Dscam1

Summary

Gene Symbol: Dscam1
Description: Down syndrome cell adhesion molecule 1
Alias: 43Bc, CG17800, CT39257, DSCAM, DScam, DmDscam, Dm_2R:13579, Dm_2R:13612, Dmel\CG17800, DsCam, Dscam, Dscam-hv, Dsm, FBgn0033159, Neu1, dScam, dscam, l(2)05518, l(2)43Bc, p270, down syndrome cell adhesion molecule 1, CG17800-PA, CG17800-PAA, CG17800-PAB, CG17800-PAC, CG17800-PAD, CG17800-PAE, CG17800-PAF, CG17800-PAG, CG17800-PAH, CG17800-PAI, CG17800-PAJ, CG17800-PAK, CG17800-PAL, CG17800-PAM, CG17800-PAN, CG17800-PAO, CG17800-PAP, CG17800-PAQ, CG17800-PAR, CG17800-PAS, CG17800-PAT, CG17800-PAU, CG17800-PAV, CG17800-PAW, CG17800-PAX, CG17800-PAY, CG17800-PAZ, CG17800-PBA, CG17800-PBB, CG17800-PBC, CG17800-PBD, CG17800-PBE, CG17800-PBF, CG17800-PBG, CG17800-PBH, CG17800-PBI, CG17800-PBJ, CG17800-PBK, CG17800-PBL, CG17800-PBM, CG17800-PBN, CG17800-PBO, CG17800-PBP, CG17800-PBQ, CG17800-PBR, CG17800-PBS, CG17800-PBT, CG17800-PBU, CG17800-PBV, CG17800-PBW, CG17800-PBX, CG17800-PBY, CG17800-PBZ, CG17800-PC, CG17800-PCA, CG17800-PCB, CG17800-PCC, CG17800-PCD, CG17800-PD, CG17800-PE, CG17800-PF, CG17800-PG, CG17800-PH, CG17800-PI, CG17800-PJ, CG17800-PL, CG17800-PM, CG17800-PO, CG17800-PR, CG17800-PT, CG17800-PV, CG17800-PW, CG17800-PX, CG17800-PY, CG17800-PZ, Down's syndrome cell adhesion molecule, Dscam1-PA, Dscam1-PAA, Dscam1-PAB, Dscam1-PAC, Dscam1-PAD, Dscam1-PAE, Dscam1-PAF, Dscam1-PAG, Dscam1-PAH, Dscam1-PAI, Dscam1-PAJ, Dscam1-PAK, Dscam1-PAL, Dscam1-PAM, Dscam1-PAN, Dscam1-PAO, Dscam1-PAP, Dscam1-PAQ, Dscam1-PAR, Dscam1-PAS, Dscam1-PAT, Dscam1-PAU, Dscam1-PAV, Dscam1-PAW, Dscam1-PAX, Dscam1-PAY, Dscam1-PAZ, Dscam1-PBA, Dscam1-PBB, Dscam1-PBC, Dscam1-PBD, Dscam1-PBE, Dscam1-PBF, Dscam1-PBG, Dscam1-PBH, Dscam1-PBI, Dscam1-PBJ, Dscam1-PBK, Dscam1-PBL, Dscam1-PBM, Dscam1-PBN, Dscam1-PBO, Dscam1-PBP, Dscam1-PBQ, Dscam1-PBR, Dscam1-PBS, Dscam1-PBT, Dscam1-PBU, Dscam1-PBV, Dscam1-PBW, Dscam1-PBX, Dscam1-PBY, Dscam1-PBZ, Dscam1-PC, Dscam1-PCA, Dscam1-PCB, Dscam1-PCC, Dscam1-PCD, Dscam1-PD, Dscam1-PE, Dscam1-PF, Dscam1-PG, Dscam1-PH, Dscam1-PI, Dscam1-PJ, Dscam1-PL, Dscam1-PM, Dscam1-PO, Dscam1-PR, Dscam1-PT, Dscam1-PV, Dscam1-PW, Dscam1-PX, Dscam1-PY, Dscam1-PZ, down syndrome cell adhesion molecule, down syndrome cell-adhesion molecule, drosophila down syndrome cell adhesion molecule, drosophila down syndrome cell adhesion molecule 1, lethal(2)43Bc
Species: fruit fly

Top Publications

  1. Wang J, Ma X, Yang J, Zheng X, Zugates C, Lee C, et al. Transmembrane/juxtamembrane domain-dependent Dscam distribution and function during mushroom body neuronal morphogenesis. Neuron. 2004;43:663-72 pubmed
    Besides 19,008 possible ectodomains, Drosophila Dscam contains two alternative transmembrane/juxtamembrane segments, respectively, derived from exon 17.1 and exon 17.2...
  2. Chen B, Kondo M, Garnier A, Watson F, Puettmann Holgado R, Lamar D, et al. The molecular diversity of Dscam is functionally required for neuronal wiring specificity in Drosophila. Cell. 2006;125:607-20 pubmed
    Alternative splicing of Dscam generates an enormous molecular diversity with maximally 38,016 different receptors. Whether this large diversity is required in vivo is currently unclear...
  3. Millard S, Flanagan J, Pappu K, Wu W, Zipursky S. Dscam2 mediates axonal tiling in the Drosophila visual system. Nature. 2007;447:720-4 pubmed
    ..Our data support a model in which Dscam2 homophilic interactions mediate repulsion between neurites of L1 cells in neighbouring columns. We propose that Dscam2 is a tiling receptor for L1 neurons. ..
  4. Shi L, Yu H, Yang J, Lee T. Specific Drosophila Dscam juxtamembrane variants control dendritic elaboration and axonal arborization. J Neurosci. 2007;27:6723-8 pubmed
    Drosophila Dscam isoforms are derived from two alternative transmembrane/juxtamembrane domains (TMs) in addition to thousands of ectodomain variants...
  5. Matthews B, Kim M, Flanagan J, Hattori D, Clemens J, Zipursky S, et al. Dendrite self-avoidance is controlled by Dscam. Cell. 2007;129:593-604 pubmed
    ..that dendrite self-avoidance in Drosophila da sensory neurons requires cell-recognition molecules encoded by the Dscam locus...
  6. Crayton M, Powell B, Vision T, Giddings M. Tracking the evolution of alternatively spliced exons within the Dscam family. BMC Evol Biol. 2006;6:16 pubmed
    The Dscam gene in the fruit fly, Drosophila melanogaster, contains twenty-four exons, four of which are composed of tandem arrays that each undergo mutually exclusive alternative splicing (4, 6, 9 and 17), potentially generating 38,016 ..
  7. Wang J, Zugates C, Liang I, Lee C, Lee T. Drosophila Dscam is required for divergent segregation of sister branches and suppresses ectopic bifurcation of axons. Neuron. 2002;33:559-71 pubmed
    ..From a genetic mosaic screen, we find that a lethal mutation in the Drosophila Down syndrome cell adhesion molecule (Dscam) specifically perturbs segregation of axonal branches in the mushroom bodies...
  8. Smith C. Alternative splicing--when two's a crowd. Cell. 2005;123:1-3 pubmed
    ..A paper in this issue of Cell (Graveley, 2005) provides a fascinating insight into the perplexing question of how only one exon at a time is chosen from an array of 48 exons in the Drosophila Dscam gene.
  9. Zhang K, Guo J, Peng Y, Xi W, Guo A. Dopamine-mushroom body circuit regulates saliency-based decision-making in Drosophila. Science. 2007;316:1901-4 pubmed
    ..Immunohistological analysis showed that mushroom bodies are densely innervated by dopaminergic axons. Thus, the circuit from the dopamine system to mushroom bodies is crucial for choice behavior in Drosophila. ..

More Information

Publications68

  1. Vlisidou I, Dowling A, Evans I, Waterfield N, Ffrench Constant R, Wood W. Drosophila embryos as model systems for monitoring bacterial infection in real time. PLoS Pathog. 2009;5:e1000518 pubmed publisher
    ..We find that embryonic hemocytes both recognise and phagocytose injected wild type, non-pathogenic E. coli in a Dscam independent manner, proving that embryonic hemocytes are phagocytically competent...
  2. Hattori D, Demir E, Kim H, Viragh E, Zipursky S, Dickson B. Dscam diversity is essential for neuronal wiring and self-recognition. Nature. 2007;449:223-7 pubmed
    ..In Drosophila, alternative splicing of the Down syndrome cell adhesion molecule (Dscam) gene potentially generates 38,016 closely related transmembrane proteins of the ..
  3. Zhan X, Clemens J, Neves G, Hattori D, Flanagan J, Hummel T, et al. Analysis of Dscam diversity in regulating axon guidance in Drosophila mushroom bodies. Neuron. 2004;43:673-86 pubmed
    b>Dscam is an immunoglobulin (Ig) superfamily member that regulates axon guidance and targeting in Drosophila. Alternative splicing potentially generates 38,016 isoforms differing in their extracellular Ig and transmembrane domains...
  4. Wojtowicz W, Flanagan J, Millard S, Zipursky S, Clemens J. Alternative splicing of Drosophila Dscam generates axon guidance receptors that exhibit isoform-specific homophilic binding. Cell. 2004;118:619-33 pubmed
    b>Dscam is an immunoglobulin (Ig) superfamily protein required for the formation of neuronal connections in Drosophila...
  5. Wojtowicz W, Wu W, Andre I, Qian B, Baker D, Zipursky S. A vast repertoire of Dscam binding specificities arises from modular interactions of variable Ig domains. Cell. 2007;130:1134-45 pubmed
    b>Dscam encodes a family of cell surface proteins required for establishing neural circuits in Drosophila...
  6. Graveley B. Mutually exclusive splicing of the insect Dscam pre-mRNA directed by competing intronic RNA secondary structures. Cell. 2005;123:65-73 pubmed
    Drosophila Dscam encodes 38,016 distinct axon guidance receptors through the mutually exclusive alternative splicing of 95 variable exons...
  7. Armitage S, Freiburg R, Kurtz J, Bravo I. The evolution of Dscam genes across the arthropods. BMC Evol Biol. 2012;12:53 pubmed publisher
    ..A gene that has evolved a hypervariable form is Down syndrome cell adhesion molecule (Dscam-hv), which in Drosophila melanogaster can produce thousands of isoforms via mutually ..
  8. Neves G, Zucker J, Daly M, Chess A. Stochastic yet biased expression of multiple Dscam splice variants by individual cells. Nat Genet. 2004;36:240-6 pubmed
    The Drosophila melanogaster gene Dscam is essential for axon guidance and has 38,016 possible alternative splice forms. This diversity can potentially be used to distinguish cells...
  9. Selcho M, Pauls D, Han K, Stocker R, Thum A. The role of dopamine in Drosophila larval classical olfactory conditioning. PLoS ONE. 2009;4:e5897 pubmed publisher
    ..Future studies of the dopaminergic system need to take into account such cellular dissociations in function in order to be meaningful. ..
  10. Wu W, Ahlsen G, Baker D, Shapiro L, Zipursky S. Complementary chimeric isoforms reveal Dscam1 binding specificity in vivo. Neuron. 2012;74:261-8 pubmed publisher
    b>Dscam1 potentially encodes 19,008 ectodomains of a cell recognition molecule of the immunoglobulin (Ig) superfamily through alternative splicing...
  11. Wang X, Li G, Yang Y, Wang W, Zhang W, Pan H, et al. An RNA architectural locus control region involved in Dscam mutually exclusive splicing. Nat Commun. 2012;3:1255 pubmed publisher
    ..most striking example of alternative splicing in a Drosophila melanogaster gene is observed in the Down syndrome cell adhesion molecule, which can generate 38,016 different isoforms...
  12. Katsov A, Clandinin T. Motion processing streams in Drosophila are behaviorally specialized. Neuron. 2008;59:322-35 pubmed publisher
    ..Thus, behavioral responses to complex stimuli can rely on surprising neural specialization from even the earliest sensory processing stages. ..
  13. Venken K, He Y, Hoskins R, Bellen H. P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. Science. 2006;314:1747-51 pubmed
    ..This transgenesis platform should greatly facilitate structure/function analyses of most Drosophila genes...
  14. Graveley B, Kaur A, Gunning D, Zipursky S, Rowen L, Clemens J. The organization and evolution of the dipteran and hymenopteran Down syndrome cell adhesion molecule (Dscam) genes. RNA. 2004;10:1499-506 pubmed publisher
    The Drosophila melanogaster Down syndrome cell adhesion molecule (Dscam) gene encodes an axon guidance receptor and can generate 38,016 different isoforms via the alternative splicing of 95 variable exons...
  15. Lai J, Lo S, Dickson B, Chiang A. Auditory circuit in the Drosophila brain. Proc Natl Acad Sci U S A. 2012;109:2607-12 pubmed publisher
    ..Our findings delineate an auditory processing pathway involving AMMC?IVLP?VLP in the Drosophila brain. ..
  16. Yang Y, Zhan L, Zhang W, Sun F, Wang W, Tian N, et al. RNA secondary structure in mutually exclusive splicing. Nat Struct Mol Biol. 2011;18:159-68 pubmed publisher
    ..Additionally, under this model, we also deciphered a similar structural code in exon clusters 4 and 9 of Dscam (38,016 isoforms) and Mhc (480 isoforms)...
  17. Funada M, Hara H, Sasagawa H, Kitagawa Y, Kadowaki T. A honey bee Dscam family member, AbsCAM, is a brain-specific cell adhesion molecule with the neurite outgrowth activity which influences neuronal wiring during development. Eur J Neurosci. 2007;25:168-80 pubmed
    ..in the brain of an invertebrate with more complex behavior, we identified and characterized a novel brain-specific Dscam family member, AbsCAM, from honey bee (Apis mellifera)...
  18. Zipursky S, Wojtowicz W, Hattori D. Got diversity? Wiring the fly brain with Dscam. Trends Biochem Sci. 2006;31:581-8 pubmed
    The Drosophila gene Dscam, encoding Down syndrome cell-adhesion molecule, is required for the development of neural circuits...
  19. Yu H, Yang J, Wang J, Huang Y, Lee T. Endodomain diversity in the Drosophila Dscam and its roles in neuronal morphogenesis. J Neurosci. 2009;29:1904-14 pubmed publisher
    b>Drosophila Down syndrome cell adhesion molecule (Dscam) can be variably spliced to encode 152,064 distinct single-pass transmembrane proteins...
  20. Morante J, Desplan C. The color-vision circuit in the medulla of Drosophila. Curr Biol. 2008;18:553-65 pubmed publisher
    ..This precise characterization of the medulla circuitry will allow us to understand how color vision is processed in the optic lobe of Drosophila, providing a paradigm for more complex systems in vertebrates. ..
  21. Sawaya M, Wojtowicz W, Andre I, Qian B, Wu W, Baker D, et al. A double S shape provides the structural basis for the extraordinary binding specificity of Dscam isoforms. Cell. 2008;134:1007-18 pubmed publisher
    Drosophila Dscam encodes a vast family of immunoglobulin (Ig)-containing proteins that exhibit isoform-specific homophilic binding. This diversity is essential for cell recognition events required for wiring the brain...
  22. He H, Kise Y, Izadifar A, Urwyler O, Ayaz D, Parthasarthy A, et al. Cell-intrinsic requirement of Dscam1 isoform diversity for axon collateral formation. Science. 2014;344:1182-6 pubmed publisher
    The isoform diversity of the Drosophila Dscam1 receptor is important for neuronal self-recognition and self-avoidance...
  23. Olson S, Blanchette M, Park J, Savva Y, Yeo G, Yeakley J, et al. A regulator of Dscam mutually exclusive splicing fidelity. Nat Struct Mol Biol. 2007;14:1134-40 pubmed
    The Down syndrome cell adhesion molecule (Dscam) gene has essential roles in neural wiring and pathogen recognition in Drosophila melanogaster. Dscam encodes 38,016 distinct isoforms via extensive alternative splicing...
  24. Diao F, Chaufty J, Waro G, Tsunoda S. SIDL interacts with the dendritic targeting motif of Shal (K(v)4) K+ channels in Drosophila. Mol Cell Neurosci. 2010;45:75-83 pubmed publisher
    ..The identification of SIDL may provide the first step for future investigation into the molecular machinery regulating the LL-motif-dependent targeting of K(+) channels. ..
  25. Anastassiou D, Liu H, Varadan V. Variable window binding for mutually exclusive alternative splicing. Genome Biol. 2006;7:R2 pubmed publisher
    ..of a conserved nucleotide 'anchor' sequence upstream of the exon 6 cluster in the pre-mRNA of the fruitfly Dscam gene binds to one of the introns, thereby activating selection of the exon directly downstream from the binding ..
  26. Sun W, You X, Gogol Döring A, He H, Kise Y, Sohn M, et al. Ultra-deep profiling of alternatively spliced Drosophila Dscam isoforms by circularization-assisted multi-segment sequencing. EMBO J. 2013;32:2029-38 pubmed publisher
    The Drosophila melanogaster gene Dscam (Down syndrome cell adhesion molecule) can generate thousands of different ectodomains via mutual exclusive splicing of three large exon clusters...
  27. Hummel T, Vasconcelos M, Clemens J, Fishilevich Y, Vosshall L, Zipursky S. Axonal targeting of olfactory receptor neurons in Drosophila is controlled by Dscam. Neuron. 2003;37:221-31 pubmed
    ..Here we demonstrate that specific ORN classes require the cell surface protein Dscam (Down Syndrome Cell Adhesion Molecule) to synapse in the correct glomeruli...
  28. Graveley B. Alternative splicing: increasing diversity in the proteomic world. Trends Genet. 2001;17:100-7 pubmed
    ..Developing a full catalog of alternatively spliced transcripts and determining each of their functions will be a major challenge of the upcoming proteomic era. ..
  29. Vömel M, Wegener C. Neuroarchitecture of aminergic systems in the larval ventral ganglion of Drosophila melanogaster. PLoS ONE. 2008;3:e1848 pubmed publisher
  30. Hattori D, Chen Y, Matthews B, Salwinski L, Sabatti C, Grueber W, et al. Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms. Nature. 2009;461:644-8 pubmed publisher
    b>Down Syndrome cell adhesion molecule (Dscam) genes encode neuronal cell recognition proteins of the immunoglobulin superfamily...
  31. Thum A, Leisibach B, Gendre N, Selcho M, Stocker R. Diversity, variability, and suboesophageal connectivity of antennal lobe neurons in D. melanogaster larvae. J Comp Neurol. 2011;519:3415-32 pubmed publisher
    ..Together with reports from adult Drosophila, these data suggest that wiring variability may be another principle of insect brain organization, in parallel with stereotypy. ..
  32. Millard S, Lu Z, Zipursky S, Meinertzhagen I. Drosophila dscam proteins regulate postsynaptic specificity at multiple-contact synapses. Neuron. 2010;67:761-8 pubmed publisher
    ..Here, we demonstrate that Drosophila Dscam1 and Dscam2, genes encoding homophilic repulsive proteins, act redundantly to ensure the invariable combination of ..
  33. Celotto A, Graveley B. Alternative splicing of the Drosophila Dscam pre-mRNA is both temporally and spatially regulated. Genetics. 2001;159:599-608 pubmed
    The Drosophila melanogaster Down syndrome cell adhesion molecule (Dscam) gene encodes an axon guidance receptor that can express 38,016 different mRNAs by virtue of alternative splicing...
  34. Du Pasquier L. Immunology. Insects diversify one molecule to serve two systems. Science. 2005;309:1826-7 pubmed
  35. Krashes M, Keene A, Leung B, Armstrong J, Waddell S. Sequential use of mushroom body neuron subsets during drosophila odor memory processing. Neuron. 2007;53:103-15 pubmed
  36. Yang J, Bai J, Lee T. Dynein-dynactin complex is essential for dendritic restriction of TM1-containing Drosophila Dscam. PLoS ONE. 2008;3:e3504 pubmed publisher
    Many membrane proteins, including Drosophila Dscam, are enriched in dendrites or axons within neurons. However, little is known about how the differential distribution is established and maintained...
  37. Kreahling J, Graveley B. The iStem, a long-range RNA secondary structure element required for efficient exon inclusion in the Drosophila Dscam pre-mRNA. Mol Cell Biol. 2005;25:10251-60 pubmed
    The Drosophila Dscam gene encodes 38,016 different proteins, due to alternative splicing of 95 of its 115 exons, that function in axon guidance and innate immunity...
  38. Soba P, Zhu S, Emoto K, Younger S, Yang S, Yu H, et al. Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization. Neuron. 2007;54:403-16 pubmed
    ..We found that Down's syndrome Cell Adhesion Molecule (Dscam) is required for dendritic self-avoidance of all four classes of Drosophila dendritic arborization (da) neurons...
  39. Brites D, Encinas Viso F, Ebert D, Du Pasquier L, Haag C. Population genetics of duplicated alternatively spliced exons of the Dscam gene in Daphnia and Drosophila. PLoS ONE. 2011;6:e27947 pubmed publisher
    In insects and crustaceans, the Down syndrome cell adhesion molecule (Dscam) occurs in many different isoforms...
  40. Schmucker D, Clemens J, Shu H, Worby C, Xiao J, Muda M, et al. Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity. Cell. 2000;101:671-84 pubmed
    A Drosophila homolog of human Down syndrome cell adhesion molecule (DSCAM), an immunoglobulin superfamily member, was isolated by its affinity to Dock, an SH3/SH2 adaptor protein required for axon guidance...
  41. May G, Olson S, McManus C, Graveley B. Competing RNA secondary structures are required for mutually exclusive splicing of the Dscam exon 6 cluster. RNA. 2011;17:222-9 pubmed publisher
    ..The Drosophila melanogaster Down Syndrome Cell Adhesion Molecule (Dscam) gene is an extreme example of mutually exclusive splicing...
  42. Andrews G, Tanglao S, Farmer W, Morin S, Brotman S, Berberoglu M, et al. Dscam guides embryonic axons by Netrin-dependent and -independent functions. Development. 2008;135:3839-48 pubmed publisher
    ..Analysis of Bolwig's nerve reveals that Netrin mutants have a similar phenotype to Down Syndrome Cell Adhesion Molecule (Dscam) mutants...
  43. Meijers R, Puettmann Holgado R, Skiniotis G, Liu J, Walz T, Wang J, et al. Structural basis of Dscam isoform specificity. Nature. 2007;449:487-91 pubmed
    The Dscam gene gives rise to thousands of diverse cell surface receptors thought to provide homophilic and heterophilic recognition specificity for neuronal wiring and immune responses...
  44. Yu J, Kanai M, Demir E, Jefferis G, Dickson B. Cellular organization of the neural circuit that drives Drosophila courtship behavior. Curr Biol. 2010;20:1602-14 pubmed publisher
    ..Sex-specific behavior may instead arise through dimorphic circuits in the brain and nerve cord that differentially couple sensory input to motor output. ..
  45. Lee C, Kim N, Roy M, Graveley B. Massive expansions of Dscam splicing diversity via staggered homologous recombination during arthropod evolution. RNA. 2010;16:91-105 pubmed publisher
    The arthropod Down syndrome cell adhesion molecule (Dscam) gene can generate tens of thousands of protein isoforms via combinatorial splicing of numerous alternative exons encoding immunoglobulin variable domains organized into three ..
  46. Hughes M, Bortnick R, Tsubouchi A, Bäumer P, Kondo M, Uemura T, et al. Homophilic Dscam interactions control complex dendrite morphogenesis. Neuron. 2007;54:417-27 pubmed
    Alternative splicing of the Drosophila gene Dscam results in up to 38,016 different receptor isoforms proposed to interact by isoform-specific homophilic binding...
  47. Watson F, P ttmann Holgado R, Thomas F, Lamar D, Hughes M, Kondo M, et al. Extensive diversity of Ig-superfamily proteins in the immune system of insects. Science. 2005;309:1874-8 pubmed publisher
    ..the potential to express more than 18,000 isoforms of the immunoglobulin (Ig)-superfamily receptor Down syndrome cell adhesion molecule (Dscam)...
  48. Peuß R, Wensing K, Woestmann L, Eggert H, Milutinović B, Sroka M, et al. Down syndrome cell adhesion molecule 1: testing for a role in insect immunity, behaviour and reproduction. R Soc Open Sci. 2016;3:160138 pubmed publisher
    b>Down syndrome cell adhesion molecule 1 (Dscam1) has wide-reaching and vital neuronal functions although the role it plays in insect and crustacean immunity is less well understood...
  49. Steele L, Coates B, Valero M, Sun W, Seong K, Muir W, et al. Selective sweep analysis in the genomes of the 91-R and 91-C Drosophila melanogaster strains reveals few of the 'usual suspects' in dichlorodiphenyltrichloroethane (DDT) resistance. PLoS ONE. 2015;10:e0123066 pubmed publisher
    ..These results suggest hitherto unknown mechanisms of DDT resistance, most of which have been overlooked in previous transcriptional studies, with some genes having orthologs in mammals. ..
  50. Karsai G, Pollak E, Wacker M, Vömel M, Selcho M, Berta G, et al. Diverse in- and output polarities and high complexity of local synaptic and non-synaptic signaling within a chemically defined class of peptidergic Drosophila neurons. Front Neural Circuits. 2013;7:127 pubmed publisher
  51. Turner T, Miller P, Cochrane V. Combining genome-wide methods to investigate the genetic complexity of courtship song variation in Drosophila melanogaster. Mol Biol Evol. 2013;30:2113-20 pubmed publisher
    ..These results suggest that experimental evolution may provide an approach for genome-scale replication in Drosophila. ..
  52. von Philipsborn A, Liu T, Yu J, Masser C, Bidaye S, Dickson B. Neuronal control of Drosophila courtship song. Neuron. 2011;69:509-22 pubmed publisher
    ..These neurons are potentially connected in a functional circuit, with the descending pIP10 neuron linking the brain and thoracic song centers. Sexual dimorphisms in each of these neurons may explain why only males sing. ..
  53. Young J, Armstrong J. Structure of the adult central complex in Drosophila: organization of distinct neuronal subsets. J Comp Neurol. 2010;518:1500-24 pubmed publisher
    ..Small-field neurons were observed in clearly organized layers. This study provides a novel insight into CX structure and connectivity and provides a set of characterized enhancer trap lines that will be valuable for future study. ..
  54. Arruda S, Dolph P. Molecular cloning of the pawn locus from Drosophila melanogaster. Gene. 2003;310:169-73 pubmed
    ..The gene is expressed throughout development with highest expression found in the late embryonic and larval stages. ..
  55. Armitage S, Sun W, You X, Kurtz J, Schmucker D, Chen W. Quantitative profiling of Drosophila melanogaster Dscam1 isoforms reveals no changes in splicing after bacterial exposure. PLoS ONE. 2014;9:e108660 pubmed publisher
    The hypervariable Dscam1 (Down syndrome cell adhesion molecule 1) gene can produce thousands of different ectodomain isoforms via mutually exclusive alternative splicing...
  56. Worby C, Simonson Leff N, Clemens J, Huddler D, Muda M, Dixon J. Drosophila Ack targets its substrate, the sorting nexin DSH3PX1, to a protein complex involved in axonal guidance. J Biol Chem. 2002;277:9422-8 pubmed
    ..These results suggest that the phosphorylation of DSH3PX1 by DAck targets this sorting nexin to a protein complex that includes Dock, an adaptor protein important for axonal guidance. ..
  57. Pillmann H, Hatje K, Odronitz F, Hammesfahr B, Kollmar M. Predicting mutually exclusive spliced exons based on exon length, splice site and reading frame conservation, and exon sequence homology. BMC Bioinformatics. 2011;12:270 pubmed publisher
    ..mutually exclusive exons in several example genes, a dynein heavy chain, a muscle myosin heavy chain, and Dscam were correctly identified...
  58. Rowshanravan B, Woodcock S, Botella J, Kiermayer C, Schneuwly S, Hughes D. RasGAP mediates neuronal survival in Drosophila through direct regulation of Rab5-dependent endocytosis. J Cell Sci. 2014;127:2849-61 pubmed publisher
    ..These results indicate that the long-term survival of adult neurons in Drosophila is crucially dependent on the activities of two GTPases, Ras and Rab5, regulated by the interplay of RasGAP and Sprint. ..
  59. MacIver B, MCCormack A, Slee R, Bownes M. Identification of an essential gene encoding a class-V unconventional myosin in Drosophila melanogaster. Eur J Biochem. 1998;257:529-37 pubmed
    ..Genetic and in situ hybridisation experiments have determined that this gene is located in the 43C region. We have evidence that it maps to a mutation in this region with an embryonic lethal phenotype. ..