ds

Summary

Gene Symbol: ds
Description: dachsous
Alias: CG17941, CT39575, Dmel\CG17941, EP-822, cad2, dachs, l(2)01855, l(2)05142, CG17941 gene product from transcript CG17941-RA, CG17941-PA, CG17941-PB, cadherin-2, daschous, ds-PA, ds-PB, lethal (2) 01855
Species: fruit fly

Top Publications

  1. pmc Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation
    Maria Willecke
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:14897-902. 2008
  2. pmc Modulation of fat:dachsous binding by the cadherin domain kinase four-jointed
    Michael A Simon
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    Curr Biol 20:811-7. 2010
  3. pmc Drosophila lowfat, a novel modulator of Fat signaling
    Yaopan Mao
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 136:3223-33. 2009
  4. pmc Processing and phosphorylation of the Fat receptor
    Yongqiang Feng
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway NJ 08854, USA
    Proc Natl Acad Sci U S A 106:11989-94. 2009
  5. ncbi The dachsous gene, a member of the cadherin family, is required for Wg-dependent pattern formation in the Drosophila wing disc
    Isabel Rodriguez
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Cantoblanco, 28049 Madrid, Spain
    Development 131:3195-206. 2004
  6. ncbi Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing
    Hitoshi Matakatsu
    Department of Zoology, University of Wisconsin, 250 North Mills Street, Madison, WI 53706, USA
    Development 131:3785-94. 2004
  7. ncbi Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling
    Eunjoo Cho
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 131:4489-500. 2004
  8. pmc Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown
    Richelle Sopko
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Curr Biol 19:1112-7. 2009
  9. ncbi Planar cell polarity in the Drosophila eye is directed by graded Four-jointed and Dachsous expression
    Michael A Simon
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Development 131:6175-84. 2004
  10. ncbi Inturned localizes to the proximal side of wing cells under the instruction of upstream planar polarity proteins
    Paul N Adler
    Biology Department, Morphogenesis and Regenerative Medicine, Institute and Cancer Center, University of Virginia, Charlottesville, Virginia 22903, USA
    Curr Biol 14:2046-51. 2004

Research Grants

Scientific Experts

Detail Information

Publications98

  1. pmc Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation
    Maria Willecke
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 105:14897-902. 2008
    ..Fat not only regulates growth but also planar cell polarity, for which it interacts with the Dachsous (Ds) Cadherin, and Four-jointed (Fj), a transmembrane kinase that modulates the interaction between Ds and Fat...
  2. pmc Modulation of fat:dachsous binding by the cadherin domain kinase four-jointed
    Michael A Simon
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    Curr Biol 20:811-7. 2010
    ..Fat is regulated by the cadherin Dachsous (Ds) and the protein kinase Four-jointed (Fj), which are expressed in gradients in many tissues...
  3. pmc Drosophila lowfat, a novel modulator of Fat signaling
    Yaopan Mao
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 136:3223-33. 2009
    ..These studies identify Lft as a novel component of the Fat signaling pathway, and the Lft-mediated elevation of Fat levels as a mechanism for modulating Fat signaling...
  4. pmc Processing and phosphorylation of the Fat receptor
    Yongqiang Feng
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway NJ 08854, USA
    Proc Natl Acad Sci U S A 106:11989-94. 2009
    ....
  5. ncbi The dachsous gene, a member of the cadherin family, is required for Wg-dependent pattern formation in the Drosophila wing disc
    Isabel Rodriguez
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Cantoblanco, 28049 Madrid, Spain
    Development 131:3195-206. 2004
    The dachsous (ds) gene encodes a member of the cadherin family involved in the non-canonical Wnt signaling pathway that controls the establishment of planar cell polarity (PCP) in Drosophila...
  6. ncbi Interactions between Fat and Dachsous and the regulation of planar cell polarity in the Drosophila wing
    Hitoshi Matakatsu
    Department of Zoology, University of Wisconsin, 250 North Mills Street, Madison, WI 53706, USA
    Development 131:3785-94. 2004
    It was recently suggested that a proximal to distal gradient of the protocadherin Dachsous (Ds) acts as a cue for planar cell polarity (PCP) in the Drosophila wing, orienting cell-cell interactions by inhibiting the activity of the ..
  7. ncbi Action of fat, four-jointed, dachsous and dachs in distal-to-proximal wing signaling
    Eunjoo Cho
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 131:4489-500. 2004
    ..We also identify dachs as a gene that is genetically required downstream of fat, both for its effects on imaginal disc growth and for the ..
  8. pmc Phosphorylation of the tumor suppressor fat is regulated by its ligand Dachsous and the kinase discs overgrown
    Richelle Sopko
    Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Curr Biol 19:1112-7. 2009
    ..Genetic studies suggest that Fat activity is regulated by binding to another large cadherin, Dachsous (Ds). The tumor suppressor discs overgrown (dco)/Casein Kinase I delta/epsilon also regulates Hippo activity and PCP...
  9. ncbi Planar cell polarity in the Drosophila eye is directed by graded Four-jointed and Dachsous expression
    Michael A Simon
    Department of Biological Sciences, Stanford University, Stanford, CA 94305 5020, USA
    Development 131:6175-84. 2004
    ..we proposed that a crucial step in this process is the establishment of graded expression of the cadherin Dachsous (Ds) and the Golgi-associated protein Four-jointed (Fj)...
  10. ncbi Inturned localizes to the proximal side of wing cells under the instruction of upstream planar polarity proteins
    Paul N Adler
    Biology Department, Morphogenesis and Regenerative Medicine, Institute and Cancer Center, University of Virginia, Charlottesville, Virginia 22903, USA
    Curr Biol 14:2046-51. 2004
    ..These data indicate that accumulation of proteins at the proximal side of wing cells is a key event for the distal activation of the cytoskeleton to form a hair...
  11. ncbi Mathematical modeling of planar cell polarity to understand domineering nonautonomy
    Keith Amonlirdviman
    Department of Aeronautics and Astronautics, Stanford University, Stanford, CA 94305 4035, USA
    Science 307:423-6. 2005
    ..The sufficiency of this model and the experimental validation of model predictions reveal how specific protein-protein interactions produce autonomy or domineering nonautonomy...
  12. doi Is anisotropic propagation of polarized molecular distribution the common mechanism of swirling patterns of planar cell polarization?
    Hao Zhu
    Division of Applied Mathematics, School of Mathematical Sciences, University of Nottingham, Nottingham NG7 2RD, UK
    J Theor Biol 256:315-25. 2009
    ....
  13. ncbi Control of planar cell polarity by interaction of DWnt4 and four-jointed
    Janghoo Lim
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Genesis 42:150-61. 2005
    ..Our results suggest that DWnt4 is involved in ommatidial polarity signaling in the ventral region of the eye and its function is mediated by interacting with Fj...
  14. ncbi Organ shape: controlling oriented cell division
    David Strutt
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Curr Biol 15:R758-9. 2005
    ..One mechanism by which organisms control the shape of growing organs is by regulating the orientation of cell divisions. This occurs in the Drosophila wing under the control of genes previously implicated in regulating cell polarity...
  15. pmc Four-jointed modulates growth and planar polarity by reducing the affinity of dachsous for fat
    Amy L Brittle
    Medical Research Council MRC Centre for Developmental and Biomedical Genetics and Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Curr Biol 20:803-10. 2010
    The Drosophila genes fat (ft) and dachsous (ds) encode large atypical cadherins that collaborate to coordinately polarize cells in the plane of the epithelium (planar cell polarity) and to affect growth via the Warts/Hippo pathway...
  16. ncbi Long-range coordination of planar polarity in Drosophila
    Helen Strutt
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Sheffield, UK
    Bioessays 27:1218-27. 2005
    ..Subsequently, this long-range polarity signal is refined by local cell-cell interactions involving the transmembrane molecules Frizzled, Strabismus and Flamingo. The role of these factors in coordinating polarity will be discussed...
  17. ncbi Separating the adhesive and signaling functions of the Fat and Dachsous protocadherins
    Hitoshi Matakatsu
    Department of Zoology, University of Wisconsin, 250 North Mills Street, Madison, WI 53706, USA
    Development 133:2315-24. 2006
    The protocadherins Fat (Ft) and Dachsous (Ds) are required for several processes in the development of Drosophila, including controlling growth of imaginal discs, planar cell polarity (PCP) and the proximodistal patterning of appendages...
  18. ncbi Dachs: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila
    Yaopan Mao
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Development 133:2539-51. 2006
    The dachs gene was first identified almost a century ago based on its requirements for appendage growth, but has been relatively little studied...
  19. ncbi Delineation of a Fat tumor suppressor pathway
    Eunjoo Cho
    Howard Hughes Medical Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Nat Genet 38:1142-50. 2006
    ..Genetic experiments position the action of discs overgrown upstream of the Fat pathway component dachs, whereas warts acts downstream of dachs...
  20. ncbi The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size
    Maria Willecke
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Curr Biol 16:2090-100. 2006
    ..However, components acting upstream of Expanded and Merlin, such as transmembrane receptors, have not yet been identified...
  21. pmc Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity
    José Casal
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Development 133:4561-72. 2006
    ..In Drosophila it depends on at least two sets of genes: one set, the Ds system, encodes the cadherins Dachsous (Ds) and Fat (Ft), as well as the Golgi protein Four-jointed...
  22. pmc The DHHC palmitoyltransferase approximated regulates Fat signaling and Dachs localization and activity
    Hitoshi Matakatsu
    Department of Zoology, University of Wisconsin, 250 North Mills Street, Madison, Wisconsin 53706, USA
    Curr Biol 18:1390-5. 2008
    ..Ft signaling was recently shown to be negatively regulated by the atypical myosin Dachs [10, 11]...
  23. pmc Planar cell polarity: one or two pathways?
    Peter A Lawrence
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
    Nat Rev Genet 8:555-63. 2007
    ..We argue that the prevailing opinion that planar polarity depends on a single genetic pathway is wrong and conclude that there are (at least) two independently acting processes. This conclusion has major consequences for the PCP field...
  24. pmc Morphogen control of wing growth through the Fat signaling pathway
    Dragana Rogulja
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Dev Cell 15:309-21. 2008
    ..Dpp signaling regulates the expression and localization of Fat pathway components, and Fat signaling through Dachs is required for the effect of the Dpp gradient on cell proliferation...
  25. pmc Four-jointed is a Golgi kinase that phosphorylates a subset of cadherin domains
    Hiroyuki O Ishikawa
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ 08854, USA
    Science 321:401-4. 2008
    ..Our results indicate that Four-jointed regulates Fat signaling by phosphorylating cadherin domains of Fat and Dachsous as they transit through the Golgi...
  26. ncbi Expression profile of the cadherin family in the developing Drosophila brain
    Siaumin Fung
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Comp Neurol 506:469-88. 2008
    ..We conclude from this analysis that cadherins are likely to play a role in 'generic' neural functions, such as neurite fasciculation, branching, and synapse formation...
  27. pmc The tumor suppressor genes dachsous and fat modulate different signalling pathways by regulating dally and dally-like
    Luis Alberto Baena-Lopez
    Developmental Neurobiology, National Institute of Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Proc Natl Acad Sci U S A 105:9645-50. 2008
    ..The Drosophila tumor suppressor genes dachsous (ds) and fat (ft) modulate organ size and pattern formation during imaginal disc development...
  28. pmc The function of the frizzled pathway in the Drosophila wing is dependent on inturned and fuzzy
    Haeryun Lee
    Biology Department and Cancer Center, University of Virginia, Charlottesville, Virginia 22903, USA
    Genetics 160:1535-47. 2002
    ..g., abdomen) the inturned-like genes were epistatic to the frizzled-like genes, but in other body regions (e.g., eye) that was not the case. Thus, the genetic control of tissue polarity is body region specific...
  29. doi Dachsous-dependent asymmetric localization of spiny-legs determines planar cell polarity orientation in Drosophila
    Tomonori Ayukawa
    Research Center for Biosignal, Akita University, Akita 010 8543, Japan Department of Cell Biology and Morphology, Akita University Graduate School of Medicine, Akita 010 8543, Japan Global COE Program, Gunma University and Akita University, Akita 010 8543, Japan
    Cell Rep 8:610-21. 2014
    In Drosophila, planar cell polarity (PCP) molecules such as Dachsous (Ds) may function as global directional cues directing the asymmetrical localization of PCP core proteins such as Frizzled (Fz)...
  30. pmc Functional modelling of planar cell polarity: an approach for identifying molecular function
    Lee D Hazelwood
    Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK
    BMC Dev Biol 13:20. 2013
    ..This polarisation is commonly known as planar cell polarity and has been found to be important in developmental processes, as planar polarity is required to define the in-plane tissue coordinate system at the cellular level...
  31. pmc Regulation of cytoskeletal organization and junctional remodeling by the atypical cadherin Fat
    Emily Marcinkevicius
    Howard Hughes Medical Institute and Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10065, USA
    Development 140:433-43. 2013
    ....
  32. doi Establishment of global patterns of planar polarity during growth of the Drosophila wing epithelium
    Andreas Sagner
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    Curr Biol 22:1296-301. 2012
    ..Thus, PCP may be guided by morphogenesis rather than morphogen gradients...
  33. pmc Propagation of Dachsous-Fat planar cell polarity
    Abhijit A Ambegaonkar
    Howard Hughes Medical Institute, Waksman Institute and Department of Molecular Biology and Biochemistry, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    Curr Biol 22:1302-8. 2012
    ..The Fj and Ds gradients direct the polarized membrane localization of the myosin Dachs, which is a crucial downstream component of Fat signaling...
  34. pmc Planar polarity specification through asymmetric subcellular localization of Fat and Dachsous
    Amy Brittle
    MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Western Bank, Sheffield, UK
    Curr Biol 22:907-14. 2012
    ..neighboring cells, and asymmetric Ds localization results in a corresponding asymmetric distribution of the myosin Dachs. We show that the generation of subcellular asymmetries of Ft and Ds and the core proteins is largely independent ..
  35. doi Mechanical control of morphogenesis by Fat/Dachsous/Four-jointed planar cell polarity pathway
    Floris Bosveld
    Polarity, Division and Morphogenesis Team, Institut Curie, CNRS UMR 3215, INSERM U934, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Science 336:724-7. 2012
    ..Furthermore, Dachsous polarizes the myosin Dachs, which in turn promotes anisotropy of junction tension...
  36. pmc Separating planar cell polarity and Hippo pathway activities of the protocadherins Fat and Dachsous
    Hitoshi Matakatsu
    Department of Zoology, University of Wisconsin Madison, 250 North Mills Street, Madison, WI 53706, USA
    Development 139:1498-508. 2012
    ..We also found that the extracellular domain of Ft can act independently of the Ft ICD in PCP and can trigger dominant-negative and boundary effects on Hippo activity, probably via binding to the protocadherin Dachsous...
  37. ncbi Cell behaviour of Drosophila fat cadherin mutations in wing development
    F Garoia
    Dipartimento di Biologia Evoluzionistica Sperimentale, Universita di Bologna, Italy
    Mech Dev 94:95-109. 2000
    ..Mutant ft cells show, in addition, smaller cell sizes during proliferation and abnormal cuticular differentiation, which reflect cell membrane and cytoskeleton anomalies, which are not modulated by the DER pathway...
  38. pmc Evolution: structural and functional diversity of cadherin at the adherens junction
    Hiroki Oda
    JT Biohistory Research Hall, Takatsuki, Osaka 569 1125, Japan
    J Cell Biol 193:1137-46. 2011
    ..An evolutionary reconstruction of cadherin structure and function provides a comprehensive framework with which to appreciate the diversity of morphogenetic mechanisms in animals...
  39. doi Fat/Hippo pathway regulates the progress of neural differentiation signaling in the Drosophila optic lobe
    Haruhiko Kawamori
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku Tokyo 113 0032, Japan
    Dev Growth Differ 53:653-67. 2011
    ..These findings provide new insights into the function of the Fat/Hippo pathway, which regulates the ordered progression of neurogenesis in the complex nervous system...
  40. pmc Zyxin links fat signaling to the hippo pathway
    Cordelia Rauskolb
    Howard Hughes Medical Institute, Waksman Institute, and Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, New Jersey, United States of America
    PLoS Biol 9:e1000624. 2011
    ..This partially overlaps the membrane localization of the myosin Dachs, which has similar effects on Fat-Hippo signaling...
  41. ncbi Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye
    Chung Hui Yang
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Cell 108:675-88. 2002
    ....
  42. pmc A feed-forward circuit linking wingless, fat-dachsous signaling, and the warts-hippo pathway to Drosophila wing growth
    Myriam Zecca
    Howard Hughes Medical Institute, Columbia University College of Physicians and Surgeons, New York, New York, USA
    PLoS Biol 8:e1000386. 2010
    ..Here, we identify the protocadherins Fat (Ft) and Dachsous (Ds), the Warts-Hippo tumor suppressor pathway, and the transcriptional co-activator Yorkie (Yki, a YES associated ..
  43. pmc Two frizzled planar cell polarity signals in the Drosophila wing are differentially organized by the Fat/Dachsous pathway
    Justin Hogan
    Department of Biological Sciences, Marshall University, Huntington, West Virginia, United States of America
    PLoS Genet 7:e1001305. 2011
    ..Normal wing PCP requires both the Frizzled (Fz) PCP pathway and the Fat/Dachsous (Ft/Ds) pathway, although the functional relationship between these pathways remains under debate...
  44. ncbi Planar polarity: photoreceptors on a high fat diet
    Helen Strutt
    Centre for Developmental Genetics, School of Medicine and Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK
    Curr Biol 12:R384-5. 2002
    ..Differential activity of Frizzled in the R3/R4 photo-receptors of Drosophila regulates the orientation of ommatidia. New evidence suggests that the cadherins Dachsous and Fat act upstream of Frizzled in this process...
  45. ncbi The cadherins fat and dachsous regulate dorsal/ventral signaling in the Drosophila eye
    Amy S Rawls
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Biol 12:1021-6. 2002
    ..We report the role of two cadherins, Fat (Ft) and Dachsous (Ds), in conveying the polarizing signal from the D/V midline in the Drosophila eye...
  46. pmc Planar polarization of the atypical myosin Dachs orients cell divisions in Drosophila
    Yanlan Mao
    Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, United Kingdom
    Genes Dev 25:131-6. 2011
    ..We show that orientation of cell divisions in the wing requires planar polarization of an atypical myosin, Dachs. Our evidence suggests that Dachs constricts cell-cell junctions to alter the geometry of cell shapes at the ..
  47. ncbi Developmental compartments and planar polarity in Drosophila
    José Casal
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Curr Biol 12:1189-98. 2002
    ....
  48. pmc Planar cell polarity: the orientation of larval denticles in Drosophila appears to depend on gradients of Dachsous and Fat
    Ada Repiso
    Department of Zoology, Downing Street, Cambridge, UK
    Development 137:3411-5. 2010
    ..We show, by altering the concentration gradients of Dachsous during development, that we can change the polarity of the denticles made by larval cells as they progress between the first and third larval instars without mitosis...
  49. ncbi Nonautonomous planar polarity patterning in Drosophila: dishevelled-independent functions of frizzled
    Helen Strutt
    Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, United Kingdom
    Dev Cell 3:851-63. 2002
    ..dsh) independent, and its loss results in polarity phenotypes that resemble those seen for mutations in dachsous (ds)...
  50. ncbi The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor
    Manolis Fanto
    Cancer Research UK ICRF, London Research Institute, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Development 130:763-74. 2003
    ....
  51. pmc Atypical cadherins Dachsous and Fat control dynamics of noncentrosomal microtubules in planar cell polarity
    Toshiyuki Harumoto
    Graduate School of Biostudies, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8507, Japan
    Dev Cell 19:389-401. 2010
    ..This characteristic alignment and asymmetry of MT growth was controlled by atypical cadherins Dachsous (Ds) and Fat (Ft). Furthermore, the action of Ft was mediated in part by PAR-1...
  52. ncbi Fidelity in planar cell polarity signalling
    Dali Ma
    Department of Pathology, Stanford University School of Medicine, Stanford, California 94305 5324, USA
    Nature 421:543-7. 2003
    ..Subsequent action of the Frizzled feedback loop is sufficient to align all the cells cooperatively. This economical system is therefore highly robust, and produces virtually error-free arrays...
  53. doi Cell flow reorients the axis of planar polarity in the wing epithelium of Drosophila
    Benoit Aigouy
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden 01307, Germany
    Cell 142:773-86. 2010
    ..Mutation of the atypical Cadherin Dachsous perturbs the global polarity pattern by altering epithelial dynamics. This mechanism utilizes the cellular movements that sculpt tissues to align planar polarity with tissue shape...
  54. ncbi Mutations in the cadherin superfamily member gene dachsous cause a tissue polarity phenotype by altering frizzled signaling
    P N Adler
    Biology Department, University of Virginia, Charlottesville, VA 22903, USA
    Development 125:959-68. 1998
    ..The direction of this domineering nonautonomy was coincident with the direction of the abnormal hair polarity. We conclude that dachsous causes a tissue polarity phenotype because it alters the direction of frizzled signaling...
  55. ncbi Cleavage and secretion is not required for Four-jointed function in Drosophila patterning
    Helen Strutt
    Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Development 131:881-90. 2004
    ..fj has similar phenotypes to those caused by mutations in the cadherin-encoding genes fat (ft) and dachsous (ds). We show that fj interacts genetically with ft and ds in planar polarity and proximodistal patterning...
  56. ncbi Dachsous encodes a member of the cadherin superfamily that controls imaginal disc morphogenesis in Drosophila
    H F Clark
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Genes Dev 9:1530-42. 1995
    ....
  57. ncbi The orientation of cell divisions determines the shape of Drosophila organs
    Luis Alberto Baena-Lopez
    Centro de Biologia Molecular Severo Ochoa, Edificio Ciencias, Universidad Autonoma de Madrid, CX 504, 28049 Madrid, Spain
    Curr Biol 15:1640-4. 2005
    ..In addition, we find that a subset of planar cell polarity genes is required for the proper orientation of cell division during organ development...
  58. pmc Genome-wide studies reveal novel and distinct biological pathways regulated by SIN3 isoforms
    Nirmalya Saha
    Department of Biological Sciences, Wayne State University, Detroit, MI, USA
    BMC Genomics 17:111. 2016
    ..Previous studies have demonstrated functional non-redundancy of SIN3 isoforms. The role of SIN3 isoforms in regulating distinct biological processes, however, is not well characterized...
  59. pmc Coordination of planar cell polarity pathways through Spiny-legs
    Abhijit A Ambegaonkar
    Howard Hughes Medical Institute, Rutgers University, Piscataway, United States
    elife 4:. 2015
    ..Two different components of the Dachsous-Fat system, Dachsous and Dachs, can each independently interact with Spiny-legs and direct its localization in vivo...
  60. pmc The role of the Hippo pathway in human disease and tumorigenesis
    DANIEL A BARRON
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA
    Clin Transl Med 3:25. 2014
    ..The common activation of YAP in many different tumor types provides an attractive target for potential therapeutic intervention. ..
  61. pmc Mathematical modeling of sub-cellular asymmetry of fat-dachsous heterodimer for generation of planar cell polarity
    Mohit Kumar Jolly
    Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, India
    PLoS ONE 9:e97641. 2014
    ..PCP has been proposed to be generated by complex sets of interactions amongst three proteins - Fat (Ft), Dachsous (Ds) and Four-jointed (Fj). Ft and Ds are two atypical cadherins, which are phosphorylated by Fj, a Golgi kinase...
  62. pmc The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration
    Phillip Karpowicz
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Development 137:4135-45. 2010
    ..prior to injury, Yki activity is constitutively repressed by the upstream Hippo pathway members Fat and Dachsous (Ds)...
  63. pmc Lamellipodia-based migrations of larval epithelial cells are required for normal closure of the adult epidermis of Drosophila
    Marcus Bischoff
    University of Cambridge, Department of Zoology, Cambridge, UK
    Dev Biol 363:179-90. 2012
    ..It furthermore provides insights into how the migratory behaviour of cells is regulated during morphogenesis...
  64. pmc The muscle pattern of the Drosophila abdomen depends on a subdivision of the anterior compartment of each segment
    Joanna Krzemien
    Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 2EJ, UK
    Development 139:75-83. 2012
    ..The dorsal adult muscles are polarised in the anteroposterior axis: we disprove the hypothesis that muscle orientation depends on genes that define planar cell polarity in the epidermis...
  65. doi Antagonistic growth regulation by Dpp and Fat drives uniform cell proliferation
    Gerald Schwank
    Institute of Molecular Life Sciences, Winterthurerstr 190, 8057 Zurich, Switzerland
    Dev Cell 20:123-30. 2011
    ..Together, our results indicate that the activities of both signaling pathways are regulated in a parallel rather than sequential manner and that uniform proliferation is achieved by their complementary action on growth...
  66. pmc dMyc functions downstream of Yorkie to promote the supercompetitive behavior of hippo pathway mutant cells
    Marcello Ziosi
    Dipartimento di Patologia Sperimentale, Alma Mater Studiorum, Bologna, Italy
    PLoS Genet 6:e1001140. 2010
    ....
  67. doi Modeling polarity buildup and cell fate decision in the fly eye: insight into the connection between the PCP and Notch pathways
    Jean François Le Garrec
    Modélisation dynamique des systèmes intégrés, Universite Pierre et Marie Curie Paris 6, 75005, Paris, France
    Dev Genes Evol 218:413-26. 2008
    ..The model provides insight into the crosstalk between the PCP and Notch modules in development and illustrates the ability of signaling modules to robustly maintain vital phenotypes in a noisy environment...
  68. ncbi Mathematical modeling of planar polarity
    David Strutt
    Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Dev Cell 8:134-6. 2005
    ..A recent paper by presents a mathematical model of a feedback loop-based mechanism for propagation of polarity between cells that can account for the known functions of Frizzled...
  69. ncbi The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing
    T Kadowaki
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 10:3116-28. 1996
    ..We identified a human sequence related to Porc suggesting the existence of a family of proteins involved in processing of Wnts...
  70. ncbi Control of epithelial cell polarity in Drosophila
    E Knust
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Germany
    Trends Genet 10:275-80. 1994
    ....
  71. ncbi Frizzled signaling and the developmental control of cell polarity
    J M Shulman
    Wellcome CRC Institute, UK
    Trends Genet 14:452-8. 1998
    ..Recently described examples from the nematode and frog suggest that the developmental control of cell polarity by FZ receptors might represent a functionally conserved signaling mechanism...
  72. ncbi Genetic analysis of cadherin function in animal morphogenesis
    U Tepass
    Department of Zoology University of Toronto 25 Harbord Street, Toronto, Ontario, M5S 3G5, Canada
    Curr Opin Cell Biol 11:540-8. 1999
    ..Fat-like cadherins are required for epithelial morphogenesis, proliferation control, and epithelial planar polarization...
  73. ncbi Engineered truncations in the Drosophila mastermind protein disrupt Notch pathway function
    W Helms
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    Dev Biol 215:358-74. 1999
    ..This system should prove useful for the investigation of the role of Mam within the Notch pathway...
  74. ncbi Growth regulation: a beginning for the hippo pathway
    Iswar K Hariharan
    Department of Molecular and Cell Biology, 361 LSA, University of California Berkeley, Berkeley, California 94720, USA
    Curr Biol 16:R1037-9. 2006
    ..A signaling pathway involving two protein kinases, Hippo and Warts, restricts the growth of imaginal discs in Drosophila. Four recent studies taken together show that the protocadherin Fat can regulate Warts in two different ways...
  75. pmc Expression patterns of cadherin genes in Drosophila oogenesis
    Jeremiah J Zartman
    Lewis Sigler Institute, Department of Chemical Engineering, Princeton University, Princeton, NJ 08544, USA
    Gene Expr Patterns 9:31-6. 2009
    ..Of particular note is the complex patterning of the region of the follicular epithelium that gives rise to the dorsal appendages, which are tubular structures that serve as respiratory organs for the developing embryo...
  76. ncbi The making of a fly leg: a model for epithelial morphogenesis
    L von Kalm
    University of California at Berkeley, Dept of Molecular and Cell Biology 94720 3200, USA
    Bioessays 17:693-702. 1995
    ..All of these products are required for the execution of normal changes in leg cell shape...
  77. ncbi An axon scaffold induced by retinal axons directs glia to destinations in the Drosophila optic lobe
    Richard Dearborn
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Development 131:2291-303. 2004
    ..These observations reveal a mechanism for coordinating photoreceptor axon arrival in the brain with the distribution of glia to multiple target destinations, where they are required for axon guidance and neuronal survival...
  78. ncbi Frizzled signaling and cell-cell interactions in planar polarity
    P N Adler
    Biology Department and Cancer Center, Gilmer Hall, University of Virginia, Charlottesville, Virginia 22903, USA
    Curr Opin Cell Biol 13:635-40. 2001
    ..This cortical mark leads to the local activation of downstream gene products and the subsequent activation of the cytoskeleton to form a hair...
  79. ncbi The ballet of morphogenesis: unveiling the hidden choreographers
    Mark Peifer
    Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 27599, USA
    Cell 109:271-4. 2002
    ..Several recent papers reveal new insights into the mechanisms by which cells turn their perceptions about fate into action, focusing on the role of Wnt signal transduction in cell polarization and migration...
  80. ncbi Specifying positional information in the embryo: looking beyond morphogens
    Michel Kerszberg
    Universite Pierre et Marie Curie Paris 6, UMR7138 CNRS, 75005 Paris, France
    Cell 130:205-9. 2007
    ..It is now becoming clear that additional or alternative mechanisms involving interactions among cells are also crucial for positional specification...
  81. doi The Drosophila gene zfh2 is required to establish proximal-distal domains in the wing disc
    Javier Terriente
    Centro de Biologia Molecular Severo Ochoa, Universidad Autónoma C S I C, Madrid, Spain
    Dev Biol 320:102-12. 2008
    ..The results we present here indicate that Zfh2 plays a critical role in both processes...
  82. ncbi Van Gogh-like2 (Strabismus) and its role in planar cell polarity and convergent extension in vertebrates
    Elena Torban
    Department of Biochemistry, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec H3G 1Y7, Canada
    Trends Genet 20:570-7. 2004
    ..This review will summarize recent findings documenting the involvement of Stbm (Vangl2) and associated proteins in planar cell polarity, non-canonical Wnt signaling and convergent extension movements...
  83. pmc A green fluorescent protein reporter genetic screen that identifies modifiers of Hox gene function in the Drosophila embryo
    Samir Merabet
    Laboratoire de Génétique et Physiologie du Développement IBDM, CNRS, Universite de la Mediterranee, 13288 Marseille Cedex 09, France
    Genetics 162:189-202. 2002
    ..Five of them encode products acting in or in connection with signal transduction pathways, which suggests an extensive use of signaling in the control of Hox gene function...
  84. ncbi Fly developments: an introspective
    Susan Parkhurst
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle WA 98109, USA
    Bioessays 25:87-9. 2003
  85. ncbi Integrins modulate Sog activity in the Drosophila wing
    Helena Araujo
    Departamento de Histologia e Embriologia, Universidade Federal do Rio de Janeiro, 21941 970, Rio de Janeiro, Brazil
    Development 130:3851-64. 2003
    ..We propose that integrins act by binding and possibly regulating the activity/availability of different forms of Sog during pupal development through an adhesion independent mechanism...
  86. pmc The abdomen of Drosophila: does planar cell polarity orient the neurons of mechanosensory bristles?
    Caroline C G Fabre
    Department of Zoology, Downing St, Cambridge CB2 3EJ, UK, MRC Laboratory of Molecular Biology, Hills Rd, Cambridge CB2 OQH, UK
    Neural Dev 3:12. 2008
    ..The neurons include a single dendrite and an axon; it is not known whether the orientation of these processes is influenced by PCP...
  87. doi Echinoid regulates Flamingo endocytosis to control ommatidial rotation in the Drosophila eye
    Yu Huei Ho
    Institute of Molecular Medicine, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan 30034, Republic of China
    Development 137:745-54. 2010
    ..Thus, co-endocytosis of Ed and Fmi provides a link between apicobasal polarity and PCP...
  88. pmc Oriented cell division as a response to cell death and cell competition
    Wei Li
    Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Curr Biol 19:1821-6. 2009
    ..These findings show that planar cell polarity genes are required for responses to cell death. Oriented mitosis may help maintain morphology as dividing cells replace those that have been lost...
  89. ncbi Orchestrating size and shape during morphogenesis
    Thomas Lecuit
    Universite de la Mediterranee, Institut de Biologie du Developpement de Marseille Luminy IBDML, Marseille Cedex 09, France
    Nature 450:189-92. 2007
    ..New models integrate how specific signals and mechanical forces shape tissues and may also control their size...
  90. ncbi Sticking together and sorting things out: adhesion as a force in development
    H McNeill
    Developmental Patterning Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London, WC2A 3PX, UK
    Nat Rev Genet 1:100-8. 2000
    ....
  91. pmc Techniques for manipulating chromosomal rearrangements and their application to Drosophila melanogaster. I. Pericentric inversions
    L Craymer
    Genetics 99:75-97. 1981
    ..In several instances, hyperploids for four to six numbered divisions were observed to be fertile in both sexes...
  92. pmc Enhancement of overgrowth by gene interactions in lethal(2)giant discs imaginal discs from Drosophila melanogaster
    M A Buratovich
    Developmental Biology Center, University of California, Irvine 92717, USA
    Genetics 147:657-70. 1997
    ..dachsous (ds) also acts as an enhancer of l(2)gd, producing dramatically overgrown discs and causing failure to pupariate in ..
  93. ncbi Cadherin superfamily proteins in Caenorhabditis elegans and Drosophila melanogaster
    E Hill
    MRC, Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK
    J Mol Biol 305:1011-24. 2001
    ..At present, the remaining cadherins have no obvious similarities in their extracellular domain architecture or homologies to their cytoplasmic domains and may, therefore, represent species-specific or phylum-specific molecules...
  94. ncbi A three-tiered mechanism for regulation of planar cell polarity
    David R P Tree
    Department of Pathology, L235, Stanford University School of Medicine, Stanford, CA 94305, USA
    Semin Cell Dev Biol 13:217-24. 2002
    ..The third modules are tissue specific, acting to translate subcellular asymmetry into the appropriate morphological manifestations in the different cell types...
  95. ncbi Frizzled signalling and cell polarisation in Drosophila and vertebrates
    David Strutt
    Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK
    Development 130:4501-13. 2003
    ..This review discusses recent findings regarding non-canonical Frizzled signalling and cell polarisation...
  96. ncbi Wg and Egfr signalling antagonise the development of the peripodial epithelium in Drosophila wing discs
    Luis Alberto Baena-Lopez
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Facultad de Ciencias, 28049, Madrid, Spain
    Development 130:6497-506. 2003
    ..These findings suggest that suppression of Wg and Egfr activities is an early step in the development of the peripodial epithelium of the wing discs...
  97. ncbi The grainy head transcription factor is essential for the function of the frizzled pathway in the Drosophila wing
    Haeryun Lee
    Department of Biology and Cancer Center, University of Virginia, Charlottesville, VA 22903, USA
    Mech Dev 121:37-49. 2004
    ..In addition, we found that grh has frizzled pathway independent functions during the development of the adult cuticle...
  98. ncbi Diverse functions of N-cadherin in dendritic and axonal terminal arborization of olfactory projection neurons
    Haitao Zhu
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Neuron 42:63-75. 2004
    ..Although the N-cadherin locus potentially encodes eight alternatively spliced isoforms, transgenic expression of one isoform is sufficient to rescue all phenotypes...

Research Grants10

  1. GENETIC ANALYSIS OF PREHAIR MORPHOGENESIS
    Paul Adler; Fiscal Year: 2005
    ....
  2. CYTOSKELETAL REGULATION BY SRC64/TEC29 KINASES
    Michael Simon; Fiscal Year: 2004
    ..abstract_text> ..
  3. MOLECULAR GENETIC OF TYROSINE KINASE AND RAS FUNCTION
    Michael Simon; Fiscal Year: 2001
    ....
  4. Cadherin regulation of tissue polarity and growth
    Michael Simon; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  5. CONFOCAL MICROSCOPE FOR LIVE CELL & MULTIWAVELENGTH WORK
    Mark Peifer; Fiscal Year: 2001
    ..Our proposal seeks to meet these new needs, by the creation of a multi-user facility that will provide a state-of-the art confocal microscope to a large group of NIH funded investigators. ..
  6. Transcriptional Repression and Cofactor Recruitment
    Susan Parkhurst; Fiscal Year: 2008
    ..Results obtained from these projects are expected to have wide implications as HES family proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..
  7. Mechanisms of Wound Healing in Drosphila
    Susan Parkhurst; Fiscal Year: 2009
    ..Controlling repair and inflammation will also be a fundamental consideration in tissue engineering where artificial and/or cell based constructs are implanted to reconstruct tissues. ..
  8. MECHANISMS OF TRANSCRIPTIONAL REPRESSION IN DROSOPHILA
    Susan Parkhurst; Fiscal Year: 2002
    ..Results obtained from these projects are expected to have wide implications as Hairy/E(spl) proteins and mechanisms of transcriptional repression are conserved throughout organisms. ..
  9. Mechanisms of Rho GTPase Function in Drosophila
    Susan Parkhurst; Fiscal Year: 2006
    ..Our results are expected to have wide implications as Rho GTPases and the diverse cellular mechanisms they mediate are conserved across a wide range of organisms. ..