Drs

Summary

Gene Symbol: Drs
Description: Drosomycin
Alias: BcDNA:LP03851, CG10810, Crp, DIM 19, DRO, DROM, DROS, DRS, Dmel\CG10810, Drm, Drom, Dros, Droso, dmy1, drm, drom, drs, drsm, CG10810-PA, Cysteine-rich-protein, Drosomycin-B, Drs-PA, cysteine-rich peptide, drosomcycin, drosomyci, drosomycin, drosomycin precursor, drosomyocin, drosophila immune induced molecule 19
Species: fruit fly

Top Publications

  1. ncbi The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    B Lemaitre
    Institut de Biologie Moléculaire at Cellulaire, UPR 9022 du Centre National de la Recherche Scientifique, Strasbourg, France
    Cell 86:973-83. 1996
  2. ncbi Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila
    Christine Kocks
    Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cell 123:335-46. 2005
  3. ncbi Two proteases defining a melanization cascade in the immune system of Drosophila
    Huaping Tang
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    J Biol Chem 281:28097-104. 2006
  4. pmc The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling
    Justin R DiAngelo
    The Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 106:20853-8. 2009
  5. pmc A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense
    B Lemaitre
    Institut de Biologie Moleculaire et Cellulaire, Unité Propre de Recherche 9022 du Centre National de la Recherche Scientifique, Strasbourg, France
    Proc Natl Acad Sci U S A 92:9465-9. 1995
  6. ncbi Phylogenetic perspectives in innate immunity
    J A Hoffmann
    Institute of Molecular and Cellular Biology, CNRS, Strasbourg, 67084, France
    Science 284:1313-8. 1999
  7. doi Innate immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in Drosophila
    Ji Hwan Ryu
    Division of Molecular Life Science, Ewha Woman s University and National Creative Research Initiative Center for Symbiosystem, Seoul 120 750, South Korea
    Science 319:777-82. 2008
  8. ncbi A Spätzle-processing enzyme required for toll signaling activation in Drosophila innate immunity
    In Hwan Jang
    Division of Molecular Life Science, Ewha Womans University, Seoul, 120 750, South Korea
    Dev Cell 10:45-55. 2006
  9. ncbi Dual activation of the Drosophila toll pathway by two pattern recognition receptors
    Vanessa Gobert
    Unité Propre de Recherche 9022 du CNRS, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F67084 Strasbourg Cedex, France
    Science 302:2126-30. 2003
  10. pmc Requirements of peptidoglycan structure that allow detection by the Drosophila Toll pathway
    Sergio R Filipe
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    EMBO Rep 6:327-33. 2005

Research Grants

Scientific Experts

Detail Information

Publications118 found, 100 shown here

  1. ncbi The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    B Lemaitre
    Institut de Biologie Moléculaire at Cellulaire, UPR 9022 du Centre National de la Recherche Scientifique, Strasbourg, France
    Cell 86:973-83. 1996
    ..for dorsal) and the extracellular Toll ligand, spätzle, control expression of the antifungal peptide gene drosomycin in adults...
  2. ncbi Eater, a transmembrane protein mediating phagocytosis of bacterial pathogens in Drosophila
    Christine Kocks
    Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cell 123:335-46. 2005
    ..Our results suggest that Eater is a major phagocytic receptor for a broad range of bacterial pathogens in Drosophila and provide a powerful model to address the role of phagocytosis in vivo...
  3. ncbi Two proteases defining a melanization cascade in the immune system of Drosophila
    Huaping Tang
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    J Biol Chem 281:28097-104. 2006
    ..We have also shown that the melanization reaction activated by MP1 and MP2 plays an important role in augmenting the effectiveness of other immune reactions, thereby promoting resistance of Drosophila to microbial infection...
  4. pmc The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling
    Justin R DiAngelo
    The Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 106:20853-8. 2009
    ..These data suggest that communication between these two regulatory systems evolved as a means to divert energy in times of need from organismal growth to the acute requirement of combating infection...
  5. pmc A recessive mutation, immune deficiency (imd), defines two distinct control pathways in the Drosophila host defense
    B Lemaitre
    Institut de Biologie Moleculaire et Cellulaire, Unité Propre de Recherche 9022 du Centre National de la Recherche Scientifique, Strasbourg, France
    Proc Natl Acad Sci U S A 92:9465-9. 1995
    ..We also report that, in contrast to the antibacterial peptides, the antifungal peptide drosomycin remains inducible in a homozygous imd mutant background...
  6. ncbi Phylogenetic perspectives in innate immunity
    J A Hoffmann
    Institute of Molecular and Cellular Biology, CNRS, Strasbourg, 67084, France
    Science 284:1313-8. 1999
    ..In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity...
  7. doi Innate immune homeostasis by the homeobox gene caudal and commensal-gut mutualism in Drosophila
    Ji Hwan Ryu
    Division of Molecular Life Science, Ewha Woman s University and National Creative Research Initiative Center for Symbiosystem, Seoul 120 750, South Korea
    Science 319:777-82. 2008
    ..These results reveal that a specific genetic deficiency within a host can profoundly influence the gut commensal microbial community and host physiology...
  8. ncbi A Spätzle-processing enzyme required for toll signaling activation in Drosophila innate immunity
    In Hwan Jang
    Division of Molecular Life Science, Ewha Womans University, Seoul, 120 750, South Korea
    Dev Cell 10:45-55. 2006
    ....
  9. ncbi Dual activation of the Drosophila toll pathway by two pattern recognition receptors
    Vanessa Gobert
    Unité Propre de Recherche 9022 du CNRS, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F67084 Strasbourg Cedex, France
    Science 302:2126-30. 2003
    ..The potential for a combination of distinct proteins to mediate detection of infectious nonself in the fly will refine the concept of pattern recognition in insects...
  10. pmc Requirements of peptidoglycan structure that allow detection by the Drosophila Toll pathway
    Sergio R Filipe
    Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    EMBO Rep 6:327-33. 2005
    ..We suggest a model whereby GNBP1 is involved in the hydrolysis of Gram-positive peptidoglycan producing new glycan reducing ends, which are subsequently detected by PGRP-SA...
  11. doi Eye transformer is a negative regulator of Drosophila JAK/STAT signaling
    Jenni Kallio
    Laboratory of Experimental Immunology, Institute of Medical Technology, Tampere University, Tampere, Finland
    FASEB J 24:4467-79. 2010
    ..In conclusion, we have identified ET as a novel negative regulator of the Drosophila JAK/STAT pathway both in vitro and in vivo, and it functions in regulating Stat92E phosphorylation...
  12. pmc Comparative pathology of bacteria in the genus Providencia to a natural host, Drosophila melanogaster
    Madeline R Galac
    Field of Genetics and Development, 3125 Comstock Hall, Cornell University, Ithaca, NY 14850, USA
    Microbes Infect 13:673-83. 2011
    ..D. melanogaster and Providencia provide a powerful system for studying general host-pathogen interactions, and for understanding how the well-studied immune model host D. melanogaster interacts with its natural bacterial pathogens...
  13. ncbi Binding of the Drosophila cytokine Spätzle to Toll is direct and establishes signaling
    Alexander N R Weber
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, United Kingdom
    Nat Immunol 4:794-800. 2003
    ..These results show that, in contrast to the human Toll-like receptors, Drosophila Toll requires only an endogenous protein ligand for activation and signaling...
  14. ncbi Expression and evolution of the Drosophila attacin/diptericin gene family
    M Hedengren
    Umea Centre for Molecular Pathogenesis, Umea University, Umea, S 901 87, Sweden
    Biochem Biophys Res Commun 279:574-81. 2000
    ..This induction is reduced in imd mutants, and unexpectedly also in Tl(-) mutants. The 18w mutation particularly affects the induction of AttC, which may be a useful marker for 18w signaling...
  15. pmc Discerning the complexity of community interactions using a Drosophila model of polymicrobial infections
    Christopher D Sibley
    Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
    PLoS Pathog 4:e1000184. 2008
    ..aeruginosa...
  16. ncbi dUbc9 negatively regulates the Toll-NF-kappa B pathways in larval hematopoiesis and drosomycin activation in Drosophila
    Hsiling Chiu
    Department of Functional Genomics, Novartis Institutes for BioMedical Research, 100 Technology Square Bldg 601 Rm 6404, Cambridge, MA 02139, USA
    Dev Biol 288:60-72. 2005
    ..In the larval fat body, dUbc9 negatively regulates the expression of the antifungal peptide gene drosomycin, which is constitutively expressed in dUbc9 mutants in the absence of immune challenge...
  17. pmc Toll and IMD pathways synergistically activate an innate immune response in Drosophila melanogaster
    Takahiro Tanji
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell Biol 27:4578-88. 2007
    ..ligand) together caused synergistic activation of representative target genes of the two pathways, including Drosomycin, Diptericin, and AttacinA...
  18. pmc Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms
    B Lemaitre
    Institut de Biologie Moleculaire et Cellulaire, Unité Propre de Recherche 9022 du Centre National de la Recherche Scientifique, 15 rue Rene Descartes, 67084 Strasbourg Cedex, France
    Proc Natl Acad Sci U S A 94:14614-9. 1997
    ..This response is mediated through the selective activation of the Toll pathway...
  19. pmc The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response
    A Basset
    Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique, F 91198 Gif sur Yvette Cedex, France
    Proc Natl Acad Sci U S A 97:3376-81. 2000
    ....
  20. ncbi Upregulation of genes belonging to the drosomycin family in diapausing adults of Drosophila triauraria
    S Daibo
    Graduate School of Environmental Earth Science, Hokkaido University, Sapporo, Hokkaido 060 0810, Japan
    Gene 278:177-84. 2001
    ..hybridization have similarity to genes encoding antifungal peptides of Drosophila melanogaster, members of the drosomycin family (drosomycin, CG10812, CG10813, CG10815 and CG11520)...
  21. pmc Nitric oxide contributes to induction of innate immune responses to gram-negative bacteria in Drosophila
    Edan Foley
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California 94143, USA
    Genes Dev 17:115-25. 2003
    ..We propose that NO mediates an early step of the signal transduction pathway, inducing the innate immune response upon natural infection with gram-negative bacteria...
  22. pmc Drosophila eiger mutants are sensitive to extracellular pathogens
    David S Schneider
    Department of Microbiology and Immunology, Stanford University, Stanford, California, United States of America
    PLoS Pathog 3:e41. 2007
    ..We propose that eiger activates the cellular immune response of the fly to aid clearance of extracellular pathogens. Intracellular pathogens, which can already defeat professional phagocytes, are unaffected by eiger...
  23. ncbi Drosophila Toll is activated by Gram-positive bacteria through a circulating peptidoglycan recognition protein
    T Michel
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, 15 rue Rene Descartes, 67084 Strasbourg Cedex, France
    Nature 414:756-9. 2001
    ..Interestingly, seml does not affect Toll activation by fungal infection, indicating the existence of a distinct recognition system for fungi to activate the Toll pathway...
  24. pmc The Drosophila caspase Dredd is required to resist gram-negative bacterial infection
    F Leulier
    Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique, France
    EMBO Rep 1:353-8. 2000
    ....
  25. ncbi Interactions between the cellular and humoral immune responses in Drosophila
    M Elrod-Erickson
    Whitehead Institute, Cambridge, MA 02142, USA
    Curr Biol 10:781-4. 2000
    ....
  26. pmc The Drosophila TNF ortholog eiger is required in the fat body for a robust immune response
    Eric M Mabery
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305 5124, USA
    J Innate Immun 2:371-8. 2010
    ..This includes reduced melanization, altered antimicrobial peptide expression and reduced feeding rates. The effect of eiger on feeding rates alone may account for the entire phenotype seen in eiger mutants infected with S. typhimurium...
  27. pmc Uptake of the necrotic serpin in Drosophila melanogaster via the lipophorin receptor-1
    Sandra Fausia Soukup
    Functional Genomics Unit, CIC bioGUNE, Derio, Spain
    PLoS Genet 5:e1000532. 2009
    ..The scavenging of serpin/proteinase complexes may be a critical step in the regulation of proteolytic cascades...
  28. pmc Circadian regulation in the ability of Drosophila to combat pathogenic infections
    Jung Eun Lee
    Graduate Program in Biochemistry, Center for Advanced Biotechnology and Medicine, Rutgers University, 679 Hoes Lane, Piscataway, New Jersey 08854, USA
    Curr Biol 18:195-9. 2008
    ..Our findings suggest that medical intervention strategies incorporating chronobiological considerations could enhance the innate immune response, boosting the efficacy of combating pathogenic infections...
  29. ncbi Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria
    Vincent Bischoff
    Institut de Biologie Moleculaire et Cellulaire, CNRS UPR 9022, 15 rue Rene Descartes, Universite Louis Pasteur, 67084 Strasbourg Cedex, France
    Nat Immunol 5:1175-80. 2004
    ..These data indicate that PGRP-SD can function as a receptor for Gram-positive bacteria and shows partial redundancy with the PGRP-SA-GNBP1 complex...
  30. ncbi In vivo RNA interference analysis reveals an unexpected role for GNBP1 in the defense against Gram-positive bacterial infection in Drosophila adults
    Sebastien Pili-Floury
    Centre de Genetique Moleculaire, CNRS, F 91198 Gif sur Yvette Cedex, France
    J Biol Chem 279:12848-53. 2004
    ..to Gram-positive bacterial infection and reduces the induction of the antifungal peptide encoding gene Drosomycin after infection by Gram-positive bacteria but not after fungal infection...
  31. ncbi Immunity regulatory DNAs share common organizational features in Drosophila
    Kate Senger
    Department of Molecular and Cellular Biology, Division of Genetics and Development, University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Cell 13:19-32. 2004
    ..Aspects of this "regulatory code" are essential for the immune response. These results suggest that immunity regulatory DNAs contain constrained organizational features, which may be a general property of eukaryotic enhancers...
  32. pmc Sensing of 'danger signals' and pathogen-associated molecular patterns defines binary signaling pathways 'upstream' of Toll
    Laure El Chamy
    Institut de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Unité Propre de Recherche 9022, Universite Louis Pasteur, Strasbourg Cedex, France
    Nat Immunol 9:1165-70. 2008
    ..Hence, Persephone defines a parallel proteolytic cascade activated by 'danger signals' such as abnormal proteolytic activities...
  33. ncbi Activation of Drosophila Toll during fungal infection by a blood serine protease
    Petros Ligoxygakis
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, 15 rue R Descartes, F67084 Strasbourg Cedex, France
    Science 297:114-6. 2002
    ..We show that ethylmethane sulfonate-induced mutations in the persephone gene, which encodes a previously unknown serine protease, block induction of the Toll pathway by fungi and resistance to this type of infection...
  34. pmc Peptidoglycan recognition protein-SD provides versatility of receptor formation in Drosophila immunity
    Lihui Wang
    Genetics Unit, Department of Biochemistry, South Parks Road, University of Oxford, Oxford OX1 3QU, United Kingdom
    Proc Natl Acad Sci U S A 105:11881-6. 2008
    ..These results indicate that the interplay between the binding affinities of different PGRPs provides sufficient flexibility for the recognition of the highly diverse Gram-positive PG...
  35. pmc Prophenoloxidase activation is not required for survival to microbial infections in Drosophila
    Vincent Leclerc
    UPR9022 du CNRS, IBMC, 15 rue Descartes, 67084 Strasbourg, France
    EMBO Rep 7:231-5. 2006
    ..This raises the question with regard to the precise function of phenoloxidase activation in defence, if any...
  36. pmc Elimination of plasmatocytes by targeted apoptosis reveals their role in multiple aspects of the Drosophila immune response
    Bernard Charroux
    Institut de Biologie du Developpement de Marseille Luminy, Unite Mixte de Recherche 6216, Centre National de la Recherche Scientifique, Université de la Méditerrannée Aix Marseille II, 13288 Marseille Cedex 9, France
    Proc Natl Acad Sci U S A 106:9797-802. 2009
    ..Finally, we show that plasmatocytes are involved in immune surveillance during pupal development, because they prevent bacterial infection that causes pupal lethality...
  37. pmc Drosophila melanogaster mounts a unique immune response to the Rhabdovirus sigma virus
    C W Tsai
    Department of Entomology, The Ohio State University OARDC, Wooster, Ohio 44691, USA
    Appl Environ Microbiol 74:3251-6. 2008
    ..SIGMAV infection did not induce PGRP-SA and the AMP genes Drosomycin-B, Metchnikowin, and Defensin that are upregulated in DCV and/or DXV infections...
  38. ncbi Requirement for a peptidoglycan recognition protein (PGRP) in Relish activation and antibacterial immune responses in Drosophila
    Kwang Min Choe
    Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Science 296:359-62. 2002
    ....
  39. ncbi Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury
    Herve Agaisse
    Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Dev Cell 5:441-50. 2003
    ....
  40. ncbi Insect immunity. Septic injury of Drosophila induces the synthesis of a potent antifungal peptide with sequence homology to plant antifungal peptides
    P Fehlbaum
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 Centre National de la Recherche Scientifique Réponse Immunitaire et Développement chez les Insectes, Strasbourg, France
    J Biol Chem 269:33159-63. 1994
    ..This novel inducible peptide, which we propose to name drosomycin, shows a significant homology with a family of 5-kDa cysteine-rich plant antifungal peptides recently isolated ..
  41. pmc The evolution of antifungal peptides in Drosophila
    Francis M Jiggins
    Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Ashworth Lab, King s Buildings, West Mains Road, Edinburgh EH9 3JT, Scotland
    Genetics 171:1847-59. 2005
    ..the selection pressures acting on Drosophila antifungal peptides (drosomycins) from both the divergence of drosomycin genes within and between five species of Drosophila and polymorphism data from Drosophila simulans and D...
  42. ncbi Drosophila immunity: a large-scale in vivo RNAi screen identifies five serine proteases required for Toll activation
    Zakaria Kambris
    Centre de Genetique Moleculaire, CNRS, Gif sur Yvette, France
    Curr Biol 16:808-13. 2006
    ..These results demonstrate the existence of a common cascade of SPs upstream of Spz, integrating signals sent by various secreted recognition molecules via more specialized SPs...
  43. pmc Chronic activation of the epithelial immune system of the fruit fly's salivary glands has a negative effect on organismal growth and induces a peculiar set of target genes
    Ahmed Abdelsadik
    Christian Albrechts University of Kiel, Zoophysiology, Kiel, Germany
    BMC Genomics 11:265. 2010
    ..Our major goal was to elucidate if the fly's salivary glands are able to mount an immune response and what the major characteristics of this immune response are...
  44. pmc A Drosophila pattern recognition receptor contains a peptidoglycan docking groove and unusual L,D-carboxypeptidase activity
    Chung I Chang
    Howard Hughes Medical Institute and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    PLoS Biol 2:E277. 2004
    ....
  45. pmc The homeobox gene Caudal regulates constitutive local expression of antimicrobial peptide genes in Drosophila epithelia
    Ji Hwan Ryu
    Division of Molecular Life Science and Center for Cell Signaling Research, Ewha Womans University, Seoul, South Korea
    Mol Cell Biol 24:172-85. 2004
    ..modulator that is responsible for the constitutive local expression of antimicrobial peptides cecropin and drosomycin in a tissue-specific manner...
  46. doi Functional analysis of Toll-related genes in Drosophila
    Yoshimasa Yagi
    Division of Biological Science, Graduate School of Science, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8602, Japan
    Dev Growth Differ 52:771-83. 2010
    ..Overall our results suggest that some of the Toll-related proteins, such as 18W, Toll-7 and Toll-8, may have redundant functions in regulating developmental processes...
  47. pmc Downregulation of the Drosophila immune response by peptidoglycan-recognition proteins SC1 and SC2
    Vincent Bischoff
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, Strasbourg, France
    PLoS Pathog 2:e14. 2006
    ..We further show that a strict control of IMD-pathway activation is essential to prevent bacteria-induced developmental defects and larval death...
  48. ncbi Expression and regulation of Spätzle-processing enzyme in Drosophila
    Shai Mulinari
    Department of Experimental Medical Science and Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, BMC B13, Klinikgatan 26, 22184 Lund, Sweden
    FEBS Lett 580:5406-10. 2006
    ....
  49. pmc Lack of an antibacterial response defect in Drosophila Toll-9 mutant
    Karine Narbonne-Reveau
    Institut de Biologie du Developpement de Marseille Luminy, CNRS UMR 6216 Aix Marseille II University, Campus de Luminy, Marseille, France
    PLoS ONE 6:e17470. 2011
    ..Our results suggest that Toll-9 is neither required to maintain a basal anti-microbial response nor to mount an efficient immune response to bacterial infection...
  50. pmc Constitutive expression of a single antimicrobial peptide can restore wild-type resistance to infection in immunodeficient Drosophila mutants
    Phoebe Tzou
    Centre de Genetique Moleculaire, Centre National de la Recherche Scientifique, 91198 Gif sur Yvette, France
    Proc Natl Acad Sci U S A 99:2152-7. 2002
    ....
  51. pmc Sensing of Gram-positive bacteria in Drosophila: GNBP1 is needed to process and present peptidoglycan to PGRP-SA
    Lihui Wang
    Genetics Unit, Department of Biochemistry, University of Oxford, Oxford, UK
    EMBO J 25:5005-14. 2006
    ..We propose a model whereby GNBP1 presents a processed form of PG for sensing by PGRP-SA and that a tripartite interaction between these proteins and PG is essential for downstream signaling...
  52. pmc Critical evaluation of the role of the Toll-like receptor 18-Wheeler in the host defense of Drosophila
    Petros Ligoxygakis
    Institut de Biologie Moléculaire and Cellulaire, Strasbourg Cedex, France
    EMBO Rep 3:666-73. 2002
    ..18-Wheeler does not qualify as a pattern recognition receptor of Gram-negative bacteria...
  53. ncbi Splice-activated UAS hairpin vector gives complete RNAi knockout of single or double target transcripts in Drosophila melanogaster
    Jean Marc Reichhart
    UPR 9022 C N R S, Institut de Biologie Moleculaire et Cellulaire, Strasbourg, France
    Genesis 34:160-4. 2002
  54. pmc Activation of the innate immunity in Drosophila by endogenous chromosomal DNA that escaped apoptotic degradation
    Naomi Mukae
    Department of Genetics, Osaka University Medical School, Osaka 565 0871, Japan
    Genes Dev 16:2662-71. 2002
    ..These results indicated that CAD and DNase II work independently to degrade chromosomal DNA during apoptosis, and if the DNA is left undigested, it can activate the innate immunity in Drosophila...
  55. doi The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila
    Safia Deddouche
    Unité Propre de Recherche 9022, Centre National de la Recherche Scientifique, Institut de Biologie Moleculaire et Cellulaire, 67084 Strasbourg, France
    Nat Immunol 9:1425-32. 2008
    ..We propose that this family represents an evolutionary conserved set of sensors that detect viral nucleic acids and direct antiviral responses...
  56. ncbi Differential activation of the NF-kappaB-like factors Relish and Dif in Drosophila melanogaster by fungi and Gram-positive bacteria
    Marika Hedengren-Olcott
    Department of Zoology, Oregon State University, 220 Nash Hall, Corvallis, OR 97331, USA
    J Biol Chem 279:21121-7. 2004
    ....
  57. doi Drosophila Serpin-28D regulates hemolymph phenoloxidase activity and adult pigmentation
    Christoph Scherfer
    Centre de Genetique Moleculaire, CNRS, 91198 Gif sur Yvette, France
    Dev Biol 323:189-96. 2008
    ..This study further highlights the complexity of the proPO cascade that can be differentially regulated in different tissues during development...
  58. ncbi PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan
    Takashi Kaneko
    Division of Infectious Disease, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Immunol 7:715-23. 2006
    ..These data demonstrate that like mammals, drosophila use both extracellular and intracellular receptors, which have conserved signaling mechanisms, for innate immune recognition...
  59. pmc The Toll pathway is important for an antiviral response in Drosophila
    Robert A Zambon
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, MD 20742, USA
    Proc Natl Acad Sci U S A 102:7257-62. 2005
    ..Additionally, our results demonstrate the validity of using a genetic approach to identify genes and pathways used in viral innate immune responses in Drosophila...
  60. pmc Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila
    Lark Kyun Kim
    Department of Biochemistry, National Creative Research Initiative Center for Genome Regulation, Yonsei University, Seoul, Korea
    PLoS Biol 5:e238. 2007
    ..We conclude that an inhibitory effect of AP-1 and STAT on NF-kappaB is required for properly balanced immune responses and appears to be evolutionarily conserved...
  61. ncbi Natural selection drives extremely rapid evolution in antiviral RNAi genes
    Darren J Obbard
    Institute of Evolutionary Biology, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, United Kingdom
    Curr Biol 16:580-5. 2006
    ..This is a signature of host-pathogen arms races and implies that the ancient battle between RNA viruses and host antiviral RNAi genes is active and significant in shaping RNAi function...
  62. doi Antiviral immunity in Drosophila requires systemic RNA interference spread
    Maria Carla Saleh
    Department of Microbiology and Immunology, University of California, San Francisco 94122 2280, USA
    Nature 458:346-50. 2009
    ..Thus, similar to protein-based immunity in vertebrates, the antiviral RNAi response in flies also relies on the systemic spread of a virus-specific immunity signal...
  63. ncbi A serpin regulates dorsal-ventral axis formation in the Drosophila embryo
    Petros Ligoxygakis
    Genetics Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Curr Biol 13:2097-102. 2003
    ..Since this serpin has been recently shown to restrain an immune reaction in the blood of Drosophila, it demonstrates that proteolysis can be regulated by the same serpin in different biological contexts...
  64. pmc Toll receptor-mediated Drosophila immune response requires Dif, an NF-kappaB factor
    X Meng
    Program in Molecular Medicine, Department of Cell Biology, and Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 USA
    Genes Dev 13:792-7. 1999
    ..The results show that the presence of Dif without Dorsal is sufficient to mediate the induction of drosomycin and defensin...
  65. pmc A mosaic analysis in Drosophila fat body cells of the control of antimicrobial peptide genes by the Rel proteins Dorsal and DIF
    P Manfruelli
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du Centre National de la Recherche Scientifique, 15, rue René Descartes, F 67084 Strasbourg CEDEX, France
    EMBO J 18:3380-91. 1999
    Expression of the gene encoding the antifungal peptide Drosomycin in Drosophila adults is controlled by the Toll signaling pathway...
  66. pmc Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae
    Aya Takehana
    Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980 8578, Japan
    Proc Natl Acad Sci U S A 99:13705-10. 2002
    ..Therefore, PGRP-LE acts as a pattern-recognition receptor to the diaminopimelic acid-type peptidoglycan and activates both the proteolytic cascade and intracellular signaling in Drosophila immunity...
  67. ncbi The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein
    Marie Gottar
    UPR 9022 du Centre National de la Recherche Scientifique, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F67084 Strasbourg, Cedex, France
    Nature 416:640-4. 2002
    ..The data on PGRP-SA with respect to the response to Gram-positive infections, together with the present report, indicate that the PGRP family has a principal role in sensing microbial infections in Drosophila...
  68. ncbi Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections
    Servane Tauszig-Delamasure
    UPR9022 du Centre National de la Recherche Scientifique, Institut de Biologie Moleculaire et Cellulaire, 15, rue René Descartes, 67000 Strasbourg, France
    Nat Immunol 3:91-7. 2002
    ..Overexpression of DmMyD88 was sufficient to induce expression of the antifungal peptide Drosomycin, and induction of Drosomycin was markedly reduced in DmMyD88-mutant flies...
  69. ncbi Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis
    P Georgel
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, Strasbourg, France
    Dev Cell 1:503-14. 2001
    ..We also show that imd is involved in the apoptotic response to UV irradiation. These data raise the possibility that antibacterial response and apoptosis share common control elements in Drosophila...
  70. ncbi Constitutive activation of toll-mediated antifungal defense in serpin-deficient Drosophila
    E A Levashina
    UPR 9022 CNRS, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, Strasbourg 67084, France
    Science 285:1917-9. 1999
    ..blood serine protease inhibitor, Spn43Ac, was shown to lead to constitutive expression of the antifungal peptide drosomycin, and this effect was mediated by the spaetzle and Toll gene products...
  71. ncbi Relish, a central factor in the control of humoral but not cellular immunity in Drosophila
    M Hedengren
    Umeå Center for Molecular Pathogenesis, Umea University, Sweden
    Mol Cell 4:827-37. 1999
    ..Our results illustrate the importance of the humoral response in Drosophila immunity and demonstrate that Relish plays a key role in this response...
  72. ncbi Gram-negative bacteria-binding protein, a pattern recognition receptor for lipopolysaccharide and beta-1,3-glucan that mediates the signaling for the induction of innate immune genes in Drosophila melanogaster cells
    Y S Kim
    Laboratory of Immunology, BK21 Center for Medical Science and Medical Research Center, Yonsei University College of Medicine, 134 Shinchon dong, CPO Box 8044, Seoul, South Korea
    J Biol Chem 275:32721-7. 2000
    ....
  73. pmc The antibacterial arm of the drosophila innate immune response requires an IkappaB kinase
    Y Lu
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Genes Dev 15:104-10. 2001
    ..The ird5 gene encodes a Drosophila homolog of mammalian IkappaB kinases (IKKs). The ird5 phenotype and sequence suggest that the gene is specifically required for the activation of Relish, a Drosophila NF-kappaB family member...
  74. ncbi The Drosophila immune system detects bacteria through specific peptidoglycan recognition
    François Leulier
    Centre de Génétique Moléculaire du CNRS, F 91198 Gif sur Yvette, France
    Nat Immunol 4:478-84. 2003
    ..Thus, the ability of Drosophila to discriminate between Gram-positive and Gram-negative bacteria relies on the recognition of specific forms of peptidoglycan...
  75. pmc Analysis of the Drosophila host defense in domino mutant larvae, which are devoid of hemocytes
    A Braun
    Unité Propre de Recherche 9022, Réponse Immunitaire et Développement chez les Insectes, Institut de Biologie Moléculaire et Cellulaire 15, rue René Descartes, F 67084 Strasbourg CEDEX, France
    Proc Natl Acad Sci U S A 95:14337-42. 1998
    ..By working in synergy, they provide Drosophila a highly effective defense against injury and/or infection...
  76. pmc Silencing of Toll pathway components by direct injection of double-stranded RNA into Drosophila adult flies
    Akira Goto
    UPR 9022 du Centre National de la Recherche Scientifique, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, F 67084 Strasbourg CEDEX, France
    Nucleic Acids Res 31:6619-23. 2003
    ....
  77. pmc Differential display of peptides induced during the immune response of Drosophila: a matrix-assisted laser desorption ionization time-of-flight mass spectrometry study
    S Uttenweiler-Joseph
    Institut de Biologie Moleculaire et Cellulaire, Unité Propre de Recherche 9022 du Centre National de la Recherche Scientifique, 15, rue René Descartes, 67084 Strasbourg Cedex, France
    Proc Natl Acad Sci U S A 95:11342-7. 1998
    ..Finally, molecular cloning and Northern blot analyses revealed that one of the DIMs is produced as a prepropeptide and is inducible on a bacterial challenge...
  78. ncbi Role of Drosophila IKK gamma in a toll-independent antibacterial immune response
    S Rutschmann
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, 15, rue R Descartes, F67084 Strasbourg, France
    Nat Immunol 1:342-7. 2000
    ..Thus, in contrast to the vertebrate inflammatory response, IKK gamma is required for the activation of only one immune signaling pathway in Drosophila...
  79. ncbi The immune response of Drosophila
    Jules A Hoffmann
    Institut de Biologie Moleculaire et Cellulaire du CNRS, 67084 Strasbourg Cedex, France
    Nature 426:33-8. 2003
    ..Recent progress in research on Drosophila immune defence provides evidence for similarities and differences between Drosophila immune responses and mammalian innate immunity...
  80. pmc Directed expression of the HIV-1 accessory protein Vpu in Drosophila fat-body cells inhibits Toll-dependent immune responses
    François Leulier
    Centre de Génétique Moléculaire Centre National de la Recherche Scientifique, Batiment 26, Avenue de la Terrasse, 91198 Gif sur Yvette, France
    EMBO Rep 4:976-81. 2003
    ....
  81. pmc A drosomycin-GFP reporter transgene reveals a local immune response in Drosophila that is not dependent on the Toll pathway
    D Ferrandon
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du Centre National de la Recherche Scientifique, 15, rue René Descartes, F67084 Strasbourg, France
    EMBO J 17:1217-27. 1998
    ..One of these peptides, drosomycin, is active primarily against fungi...
  82. pmc A serpin that regulates immune melanization in the respiratory system of Drosophila
    Huaping Tang
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Dev Cell 15:617-26. 2008
    ..tracheal melanization resulting from Spn77Ba disruption induces systemic expression of the antifungal peptide Drosomycin via the Toll pathway...
  83. pmc Short-term starvation of immune deficient Drosophila improves survival to gram-negative bacterial infections
    Anthony E Brown
    Genetics Unit Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    PLoS ONE 4:e4490. 2009
    ..Since the TIR-NF-kappaB circuit is a conserved component of the host defence in higher animals, genetically tractable models may contribute ideas for clinical interventions...
  84. ncbi The Rel protein DIF mediates the antifungal but not the antibacterial host defense in Drosophila
    S Rutschmann
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, Strasbourg, France
    Immunity 12:569-80. 2000
    ..demonstrate that Dif mediates the Toll-dependent control of the inducibility of the antifungal peptide gene Drosomycin. Strikingly, DIF alone is required for the antifungal response in adults, but is redundant in larvae with Dorsal,..
  85. pmc Cooperative regulation of the induction of the novel antibacterial Listericin by peptidoglycan recognition protein LE and the JAK-STAT pathway
    Akira Goto
    Graduate School of Pharmaceutical Science, Tohoku University, Sendai 980 8578, Japan
    J Biol Chem 285:15731-8. 2010
    ..Based on these findings, we propose that the Listericin gene encodes a novel antibacterial peptide-like protein whose induction is cooperatively regulated by PGRP-LE and the JAK-STAT pathway...
  86. pmc Clustering of peptidoglycan recognition protein-SA is required for sensing lysine-type peptidoglycan in insects
    Ji Won Park
    National Research Laboratory of Defense Proteins, College of Pharmacy, Pusan National University, Busan 609 735, Korea
    Proc Natl Acad Sci U S A 104:6602-7. 2007
    ....
  87. ncbi Interaction and specificity of Rel-related proteins in regulating Drosophila immunity gene expression
    Z S Han
    Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 274:21355-61. 1999
    ..Furthermore, the drosomycin and defensin expression is best induced by the Relish/Dif and the Relish/Dorsal heterodimers, respectively, ..
  88. doi Transcriptional profiling of the sperm storage organs of Drosophila melanogaster
    A M Prokupek
    School of Biological Sciences, University of Nebraska Lincoln, Lincoln, Nebraska, USA
    Insect Mol Biol 18:465-75. 2009
    ..Differences in functional gene categories indicate that these organs play unique roles in sperm storage...
  89. pmc Sex-specific variation in the emphasis, inducibility and timing of the post-mating immune response in Drosophila melanogaster
    Wade E Winterhalter
    Department of Biology, University of Central Florida, 4000 Central Florida Boulevard, Orlando, FL 32816, USA
    Proc Biol Sci 276:1109-17. 2009
    ..Our results suggest that variation in the effectiveness of the immune response between the sexes may be driven by differences in emphasis rather than overall investment...
  90. ncbi A Drosophila ortholog of the human cylindromatosis tumor suppressor gene regulates triglyceride content and antibacterial defense
    Theodore Tsichritzis
    Institute of Immunology, Biomedical Sciences Research Center Al Fleming, 34 Al Fleming Street, 16672 Vari, Greece
    Development 134:2605-14. 2007
    ..All mutant phenotypes described were reversible upon conditional expression of CYLD transgenes. Our results implicate CYLD in a broad range of functions associated with fat homeostasis and host defence in Drosophila...
  91. pmc Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways
    Guang Ho Cha
    National Creative Research Initiatives Center for Cell Growth Regulation, and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, 373 1 Kusong Dong, Yusong, Taejon 305 701, Republic of Korea
    Mol Cell Biol 23:7982-91. 2003
    ..activating the transcription of the antimicrobial peptide genes diptericin, diptericin-like protein, and drosomycin. Consistently, the null mutant of DTRAF2 showed immune deficiencies in which NF-kappaB nuclear translocation and ..
  92. pmc Biological functions of the ISWI chromatin remodeling complex NURF
    Paul Badenhorst
    Laboratory of Molecular Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda Maryland 20892 4255, USA
    Genes Dev 16:3186-98. 2002
    ..Finally, mutants in NURF subunits exhibit neoplastic transformation of larval blood cells that causes melanotic tumors to form...
  93. ncbi Tissue-specific inducible expression of antimicrobial peptide genes in Drosophila surface epithelia
    P Tzou
    Centre de Génétique Moléculaire du CNRS, 91198 Gif sur Yvette, France
    Immunity 13:737-48. 2000
    ..The imd gene plays a critical role in the activation of this local response to infection. In particular, drosomycin expression, which is regulated by the Toll pathway during the systemic response, is regulated by imd in the ..
  94. pmc A Drosophila p38 orthologue is required for environmental stress responses
    Caroline R Craig
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8103, Saint Louis, Missouri 63110, USA
    EMBO Rep 5:1058-63. 2004
    ..These phenotypes only partially overlap those caused by mutations in D-MEKK1 and dTAK1, suggesting that the D-p38a gene is required to mediate some, but not all, of the functions ascribed to p38 signalling...
  95. ncbi Two distinct pathways can control expression of the gene encoding the Drosophila antimicrobial peptide metchnikowin
    E A Levashina
    Réponse Immunitaire et Développement chez les Insectes, UPR 9022 du CNRS, Institut de Biologie Moleculaire et Cellulaire, 15 rue Rene Descartes, Strasbourg, 67000, France
    J Mol Biol 278:515-27. 1998
    ..5 kb of metchnikowin gene upstream sequences indicates that this fragment is able to confer full immune inducibility and tissue specificity of expression on the transgene...
  96. pmc Drosomycin, an innate immunity peptide of Drosophila melanogaster, interacts with the fly voltage-gated sodium channel
    Lior Cohen
    Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    J Biol Chem 284:23558-63. 2009
    ..The high structural similarity between two peptides containing this scaffold, drosomycin and a truncated scorpion beta-toxin, has prompted us to examine and compare their biological effects...
  97. ncbi Related signaling networks in Drosophila that control dorsoventral patterning in the embryo and the immune response
    L P Wu
    Molecular Biology Program, Sloan Kettering Institute, New York, New York 10021, USA
    Cold Spring Harb Symp Quant Biol 62:97-103. 1997
  98. pmc Similar gene expression patterns characterize aging and oxidative stress in Drosophila melanogaster
    Gary N Landis
    Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089 1340, USA
    Proc Natl Acad Sci U S A 101:7663-8. 2004
    ..Immune reporter expression in young flies was partially predictive of remaining life span, suggesting their potential as biomonitors of aging...
  99. ncbi DNase II: genes, enzymes and function
    Cory J Evans
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Gene 322:1-15. 2003
    ..In this review, we have compiled information from studies on DNase II from various organisms to provide a consensus model for the role of DNase II enzymes in DNA degradation...
  100. ncbi In vivo regulation of the IkappaB homologue cactus during the immune response of Drosophila
    E Nicolas
    Institut de Biologie Moleculaire et Cellulaire, UPR 9022 du CNRS, 15 rue Rene Descartes, 67084 Strasbourg Cedex, France
    J Biol Chem 273:10463-9. 1998
    ..This degradation is also dependent on the Toll signaling pathway. Altogether, our results underline the striking similarities between the regulation of IkappaB and cactus during the immune response...
  101. ncbi Drosophila hemolectin gene is expressed in embryonic and larval hemocytes and its knock down causes bleeding defects
    Akira Goto
    Graduate Program for Regulation of Biological Signals, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464 8601, Japan
    Dev Biol 264:582-91. 2003
    ..The expression of antimicrobial peptides was not significantly affected on hml RNAi adults. Altogether, our data strongly suggest that Hml is involved in hemostasis and/or coagulation in Drosophila larvae...

Research Grants16

  1. A Model System For Host-Pathogen Interactions: Drosophila And Its Parasitic Wasps
    TODD ALEXANDER SCHLENKE; Fiscal Year: 2010
    ....
  2. Adaptation in the Drosophila innate immune response
    David S Schneider; Fiscal Year: 2010
    ..2. Determine where and when candidate molecules are required for immunity against S. pneumoniae. (Toll signaling, JAK/STAT signaling and Dscam) 3. Identify transcriptional changes occurring during a priming response. ..
  3. Adaptation in the Drosophila innate immune response
    David Schneider; Fiscal Year: 2007
    ..2. Determine where and when candidate molecules are required for immunity against S. pneumoniae. (Toll signaling, JAK/STAT signaling and Dscam) 3. Identify transcriptional changes occurring during a priming response. ..
  4. Using Drosphila Macrophages to Study Innate Immunity
    David Schneider; Fiscal Year: 2007
    ..These experiments will provide tools to analyze a collection of Drosophila mutants isolated based upon a phenotype that is likely to involve the cellular immune response. ..
  5. The Role of Peroxiredoxins in Immunity and Aging
    SVETLANA RADYUK; Fiscal Year: 2006
    ..This will set the stage for a more thorough investigation of the molecular underpinnings of innate immunity during aging. ..
  6. Using Drosphila Macrophages to Study Innate Immunity
    David Schneider; Fiscal Year: 2006
    ..These experiments will provide tools to analyze a collection of Drosophila mutants isolated based upon a phenotype that is likely to involve the cellular immune response. ..
  7. Using Drosphila Macrophages to Study Innate Immunity
    David Schneider; Fiscal Year: 2003
    ..These experiments will provide tools to analyze a collection of Drosophila mutants isolated based upon a phenotype that is likely to involve the cellular immune response. ..
  8. REGULATION OF IMMUNE RESPONSE AND CELL GROWTH
    DEBORAH KIMBRELL; Fiscal Year: 2001
    ..abstract_text> ..