Gene Symbol: EF2
Description: Elongation factor 2
Alias: CG2238, Dmel\CG2238, EF-2, EF-2b, EF2B, EF2b, Ef2, Ef2B, Ef2b, anon-EST:Liang-1.44, chr2L:21668915..21669164, clone 1.44, eEF2, eF2, ef2b, elongation factor 2, CG2238-PA, CG2238-PC, CG2238-PD, EF2-PA, EF2-PC, EF2-PD, ELONGATION FACTOR 2, elongation factor 2b, eukaryotic translation elongation factor 2b
Species: fruit fly
Costello J, Dalkilic M, Beason S, Gehlhausen J, Patwardhan R, Middha S, et al
. Gene networks in Drosophila melanogaster: integrating experimental data to predict gene function. Genome Biol. 2009;10:R97 pubmed publisher
..melanogaster. The network enables the exploration, mining, and reanalysis of experimental data, as well as the interpretation of new data. The inferred annotations provide testable hypotheses of previously uncharacterized genes. ..
Haney R, Feder M. Contrasting patterns of transposable element insertions in Drosophila heat-shock promoters. PLoS ONE. 2009;4:e8486 pubmed publisher
..melanogaster. These results suggest that D. melanogaster heat-shock promoters are unique in terms of their interaction with transposable elements, and confirm that Hsp70 promoters are distinctive in TE insertions across Drosophila. ..
Cammarano P, Palm P, Creti R, Ceccarelli E, Sanangelantoni A, Tiboni O. Early evolutionary relationships among known life forms inferred from elongation factor EF-2/EF-G sequences: phylogenetic coherence and structure of the archaeal domain. J Mol Evol. 1992;34:396-405 pubmed
..This division was not confirmed by evolutionary parsimony, which identified Halobacterium rather than Sulfolobus as the deepest offspring within the Archaea. ..
Grinblat Y, Brown N, Kafatos F. Isolation and characterization of the Drosophila translational elongation factor 2 gene. Nucleic Acids Res. 1989;17:7303-14 pubmed
We have isolated a cDNA clone that encodes the Drosophila melanogaster elongation factor 2 (EF2), a protein involved in the elongation step of protein synthesis...
Bernard F, Krejci A, Housden B, Adryan B, Bray S. Specificity of Notch pathway activation: twist controls the transcriptional output in adult muscle progenitors. Development. 2010;137:2633-42 pubmed publisher
Sharma A, Fitzgerald D. Pseudomonas exotoxin kills Drosophila S2 cells via apoptosis. Toxicon. 2010;56:1025-34 pubmed publisher
..it enters cells by receptor-mediated endocytosis, translocates to the cell cytosol and ADP-ribosylates elongation factor 2 (EF2)...
Parry T, Theisen J, Hsu J, Wang Y, Corcoran D, Eustice M, et al
. The TCT motif, a key component of an RNA polymerase II transcription system for the translational machinery. Genes Dev. 2010;24:2013-8 pubmed publisher
..Thus, the TCT motif is a novel transcriptional element that is distinct from the Inr. These findings reveal a specialized TCT-based transcription system that is directed toward the synthesis of ribosomal proteins. ..
Gilchrist D, dos Santos G, Fargo D, Xie B, Gao Y, Li L, et al
. Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation. Cell. 2010;143:540-51 pubmed publisher