Gene Symbol: Efa6
Description: Exchange factor for Arf 6
Alias: CG18185, CG31158, CG6941, Dmel\CG31158, EFA6, dEfa6, dPsd, exchange factor for Arf 6, CG31158-PC, CG31158-PD, CG31158-PG, CG31158-PH, CG31158-PI, Efa6 pleckstrin and Sec7 domain containing, Efa6-PC, Efa6-PD, Efa6-PG, Efa6-PH, Efa6-PI, exchange factor for Arf 6 ortholog
Species: fruit fly

Top Publications

  1. Huang J, Zhou W, Dong W, Watson A, Hong Y. From the Cover: Directed, efficient, and versatile modifications of the Drosophila genome by genomic engineering. Proc Natl Acad Sci U S A. 2009;106:8284-9 pubmed publisher
    ..We have successfully applied the genomic engineering scheme on 6 different genes and have generated at their loci more than 70 unique alleles. ..
  2. Cox R, Mason Gamer R, Jackson C, Segev N. Phylogenetic analysis of Sec7-domain-containing Arf nucleotide exchangers. Mol Biol Cell. 2004;15:1487-505 pubmed
    ..Determination of the importance of these conserved elements in Arf exchange activity and other cellular functions is now possible. ..
  3. Casanova J. Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors. Traffic. 2007;8:1476-85 pubmed
    ..Here we review recent progress in our understanding of the structure, localization and biology of the different classes of Arf GEFs. ..
  4. Johnson R, Sedgwick A, D SOUZA SCHOREY C, Cagan R. Role for a Cindr-Arf6 axis in patterning emerging epithelia. Mol Biol Cell. 2011;22:4513-26 pubmed publisher
    ..by the Arf GTPase-activating proteins (ArfGAPs) dAsap and dArfGAP3 and the Arf GTP exchange factors Schizo and dPsd-promoted large cellular extensions; time-lapse microscopy indicated that these extensions presage cell ..
  5. Dembeck L, Huang W, Magwire M, Lawrence F, Lyman R, Mackay T. Genetic Architecture of Abdominal Pigmentation in Drosophila melanogaster. PLoS Genet. 2015;11:e1005163 pubmed publisher
    ..Variation in these novel candidates may serve as targets for adaptive evolution and sexual selection in D. melanogaster. ..
  6. Chang L, Kreko Pierce T, Eaton B. The guanine exchange factor Gartenzwerg and the small GTPase Arl1 function in the same pathway with Arfaptin during synapse growth. Biol Open. 2015;4:947-53 pubmed publisher
    ..Our data define a new signaling pathway composed of Arfaptin, Arl1, and Garz, required for the generation of normal synapse morphology. ..