Gene Symbol: Dysb
Description: Dysbindin
Alias: CG6856, Ddysb, Dmel\CG6856, NP_649064, dysb, dysbindin, CG6856-PA, CG6856-PB, Dysb-PA, Dysb-PB, dysbindin ortholog
Species: fruit fly

Top Publications

  1. Falcon Perez J, Romero Calderon R, Brooks E, Krantz D, Dell Angelica E. The Drosophila pigmentation gene pink (p) encodes a homologue of human Hermansky-Pudlak syndrome 5 (HPS5). Traffic. 2007;8:154-68 pubmed
    ..The phenotype of pink mutants was exacerbated by mutations in AP-3 subunits or in the orthologs of VPS33A and Rab38. These results validate D. melanogaster as a genetic model to study the function of the BLOCs. ..
  2. Dickman D, Tong A, Davis G. Snapin is critical for presynaptic homeostatic plasticity. J Neurosci. 2012;32:8716-24 pubmed publisher
    ..This screen identified a critical function for dysbindin, a gene linked to schizophrenia in humans (Dickman and Davis, 2009)...
  3. Lu B, Shao L, Feng S, Wang T, Zhong Y. The ?-alanyl-monoamine synthase ebony is regulated by schizophrenia susceptibility gene dysbindin in Drosophila. Sci China Life Sci. 2014;57:46-51 pubmed publisher
    The Drosophila homolog of schizophrenia susceptibility gene dysbindin (Ddysb) affects a range of behaviors through regulation of multiple neurotransmitter signals, including dopamine activity...
  4. Gokhale A, Mullin A, Zlatic S, Easley C, Merritt M, Raj N, et al. The N-ethylmaleimide-sensitive factor and dysbindin interact to modulate synaptic plasticity. J Neurosci. 2015;35:7643-53 pubmed publisher
    b>Dysbindin is a schizophrenia susceptibility factor and subunit of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) required for lysosome-related organelle biogenesis, and in neurons, synaptic vesicle assembly, ..
  5. Chen X, Ma W, Zhang S, Paluch J, Guo W, Dickman D. The BLOC-1 Subunit Pallidin Facilitates Activity-Dependent Synaptic Vesicle Recycling. Eneuro. 2017;4: pubmed publisher
    ..cytoskeletal structures, and that the stability of Pallidin protein is highly dependent on the BLOC-1 components Dysbindin and Blos1...
  6. Wentzel C, Delvendahl I, Sydlik S, Georgiev O, Müller M. Dysbindin links presynaptic proteasome function to homeostatic recruitment of low release probability vesicles. Nat Commun. 2018;9:267 pubmed publisher
    ..release after loss of specific homeostatic plasticity genes, including the schizophrenia-susceptibility gene dysbindin. Finally, we provide genetic evidence that Dysbindin levels regulate the access to EGTA-sensitive vesicles...
  7. Cheli V, Dell Angelica E. Early origin of genes encoding subunits of biogenesis of lysosome-related organelles complex-1, -2 and -3. Traffic. 2010;11:579-86 pubmed publisher
    ..Potential orthologs of Mon1 and Ccz1 were found in humans and several other eukaryotes...
  8. Gokhale A, Vrailas Mortimer A, Larimore J, Comstra H, Zlatic S, Werner E, et al. Neuronal copper homeostasis susceptibility by genetic defects in dysbindin, a schizophrenia susceptibility factor. Hum Mol Genet. 2015;24:5512-23 pubmed publisher
    ..Here we focus on the schizophrenia susceptibility gene DTNBP1 and its product dysbindin, a subunit of the BLOC-1 complex, and describe a neuronal pathway modulating copper metabolism via ATP7A...
  9. Furukubo Tokunaga K, Kurita K, Honjo K, Pandey H, Ando T, Takayama K, et al. DISC1 causes associative memory and neurodevelopmental defects in fruit flies. Mol Psychiatry. 2016;21:1232-43 pubmed publisher
    ..Finally, we show that DISC1 functionally interacts with the fly homolog of Dysbindin (DTNBP1) via direct protein-protein interaction in developing synapses.

More Information


  1. Shao L, Shuai Y, Wang J, Feng S, Lu B, Li Z, et al. Schizophrenia susceptibility gene dysbindin regulates glutamatergic and dopaminergic functions via distinctive mechanisms in Drosophila. Proc Natl Acad Sci U S A. 2011;108:18831-6 pubmed publisher
    ..Here we show that manipulation of a single schizophrenia susceptibility gene, dysbindin, is capable of regulating both glutamatergic and dopaminergic functions through two independent mechanisms, ..
  2. Mullin A, Sadanandappa M, Ma W, Dickman D, Vijayraghavan K, Ramaswami M, et al. Gene dosage in the dysbindin schizophrenia susceptibility network differentially affect synaptic function and plasticity. J Neurosci. 2015;35:325-38 pubmed publisher
    ..Here, we studied phenotypes associated with mutations in the schizophrenia susceptibility gene dysbindin (dysb), in isolation or in combination with null alleles in the dysb network component Blos1...
  3. Rodriguez Fernandez I, Dell Angelica E. A data-mining approach to rank candidate protein-binding partners-The case of biogenesis of lysosome-related organelles complex-1 (BLOC-1). J Inherit Metab Dis. 2009;32:190-203 pubmed publisher
    ..The data-mining approach described herein can be customized to study candidate binding partners for other proteins or possibly candidates derived from other types of 'omics' data. ..
  4. Dickman D, Davis G. The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis. Science. 2009;326:1127-30 pubmed publisher
    ..This screen ruled out the involvement of numerous synaptic proteins and identified a critical function for dysbindin, a gene linked to schizophrenia in humans...