Egfr

Summary

Gene Symbol: Egfr
Description: Epidermal growth factor receptor
Alias: C-erb, CG10079, D-EGFR, D-Egf, DEGFR, DER, DER flb, DER/EGFR, DER/top, DER/torpedo, DER1, DEgfr, Degfr, Der, DmHD-33, Dmel\CG10079, EC2-4, EFG-R, EGF-R, EGFR, EGFr, EGfr, EK2-6, Egf, Egf-r, EgfR, Elp, Elp-1, Elp-B1, Elp-B1RB1, Flb, HD-33, TOP, Tor, Torpedo/DER, Torpedo/Egfr, c-erbB, d-egf-r, dEGFR, dEGFR1, dEGFr, dEgfr, degfr, der, egfr, flb, l(2)05351, l(2)09261, l(2)57DEFa, l(2)57EFa, l(2)57Ea, mor1, top, top/DER, top/flb, torpedo/Egfr, torpedo/egfr, epidermal growth factor receptor, CG10079-PA, CG10079-PB, DER-Ellipse, EGF-receptor, EGFR, Egf receptor, Egfr-PA, Egfr-PB, dEGFR, drosophila epidermal growth factor receptor homologue, ellipse, ellipse torpedo, faint little ball, morphological defects 1, torpedo, torpedo/DER
Species: fruit fly
Products:     Egfr

Top Publications

  1. Guo Z, Driver I, Ohlstein B. Injury-induced BMP signaling negatively regulates Drosophila midgut homeostasis. J Cell Biol. 2013;201:945-61 pubmed publisher
    ..Our data establish a new link between injury and hyperplasia and may provide insight into how BMP signaling mutations drive formation of human intestinal cancers...
  2. Goering L, Gibson G. Genetic variation for dorsal-ventral patterning of the Drosophila melanogaster eggshell. Evol Dev. 2005;7:81-8 pubmed
    ..two dorsal-anterior respiratory appendages are produced in response to signaling through the Epidermal growth factor receptor (Egfr)...
  3. Liu M, Lim T, Cai Y. The Drosophila female germline stem cell lineage acts to spatially restrict DPP function within the niche. Sci Signal. 2010;3:ra57 pubmed publisher
    ..the stem cells themselves participate in the spatial restriction of DPP function by activating epidermal growth factor receptor (EGFR)-mitogen-activated protein kinase (MAPK) signaling in the surrounding somatic cells...
  4. Palsson A, Rouse A, Riley Berger R, Dworkin I, Gibson G. Nucleotide variation in the Egfr locus of Drosophila melanogaster. Genetics. 2004;167:1199-212 pubmed
    The Epidermal growth factor receptor is an essential gene with diverse pleiotropic roles in development throughout the animal kingdom. Analysis of sequence diversity in 10.9 kb covering the complete coding region and 6...
  5. Yogev S, Schejter E, Shilo B. Polarized secretion of Drosophila EGFR ligand from photoreceptor neurons is controlled by ER localization of the ligand-processing machinery. PLoS Biol. 2010;8: pubmed publisher
    ..In the developing Drosophila visual system, photoreceptor neurons secrete the epidermal growth factor receptor ligand Spitz (Spi) from their cell bodies, as well as from their axonal termini...
  6. Moon N, Di Stefano L, Dyson N. A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis. Mol Cell Biol. 2006;26:7601-15 pubmed
    ..but instead involves the action of Argos, a secreted protein that negatively regulates Drosophila epidermal growth factor receptor (EGFR [DER]) activity...
  7. Jiang H, Grenley M, Bravo M, Blumhagen R, Edgar B. EGFR/Ras/MAPK signaling mediates adult midgut epithelial homeostasis and regeneration in Drosophila. Cell Stem Cell. 2011;8:84-95 pubmed publisher
    ..we show that in response to damage or stress in the intestinal (midgut) epithelium of adult Drosophila, multiple EGFR ligands and rhomboids (intramembrane proteases that activate some EGFR ligands) are induced, leading to the ..
  8. Tsuda L, Nagaraj R, Zipursky S, Banerjee U. An EGFR/Ebi/Sno pathway promotes delta expression by inactivating Su(H)/SMRTER repression during inductive notch signaling. Cell. 2002;110:625-37 pubmed
    The Notch and Epidermal Growth Factor Receptor (EGFR) pathways both regulate proliferation and differentiation, and the cellular response to each is often influenced by the other...
  9. Vidal M, Wells S, Ryan A, Cagan R. ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia syndromes and papillary thyroid carcinoma. Cancer Res. 2005;65:3538-41 pubmed
    ..This compound failed to significantly suppress an activated form of another RTK, the Drosophila epidermal growth factor receptor, nor did it suppress the activity of downstream components of the RET/Ras pathway...

More Information

Publications96

  1. Gilboa L, Lehmann R. Soma-germline interactions coordinate homeostasis and growth in the Drosophila gonad. Nature. 2006;443:97-100 pubmed
    ..PGCs express the EGF receptor (EGFR) ligand Spitz, which is required for IC survival. In turn, ICs inhibit PGC proliferation...
  2. Jiang H, Edgar B. EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors. Development. 2009;136:483-93 pubmed publisher
    ..We find that signaling through the EGFR/RAS/MAPK pathway is necessary and limiting for AMP proliferation...
  3. Grigorian M, Mandal L, Hakimi M, Ortiz I, Hartenstein V. The convergence of Notch and MAPK signaling specifies the blood progenitor fate in the Drosophila mesoderm. Dev Biol. 2011;353:105-18 pubmed publisher
    ..Concomitant activation of the Mitogen Activated Protein Kinase (MAPK) pathway by Epidermal Growth Factor Receptor (EGFR) and Fibroblast Growth Factor Receptor (FGFR) is required for the specification and maintenance ..
  4. Yogev S, Schejter E, Shilo B. Drosophila EGFR signalling is modulated by differential compartmentalization of Rhomboid intramembrane proteases. EMBO J. 2008;27:1219-30 pubmed publisher
    We explore the role of differential compartmentalization of Rhomboid (Rho) proteases that process the Drosophila EGF receptor ligands, in modulating the amount of secreted ligand and consequently the level of EGF receptor (EGFR) ..
  5. Jang A, Chang Y, Bai J, Montell D. Border-cell migration requires integration of spatial and temporal signals by the BTB protein Abrupt. Nat Cell Biol. 2009;11:569-79 pubmed publisher
    ..Taken together, these findings provide a molecular mechanism by which spatial and temporal cues are integrated. ..
  6. Reeves G, Kalifa R, Klein D, Lemmon M, Shvartsman S. Computational analysis of EGFR inhibition by Argos. Dev Biol. 2005;284:523-35 pubmed
    Argos, a secreted inhibitor of the Drosophila epidermal growth factor receptor, and the only known secreted receptor tyrosine kinase inhibitor, acts by sequestering the EGFR ligand Spitz...
  7. Schlesinger A, Kiger A, Perrimon N, Shilo B. Small wing PLCgamma is required for ER retention of cleaved Spitz during eye development in Drosophila. Dev Cell. 2004;7:535-45 pubmed
    The Drosophila EGF receptor ligand Spitz is cleaved by Rhomboid to generate an active secreted molecule. Surprisingly, when a cleaved variant of Spitz (cSpi) was expressed, it accumulated in the ER, both in embryos and in cell culture...
  8. Pallavi S, Shashidhara L. Egfr/Ras pathway mediates interactions between peripodial and disc proper cells in Drosophila wing discs. Development. 2003;130:4931-41 pubmed
    ..The Egfr/Ras pathway mediates this function of the peripodial membrane...
  9. Biteau B, Jasper H. EGF signaling regulates the proliferation of intestinal stem cells in Drosophila. Development. 2011;138:1045-55 pubmed publisher
    ..How these signals are integrated is poorly understood. Here, we show that EGF receptor signaling is required to maintain the proliferative capacity of ISCs...
  10. Wildonger J, Sosinsky A, Honig B, Mann R. Lozenge directly activates argos and klumpfuss to regulate programmed cell death. Genes Dev. 2005;19:1034-9 pubmed
    ..These results provide novel insights into the control of programmed cell death (PCD) by Lz during Drosophila eye development. ..
  11. Baonza A, Freeman M. Control of cell proliferation in the Drosophila eye by Notch signaling. Dev Cell. 2005;8:529-39 pubmed
    ..Delta to Notch signaling derepresses the inhibition of dE2F1 by RBF, and Delta expression depends on the secreted proteins Hedgehog and Dpp. Notch is also required for the expression of Cyclin A in the SMW. ..
  12. Hagedorn E, Bayraktar J, Kandachar V, Bai T, Englert D, Chang H. Drosophila melanogaster auxilin regulates the internalization of Delta to control activity of the Notch signaling pathway. J Cell Biol. 2006;173:443-52 pubmed
    ..Furthermore, the fact that auxilin is required for Notch signaling suggests that ligand endocytosis in the signal-sending cells needs to proceed past coat disassembly to activate Notch. ..
  13. Wang X, He L, Wu Y, Hahn K, Montell D. Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo. Nat Cell Biol. 2010;12:591-7 pubmed publisher
    ..Communication between cells of the cluster required Jun amino-terminal kinase (JNK) but not guidance receptor signalling. These studies further show that photoactivatable proteins are effective tools in vivo. ..
  14. Kumar J, Hsiung F, Powers M, Moses K. Nuclear translocation of activated MAP kinase is developmentally regulated in the developing Drosophila eye. Development. 2003;130:3703-14 pubmed
    ..We also show that MAPK cytoplasmic hold has an essential function in vivo: if it is overcome, developmental patterning in the furrow is disrupted. ..
  15. Page D. A function for Egf receptor signaling in expanding the developing brain in Drosophila. Curr Biol. 2003;13:474-82 pubmed
    ..neural midline marker Single-minded is expressed in foregut cells adjacent to the brain, as are members of the Egf receptor signaling pathway...
  16. Schweisguth F. Regulation of notch signaling activity. Curr Biol. 2004;14:R129-38 pubmed
    ..Recent analyses of the cell biology of the Notch receptor have identified several fundamental mechanisms that contribute to regulate Notch signaling activity in space and time. ..
  17. Gallagher C, Knoblich J. The conserved c2 domain protein lethal (2) giant discs regulates protein trafficking in Drosophila. Dev Cell. 2006;11:641-53 pubmed
    ..Our experiments suggest that Lgd is a critical regulator of endocytosis that is not present in yeast and acts in the degradative pathway after Hrs. ..
  18. Prasad M, Montell D. Cellular and molecular mechanisms of border cell migration analyzed using time-lapse live-cell imaging. Dev Cell. 2007;12:997-1005 pubmed
    ..Reducing the activities of the guidance receptors EGFR and PVR did not result in the expected inhibition of protrusion, but instead resulted in protrusion in all ..
  19. Yasugi T, Sugie A, Umetsu D, Tabata T. Coordinated sequential action of EGFR and Notch signaling pathways regulates proneural wave progression in the Drosophila optic lobe. Development. 2010;137:3193-203 pubmed publisher
    ..We found that the epidermal growth factor receptor (EGFR) signaling pathway promotes proneural wave progression...
  20. Herranz H, Hong X, Hung N, Voorhoeve P, Cohen S. Oncogenic cooperation between SOCS family proteins and EGFR identified using a Drosophila epithelial transformation model. Genes Dev. 2012;26:1602-11 pubmed publisher
    ..In this study, we identify the growth regulatory miRNA bantam and its target, Socs36E, as cooperating factors in EGFR-driven tumorigenesis and metastasis in a Drosophila model of epithelial transformation...
  21. de Navascués J, Modolell J. tailup, a LIM-HD gene, and Iro-C cooperate in Drosophila dorsal mesothorax specification. Development. 2007;134:1779-88 pubmed
    ..Whereas the Iro-C genes are activated in the notum anlage by EGFR signalling, tup is positively regulated by Dpp signalling...
  22. Alvarado D, Klein D, Lemmon M. ErbB2 resembles an autoinhibited invertebrate epidermal growth factor receptor. Nature. 2009;461:287-91 pubmed publisher
    ..among the four human ErbB receptors, here we show that it is the closest structural relative of the single EGF receptor family member in Drosophila melanogaster (dEGFR)...
  23. Zhou F, Rasmussen A, Lee S, Agaisse H. The UPD3 cytokine couples environmental challenge and intestinal stem cell division through modulation of JAK/STAT signaling in the stem cell microenvironment. Dev Biol. 2013;373:383-93 pubmed publisher
    ..Our results suggest that EBs and VMs modulate the rate of the EGFR-dependent ISC division through upd3-dependent production of the EGF ligands Spitz and Vein, respectively...
  24. Brown K, Kerr M, Freeman M. The EGFR ligands Spitz and Keren act cooperatively in the Drosophila eye. Dev Biol. 2007;307:105-13 pubmed
    The EGFR signalling cascade is responsible for coordinating a wide variety of events during Drosophila eye development...
  25. Wang P, Pai L. D-Cbl binding to Drk leads to dose-dependent down-regulation of EGFR signaling and increases receptor-ligand endocytosis. PLoS ONE. 2011;6:e17097 pubmed publisher
    Proper control of Epidermal Growth Factor Receptor (EGFR) signaling is critical for normal development and regulated cell behaviors. Abnormal EGFR signaling is associated with tumorigenic process of various cancers...
  26. Weber U, Pataki C, Mihaly J, Mlodzik M. Combinatorial signaling by the Frizzled/PCP and Egfr pathways during planar cell polarity establishment in the Drosophila eye. Dev Biol. 2008;316:110-23 pubmed publisher
    ..Here we demonstrate a specific requirement for Egfr-signaling and the transcription factors Fos (AP-1), Yan and Pnt in PCP dependent R3/R4 specification...
  27. Chen Y, Schupbach T. The role of brinker in eggshell patterning. Mech Dev. 2006;123:395-406 pubmed
    ..From our results and previously published data, it appears that anterior follicle cells integrate the levels of EGF receptor activation and TGFbeta receptor activation...
  28. Jeon M, Zinn K. Receptor tyrosine phosphatases control tracheal tube geometries through negative regulation of Egfr signaling. Development. 2009;136:3121-9 pubmed publisher
    ..Cyst size and number are increased by tracheal expression of activated Egfr tyrosine kinase, and decreased by reducing Egfr levels. Ptp10D forms a complex with Egfr in transfected cells...
  29. Srahna M, Leyssen M, Choi C, Fradkin L, Noordermeer J, Hassan B. A signaling network for patterning of neuronal connectivity in the Drosophila brain. PLoS Biol. 2006;4:e348 pubmed
    ..JNK activity is necessary and sufficient for axon extension, whereas the antagonistic Wnt and FGF signals act to balance the extension and retraction required for the generation of the precise wiring pattern. ..
  30. Miura G, Buglino J, Alvarado D, Lemmon M, Resh M, Treisman J. Palmitoylation of the EGFR ligand Spitz by Rasp increases Spitz activity by restricting its diffusion. Dev Cell. 2006;10:167-76 pubmed
    ..that rasp is also essential for the developmental functions of Spitz, a ligand for the Drosophila epidermal growth factor receptor (EGFR)...
  31. Sen A, Kuruvilla D, Pinto L, Sarin A, Rodrigues V. Programmed cell death and context dependent activation of the EGF pathway regulate gliogenesis in the Drosophila olfactory system. Mech Dev. 2004;121:65-78 pubmed
    ..express the extracellular-signal regulated kinase transiently, and antagonism of Epidermal Growth Factor (EGF) pathway signaling compromises their development...
  32. Shirai T, Maehara A, Kiritooshi N, Matsuzaki F, Handa H, Nakagoshi H. Differential requirement of EGFR signaling for the expression of defective proventriculus gene in the Drosophila endoderm and ectoderm. Biochem Biophys Res Commun. 2003;311:473-7 pubmed
    ..of dve in the ventral ectoderm, in which dve expression is induced by Spitz, a ligand for Drosophila epidermal growth factor receptor (EGFR)...
  33. Geiger J, Carvalho L, Campos I, Santos A, Jacinto A. Hole-in-one mutant phenotypes link EGFR/ERK signaling to epithelial tissue repair in Drosophila. PLoS ONE. 2011;6:e28349 pubmed publisher
    ..Finally, we show that wound healing requires the function of EGFR and ERK signaling...
  34. Firth L, Baker N. Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev Cell. 2005;8:541-51 pubmed
    ..Cell cycle entry is induced by Notch signaling and opposed in subsets of cells by EGF receptor activity. Unusually, Cyclin E levels are not limiting for retinal cell cycles...
  35. Foltenyi K, Greenspan R, NEWPORT J. Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila. Nat Neurosci. 2007;10:1160-7 pubmed
    b>Epidermal growth factor receptor (EGFR) signaling in the mammalian hypothalamus is important in the circadian regulation of activity. We have examined the role of this pathway in the regulation of sleep in Drosophila melanogaster...
  36. Li X, Cassidy J, Reinke C, Fischboeck S, Carthew R. A microRNA imparts robustness against environmental fluctuation during development. Cell. 2009;137:273-82 pubmed publisher
    ..We suggest that some conserved microRNAs like miR-7 may enter into novel genetic relationships to buffer developmental programs against variation and impart robustness to diverse regulatory networks. ..
  37. Brachmann C, Cagan R. Patterning the fly eye: the role of apoptosis. Trends Genet. 2003;19:91-6 pubmed
    ..But, we have yet to understand how this signaling is regulated spatially to result in such precision. In this article, we describe and speculate on the role of selective cell death during maturation of the fly eye. ..
  38. Li J, Li W. Drosophila gain-of-function mutant RTK torso triggers ectopic Dpp and STAT signaling. Genetics. 2003;164:247-58 pubmed
    ..systematic survey for genes that are required for signaling by a gain-of-function mutant Drosophila RTK Torso (Tor)...
  39. Li X, Carthew R. A microRNA mediates EGF receptor signaling and promotes photoreceptor differentiation in the Drosophila eye. Cell. 2005;123:1267-77 pubmed
    ..This is dependent on EGF receptor (EGFR) signaling that triggers ERK-mediated degradation of the transcription factor Yan...
  40. Botella J, Kretzschmar D, Kiermayer C, Feldmann P, Hughes D, Schneuwly S. Deregulation of the Egfr/Ras signaling pathway induces age-related brain degeneration in the Drosophila mutant vap. Mol Biol Cell. 2003;14:241-50 pubmed
    ..These mutants show age-related brain degeneration that is dependent on activation of the EGF receptor signaling pathway in adult neurons, leading to autophagic cell death (cell death type 2)...
  41. Sprecher S, Desplan C. Switch of rhodopsin expression in terminally differentiated Drosophila sensory neurons. Nature. 2008;454:533-7 pubmed publisher
    ..This fate switch of functioning, terminally differentiated neurons provides a novel, unexpected example of hard-wired sensory plasticity. ..
  42. Xi R, McGregor J, Harrison D. A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium. Dev Cell. 2003;4:167-77 pubmed
    ..Further, the coordinated activities of the JAK/STAT and epidermal growth factor receptor (EGFR) pathways are required to specify the posterior terminal cell fate...
  43. Ghiglione C, Amundadottir L, Andresdottir M, Bilder D, Diamonti J, Noselli S, et al. Mechanism of inhibition of the Drosophila and mammalian EGF receptors by the transmembrane protein Kekkon 1. Development. 2003;130:4483-93 pubmed
    ..1 (Kek1) has previously been shown to act in a negative feedback loop to downregulate the Drosophila Epidermal Growth Factor Receptor (DER) during oogenesis...
  44. de Celis J, Diaz Benjumea F. Developmental basis for vein pattern variations in insect wings. Int J Dev Biol. 2003;47:653-63 pubmed
    ..Assuming a general conservation of the processes involved in different species, the transitions between different patterns may require few changes in the regulatory gene networks involved. ..
  45. Pai L, Wang P, Chen S, Barcelo G, Chang W, Nilson L, et al. Differential effects of Cbl isoforms on Egfr signaling in Drosophila. Mech Dev. 2006;123:450-62 pubmed
    The Cbl family of proteins downregulate epidermal growth factor receptor (Egfr) signaling via receptor internalization and destruction...
  46. Dworkin I, Palsson A, Gibson G. Replication of an Egfr-wing shape association in a wild-caught cohort of Drosophila melanogaster. Genetics. 2005;169:2115-25 pubmed
    ..and a wild-caught cohort of Drosophila melanogaster, an association between a putative regulatory polymorphism in Egfr and wing shape can be replicated...
  47. Sotillos S, de Celis J. Interactions between the Notch, EGFR, and decapentaplegic signaling pathways regulate vein differentiation during Drosophila pupal wing development. Dev Dyn. 2005;232:738-52 pubmed
    ..cell interactions mediated by the conserved signaling pathways Decapentaplegic (Dpp), Notch, and epidermal growth factor receptor (EGFR)...
  48. Yu L, Lee T, Lin N, Wolf M. Affecting Rhomboid-3 function causes a dilated heart in adult Drosophila. PLoS Genet. 2010;6:e1000969 pubmed publisher
    ..multiple approaches based on the examination of deficiency stocks, a series of mutants in the rhomboid-Spitz-EGF receptor pathway, and cardiac-specific transgenic rescue or dominant-negative repression of EGFR, we demonstrate that ..
  49. Ninov N, Manjón C, Martin Blanco E. Dynamic control of cell cycle and growth coupling by ecdysone, EGFR, and PI3K signaling in Drosophila histoblasts. PLoS Biol. 2009;7:e1000079 pubmed publisher
    ..histoblasts proceed to a stage of slower proliferation that, in contrast to the preceding, depends on epidermal growth factor receptor (EGFR) signaling for progression through the G2/M transition and on insulin receptor/PI3K-mediated ..
  50. Brown K, Baonza A, Freeman M. Epithelial cell adhesion in the developing Drosophila retina is regulated by Atonal and the EGF receptor pathway. Dev Biol. 2006;300:710-21 pubmed
    ..Here, we report that the transcription factor Atonal and the canonical EGF receptor signalling cascade are both required for this clustering and for the accompanying changes in cellular adhesion...
  51. Gallio M, Englund C, Kylsten P, Samakovlis C. Rhomboid 3 orchestrates Slit-independent repulsion of tracheal branches at the CNS midline. Development. 2004;131:3605-14 pubmed
    ..Expression of dominant-negative Egfr or Ras induces midline crosses, whereas activation of the Egfr or Ras in the leading cell of the ganglionic branch ..
  52. Yang L, Baker N. Notch activity opposes Ras-induced differentiation during the Second Mitotic Wave of the developing Drosophila eye. BMC Dev Biol. 2006;6:8 pubmed
    b>EGF receptor acts through Ras and the MAPK cascade to trigger differentiation and maintain survival of most of cell types in the Drosophila retina. Cell types are specified sequentially by separate episodes of EGFR activity...
  53. Affolter M, Bellusci S, Itoh N, Shilo B, Thiery J, Werb Z. Tube or not tube: remodeling epithelial tissues by branching morphogenesis. Dev Cell. 2003;4:11-8 pubmed
  54. De Velasco B, Erclik T, Shy D, Sclafani J, Lipshitz H, McInnes R, et al. Specification and development of the pars intercerebralis and pars lateralis, neuroendocrine command centers in the Drosophila brain. Dev Biol. 2007;302:309-23 pubmed
    ..The other early activated signaling pathway, EGFR, is positively required for the maintenance of the PI placode...
  55. Poulton J, Deng W. Dystroglycan down-regulation links EGF receptor signaling and anterior-posterior polarity formation in the Drosophila oocyte. Proc Natl Acad Sci U S A. 2006;103:12775-80 pubmed
    Anterior-posterior axis formation in the Drosophila oocyte requires activation of the EGF receptor (EGFR) pathway in the posterior follicle cells (PFC), where it also redirects them from the default anterior to the posterior cell fate...
  56. Frankfort B, Mardon G. Senseless represses nuclear transduction of Egfr pathway activation. Development. 2004;131:563-70 pubmed
    The Epidermal growth factor receptor (Egfr) pathway controls cell fate decisions throughout phylogeny...
  57. Chang T, Shy D, Hartenstein V. Antagonistic relationship between Dpp and EGFR signaling in Drosophila head patterning. Dev Biol. 2003;263:103-13 pubmed
    ..The eye field expresses and requires both Dpp and EGFR signaling for its development...
  58. Weber U, Eroglu C, Mlodzik M. Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development. Dev Cell. 2003;5:559-70 pubmed
    ..As a consequence, an increase in endocytic localization of EGF receptor (Egfr) and Notch is observed, and this correlates with a reduction in signaling strength and leads to ..
  59. Herranz H, Hong X, Cohen S. Mutual repression by bantam miRNA and Capicua links the EGFR/MAPK and Hippo pathways in growth control. Curr Biol. 2012;22:651-7 pubmed publisher
    The epidermal growth factor receptor (EGFR) and Hippo signaling pathways control cell proliferation and apoptosis to promote tissue growth during development. Misregulation of these pathways is implicated in cancer...
  60. Li Z, Zhang Y, Han L, Shi L, Lin X. Trachea-derived dpp controls adult midgut homeostasis in Drosophila. Dev Cell. 2013;24:133-43 pubmed publisher
    ..This work will provide important insights into the mechanisms of tissue homeostasis control by interorgan communication...
  61. Reddy B, Irvine K. Regulation of Hippo signaling by EGFR-MAPK signaling through Ajuba family proteins. Dev Cell. 2013;24:459-71 pubmed publisher
    b>EGFR and Hippo signaling pathways both control growth and, when dysregulated, contribute to tumorigenesis...
  62. O Keefe D, Prober D, Moyle P, Rickoll W, Edgar B. Egfr/Ras signaling regulates DE-cadherin/Shotgun localization to control vein morphogenesis in the Drosophila wing. Dev Biol. 2007;311:25-39 pubmed
    b>Egfr/Ras signaling promotes vein cell fate specification in the developing Drosophila wing...
  63. Nishimura M, Inoue Y, Hayashi S. A wave of EGFR signaling determines cell alignment and intercalation in the Drosophila tracheal placode. Development. 2007;134:4273-82 pubmed
    ..b>EGFR signaling is required for myosin accumulation and cell boundary smoothing, suggesting its propagation polarizes the ..
  64. Wang Y, Werz C, Xu D, Chen Z, Li Y, Hafen E, et al. Drosophila cbl is essential for control of cell death and cell differentiation during eye development. PLoS ONE. 2008;3:e1447 pubmed publisher
    ..role for the ligand-dependent inactivation of receptor tyrosine kinases (RTKs), most notably the Epidermal Growth Factor Receptor (EGFR) through ubiquitin-mediated endocytosis and lysosomal degradation...
  65. Yang L, Baker N. Cell cycle withdrawal, progression, and cell survival regulation by EGFR and its effectors in the differentiating Drosophila eye. Dev Cell. 2003;4:359-69 pubmed
    Receptor tyrosine kinases such as the EGF receptor transduce extracellular signals into multiple cellular responses. In the developing Drosophila eye, EGFR activity triggers cell differentiation...
  66. Cela C, Llimargas M. Egfr is essential for maintaining epithelial integrity during tracheal remodelling in Drosophila. Development. 2006;133:3115-25 pubmed
    ..Here, we report a new role for the Egfr pathway in maintaining epithelial integrity during tracheal development in Drosophila...
  67. McDonald J, Pinheiro E, Kadlec L, Schupbach T, Montell D. Multiple EGFR ligands participate in guiding migrating border cells. Dev Biol. 2006;296:94-103 pubmed
    ..It was previously shown that two receptor tyrosine kinases, epidermal growth factor receptor (EGFR) and PDGF- and VEGF-related receptor (PVR), together contribute to border cell migration...
  68. Yakoby N, Lembong J, Schupbach T, Shvartsman S. Drosophila eggshell is patterned by sequential action of feedforward and feedback loops. Development. 2008;135:343-51 pubmed
    During Drosophila oogenesis, patterning activities of the EGFR and Dpp pathways specify several subpopulations of the follicle cells that give rise to dorsal eggshell structures...
  69. Letizia A, Sotillos S, Campuzano S, Llimargas M. Regulated Crb accumulation controls apical constriction and invagination in Drosophila tracheal cells. J Cell Sci. 2011;124:240-51 pubmed publisher
    ..There, Crb, acting in parallel with the epidermal growth factor receptor (Egfr) pathway, is required for tracheal cell apical constriction and for organising an actomyosin ..
  70. Parrott B, Hudson A, Brady R, Schulz C. Control of germline stem cell division frequency--a novel, developmentally regulated role for epidermal growth factor signaling. PLoS ONE. 2012;7:e36460 pubmed publisher
    ..by restoring EGF signaling in the GSCs, and reproduced in testes from animals with soma-depleted EGF-Receptor (EGFR)...
  71. Cabernard C, Affolter M. Distinct roles for two receptor tyrosine kinases in epithelial branching morphogenesis in Drosophila. Dev Cell. 2005;9:831-42 pubmed
    ..Fgf signaling directs cell migration at the tip of the structure, while Egf signaling is instrumental for cell division and cell survival in the growing epithelial structure...
  72. Dworkin I, Palsson A, Birdsall K, Gibson G. Evidence that Egfr contributes to cryptic genetic variation for photoreceptor determination in natural populations of Drosophila melanogaster. Curr Biol. 2003;13:1888-93 pubmed
    ..A survey of association between 267 SNPs in almost 11 kb of the D. melanogaster Egfr and the degree of eye roughening due to a gain-of-function Egfr(E1) allele crossed into 210 isogenic wild-type ..
  73. Klein D, Nappi V, Reeves G, Shvartsman S, Lemmon M. Argos inhibits epidermal growth factor receptor signalling by ligand sequestration. Nature. 2004;430:1040-4 pubmed
    The epidermal growth factor receptor (EGFR) has critical functions in development and in many human cancers...
  74. Ni J, Liu L, Binari R, Hardy R, Shim H, Cavallaro A, et al. A Drosophila resource of transgenic RNAi lines for neurogenetics. Genetics. 2009;182:1089-100 pubmed publisher
  75. Almudi I, Stocker H, Hafen E, Corominas M, Serras F. SOCS36E specifically interferes with Sevenless signaling during Drosophila eye development. Dev Biol. 2009;326:212-23 pubmed publisher
    ..The SOCS family of adaptor proteins may have evolved as modulators of specific signaling pathways that contribute to the robustness and precision of cell fate specification. ..
  76. Kim S, Jung K, Kim S, Jeon S. Dpp represses eagle expression at short-range, but can repress its expression at a long-range via EGFR signal repression. Mol Cells. 2008;26:576-82 pubmed
    ..This result demonstrated that this discrepancy seems to be due to the repression of Dpp to EGFR signaling in sim;;dpp embryos...
  77. McNeill H, Craig G, Bateman J. Regulation of neurogenesis and epidermal growth factor receptor signaling by the insulin receptor/target of rapamycin pathway in Drosophila. Genetics. 2008;179:843-53 pubmed publisher
    ..also show, for the first time in Drosophila, that there is crosstalk between the InR/TOR pathway and epidermal growth factor receptor (EGFR) signaling...
  78. Angulo M, Corominas M, Serras F. Activation and repression activities of ash2 in Drosophila wing imaginal discs. Development. 2004;131:4943-53 pubmed
    ..of the intervein-promoting genes net and blistered (bs) and to repress rhomboid (rho), a component of the EGF receptor (Egfr) pathway...
  79. Zettervall C, Anderl I, Williams M, Palmer R, Kurucz E, Ando I, et al. A directed screen for genes involved in Drosophila blood cell activation. Proc Natl Acad Sci U S A. 2004;101:14192-7 pubmed
    ..A drastic increase in the number of circulating hemocytes is caused by receptor tyrosine kinases, such as Egfr, Pvr, and Alk, as well as by the downstream signaling components Ras85D and pointed, supporting the notion that the ..
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