Gene Symbol: egr
Description: eiger
Alias: BcDNA:RH51659, CG12919, Dmel\CG12919, Ect1, Egr, Regg1, TNF, TNF-alpha, TNFalpha, darth, dt1, regg1, eiger, CG12919-PA, CG12919-PB, TNF-alpha, drosophila aspartate rich TNF homolog, egr-PA, egr-PB, tumor necrosis factor family member DT1, wengen
Species: fruit fly

Top Publications

  1. Jiang Y, Scott K, Kwak S, Chen R, Mardon G. Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling. Oncogene. 2011;30:3248-60 pubmed publisher
  2. Babcock D, Shi S, Jo J, Shaw M, Gutstein H, Galko M. Hedgehog signaling regulates nociceptive sensitization. Curr Biol. 2011;21:1525-33 pubmed publisher
    ..Genetic analysis shows that Hh signaling acts in parallel to tumor necrosis factor (TNF) signaling to mediate allodynia and that distinct transient receptor potential (TRP) channels mediate allodynia and ..
  3. Igaki T, Pagliarini R, Xu T. Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila. Curr Biol. 2006;16:1139-46 pubmed
    ..Similar oncogenic cooperation mediated through these evolutionarily conserved signaling pathways could contribute to human cancer progression. ..
  4. Moreno E, Yan M, Basler K. Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. Curr Biol. 2002;12:1263-8 pubmed
    ..Here, we describe the cloning and characterization of Eiger, a unique TNF homolog in Drosophila...
  5. Kauppila S, Maaty W, Chen P, Tomar R, Eby M, Chapo J, et al. Eiger and its receptor, Wengen, comprise a TNF-like system in Drosophila. Oncogene. 2003;22:4860-7 pubmed
    ..describe the isolation and characterization of a novel Drosophila member of the TNF receptor family, designated Wengen, which is a type I membrane protein that can physically interact with the recently described TRAF2 homolog dTRAF2...
  6. Kanda H, Igaki T, Okano H, Miura M. Conserved metabolic energy production pathways govern Eiger/TNF-induced nonapoptotic cell death. Proc Natl Acad Sci U S A. 2011;108:18977-82 pubmed publisher
    ..b>Eiger is the sole fly ortholog of TNF...
  7. Maezawa T, Arita K, Shigenobu S, Kobayashi S. Expression of the apoptosis inducer gene head involution defective in primordial germ cells of the Drosophila embryo requires eiger, p53, and loki function. Dev Growth Differ. 2009;51:453-61 pubmed publisher
    ..However, it remains unclear how hid mRNA is regulated in pole cells. Here, we report that hid expression requires eiger (egr), a tumor necrosis factor ligand (TNF) homologue, which is induced in pole cells by decapentaplegic (dpp)...
  8. Igaki T, Pastor Pareja J, Aonuma H, Miura M, Xu T. Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila. Dev Cell. 2009;16:458-65 pubmed publisher
    ..Here, we show that Eiger, the Drosophila tumor necrosis factor (TNF), behaves like a tumor suppressor that eliminates oncogenic cells from ..
  9. Lee J, Koh H, Kim M, Park J, Lee S, Lee S, et al. JNK pathway mediates apoptotic cell death induced by tumor suppressor LKB1 in Drosophila. Cell Death Differ. 2006;13:1110-22 pubmed
    ..Collectively, our studies unprecedentedly elucidate JNK as the downstream mediator of the LKB1-dependent apoptosis, and provide a new paradigm for understanding the diverse LKB1 functions in vivo. ..

More Information


  1. Mabery E, Schneider D. The Drosophila TNF ortholog eiger is required in the fat body for a robust immune response. J Innate Immun. 2010;2:371-8 pubmed publisher
    b>Eiger is the sole TNF family member found in Drosophila melanogaster...
  2. Rhiner C, López Gay J, Soldini D, Casas Tinto S, Martín F, Lombardia L, et al. Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila. Dev Cell. 2010;18:985-98 pubmed publisher
    ..Cell-cell comparison of relative fwe(Lose) and fwe(ubi) levels ultimately determines which cell undergoes apoptosis. This "extracellular code" may constitute an ancient mechanism to terminate competitive conflicts among cells. ..
  3. Schneider D, Ayres J, Brandt S, Costa A, Dionne M, Gordon M, et al. Drosophila eiger mutants are sensitive to extracellular pathogens. PLoS Pathog. 2007;3:e41 pubmed
    We showed previously that eiger, the Drosophila tumor necrosis factor homolog, contributes to the pathology induced by infection with Salmonella typhimurium...
  4. Grusche F, Degoutin J, Richardson H, Harvey K. The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster. Dev Biol. 2011;350:255-66 pubmed publisher
  5. Geuking P, Narasimamurthy R, Lemaitre B, Basler K, Leulier F. A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK. PLoS ONE. 2009;4:e7709 pubmed publisher
    ..Mkk7 plays a prominent role upon Tumor Necrosis Factor (TNF) stimulation. Eiger, the unique TNF-superfamily ligand in Drosophila, potently activates JNK signaling through the activation of the ..
  6. Kato K, Awasaki T, Ito K. Neuronal programmed cell death induces glial cell division in the adult Drosophila brain. Development. 2009;136:51-9 pubmed publisher
    ..b>Eiger, a tumour necrosis factor superfamily ligand, appears to be a link between developmental PCD/neural injury and ..
  7. Ma X, Huang J, Yang L, Yang Y, Li W, Xue L. NOPO modulates Egr-induced JNK-independent cell death in Drosophila. Cell Res. 2012;22:425-31 pubmed publisher
    ..Expression of Drosophila TNF ortholog Eiger (Egr) induces JNK-dependent cell death, while the roles of caspases in this process remain elusive...
  8. Polaski S, Whitney L, Barker B, Stronach B. Genetic analysis of slipper/mixed lineage kinase reveals requirements in multiple Jun-N-terminal kinase-dependent morphogenetic events during Drosophila development. Genetics. 2006;174:719-33 pubmed
    ..Although SLPR and TAK1, another JNKKK family member, are differentially used in dorsal closure and TNF/Eiger-stimulated apoptosis, respectively, a Tak1 mutant shows dominant genetic interactions with slpr, suggesting ..
  9. Neisch A, Speck O, Stronach B, Fehon R. Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane. J Cell Biol. 2010;189:311-23 pubmed publisher
    ..Together, these results suggest that Rho1 functions at the cell cortex to regulate JNK activity and implicate Rho1 and Moe in epithelial cell survival. ..
  10. Babcock D, Landry C, Galko M. Cytokine signaling mediates UV-induced nociceptive sensitization in Drosophila larvae. Curr Biol. 2009;19:799-806 pubmed publisher
    ..upon a tumor necrosis factor (TNF) homolog, Eiger, released from apoptotic epidermal cells, and the TNF receptor, Wengen, expressed on nociceptive sensory neurons...
  11. Wang H, Cai Y, Chia W, Yang X. Drosophila homologs of mammalian TNF/TNFR-related molecules regulate segregation of Miranda/Prospero in neuroblasts. EMBO J. 2006;25:5783-93 pubmed
    ..that the Drosophila homolog of the mammalian tumor-necrosis factor (TNF) receptor-associated factor (DTRAF1) and Eiger (Egr), the homolog of the mammalian TNF, are required for telophase rescue of Mira/Pros...
  12. Igaki T, Kanda H, Yamamoto Goto Y, Kanuka H, Kuranaga E, Aigaki T, et al. Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway. EMBO J. 2002;21:3009-18 pubmed
    ..In our large-scale gain-of-function screen, we identified Eiger, the first invertebrate tumor necrosis factor (TNF) superfamily ligand that can induce cell death...
  13. Parisi F, Stefanatos R, Strathdee K, Yu Y, Vidal M. Transformed epithelia trigger non-tissue-autonomous tumor suppressor response by adipocytes via activation of Toll and Eiger/TNF signaling. Cell Rep. 2014;6:855-67 pubmed publisher
    ..Tumors trigger a systemic immune response through activation of Eiger/TNF signaling, which leads to Toll pathway upregulation in adipocytes...
  14. Xue L, Igaki T, Kuranaga E, Kanda H, Miura M, Xu T. Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila. Dev Cell. 2007;13:446-54 pubmed
    ..regulates TNF-induced JNK activation and cell death through dTRAF2, which acts downstream of the TNF receptor Wengen and upstream of the JNKK kinase dTAK1...
  15. Ma X, Yang L, Yang Y, Li M, Li W, Xue L. dUev1a modulates TNF-JNK mediated tumor progression and cell death in Drosophila. Dev Biol. 2013;380:211-21 pubmed publisher
    ..Furthermore, loss of dUev1a suppressed TNF ortholog Eiger-induced JNK-mediated cell invasion and cell death...
  16. Geuking P, Narasimamurthy R, Basler K. A genetic screen targeting the tumor necrosis factor/Eiger signaling pathway: identification of Drosophila TAB2 as a functionally conserved component. Genetics. 2005;171:1683-94 pubmed
    ..A single TNF family member, Eiger, is encoded in the Drosophila genome, offering the possibility of applying genetic approaches for pursuing this ..
  17. Cordero J, Macagno J, Stefanatos R, Strathdee K, Cagan R, Vidal M. Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter. Dev Cell. 2010;18:999-1011 pubmed publisher
    ..In the case of tumor necrosis factor (TNF), there is undisputed evidence indicating both protumor and antitumor activities...
  18. Keller L, Cheng L, Locke C, Muller M, Fetter R, Davis G. Glial-derived prodegenerative signaling in the Drosophila neuromuscular system. Neuron. 2011;72:760-75 pubmed publisher
    ..that Drosophila TNF-? (eiger) is expressed in a subset of peripheral glia, and the TNF-? receptor (TNFR), Wengen, is expressed in motoneurons...
  19. Ohsawa S, Sugimura K, Takino K, Xu T, Miyawaki A, Igaki T. Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila. Dev Cell. 2011;20:315-28 pubmed publisher
    ..Our data indicate that JNK-mediated cell engulfment could be an evolutionarily conserved intrinsic tumor-suppression mechanism that eliminates premalignant cells from epithelia. ..
  20. Ma X, Li W, Yu H, Yang Y, Li M, Xue L, et al. Bendless modulates JNK-mediated cell death and migration in Drosophila. Cell Death Differ. 2014;21:407-15 pubmed publisher
    ..carried out a genetic screen for dominant modifiers of the cell death phenotype triggered by ectopic expression of Eiger (Egr), the Drosophila TNF ortholog...
  21. Brandt S, Dionne M, Khush R, Pham L, Vigdal T, Schneider D. Secreted Bacterial Effectors and Host-Produced Eiger/TNF Drive Death in aSalmonella-Infected Fruit Fly. PLoS Biol. 2004;2:e418 pubmed
    ..In support of this model, we show that mutations in the fly gene eiger, a TNF homolog, delay the lethality of Salmonella infection. These results suggest that S...
  22. Kanda H, Igaki T, Kanuka H, Yagi T, Miura M. Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling. J Biol Chem. 2002;277:28372-5 pubmed
    We identified Wengen, the first member of the Drosophila tumor necrosis factor receptor (TNFR) superfamily...
  23. Portela M, Casas Tinto S, Rhiner C, López Gay J, Dominguez O, Soldini D, et al. Drosophila SPARC is a self-protective signal expressed by loser cells during cell competition. Dev Cell. 2010;19:562-73 pubmed publisher
    ..Overall, we describe the unexpected existence of a physiological mechanism that counteracts cell competition during development. ..
  24. Smith Bolton R, Worley M, Kanda H, Hariharan I. Regenerative growth in Drosophila imaginal discs is regulated by Wingless and Myc. Dev Cell. 2009;16:797-809 pubmed publisher
    ..This system is conducive to forward genetic screens, enabling an unbiased search for genes that regulate both the extent of and the capacity for regeneration. ..
  25. Wandler A, Guillemin K. Transgenic expression of the Helicobacter pylori virulence factor CagA promotes apoptosis or tumorigenesis through JNK activation in Drosophila. PLoS Pathog. 2012;8:e1002939 pubmed publisher
    ..and is enhanced by loss of the neoplastic tumor suppressors in CagA-expressing cells or loss of the TNF homolog Eiger in wild type neighboring cells...
  26. Etchegaray J, Timmons A, Klein A, Pritchett T, Welch E, Meehan T, et al. Draper acts through the JNK pathway to control synchronous engulfment of dying germline cells by follicular epithelial cells. Development. 2012;139:4029-39 pubmed publisher
    ..The induction of JNK and Draper in follicle cells occurs independently of caspase activity in the germline, indicating that at least two pathways are necessary to coordinate germline cell death with engulfment by the somatic epithelium. ..
  27. Zhu C, Bornemann D, Zhitomirsky D, Miller E, O Connor M, Simon J. Drosophila histone deacetylase-3 controls imaginal disc size through suppression of apoptosis. PLoS Genet. 2008;4:e1000009 pubmed publisher
    ..However, the specific HDACs implicated in tumor cell killing have not been identified. Our results indicate that protein deacetylation by HDAC3 plays a key role in suppression of apoptosis in Drosophila imaginal tissue. ..
  28. Tiwari A, Roy J. Mutation in Rab11 results in abnormal organization of ommatidial cells and activation of JNK signaling in the Drosophila eye. Eur J Cell Biol. 2009;88:445-60 pubmed publisher
    ..rescued the phenotype in Rab11 mutant eyes significantly while overexpression of JNK in the eyes using UAS-eiger, UAS-dtak1 or EP(2)0578, resulted in enhancement of the eye phenotype indicating a link between Rab11 and the JNK ..
  29. Cruz C, Glavic A, Casado M, de Celis J. A gain-of-function screen identifying genes required for growth and pattern formation of the Drosophila melanogaster wing. Genetics. 2009;183:1005-26 pubmed publisher
    ..Finally, we present a preliminary characterization of a gene identified in the screen, the function of which is required for the development of the L5 longitudinal vein. ..
  30. Su T. Non-autonomous consequences of cell death and other perks of being metazoan. AIMS Genet. 2015;2:54-69 pubmed
    ..Key insights from Drosophila will be discussed in the context of analogous processes in mammalian development and cancer biology. ..
  31. Park S, Stultz B, Hursh D. Dual Role of Jun N-Terminal Kinase Activity in Bone Morphogenetic Protein-Mediated Drosophila Ventral Head Development. Genetics. 2015;201:1411-26 pubmed publisher
  32. Chen C, Schroeder M, Kango Singh M, Tao C, Halder G. Tumor suppression by cell competition through regulation of the Hippo pathway. Proc Natl Acad Sci U S A. 2012;109:484-9 pubmed publisher
    ..Thus, cell competition acts as a tumor-suppressing mechanism by regulating the Hippo pathway in scrib(-) cells. ..
  33. Herrera S, Martin R, Morata G. Tissue homeostasis in the wing disc of Drosophila melanogaster: immediate response to massive damage during development. PLoS Genet. 2013;9:e1003446 pubmed publisher
  34. Chabu C, Xu T. Oncogenic Ras stimulates Eiger/TNF exocytosis to promote growth. Development. 2014;141:4729-39 pubmed publisher
    ..We found that oncogenic Ras elevates exocytosis and promotes the export of the pro-apoptotic ligand Eiger (Drosophila TNF)...
  35. Jo J, Im S, Babcock D, Iyer S, Gunawan F, Cox D, et al. Drosophila caspase activity is required independently of apoptosis to produce active TNF/Eiger during nociceptive sensitization. Cell Death Dis. 2017;8:e2786 pubmed publisher
    ..larvae following UV-induced tissue damage is accompanied by epidermal apoptosis and requires epidermal-derived TNF/Eiger and the initiator caspase, Dronc...
  36. Igaki T, Kanda H, Okano H, Xu T, Miura M. Eiger and wengen: the Drosophila orthologs of TNF/TNFR. Adv Exp Med Biol. 2011;691:45-50 pubmed publisher
  37. Sun N, Sun C, Lin C, Pai L, Chao C. Damaged DNA-binding protein 2 (DDB2) protects against UV irradiation in human cells and Drosophila. J Biomed Sci. 2010;17:27 pubmed publisher
    ..the other hand, expression of DDB2 failed to rescue a different type of apoptosis induced by the genes Reaper or eiger. Our results show that DDB2 protects against UV stress in a cFLIP-dependent manner...
  38. Zeitlinger J, Stark A, Kellis M, Hong J, Nechaev S, Adelman K, et al. RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo. Nat Genet. 2007;39:1512-6 pubmed
    ..We propose that Pol II stalling facilitates rapid temporal and spatial changes in gene activity during development. ..
  39. Danial N, Korsmeyer S. Cell death: critical control points. Cell. 2004;116:205-19 pubmed
    ..The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics. ..
  40. O Keefe L, Lee C, Choo A, Richards R. Tumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogaster. PLoS ONE. 2015;10:e0136356 pubmed publisher
    ..Using Drosophila melanogaster as an in vivo model system, we find that WWOX is a modulator of TNFα/Egr-mediated cell death...
  41. Bauer J, Poon P, Glatt Deeley H, Abrams J, Helfand S. Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Curr Biol. 2005;15:2063-8 pubmed
  42. Peterson J, Bass B, Jue D, Rodriguez A, Abrams J, McCall K. Noncanonical cell death pathways act during Drosophila oogenesis. Genesis. 2007;45:396-404 pubmed
    ..These results indicate that novel pathways must control PCD in the ovary. ..
  43. Jones R, Wu H, Wentworth C, Luo L, Collier Hyams L, Neish A. Salmonella AvrA Coordinates Suppression of Host Immune and Apoptotic Defenses via JNK Pathway Blockade. Cell Host Microbe. 2008;3:233-44 pubmed publisher
    ..Our findings suggest that targeting JNK signaling to dampen apoptosis may be a conserved strategy for intracellular pathogens. ..
  44. Zhang M, Zhang Y, Xu Z. POSH is involved in Eiger-Basket (TNF-JNK) signaling and embryogenesis in Drosophila. J Genet Genomics. 2010;37:605-19 pubmed publisher
    ..In this study, we provide evidence that the JNK pathway scaffold protein, POSH, is involved in TNF (Eiger) signaling in Drosophila...
  45. Wu L, Silverman N. Fighting infection fly-style. Fly (Austin). 2007;1:106-9 pubmed
  46. Pechkovsky A, Lahav M, Bitman E, Salzberg A, Kleinberger T. E4orf4 induces PP2A- and Src-dependent cell death in Drosophila melanogaster and at the same time inhibits classic apoptosis pathways. Proc Natl Acad Sci U S A. 2013;110:E1724-33 pubmed publisher
  47. Ruan W, Unsain N, Desbarats J, Fon E, Barker P. Wengen, the sole tumour necrosis factor receptor in Drosophila, collaborates with moesin to control photoreceptor axon targeting during development. PLoS ONE. 2013;8:e60091 pubmed publisher
    ..Here, we show that Wengen (Wgn) directly binds Moesin (Moe) through a cytosolic membrane proximal domain and this interaction is important ..
  48. Samaraweera S, O Keefe L, Price G, Venter D, Richards R. Distinct roles for Toll and autophagy pathways in double-stranded RNA toxicity in a Drosophila model of expanded repeat neurodegenerative diseases. Hum Mol Genet. 2013;22:2811-9 pubmed publisher
    ..In exhibiting molecular and cellular hallmarks of HD, double-stranded RNA-mediated activation of innate immunity is, therefore, a candidate pathway for this group of human genetic diseases. ..
  49. Tsuda M, Kawaida R, Kobayashi K, Shinagawa A, Sawada T, Yamada R, et al. POSH promotes cell survival in Drosophila and in human RASF cells. FEBS Lett. 2010;584:4689-94 pubmed publisher
    In Drosophila, Eiger, a tumor necrosis factor ? (TNF?) superfamily ligand, induces cell death by activating the c-Jun N-terminal kinase (JNK) pathway...
  50. Nakamura M, Ohsawa S, Igaki T. Mitochondrial defects trigger proliferation of neighbouring cells via a senescence-associated secretory phenotype in Drosophila. Nat Commun. 2014;5:5264 pubmed publisher
    ..Our data suggest that mitochondrial defects promote Ras-induced cellular senescence and thereby contribute to tumour progression through SASP. ..
  51. Stevens L, Page McCaw A. A secreted MMP is required for reepithelialization during wound healing. Mol Biol Cell. 2012;23:1068-79 pubmed publisher
    ..A primary function of Mmp1, under the control of the JNK pathway, is to promote basement membrane repair, which in turn may permit cell migration and the restoration of a continuous tissue. ..
  52. Lim Y, Hayashi S, Tsuda L. Ebi/AP-1 suppresses pro-apoptotic genes expression and permits long-term survival of Drosophila sensory neurons. PLoS ONE. 2012;7:e37028 pubmed publisher
    ..These results suggest that Ebi/AP-1 suppresses basal transcription levels of apoptotic genes and thereby protects sensory neurons from degeneration. ..
  53. Gordon M, Ayres J, Schneider D, Nusse R. Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin. PLoS Pathog. 2008;4:e1000111 pubmed publisher
    ..These genes include the TNF family member eiger and the novel immunity gene edin (elevated during infection; synonym CG32185), both of which are more strongly ..
  54. Marchal C, Vinatier G, Sanial M, Plessis A, Pret A, Limbourg Bouchon B, et al. The HIV-1 Vpu protein induces apoptosis in Drosophila via activation of JNK signaling. PLoS ONE. 2012;7:e34310 pubmed publisher
    ..Our results in the fly thus provide the first functional evidence linking Vpu pro-apoptotic effects to activation of the conserved JNK pathway. ..
  55. Liu J, Ghanim M, Xue L, Brown C, Iossifov I, Angeletti C, et al. Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer. Science. 2009;323:1218-22 pubmed publisher
    ..SPOP mediates degradation of the Jun kinase phosphatase Puckered, thereby inducing tumor necrosis factor (TNF)/Eiger-dependent apoptosis...
  56. Richards R, Samaraweera S, van Eyk C, O Keefe L, Suter C. RNA pathogenesis via Toll-like receptor-activated inflammation in expanded repeat neurodegenerative diseases. Front Mol Neurosci. 2013;6:25 pubmed publisher
  57. Stronach B, Lennox A, Garlena R. Domain specificity of MAP3K family members, MLK and Tak1, for JNK signaling in Drosophila. Genetics. 2014;197:497-513 pubmed publisher
    ..Altogether, our findings suggest that the selective deployment of a particular MAP3K can be attributed in part to its inherent sequence differences, cellular localization, and binding partner availability. ..
  58. Agrawal N, Delanoue R, Mauri A, Basco D, Pasco M, Thorens B, et al. The Drosophila TNF Eiger Is an Adipokine that Acts on Insulin-Producing Cells to Mediate Nutrient Response. Cell Metab. 2016;23:675-84 pubmed publisher
    ..Here we show that Eiger, the Drosophila TNF-?, is a metabolic hormone that mediates nutrient response by remotely acting on insulin-..
  59. Lawen A. Apoptosis-an introduction. Bioessays. 2003;25:888-96 pubmed
  60. Gavin Smyth J, Wang Y, Butler I, Ferguson E. A genetic network conferring canalization to a bistable patterning system in Drosophila. Curr Biol. 2013;23:2296-2302 pubmed publisher
    ..The BMP target eiger (egr) acts in the positive feedback circuit to promote signaling, while the BMP binding protein encoded by ..
  61. Tang H, Liao H, Peng W, Lin H, Chen C, Chen G. Atg9 interacts with dTRAF2/TRAF6 to regulate oxidative stress-induced JNK activation and autophagy induction. Dev Cell. 2013;27:489-503 pubmed publisher
    ..Our findings indicate a dual role for Atg9 in the regulation of JNK signaling and autophagy under oxidative stress conditions. ..
  62. Bidla G, Dushay M, Theopold U. Crystal cell rupture after injury in Drosophila requires the JNK pathway, small GTPases and the TNF homolog Eiger. J Cell Sci. 2007;120:1209-15 pubmed
    ..transduction pathways, we show that prophenoloxidase release requires Jun N-terminal kinase, small Rho GTPases and Eiger, the Drosophila homolog of tumor necrosis factor...
  63. Bergwitz C, Wee M, Sinha S, Huang J, Derobertis C, Mensah L, et al. Genetic determinants of phosphate response in Drosophila. PLoS ONE. 2013;8:e56753 pubmed publisher
    ..We identified a number of candidate genes potentially important for the cellular response to phosphate. Evaluation of 51 genes in live flies revealed some that affect larval development, adult life span and hemolymph phosphate levels. ..
  64. Froldi F, Ziosi M, Garoia F, Pession A, Grzeschik N, Bellosta P, et al. The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy. BMC Biol. 2010;8:33 pubmed publisher
    ..Furthermore, we show that the eiger-dependent Intrinsic Tumour Suppressor pathway plays only a minor role in eliminating lgl mutant cells in the wing ..
  65. Agaisse H, Perrimon N. The roles of JAK/STAT signaling in Drosophila immune responses. Immunol Rev. 2004;198:72-82 pubmed
  66. Zhao H, Zhou D, Nizet V, Haddad G. Experimental selection for Drosophila survival in extremely high O2 environments. PLoS ONE. 2010;5:e11701 pubmed publisher
    ..Thus our study provides a molecular basis for understanding the mechanisms of hyperoxia tolerance. ..
  67. Zhang S, Guo X, CHEN C, Chen Y, Li J, Sun Y, et al. dFoxO promotes Wingless signaling in Drosophila. Sci Rep. 2016;6:22348 pubmed publisher
    ..Thus, we have characterized a previously unknown role of dFoxO in promoting Wg signaling, and that a dFoxO-Arm complex is likely involved in their mutual functions, e.g. cell death. ..
  68. Jones R, Luo L, Moberg K. Aeromonas salmonicida-secreted protein AopP is a potent inducer of apoptosis in a mammalian and a Drosophila model. Cell Microbiol. 2012;14:274-85 pubmed publisher
    ..Furthermore, apoptosis was significantly elevated upon concurrent AopP expression and TNF-? cellular stimulation...
  69. Liu D, Shaukat Z, Saint R, Gregory S. Chromosomal instability triggers cell death via local signalling through the innate immune receptor Toll. Oncotarget. 2015;6:38552-65 pubmed publisher
    ..pathway strongly affects the survival of CIN cells, primarily via JNK, which responds to both Toll and TNFα/Eiger. This pathway also activates Mmp1, which recruits hemocytes to the CIN tissue to provide local amplification of ..
  70. Fogarty C, Diwanji N, Lindblad J, Tare M, Amcheslavsky A, Makhijani K, et al. Extracellular Reactive Oxygen Species Drive Apoptosis-Induced Proliferation via Drosophila Macrophages. Curr Biol. 2016;26:575-84 pubmed publisher turn trigger JNK activity in epithelial cells by signaling through the tumor necrosis factor (TNF) ortholog Eiger. We propose that in an immortalized ("undead") model of AiP, signaling back and forth between epithelial disc ..