Gene Symbol: Drsl2
Description: Drosomycin-like 2
Alias: CG10813, CG32279, CT30310, Dmel\CG32279, Dro-D, Dro2, Drs-lD, dmy2, dro-2, dro2, Drosomycin-like 2, CG32279-PA, Drosomycin-like D, Drsl2-PA, drosomycin, drosomycin 2, drosomycin-2, drosomycin-D
Species: fruit fly

Top Publications

  1. Jiggins F, Kim K. The evolution of antifungal peptides in Drosophila. Genetics. 2005;171:1847-59 pubmed publisher
    ..the selection pressures acting on Drosophila antifungal peptides (drosomycins) from both the divergence of drosomycin genes within and between five species of Drosophila and polymorphism data from Drosophila simulans and D...
  2. Yang W, Wen S, Huang Y, Ye M, Deng X, Han D, et al. Functional divergence of six isoforms of antifungal peptide Drosomycin in Drosophila melanogaster. Gene. 2006;379:26-32 pubmed
    b>Drosomycin (Drs) gene encodes a 44-residue inducible antifungal peptide, Drosomycin, in Drosophila melanogaster...
  3. Tian C, Gao B, Rodriguez M, Lanz Mendoza H, Ma B, Zhu S. Gene expression, antiparasitic activity, and functional evolution of the drosomycin family. Mol Immunol. 2008;45:3909-16 pubmed publisher
    Drosophila employs various antimicrobial peptides as effective weapons to defend against diverse pathogens. Drosomycin is an inducible antifungal peptide initially isolated from the Drosophila melanogaster haemolymph...
  4. Daibo S, Kimura M, Goto S. Upregulation of genes belonging to the drosomycin family in diapausing adults of Drosophila triauraria. Gene. 2001;278:177-84 pubmed
    ..hybridization have similarity to genes encoding antifungal peptides of Drosophila melanogaster, members of the drosomycin family (drosomycin, CG10812, CG10813, CG10815 and CG11520)...
  5. Bhattacharya A, Steward R. The Drosophila homolog of NTF-2, the nuclear transport factor-2, is essential for immune response. EMBO Rep. 2002;3:378-83 pubmed
    ..not target to the nucleus after infection, and, consequently, the expression of the anti-microbial peptide genes drosomycin, attacin and drosocin is severely impaired...
  6. Heger A, Ponting C. Evolutionary rate analyses of orthologs and paralogs from 12 Drosophila genomes. Genome Res. 2007;17:1837-49 pubmed
    ..Duplications were significantly more frequent among trypsin-like proteases and DM8 putative lipid-binding domain proteins. ..
  7. Winterhalter W, Fedorka K. Sex-specific variation in the emphasis, inducibility and timing of the post-mating immune response in Drosophila melanogaster. Proc Biol Sci. 2009;276:1109-17 pubmed publisher
    ..Our results suggest that variation in the effectiveness of the immune response between the sexes may be driven by differences in emphasis rather than overall investment. ..
  8. Marshall K, Sinclair B. Repeated stress exposure results in a survival-reproduction trade-off in Drosophila melanogaster. Proc Biol Sci. 2010;277:963-9 pubmed publisher
    ..Given that many environments are not static, this trade-off indicates that investigating the effects of repeated stress exposure is important for understanding and predicting physiological responses in the wild. ..
  9. Zhang Z, Zhu S. Functional role of charged residues in drosomycin, a Drosophila antifungal peptide. Dev Comp Immunol. 2010;34:953-8 pubmed publisher
    ..To address this question, we investigated the functional role of charged residues in drosomycin, a specific Drosophila antifungal peptide, using site-directed mutagenesis in combination with circular ..

More Information


  1. Doroszuk A, Jonker M, Pul N, Breit T, Zwaan B. Transcriptome analysis of a long-lived natural Drosophila variant: a prominent role of stress- and reproduction-genes in lifespan extension. BMC Genomics. 2012;13:167 pubmed publisher
    ..The results suggest that natural genetic variation for SR and lifespan can operate through similar transcriptional mechanisms as those of dietary restriction and life-extending mutations. ..
  2. Remolina S, Chang P, Leips J, Nuzhdin S, Hughes K. Genomic basis of aging and life-history evolution in Drosophila melanogaster. Evolution. 2012;66:3390-403 pubmed publisher
    ..More generally, we argue that hitchhiking mapping can be a powerful tool for uncovering the molecular bases of quantitative genetic variation. ..
  3. Sackton T, Clark A. Comparative profiling of the transcriptional response to infection in two species of Drosophila by short-read cDNA sequencing. BMC Genomics. 2009;10:259 pubmed publisher
    ..virilis hemolymph and validate our transcriptional data. These results suggest that the acquisition of novel components of the immune system, and particularly novel effector proteins, may be a common evolutionary phenomenon. ..
  4. Deng X, Yang W, Huang Y, Cao Y, Wen S, Xia Q, et al. Gene expression divergence and evolutionary analysis of the drosomycin gene family in Drosophila melanogaster. J Biomed Biotechnol. 2009;2009:315423 pubmed publisher
    b>Drosomycin (Drs) encoding an inducible 44-residue antifungal peptide is clustered with six additional genes, Dro1, Dro2, Dro3, Dro4, Dro5, and Dro6, forming a multigene family on the 3L chromosome arm in Drosophila melanogaster...
  5. Yeh S, von Grotthuss M, Gandasetiawan K, Jayasekera S, Xia X, Chan C, et al. Functional divergence of the miRNA transcriptome at the onset of Drosophila metamorphosis. Mol Biol Evol. 2014;31:2557-72 pubmed publisher
    ..Collectively, our results show contrasting patterns of functional divergence associated with miRNA expression levels during Drosophila ontogeny. ..