Gene Symbol: east
Description: enhanced adult sensory threshold
Alias: CG4399, Dmel\CG4399, EAST, EG:133E12.4, East, anon-WO03040301.224, l(1)G0014, l(1)G0500, su(w[sp]), enhanced adult sensory threshold, CG4399-PB, CG4399-PC, CG4399-PD, CG4399-PE, CG4399-PF, CG4399-PG, east-PB, east-PC, east-PD, east-PE, east-PF, east-PG, enhanced adult salt tolerance, suppressor of white-spotted
Species: fruit fly

Top Publications

  1. Vijayraghavan K, Kaur J, Paranjape J, Rodrigues V. The east gene of Drosophila melanogaster is expressed in the developing embryonic nervous system and is required for normal olfactory and gustatory responses of the adult. Dev Biol. 1992;154:23-36 pubmed
    ..We describe the genetics and developmental expression of the east gene, mutations which result in adult-specific chemosensory defects...
  2. Davison D, Chapman C, Wedeen C, Bingham P. Genetic and physical studies of a portion of the white locus participating in transcriptional regulation and in synapsis-dependent interactions in Drosophila adult tissues. Genetics. 1985;110:479-94 pubmed
    ..We discuss the regulation of white expression in light of our studies. We also demonstrate unusual structures for an X-ray-induced deletion and a spontaneous deletion. ..
  3. Wasser M, Chia W. The Drosophila EAST protein associates with a nuclear remnant during mitosis and constrains chromosome mobility. J Cell Sci. 2003;116:1733-43 pubmed
    Drosophila EAST protein associates with an interior nonchromosomal compartment of the interphase nucleus...
  4. Wasser M, Bte Osman Z, Chia W. EAST and Chromator control the destruction and remodeling of muscles during Drosophila metamorphosis. Dev Biol. 2007;307:380-93 pubmed
    ..In this study, we demonstrate the role of the Drosophila nuclear proteins EAST and Chromator in tissue destruction and remodeling...
  5. Wasser M, Chia W. The EAST protein of drosophila controls an expandable nuclear endoskeleton. Nat Cell Biol. 2000;2:268-75 pubmed
    ..EAST, a novel ubiquitous protein, the product of the east (enhanced adult sensory threshold) locus, is localized to an extrachromosomal domain of the nucleus...
  6. Qi H, Rath U, Ding Y, Ji Y, Blacketer M, Girton J, et al. EAST interacts with Megator and localizes to the putative spindle matrix during mitosis in Drosophila. J Cell Biochem. 2005;95:1284-91 pubmed
    We have used immunocytochemistry to demonstrate that the EAST protein in Drosophila, which forms an expandable nuclear endoskeleton at interphase, redistributes during mitosis to colocalize with the spindle matrix proteins, Megator and ..
  7. Rowshanravan B, Woodcock S, Botella J, Kiermayer C, Schneuwly S, Hughes D. RasGAP mediates neuronal survival in Drosophila through direct regulation of Rab5-dependent endocytosis. J Cell Sci. 2014;127:2849-61 pubmed publisher
    ..These results indicate that the long-term survival of adult neurons in Drosophila is crucially dependent on the activities of two GTPases, Ras and Rab5, regulated by the interplay of RasGAP and Sprint. ..
  8. Carlson J. Olfaction in Drosophila: from odor to behavior. Trends Genet. 1996;12:175-80 pubmed
    ..Genetic and molecular analyses of the Drosophila olfactory system have identified some of its molecular components, and have revealed some principles of its function and organization. ..
  9. Bhadra U, Pal Bhadra M, Birchler J. A trans-acting modifier causing extensive overexpression of genes in Drosophila melanogaster. Mol Gen Genet. 1997;254:621-34 pubmed
    ..Regulatory genes such as Ufo may contribute to the wide fluctuations in gene expression between tissues and stages of development...

More Information


  1. Balicky E, Endres M, Lai C, Bickel S. Meiotic cohesion requires accumulation of ORD on chromosomes before condensation. Mol Biol Cell. 2002;13:3890-900 pubmed
  2. Li S, Koe C, Tay S, Tan A, Zhang S, Zhang Y, et al. An intrinsic mechanism controls reactivation of neural stem cells by spindle matrix proteins. Nat Commun. 2017;8:122 pubmed publisher
  3. Brumby A, Goulding K, Schlosser T, Loi S, Galea R, Khoo P, et al. Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis. Genetics. 2011;188:105-25 pubmed publisher
    ..Ras(ACT)-cooperating genes identified were Rac1 Rho1, RhoGEF2, pbl, rib, and east, which encode cell morphology regulators...
  4. Campos Ortega J. Cellular interactions in the developing nervous system of Drosophila. Cell. 1994;77:969-75 pubmed
  5. Wasser M, Chia W. The extrachromosomal East protein of Drosophila can associate with polytene chromosomes and regulate gene expression. PLoS ONE. 2007;2:e412 pubmed
    The EAST protein of Drosophila is a component of an expandable extrachromosomal domain of the nucleus. To better understand its function, we studied the dynamics and localization of GFP-tagged EAST...
  6. Mel nikova L, Krivega I, Georgiev P, Golovnin A. Nuclear matrix protein EAST is involved in regulation of transcription of the yellow gene in Drosophila melanogaster. Dokl Biol Sci. 2007;415:313-6 pubmed
  7. Soriano S, Velazquez A, Marcos R, Cabre O, Xamena N. Induced somatic and germinal reversion of the white-spotted-1 insertional mutant phenotype in Drosophila melanogaster. Mutagenesis. 1998;13:199-206 pubmed
    ..Such modifiers map near the white locus and, at least in one case, may correspond to suppressor-of-white-spotted...
  8. Chinta R, Tan J, Wasser M. The study of muscle remodeling in Drosophila metamorphosis using in vivo microscopy and bioimage informatics. BMC Bioinformatics. 2012;13 Suppl 17:S14 pubmed publisher
    ..We demonstrate how the temporal alignment can reveal novel insights into the east gene which is involved in muscle remodeling...
  9. Rabinow L, Nguyen Huynh A, Birchler J. A trans-acting regulatory gene that inversely affects the expression of the white, brown and scarlet loci in Drosophila. Genetics. 1991;129:463-80 pubmed
    ..These experiments demonstrate that a single regulatory gene can exert an inverse effect on a target structural locus, a situation postulated from segmental aneuploid studies of gene expression and dosage compensation. ..
  10. Bajpe P, van der Knaap J, Demmers J, Bezstarosti K, Bassett A, van Beusekom H, et al. Deubiquitylating enzyme UBP64 controls cell fate through stabilization of the transcriptional repressor tramtrack. Mol Cell Biol. 2008;28:1606-15 pubmed
    ..We conclude that the balance of TTK ubiquitylation by SINA and deubiquitylation by UBP64 constitutes a specific posttranslational switch controlling cell fate. ..
  11. Johansen J, Johansen K. The spindle matrix through the cell cycle in Drosophila. Fly (Austin). 2009;3:213-20 pubmed