Gene Symbol: DSK R1
Description: Cholecystokinin-like receptor at 17D3
Alias: CCKLR-D3, CG32540, CG6861, CG6881, CG6894, DSK-R1, Dmel\CG32540, DskR-1, SK-R, anon-WO0131005.21, anon-WO0170980.64, anon-WO0170980.65, Cholecystokinin-like receptor at 17D3, CCK-like receptor at 17D3, CCKLR-17D3-PB, CG32540-PB, DSK-receptor2, sulfakinin receptor
Species: fruit fly

Top Publications

  1. Chen X, Ganetzky B. A neuropeptide signaling pathway regulates synaptic growth in Drosophila. J Cell Biol. 2012;196:529-43 pubmed publisher
    ..Moreover, because the cAMP-PKA-CREB pathway is required for structural synaptic plasticity in learning and memory, DSK/CCKLR signaling may also contribute to these mechanisms. ..
  2. Bass C, Katanski C, Maynard B, Zurro I, Mariane E, Matta M, et al. Conserved residues in RF-NH? receptor models identify predicted contact sites in ligand-receptor binding. Peptides. 2014;53:278-85 pubmed publisher
    ..Our novel results predicted conserved residues as RF-NH2 ligand-receptor contact sites and identified unique and classic structural features. These discoveries will aid antagonist design to modulate RF-NH2 signaling. ..
  3. Kubiak T, Larsen M, Burton K, Bannow C, Martin R, Zantello M, et al. Cloning and functional expression of the first Drosophila melanogaster sulfakinin receptor DSK-R1. Biochem Biophys Res Commun. 2002;291:313-20 pubmed
    Described in this report is a successful cloning and characterization of a functionally active Drosophila sulfakinin receptor designated DSK-R1...
  4. Kiss B, Szlanka T, Zvara A, Zurovec M, Sery M, Kakaš S, et al. Selective elimination/RNAi silencing of FMRF-related peptides and their receptors decreases the locomotor activity in Drosophila melanogaster. Gen Comp Endocrinol. 2013;191:137-45 pubmed publisher
    ..RNAi silencing of the FaRP and FaRP-receptor genes effectively decreased the startle-induced locomotor activity of flies. Ablation of FMRF-positive neurons by the RS8-Gal4 and/or RS17-Gal4 drivers also decreased the flies' activity. ..
  5. Nässel D, Williams M. Cholecystokinin-Like Peptide (DSK) in Drosophila, Not Only for Satiety Signaling. Front Endocrinol (Lausanne). 2014;5:219 pubmed publisher
    ..Activity in the DSK-producing neurons is regulated by octopamine. We discuss mechanisms behind CCK function in satiety, aggression, and locomotion in some detail and highlight similarities to mammalian CCK signaling. ..
  6. Rasmussen M, Leander M, Ons S, Nichols R. Conserved molecular switch interactions in modeled cardioactive RF-NH2 peptide receptors: Ligand binding and activation. Peptides. 2015;71:259-67 pubmed publisher
    ..AKH receptor motifs were not representative of a RF-NH2 subfamily. The motifs and interactions of switches in the RFa-Rs were consistent with receptor activation and ligand-specific binding. ..
  7. Mohammad F, Aryal S, Ho J, Stewart J, Norman N, Tan T, et al. Ancient Anxiety Pathways Influence Drosophila Defense Behaviors. Curr Biol. 2016;26:981-6 pubmed publisher
    ..The presence of conserved neurogenetic pathways in the insect brain identifies Drosophila as an attractive genetic model for the study of anxiety and anxiety-related disorders, complementing existing rodent systems. ..