenic expression of the missing otu splice form can rescue the ovarian phenotypes of hfp. ..
  26. Penney J, Tsurudome K, Liao E, Elazzouzi F, Livingstone M, González M, et al. TOR is required for the retrograde regulation of synaptic homeostasis at the Drosophila neuromuscular junction. Neuron. 2012;74:166-78 pubmed publisher
    ..Interestingly, heterozygosity for eIF4E, a critical component of the cap-binding protein complex, blocks the retrograde signal in all these cases...
  27. Myrick K, Dearolf C. Hyperactivation of the Drosophila Hop jak kinase causes the preferential overexpression of eIF1A transcripts in larval blood cells. Gene. 2000;244:119-25 pubmed
    ..Our results support the model that D-eIF1A is one of the target genes through which the Drosophila Jak kinase pathway regulates hemocyte development. ..
  28. Bernal A, Kimbrell D. Drosophila Thor participates in host immune defense and connects a translational regulator with innate immunity. Proc Natl Acad Sci U S A. 2000;97:6019-24 pubmed
    ..defined as critical regulators in a pathway that controls initiation of translation through binding eukaryotic initiation factor 4E (eIF4E)...
  29. DiAntonio A. Neurobiology. Translating activity into plasticity. Nature. 2000;405:1011-2 pubmed
  30. Hernández G, Lalioti V, Vandekerckhove J, Sierra J, Santarén J. Identification and characterization of the expression of the translation initiation factor 4A (eIF4A) from Drosophila melanogaster. Proteomics. 2004;4:316-26 pubmed
    ..We observed ubiquitous expression of eIF4A mRNA and protein during Drosophila embryogenesis. Yeast two-hybrid analysis demonstrated the in vivo interaction of Drosophila eIF4G with the N-terminal third of eIF4A. ..
  31. Sigrist S, Reiff D, Thiel P, Steinert J, Schuster C. Experience-dependent strengthening of Drosophila neuromuscular junctions. J Neurosci. 2003;23:6546-56 pubmed
    ..Such temporal mapping of experience-dependent adaptations at developing wild-type and mutant NMJs will provide detailed insights into the dynamic control of glutamatergic signal transmission. ..
  32. Friday A, Keiper B. Positive mRNA Translational Control in Germ Cells by Initiation Factor Selectivity. Biomed Res Int. 2015;2015:327963 pubmed publisher
    ..In this review, we focus on the selective, positive function of translation initiation factors eIF4E and eIF4G, which recruit mRNAs to ribosomes upon derepression...
  33. Reiling J, Doepfner K, Hafen E, Stocker H. Diet-dependent effects of the Drosophila Mnk1/Mnk2 homolog Lk6 on growth via eIF4E. Curr Biol. 2005;15:24-30 pubmed
    ..A key function in translation initiation is fulfilled by the 5' cap binding eukaryotic initiation factor 4E (eIF4E), and dysregulation of eIF4E is associated with malignant transformation and tumorigenesis ...
  34. Macdonald P. Translational control: a cup half full. Curr Biol. 2004;14:R282-3 pubmed
    ..The Cup protein is now found to have an important role in repression of both mRNAs, and apparently does so in a manner similar to the action of the Xenopus Maskin protein. ..
  35. Yan Y, Wang H, Chen H, Lindström Battle A, Jiao R. Ecdysone and insulin signaling play essential roles in readjusting the altered body size caused by the dGPAT4 mutation in Drosophila. J Genet Genomics. 2015;42:487-94 pubmed publisher
    ..Thus, we propose that a strategy has been evolved by the animals to reach final body size when challenged by genetic alterations, which requires the coordinated ecdysone and insulin signaling. ..
  36. Grewal S, Evans J, Edgar B. Drosophila TIF-IA is required for ribosome synthesis and cell growth and is regulated by the TOR pathway. J Cell Biol. 2007;179:1105-13 pubmed
    ..Stimulation of rRNA synthesis by TIF-IA may therefore provide a feed-forward mechanism to coregulate the levels of other ribosome components. ..
  37. Calap Quintana P, Soriano S, Llorens J, Al Ramahi I, Botas J, Moltó M, et al. TORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich's Ataxia. PLoS ONE. 2015;10:e0132376 pubmed publisher
    ..These results point to the TORC1 pathway as a new potential therapeutic target for FRDA and as a guide to finding new promising molecules for disease treatment. ..
  38. Duncan R. Rapamycin conditionally inhibits Hsp90 but not Hsp70 mRNA translation in Drosophila: implications for the mechanisms of Hsp mRNA translation. Cell Stress Chaperones. 2008;13:143-55 pubmed publisher
    ..characterized as one dedicated to translational regulation through modulating cap-dependent translation, involving eIF4E binding protein (eIF4E-BP) or 4E-BP...
  39. Chakkalakal J, Jasmin B. Localizing synaptic mRNAs at the neuromuscular junction: it takes more than transcription. Bioessays. 2003;25:25-31 pubmed
    ..Finally, we discuss the possibility that mis-regulation of post-transcriptional events can occur in certain neuromuscular diseases and cause abnormalities of the neuromuscular junction. ..
  40. Peter D, Weber R, Köne C, Chung M, Ebertsch L, Truffault V, et al. Mextli proteins use both canonical bipartite and novel tripartite binding modes to form eIF4E complexes that display differential sensitivity to 4E-BP regulation. Genes Dev. 2015;29:1835-49 pubmed publisher
    The eIF4E-binding proteins (4E-BPs) are a diverse class of translation regulators that share a canonical eIF4E-binding motif (4E-BM) with eIF4G...
  41. Jiang Y, Reichert H. Drosophila neural stem cells in brain development and tumor formation. J Neurogenet. 2014;28:181-9 pubmed publisher
    ..Here, the authors review the molecular genetics of Drosophila neuroblasts and discuss some recent advances in stem cell and cancer biology using this model system. ..
  42. Singh N, Morlock H, Hanes S. The Bin3 RNA methyltransferase is required for repression of caudal translation in the Drosophila embryo. Dev Biol. 2011;352:104-15 pubmed publisher
    ..reduced binding of Bicoid to the caudal 3' UTR, and (3) genetic interactions with bicoid, and with genes encoding eIF4E, Larp1, polyA binding protein (PABP), and Ago2...
  43. Glatter T, Schittenhelm R, Rinner O, Roguska K, Wepf A, Jünger M, et al. Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome. Mol Syst Biol. 2011;7:547 pubmed publisher
    ..Subsequent genetic studies in flies suggest a role for dTTT in controlling cell growth via a dTORC1- and dTORC2-dependent mechanism. ..
  44. Vazquez Pianzola P, Hernandez G, Suter B, Rivera Pomar R. Different modes of translation for hid, grim and sickle mRNAs in Drosophila. Cell Death Differ. 2007;14:286-95 pubmed
    ..Our results show that IRES-dependent initiation may play a role in the translation of Drosophila proapoptotic genes and suggest a variety of regulatory pathways. ..
  45. Carrera P, Johnstone O, Nakamura A, Casanova J, Jackle H, Lasko P. VASA mediates translation through interaction with a Drosophila yIF2 homolog. Mol Cell. 2000;5:181-7 pubmed
    ..We conclude that VAS regulates translation of germline mRNAs by specific interaction with dIF2, an essential factor conserved from bacteria to humans. ..
  46. Zacharogianni M, Aguilera Gomez A, Veenendaal T, Smout J, Rabouille C. A stress assembly that confers cell viability by preserving ERES components during amino-acid starvation. elife. 2014;3: pubmed publisher
    ..Taken together, we propose that the formation of these structures is a novel stress response mechanism to provide cell viability during and after nutrient stress. ..
  47. Ivshina M, Lasko P, Richter J. Cytoplasmic polyadenylation element binding proteins in development, health, and disease. Annu Rev Cell Dev Biol. 2014;30:393-415 pubmed publisher
    ..We review the biochemical features of the CPEB proteins, discuss their activities in several biological systems, and illustrate how understanding CPEB activity in model organisms has an important impact on neurological disease. ..
  48. Tettweiler G, Kowanda M, Lasko P, Sonenberg N, Hernández G. The Distribution of eIF4E-Family Members across Insecta. Comp Funct Genomics. 2012;2012:960420 pubmed publisher
    ..genomic sequences to investigate in insects the distribution of the genes encoding the cap-binding protein eIF4E, a protein that plays a crucial role in eukaryotic translation...
  49. Teleman A, Chen Y, Cohen S. 4E-BP functions as a metabolic brake used under stress conditions but not during normal growth. Genes Dev. 2005;19:1844-8 pubmed
    4E-BP is an important regulator of overall translation levels in cells. By binding eIF4E, 4E-BP impairs recruitment of the 40S ribosomal subunit to the cap structure present at the 5'-end of all eukaryotic cellular mRNAs...
  50. Lee S, Nahm M, Lee M, Kwon M, Kim E, Zadeh A, et al. The F-actin-microtubule crosslinker Shot is a platform for Krasavietz-mediated translational regulation of midline axon repulsion. Development. 2007;134:1767-77 pubmed
    ..Together, these data suggest that Kra-mediated translational regulation plays important roles in midline axon repulsion and that Shot functions as a direct physical link between translational regulation and cytoskeleton reorganization. ..
  51. Jeske M, Moritz B, Anders A, Wahle E. Smaug assembles an ATP-dependent stable complex repressing nanos mRNA translation at multiple levels. EMBO J. 2011;30:90-103 pubmed publisher
    ..In the embryo extract, recombinant Oskar relieves translational repression and deadenylation by preventing Smaug's binding to the SREs. ..
  52. Garrey J, Lee Y, Au H, Bushell M, Jan E. Host and viral translational mechanisms during cricket paralysis virus infection. J Virol. 2010;84:1124-38 pubmed publisher
    ..CrPV infection resulted in the dissociation of eukaryotic translation initiation factor 4G (eIF4G) and eIF4E early in infection and the induction of deIF2alpha phosphorylation at 3 h postinfection, which lags after the ..
  53. Wessells R, Fitzgerald E, Piazza N, Ocorr K, Morley S, Davies C, et al. d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila. Aging Cell. 2009;8:542-52 pubmed publisher
    ..d4eBP) is sufficient to protect long-term cardiac function against age-related decline and that up-regulation of dEif4e is sufficient to recapitulate the effects of high dTOR or insulin signaling...
  54. Oldham S, Hafen E. Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol. 2003;13:79-85 pubmed
    ..This review summarizes current studies primarily from Drosophila regarding the function of the insulin/IGF system in the control of growth. ..
  55. Lehner C. The beauty of small flies. Nat Cell Biol. 1999;1:E129-30 pubmed
  56. Yan N, Macdonald P. Genetic interactions of Drosophila melanogaster arrest reveal roles for translational repressor Bruno in accumulation of Gurken and activity of Delta. Genetics. 2004;168:1433-42 pubmed
    ..One is Lk6, which encodes a protein kinase predicted to regulate the rate-limiting initiation factor eIF4E. The second is Delta...
  57. Semotok J, Cooperstock R, Pinder B, Vari H, Lipshitz H, Smibert C. Smaug recruits the CCR4/POP2/NOT deadenylase complex to trigger maternal transcript localization in the early Drosophila embryo. Curr Biol. 2005;15:284-94 pubmed
    ..In contrast, Smaug-mediated translational repression is accomplished via an indirect interaction between Smaug and eIF4E, a component of the basic translation machinery...
  58. Shimada Y, Burn K, Niwa R, Cooley L. Reversible response of protein localization and microtubule organization to nutrient stress during Drosophila early oogenesis. Dev Biol. 2011;355:250-62 pubmed publisher
    ..This response implies a mechanism for preserving young egg chambers so that egg production can rapidly resume when nutrient availability improves. ..
  59. Ottone C, Galasso A, Gemei M, Pisa V, Gigliotti S, Piccioni F, et al. Diminution of eIF4E activity suppresses parkin mutant phenotypes. Gene. 2011;470:12-9 pubmed publisher
    ..Here we report that reducing the level of eukaryotic translation initiation factor 4E (eIF4E) activity specifically rescues the female sterile phenotypes associated with the parkin(..
  60. Nuzhdin S, Brisson J, Pickering A, Wayne M, Harshman L, McIntyre L. Natural genetic variation in transcriptome reflects network structure inferred with major effect mutations: insulin/TOR and associated phenotypes in Drosophila melanogaster. BMC Genomics. 2009;10:124 pubmed publisher
    ..In summary, our results question the assertion of the 'sparse' nature of genetic networks, while validating and extending candidate gene approaches in the analyses of complex traits. ..
  61. Lee L, Davies S, Liu J. The spinal muscular atrophy protein SMN affects Drosophila germline nuclear organization through the U body-P body pathway. Dev Biol. 2009;332:142-55 pubmed publisher
    ..Taken together, our results suggest that SMN is required for the functional integrity of the U body-P body pathway, which in turn is important for maintaining proper nuclear architecture. ..
  62. Gehrke S, Imai Y, SOKOL N, Lu B. Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression. Nature. 2010;466:637-41 pubmed publisher
    ..Our results implicate deregulated synthesis of E2F1/DP caused by the miRNA pathway impairment as a key event in LRRK2 pathogenesis and suggest novel miRNA-based therapeutic strategies. ..
  63. Gouw J, Pinkse M, Vos H, Moshkin Y, Verrijzer C, Heck A, et al. In vivo stable isotope labeling of fruit flies reveals post-transcriptional regulation in the maternal-to-zygotic transition. Mol Cell Proteomics. 2009;8:1566-78 pubmed publisher
  64. Liu S, Lu B. Reduction of protein translation and activation of autophagy protect against PINK1 pathogenesis in Drosophila melanogaster. PLoS Genet. 2010;6:e1001237 pubmed publisher
    ..Our results reveal complex cellular responses to PINK1 inactivation and suggest novel therapeutic strategies through manipulation of the compensatory responses. ..
  65. Sigrist S, Thiel P, Reiff D, Schuster C. The postsynaptic glutamate receptor subunit DGluR-IIA mediates long-term plasticity in Drosophila. J Neurosci. 2002;22:7362-72 pubmed
  66. Zapata J, Maroto F, Sierra J. Inactivation of mRNA cap-binding protein complex in Drosophila melanogaster embryos under heat shock. J Biol Chem. 1991;266:16007-14 pubmed
    We have studied the role of Drosophila 35-kDa cap-binding protein (CBP) and CBP complex in the mechanism of messenger RNA discrimination established in heat-shocked Drosophila embryos...
  67. Duncan R, Cavener D, Qu S. Heat shock effects on phosphorylation of protein synthesis initiation factor proteins eIF-4E and eIF-2 alpha in Drosophila. Biochemistry. 1995;34:2985-97 pubmed
    ..Several distinctive characteristics of this phosphoprotein suggest it is Drosophila eIF-4B. ..
  68. Pirone L, Xolalpa W, Sigurðsson J, Ramirez J, Pérez C, Gonzalez M, et al. A comprehensive platform for the analysis of ubiquitin-like protein modifications using in vivo biotinylation. Sci Rep. 2017;7:40756 pubmed publisher
    ..Ease of use and the flexibility to modify existing vectors will make the bioUbL system a powerful complement to existing strategies for studying this important mode of protein regulation. ..
  69. Ghosh S, Lasko P. Loss-of-function analysis reveals distinct requirements of the translation initiation factors eIF4E, eIF4E-3, eIF4G and eIF4G2 in Drosophila spermatogenesis. PLoS ONE. 2015;10:e0122519 pubmed publisher
    ..Testes-specific translation initiation factors eIF4E-3 and eIF4G2 are essential specifically for male fertility...
  70. Timakov B, Liu X, Turgut I, Zhang P. Timing and targeting of P-element local transposition in the male germline cells of Drosophila melanogaster. Genetics. 2002;160:1011-22 pubmed
    ..Our analysis shows that local transposition of the P element is highly regulated, displaying a cell-type specificity and a target specificity. ..
  71. Killip L, Grewal S. DREF is required for cell and organismal growth in Drosophila and functions downstream of the nutrition/TOR pathway. Dev Biol. 2012;371:191-202 pubmed publisher
    ..Given that DREF is conserved, this role may also be important in the control of growth in other animals. ..
  72. Ganesan S, Karr J, Featherstone D. Drosophila glutamate receptor mRNA expression and mRNP particles. RNA Biol. 2011;8:771-81 pubmed publisher
    ..These mRNA aggregates do not colocalize with eIF4E, but nevertheless presumably represent mRNP particles of unknown function...