Gene Symbol: E2f1
Description: E2F transcription factor 1
Alias: CG6376, DRTF1/E2F, DmE2F-1, Dmel\CG6376, E(Sev-CycE)3A, E(var)3-93E, E(var)3-95E, E(var)93E, E2F, E2F-1, E2F1, E2f, Evar(3)164, dE2F, dE2F1, dE2f, dE2f1, de2f1, def21, drosE2F1, e2f, e2f1, l(3)07172, l(3)j3B1, l(3)j3C2, l(3)rM729, E2F transcription factor 1, CG6376-PA, CG6376-PB, CG6376-PC, CG6376-PD, CG6376-PE, CG6376-PF, E2-promoter binding factor, E2F transcription factor, E2f1-PA, E2f1-PB, E2f1-PC, E2f1-PD, E2f1-PE, E2f1-PF
Species: fruit fly
Products:     E2f1

Top Publications

  1. Du W, Vidal M, Xie J, Dyson N. RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev. 1996;10:1206-18 pubmed
    Genetic studies have shown that cyclin E and dE2F are critical regulators of S-phase entry during Drosophila embryogenesis...
  2. Du W, Dyson N. The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis. EMBO J. 1999;18:916-25 pubmed
    ..first appearance of G1 during Drosophila embryogenesis, at cell cycle 17, is accompanied by the down-regulation of E2F-dependent transcription...
  3. Whittaker A, Royzman I, Orr Weaver T. Drosophila double parked: a conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase transcripts. Genes Dev. 2000;14:1765-76 pubmed
    ..The dup transcript is cell cycle regulated and is under the control of E2F and Cyclin E...
  4. Maqbool S, Mehrotra S, Kolpakas A, Durden C, Zhang B, Zhong H, et al. Dampened activity of E2F1-DP and Myb-MuvB transcription factors in Drosophila endocycling cells. J Cell Sci. 2010;123:4095-106 pubmed publisher
    ..The results indicated that many genes that are positively regulated by the heterodimeric E2F1-DP or Myb-MuvB complex transcription factors are expressed at lower levels in endocycling cells...
  5. Lim Y, Yamasaki Y, Tsuda L. Ebi alleviates excessive growth signaling through multiple epigenetic functions in Drosophila. Genes Cells. 2013;18:909-20 pubmed publisher
    ..RBF), a Drosophila homologue of retinoblastoma, and regulating the expression of specific target genes of the Rbf/E2F pathway...
  6. Stevaux O, Dimova D, Frolov M, Taylor Harding B, Morris E, Dyson N. Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2. EMBO J. 2002;21:4927-37 pubmed
    ..Analysis of in vivo protein complexes reveals that RBF1 and RBF2 interact with different subsets of E2F proteins. dE2F1, a potent transcriptional activator, is regulated specifically by RBF1...
  7. Moon N, Di Stefano L, Morris E, Patel R, White K, Dyson N. E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet. 2008;4:e1000153 pubmed publisher
    ..of one another when examined in the context of Drosophila development: apoptosis induced by the deregulation of dE2F1, or by the overexpression of dE2F1, is unaffected by the elimination of dp53; conversely, dp53-induced phenotypes ..
  8. Sawado T, Yamaguchi M, Nishimoto Y, Ohno K, Sakaguchi K, Matsukage A. dE2F2, a novel E2F-family transcription factor in Drosophila melanogaster. Biochem Biophys Res Commun. 1998;251:409-15 pubmed
    ..In Drosophila melanogaster, only a single E2F-related transcription factor, dE2F, has been reported...
  9. Duronio R, Bonnette P, O Farrell P. Mutations of the Drosophila dDP, dE2F, and cyclin E genes reveal distinct roles for the E2F-DP transcription factor and cyclin E during the G1-S transition. Mol Cell Biol. 1998;18:141-51 pubmed
    ..Mutation of the Drosophila melanogaster dE2F gene eliminates transcriptional activation of several replication factors at the G1-S transition and compromises ..

More Information


  1. Truscott M, Islam A, Lopez Bigas N, Frolov M. mir-11 limits the proapoptotic function of its host gene, dE2f1. Genes Dev. 2011;25:1820-34 pubmed publisher
    ..The mir-11 gene is located in the last intron of the Drosophila E2F1 homolog gene dE2f1, and its expression parallels that of dE2f1...
  2. Hirose F, Ohshima N, Shiraki M, Inoue Y, Taguchi O, Nishi Y, et al. Ectopic expression of DREF induces DNA synthesis, apoptosis, and unusual morphogenesis in the Drosophila eye imaginal disc: possible interaction with Polycomb and trithorax group proteins. Mol Cell Biol. 2001;21:7231-42 pubmed
    ..encoding DNA replication-related proteins contain transcription regulatory element DRE (5'-TATCGATA) in addition to E2F recognition sites. A specific DRE-binding factor, DREF, positively regulates DRE-containing genes...
  3. Neufeld T, de la Cruz A, Johnston L, Edgar B. Coordination of growth and cell division in the Drosophila wing. Cell. 1998;93:1183-93 pubmed
    ..Constitutive overproduction of the transcriptional regulator dE2F increased expression of the S- and M-phase initiators Cyclin E and String (Cdc25), thereby accelerating cell ..
  4. Wichmann A, Uyetake L, Su T. E2F1 and E2F2 have opposite effects on radiation-induced p53-independent apoptosis in Drosophila. Dev Biol. 2010;346:80-9 pubmed publisher
    ..We report here that dE2F1 promotes IR-induced p53-independent apoptosis in larval imaginal discs...
  5. Brook A, Xie J, Du W, Dyson N. Requirements for dE2F function in proliferating cells and in post-mitotic differentiating cells. EMBO J. 1996;15:3676-83 pubmed
    ..The recent identification of mutant alleles of the Drosophila E2F gene (dE2F) has shown that dE2F is required for embryogenesis...
  6. Follette P, Duronio R, O Farrell P. Fluctuations in cyclin E levels are required for multiple rounds of endocycle S phase in Drosophila. Curr Biol. 1998;8:235-8 pubmed
    ..the kinase inhibitor 6-dimethylaminopurine (6-DMAP), but not by expression of subunits of the transcription factor E2F. These results indicate that endocycle S phases require oscillations in Cdk activity, but, in contrast to ..
  7. Brennecke J, Hipfner D, Stark A, Russell R, Cohen S. bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell. 2003;113:25-36 pubmed
    ..bantam microRNA simultaneously stimulates cell proliferation and prevents apoptosis. We identify the pro-apoptotic gene hid as a target for regulation by bantam miRNA, providing an explanation for bantam's anti-apoptotic activity. ..
  8. Royzman I, Austin R, Bosco G, Bell S, Orr Weaver T. ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP. Genes Dev. 1999;13:827-40 pubmed
    ..Mutations in the DNA-binding domains of dE2F or dDP reduce amplification, and in these mutants specific localization of ORC2 to amplification loci is lost...
  9. Goulev Y, Fauny J, Gonzalez Marti B, Flagiello D, Silber J, Zider A. SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila. Curr Biol. 2008;18:435-41 pubmed publisher
    ..The dimer drives cell-cycle progression by inducing expression of the dE2F1 transcription factor [7], which regulates genes involved in DNA replication and cell-cycle progression...
  10. Weng L, Zhu C, Xu J, Du W. Critical role of active repression by E2F and Rb proteins in endoreplication during Drosophila development. EMBO J. 2003;22:3865-75 pubmed
    ..The role of active repression during normal development has not been analyzed in detail. dE2F1(su89) is a novel allele of dE2F1 that disrupts dE2F1's association with RBF [the Drosophila retinoblastoma protein ..
  11. Hartl T, Boswell C, Orr Weaver T, Bosco G. Developmentally regulated histone modifications in Drosophila follicle cells: initiation of gene amplification is associated with histone H3 and H4 hyperacetylation and H1 phosphorylation. Chromosoma. 2007;116:197-214 pubmed
    ..These data suggest that amplification origins are able to initiate when the cells are in a late S-phase, when the genome is normally not licensed for replication. ..
  12. Nicolay B, Frolov M. Context-dependent requirement for dE2F during oncogenic proliferation. PLoS Genet. 2008;4:e1000205 pubmed publisher
    ..In Drosophila, there is a single activator, dE2F1, and a single repressor, dE2F2, which act antagonistically to each other during development...
  13. Oldham S, Bohni R, Stocker H, Brogiolo W, Hafen E. Genetic control of size in Drosophila. Philos Trans R Soc Lond B Biol Sci. 2000;355:945-52 pubmed
    ..In this article we will review recent evidence from vertebrates and particularly from Drosophila that implicates insulin/insulin-like growth factor-I and other growth pathways in the control of cell, organ and body size. ..
  14. Duronio R, O Farrell P. Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F. Genes Dev. 1995;9:1456-68 pubmed
    The E2F transcription factor is required for S phase in Drosophila...
  15. Reis T, Edgar B. Negative regulation of dE2F1 by cyclin-dependent kinases controls cell cycle timing. Cell. 2004;117:253-64 pubmed
    ..negative feedback in which the cyclin-dependent kinases Cdk1 and Cdk2 downregulate the transcription factor dE2F1. dE2F1, in turn, positively regulates cyclin E and string/cdc25, which activate the Cdks to drive cell cycle ..
  16. Frolov M, Stevaux O, Moon N, Dimova D, Kwon E, Morris E, et al. G1 cyclin-dependent kinases are insufficient to reverse dE2F2-mediated repression. Genes Dev. 2003;17:723-8 pubmed
    Here we show that the cell cycle defects of dE2F1-depleted cells depend on the cooperative effects of dE2F2 and DACAPO (DAP), an inhibitor of Cyclin E/cyclin-dependent kinase 2 (CycE/cdk2)...
  17. Hyun J, Jasper H, Bohmann D. DREF is required for efficient growth and cell cycle progression in Drosophila imaginal discs. Mol Cell Biol. 2005;25:5590-8 pubmed
    ..These data establish DREF as a global regulator of transcriptional programs that mediate cell proliferation and organ growth during animal development. ..
  18. Shibutani S, Swanhart L, Duronio R. Rbf1-independent termination of E2f1-target gene expression during early Drosophila embryogenesis. Development. 2007;134:467-78 pubmed
    ..The maintenance of G1(17) arrest requires Rbf1-dependent repression of E2f1-regulated replication factor genes, which are expressed continuously during cycles 1-16 when S phase immediately ..
  19. Bosco G, Du W, Orr Weaver T. DNA replication control through interaction of E2F-RB and the origin recognition complex. Nat Cell Biol. 2001;3:289-95 pubmed
    The E2F transcription factor and retinoblastoma protein control cell-cycle progression and DNA replication during S phase...
  20. Jin Z, Kirilly D, Weng C, Kawase E, Song X, Smith S, et al. Differentiation-defective stem cells outcompete normal stem cells for niche occupancy in the Drosophila ovary. Cell Stem Cell. 2008;2:39-49 pubmed publisher
  21. Asano M, Nevins J, Wharton R. Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs. Genes Dev. 1996;10:1422-32 pubmed
    ..in the commitment of cultured mammalian cells to entering S phase is a rise in activity of the transcription factor E2F. In this report, we study the role of Drosophila E2F in imaginal disc cells in vivo, by examining the distribution ..
  22. Baonza A, Freeman M. Control of cell proliferation in the Drosophila eye by Notch signaling. Dev Cell. 2005;8:529-39 pubmed
    ..the onset of proliferation by multiple pathways, including the activation of dE2F1, a member of the E2F transcription factor family...
  23. Xin S, Weng L, Xu J, Du W. The role of RBF in developmentally regulated cell proliferation in the eye disc and in Cyclin D/Cdk4 induced cellular growth. Development. 2002;129:1345-56 pubmed
    ..These observations suggest that RB/E2F control the rate of S-phase progression instead of G1/S transition in the second mitotic wave...
  24. Royzman I, Whittaker A, Orr Weaver T. Mutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program. Genes Dev. 1997;11:1999-2011 pubmed
    The E2F transcription factor, a heterodimer of E2F and DP subunits, is capable of driving the G1-S transition of the cell cycle...
  25. Li L, Vaessin H. Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis. Genes Dev. 2000;14:147-51 pubmed
    ..pros activity, hence, provides a critical regulatory link between neuronal lineage development and transcriptional regulation of cell cycle regulatory genes. ..
  26. Cayirlioglu P, Bonnette P, Dickson M, Duronio R. Drosophila E2f2 promotes the conversion from genomic DNA replication to gene amplification in ovarian follicle cells. Development. 2001;128:5085-98 pubmed
    Drosophila contains two members of the E2F transcription factor family (E2f and E2f2), which controls the expression of genes that regulate the G1-S transition of the cell cycle...
  27. Moon N, Di Stefano L, Dyson N. A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis. Mol Cell Biol. 2006;26:7601-15 pubmed
    ..These results demonstrate that a gradient of DER/ras/raf signaling that occurs naturally during development provides the contextual signals that determine when and where the inactivation of rbf1 results in dE2F1-dependent apoptosis.
  28. Berger C, Pallavi S, Prasad M, Shashidhara L, Technau G. A critical role for cyclin E in cell fate determination in the central nervous system of Drosophila melanogaster. Nat Cell Biol. 2005;7:56-62 pubmed
    ..However, other components of the cell cycle seem to have a minor role in this process, suggesting a critical role for CycE in regulating cell fate in segment-specific neural lineages. ..
  29. Miles W, Tschop K, Herr A, Ji J, Dyson N. Pumilio facilitates miRNA regulation of the E2F3 oncogene. Genes Dev. 2012;26:356-68 pubmed publisher
    ..we used Drosophila as a model system to screen for mutations that modify phenotypes caused by reduced levels of dE2F1. This screen identified components of the Pumilio translational repressor complex (Pumilio, Nanos, and Brain tumor)..
  30. Pagliarini R, Xu T. A genetic screen in Drosophila for metastatic behavior. Science. 2003;302:1227-31 pubmed
    ..These findings suggest that the oncogenic background of tissues makes a distinct contribution toward metastatic development. ..
  31. Longworth M, Herr A, Ji J, Dyson N. RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3. Genes Dev. 2008;22:1011-24 pubmed publisher
    ..homologs (pRB, p130, and p107) are best known for their regulation of the G1/S transition via the repression of E2F-dependent transcription. However, RB family members also possess additional functions...
  32. Swanhart L, Sanders A, Duronio R. Normal regulation of Rbf1/E2f1 target genes in Drosophila type 1 protein phosphatase mutants. Dev Dyn. 2007;236:2567-77 pubmed
    ..While Rbf1 is required for E2f1 inhibition and G1 arrest in the embryonic epidermis and for the periodic expression of E2f1 target genes during ..
  33. Buttitta L, Katzaroff A, Edgar B. A robust cell cycle control mechanism limits E2F-induced proliferation of terminally differentiated cells in vivo. J Cell Biol. 2010;189:981-96 pubmed publisher
    ..cells in Drosophila melanogaster wings and eyes are largely resistant to proliferation upon deregulation of either E2F or cyclin E (CycE), but exogenous expression of both factors together can bypass cell cycle exit...
  34. Edgar B, Orr Weaver T. Endoreplication cell cycles: more for less. Cell. 2001;105:297-306 pubmed
  35. Korenjak M, Taylor Harding B, Binné U, Satterlee J, Stevaux O, Aasland R, et al. Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes. Cell. 2004;119:181-93 pubmed
    The retinoblastoma tumor suppressor protein (pRb) regulates gene transcription by binding E2F transcription factors...
  36. Johnston L, Edgar B. Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing. Nature. 1998;394:82-4 pubmed
    ..Notch activity creates a third domain by preventing arrest at G2 in wg-expressing cells, resulting in their arrest in G1. ..
  37. Tanaka Matakatsu M, Xu J, Cheng L, Du W. Regulation of apoptosis of rbf mutant cells during Drosophila development. Dev Biol. 2009;326:347-56 pubmed publisher
    ..cues as well as to radiation and demonstrated that this hid enhancer is directly repressed by RBF through an E2F binding site. These observations indicate that apoptosis of rbf mutant cells is mediated by an upregulation of hid...
  38. Duronio R, O Farrell P, Xie J, Brook A, Dyson N. The transcription factor E2F is required for S phase during Drosophila embryogenesis. Genes Dev. 1995;9:1445-55 pubmed
    ..Here we identify mutations in a single essential Drosophila gene, dE2F, that encodes a homolog of the mammalian E2F gene family...
  39. Nicholson S, Gilbert M, Nicolay B, Frolov M, Moberg K. The archipelago tumor suppressor gene limits rb/e2f-regulated apoptosis in developing Drosophila tissues. Curr Biol. 2009;19:1503-10 pubmed publisher
    ..This reflects a requirement for ago to restrict apoptotic activity of the rbf1/de2f1 pathway adjacent to the eye-specific morphogenetic furrow (MF): ago mutant cells display elevated de2f1 activity, ..
  40. Moon N, Frolov M, Kwon E, Di Stefano L, Dimova D, Morris E, et al. Drosophila E2F1 has context-specific pro- and antiapoptotic properties during development. Dev Cell. 2005;9:463-75 pubmed
    ..E2F transcription factors are generally believed to be positive regulators of apoptosis. In this study, we show that dE2F1 and dDP are important for the normal pattern of DNA damage-induced apoptosis in Drosophila wing discs...
  41. Yamaguchi M, Hayashi Y, Matsukage A. Essential role of E2F recognition sites in regulation of the proliferating cell nuclear antigen gene promoter during Drosophila development. J Biol Chem. 1995;270:25159-65 pubmed
    We have found sequences similar to the transcription factor E2F recognition site within the Drosophila proliferating cell nuclear antigen (PCNA) gene promoter. These sequences are located at positions -43 to -36 (site I)...
  42. Duronio R, Brook A, Dyson N, O Farrell P. E2F-induced S phase requires cyclin E. Genes Dev. 1996;10:2505-13 pubmed
    ..Simultaneous overexpression of both Drosophila E2F subunits, dE2F and dDP, in embryos stimulated the expression of multiple E2F-target genes including cyclin E, and also caused the ..
  43. Britton J, Edgar B. Environmental control of the cell cycle in Drosophila: nutrition activates mitotic and endoreplicative cells by distinct mechanisms. Development. 1998;125:2149-58 pubmed
    ..We also show that ectopic expression of Drosophila Cyclin E or the E2F transcription factor can drive quiescent endoreplicating cells, but not quiescent imaginal neuroblasts, into S-phase...
  44. Frolov M, Huen D, Stevaux O, Dimova D, Balczarek Strang K, Elsdon M, et al. Functional antagonism between E2F family members. Genes Dev. 2001;15:2146-60 pubmed
    ..mammalian cells, that have a large number of E2F-related genes, the Drosophila genome encodes just two E2F genes, de2f1 and de2f2...
  45. Zhou L, Steller H. Distinct pathways mediate UV-induced apoptosis in Drosophila embryos. Dev Cell. 2003;4:599-605 pubmed
    ..This early UV response requires E2F but not mei-41 function and appears to be independent of DNA damage.
  46. Frolov M, Moon N, Dyson N. dDP is needed for normal cell proliferation. Mol Cell Biol. 2005;25:3027-39 pubmed
    ..Our results show that dDP requires dE2F1 and dE2F2 for DNA-binding activity in vitro and in vivo...
  47. Thacker S, Bonnette P, Duronio R. The contribution of E2F-regulated transcription to Drosophila PCNA gene function. Curr Biol. 2003;13:53-8 pubmed
    b>E2F proteins control cell cycle progression by predominantly acting as either activators or repressors of transcription...
  48. Datar S, Jacobs H, de la Cruz A, Lehner C, Edgar B. The Drosophila cyclin D-Cdk4 complex promotes cellular growth. EMBO J. 2000;19:4543-54 pubmed
    ..stimulation, and they can phosphorylate and thus neutralize Retinoblastoma (Rb) family proteins to promote an E2F-dependent transcriptional program and S-phase entry...
  49. Hériché J, Ang D, Bier E, O Farrell P. Involvement of an SCFSlmb complex in timely elimination of E2F upon initiation of DNA replication in Drosophila. BMC Genet. 2003;4:9 pubmed
    ..A screen for mutations that dominantly modify this phenotype showed effective suppression upon reduction of E2F function, suggesting that compromised downregulation of E2F contributes to the phenotype...
  50. Du W, Xie J, Dyson N. Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye. EMBO J. 1996;15:3684-92 pubmed
    ..To address this issue, transgenic lines of Drosophila were studied in which ectopic expression of dE2F and dDP was targeted to the developing eye...
  51. Dynlacht B, Brook A, Dembski M, Yenush L, Dyson N. DNA-binding and trans-activation properties of Drosophila E2F and DP proteins. Proc Natl Acad Sci U S A. 1994;91:6359-63 pubmed
    ..One of these genes, dE2F, contains three domains that are highly conserved in the human homologs E2F-1, E2F-2, and E2F-3...
  52. Zielke N, Kim K, Tran V, Shibutani S, Bravo M, Nagarajan S, et al. Control of Drosophila endocycles by E2F and CRL4(CDT2). Nature. 2011;480:123-7 pubmed publisher
    ..modelling, we show that the endocycles of Drosophila are driven by a molecular oscillator in which the E2F1 transcription factor promotes CycE expression and S-phase initiation, S-phase then activates the CRL4(CDT2) ..
  53. Shibutani S, de la Cruz A, Tran V, Turbyfill W, Reis T, Edgar B, et al. Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase. Dev Cell. 2008;15:890-900 pubmed publisher
    ..Here, we show that S phase-specific destruction of Drosophila E2f1 provides a novel mechanism for cell cycle regulation...
  54. Lane M, Elend M, Heidmann D, Herr A, Marzodko S, Herzig A, et al. A screen for modifiers of cyclin E function in Drosophila melanogaster identifies Cdk2 mutations, revealing the insignificance of putative phosphorylation sites in Cdk2. Genetics. 2000;155:233-44 pubmed
    ..that we have identified fall into four complementation groups corresponding to the genes split ends, dacapo, dE2F1, and Cdk2(Cdc2c)...
  55. Morris E, Michaud W, Ji J, Moon N, Rocco J, Dyson N. Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. PLoS Genet. 2006;2:e196 pubmed
    ..Genetic interactions show that dE2F1-dependent apoptosis in vivo involves dArk/Apaf1 apoptosome-dependent activation of both initiator and effector ..
  56. Korenjak M, Anderssen E, Ramaswamy S, Whetstine J, Dyson N. RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes. Mol Cell Biol. 2012;32:4375-87 pubmed publisher
    ..The best-known target of RB protein (pRB) is the E2F transcription factor; however, many other chromatin-associated proteins have been described that may allow RB family members ..
  57. Buttitta L, Katzaroff A, Perez C, de la Cruz A, Edgar B. A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila. Dev Cell. 2007;12:631-43 pubmed
    ..cycle exit can be prevented or even reversed in terminally differentiating cells by the simultaneous activation of E2F1 and either Cyclin E/Cdk2 or Cyclin D/Cdk4...
  58. Harbour J, Dean D. The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev. 2000;14:2393-409 pubmed
  59. Brumby A, Richardson H. scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J. 2003;22:5769-79 pubmed
  60. Du W. Suppression of the rbf null mutants by a de2f1 allele that lacks transactivation domain. Development. 2000;127:367-79 pubmed
    ..Drosophila homologs of the RB and E2F family of proteins RBF and dE2F1 have been identified...
  61. Morris E, Ji J, Yang F, Di Stefano L, Herr A, Moon N, et al. E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8. Nature. 2008;455:552-6 pubmed publisher
    The E2F1 transcription factor can promote proliferation or apoptosis when activated, and is a key downstream target of the retinoblastoma tumour suppressor protein (pRB)...
  62. Ambrus A, Nicolay B, Rasheva V, Suckling R, Frolov M. dE2F2-independent rescue of proliferation in cells lacking an activator dE2F1. Mol Cell Biol. 2007;27:8561-70 pubmed
    In Drosophila melanogaster, the loss of activator de2f1 leads to a severe reduction in cell proliferation and repression of E2F targets...