Dronc

Summary

Gene Symbol: Dronc
Description: Death regulator Nedd2-like caspase
Alias: CG8090, CG8091, DRONC, Dmel\CG8091, Dronc/Casp9, Nc\Dronc, anon-EST:GreesD6, anon-EST:GressD6, anon-WO0118547.313, caspase-9, dronc, death regulator Nedd2-like caspase, CG8091-PA, Caspase-9-like, Dronc-PA, Nedd2-like caspase, caspase-9, dronc, drosophila Caspase-9 homologue, drosophila Nedd2-like caspase, nedd 2-like caspase
Species: fruit fly

Top Publications

  1. Igaki T, Yamamoto Goto Y, Tokushige N, Kanda H, Miura M. Down-regulation of DIAP1 triggers a novel Drosophila cell death pathway mediated by Dark and DRONC. J Biol Chem. 2002;277:23103-6 pubmed
    ..We found that DIAP1 depletion-induced cell death was strongly suppressed by a reduction in the Drosophila caspase DRONC or the Drosophila apoptotic protease-activating factor-1 (Apaf-1) homolog, Dark...
  2. Kumar S, Doumanis J. The fly caspases. Cell Death Differ. 2000;7:1039-44 pubmed
    ..For example, the transcript for the fly caspase DRONC is regulated by the hormone ecdysone during programmed cell death in specific tissues...
  3. Oshima K, Takeda M, Kuranaga E, Ueda R, Aigaki T, Miura M, et al. IKK epsilon regulates F actin assembly and interacts with Drosophila IAP1 in cellular morphogenesis. Curr Biol. 2006;16:1531-7 pubmed
    ..were sensitive to a change in the dosage of Drosophila inhibitor of apoptosis protein 1 (DIAP1) and the caspase DRONC without apparent change in cell viability...
  4. Kanuka H, Kuranaga E, Takemoto K, Hiratou T, Okano H, Miura M. Drosophila caspase transduces Shaggy/GSK-3beta kinase activity in neural precursor development. EMBO J. 2005;24:3793-806 pubmed
    ..These results imply a novel role for caspases in modulating cell signaling pathways through substrate cleavage in neural precursor development...
  5. Igaki T, Kanuka H, Inohara N, Sawamoto K, Nunez G, Okano H, et al. Drob-1, a Drosophila member of the Bcl-2/CED-9 family that promotes cell death. Proc Natl Acad Sci U S A. 2000;97:662-7 pubmed
    ..Our identification of Drob-1 and further genetic analysis should provide increased understanding of the universal mechanisms by which the Bcl-2/CED-9 family members and other related proteins regulate apoptosis. ..
  6. Luo X, Puig O, Hyun J, Bohmann D, Jasper H. Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation. EMBO J. 2007;26:380-90 pubmed
    ..These data suggest that integrating stress and survival signals through Foxo drives the decision between cell death and repair of damaged cells in vivo. ..
  7. Wells B, Yoshida E, Johnston L. Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity. Curr Biol. 2006;16:1606-15 pubmed
    ..regulated by dp53 in a manner that is independent of DNA-damage sensing but that requires the initiator caspase Dronc. Our results indicate that once induced, dp53 amplifies and sustains the response through a positive feedback loop ..
  8. Mills K, Daish T, Harvey K, Pfleger C, Hariharan I, Kumar S. The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death. J Cell Biol. 2006;172:809-15 pubmed
    ..the only Apaf-1/CED-4 homologue, ARK, is required for the activation of the caspase-9/CED-3-like caspase DRONC. Using specific mutants that are deficient for ark function, we demonstrate that ARK is essential for most ..
  9. Doumanis J, Quinn L, Richardson H, Kumar S. STRICA, a novel Drosophila melanogaster caspase with an unusual serine/threonine-rich prodomain, interacts with DIAP1 and DIAP2. Cell Death Differ. 2001;8:387-94 pubmed
    ..Interestingly, unlike other fly caspases, STRICA showed physical association with DIAP2, in cotransfection experiments. These results suggest that STRICA may have a unique cellular function. ..

More Information

Publications86

  1. Mesquita D, Dekanty A, Milan M. A dp53-dependent mechanism involved in coordinating tissue growth in Drosophila. PLoS Biol. 2010;8:e1000566 pubmed publisher
  2. Rudrapatna V, Bangi E, Cagan R. Caspase signalling in the absence of apoptosis drives Jnk-dependent invasion. EMBO Rep. 2013;14:172-7 pubmed publisher
  3. Denton D, Shravage B, Simin R, Mills K, Berry D, Baehrecke E, et al. Autophagy, not apoptosis, is essential for midgut cell death in Drosophila. Curr Biol. 2009;19:1741-6 pubmed publisher
    ..The initiator caspase Dronc and its activator Ark are required for the death of salivary glands, but not for midgut removal [2, 3]...
  4. Kornbluth S, White K. Apoptosis in Drosophila: neither fish nor fowl (nor man, nor worm). J Cell Sci. 2005;118:1779-87 pubmed
    ..Thus, although Drosophila, worms and humans share a host of apoptotic regulators, the way in which they function may not be identical. ..
  5. Babcock D, Landry C, Galko M. Cytokine signaling mediates UV-induced nociceptive sensitization in Drosophila larvae. Curr Biol. 2009;19:799-806 pubmed publisher
  6. Brachmann C, Cagan R. Patterning the fly eye: the role of apoptosis. Trends Genet. 2003;19:91-6 pubmed
    ..But, we have yet to understand how this signaling is regulated spatially to result in such precision. In this article, we describe and speculate on the role of selective cell death during maturation of the fly eye. ..
  7. Shapiro P, Hsu H, Jung H, Robbins E, Ryoo H. Regulation of the Drosophila apoptosome through feedback inhibition. Nat Cell Biol. 2008;10:1440-6 pubmed publisher
    ..Specifically, the adaptor protein Apaf-1 lowers the level of its associated initiator caspase Dronc, without triggering apoptosis. Conversely, Dronc lowers Apaf-1 protein levels...
  8. Xu D, Woodfield S, Lee T, Fan Y, Antonio C, Bergmann A. Genetic control of programmed cell death (apoptosis) in Drosophila. Fly (Austin). 2009;3:78-90 pubmed
    ..Here, we review the key players of the cell death pathway in Drosophila and discuss their roles in apoptotic and non-apoptotic processes. ..
  9. Hawkins C, Yoo S, Peterson E, Wang S, Vernooy S, Hay B. The Drosophila caspase DRONC cleaves following glutamate or aspartate and is regulated by DIAP1, HID, and GRIM. J Biol Chem. 2000;275:27084-93 pubmed
    ..Here we show that the Drosophila caspase DRONC cleaves COOH-terminal to glutamate as well as aspartate...
  10. Daish T, Mills K, Kumar S. Drosophila caspase DRONC is required for specific developmental cell death pathways and stress-induced apoptosis. Dev Cell. 2004;7:909-15 pubmed
    ..Here, we describe the generation of a specific mutant of the Drosophila gene encoding DRONC, the only caspase recruitment domain (CARD) containing apical caspase in the fly...
  11. Suissa Y, Ziv O, Dinur T, Arama E, Gerlitz O. The NAB-Brk signal bifurcates at JNK to independently induce apoptosis and compensatory proliferation. J Biol Chem. 2011;286:15556-64 pubmed publisher
    ..In particular, it was suggested that the initiator caspase Dronc mediates compensatory proliferation (CP) through Dp53 in wing discs...
  12. Geisbrecht E, Montell D. A role for Drosophila IAP1-mediated caspase inhibition in Rac-dependent cell migration. Cell. 2004;118:111-25 pubmed
    ..Mutations affecting the Dark protein, an activator of the upstream caspase Dronc, also rescued RacN17 migration defects...
  13. Yan N, Wu J, Chai J, Li W, Shi Y. Molecular mechanisms of DrICE inhibition by DIAP1 and removal of inhibition by Reaper, Hid and Grim. Nat Struct Mol Biol. 2004;11:420-8 pubmed
    ..These studies define novel molecular mechanisms for the inhibition and activation of a representative D. melanogaster effector caspase. ..
  14. Neto Silva R, de Beco S, Johnston L. Evidence for a growth-stabilizing regulatory feedback mechanism between Myc and Yorkie, the Drosophila homolog of Yap. Dev Cell. 2010;19:507-20 pubmed publisher
    ..We propose that the codependent regulatory relationship functionally coordinates the cellular activities of Yki and Myc and provides a mechanism of growth control that regulates organ size and has broad implications for cancer. ..
  15. Cakouros D, Daish T, Martin D, Baehrecke E, Kumar S. Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex. J Cell Biol. 2002;157:985-95 pubmed
    ..These genes in turn regulate the transcription of a number of downstream genes. DRONC, a key apical caspase in Drosophila, is the only known caspase that is transcriptionally regulated by ecdysone ..
  16. Ahamed M, Posgai R, Gorey T, Nielsen M, Hussain S, Rowe J. Silver nanoparticles induced heat shock protein 70, oxidative stress and apoptosis in Drosophila melanogaster. Toxicol Appl Pharmacol. 2010;242:263-9 pubmed publisher
    ..This study suggests that the organism is stressed and thus warrants more careful assessment of Ag NPs using in vivo models to determine if chronic exposure presents developmental and reproductive toxicity. ..
  17. Koto A, Kuranaga E, Miura M. Temporal regulation of Drosophila IAP1 determines caspase functions in sensory organ development. J Cell Biol. 2009;187:219-31 pubmed publisher
  18. Snipas S, Drag M, Stennicke H, Salvesen G. Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC. Cell Death Differ. 2008;15:938-45 pubmed publisher
    Drosophila Nedd2-like caspase (DRONC), an initiator caspase in Drosophila melanogaster and ortholog of human caspase-9, is cleaved during its activation in vitro and in vivo...
  19. Lee C, Wendel D, Reid P, Lam G, Thummel C, Baehrecke E. E93 directs steroid-triggered programmed cell death in Drosophila. Mol Cell. 2000;6:433-43 pubmed
    ..Furthermore, expression of E93 is sufficient to induce programmed cell death. We propose that the steroid induction of E93 determines a programmed cell death response during development. ..
  20. Dorstyn L, Colussi P, Quinn L, Richardson H, Kumar S. DRONC, an ecdysone-inducible Drosophila caspase. Proc Natl Acad Sci U S A. 1999;96:4307-12 pubmed
    ..Here we describe the identification and characterization of a Drosophila caspase, DRONC, that contains an amino terminal caspase recruitment domain...
  21. Danial N, Korsmeyer S. Cell death: critical control points. Cell. 2004;116:205-19 pubmed
    ..The identification of critical control points in the cell death pathway has yielded fundamental insights for basic biology, as well as provided rational targets for new therapeutics. ..
  22. Baum J, Arama E, Steller H, McCall K. The Drosophila caspases Strica and Dronc function redundantly in programmed cell death during oogenesis. Cell Death Differ. 2007;14:1508-17 pubmed
    ..While null mutants of strica or another initiator caspase, dronc, display no ovary phenotype, we find that strica exhibits redundancy with dronc, during both mid- and late ..
  23. Herman Bachinsky Y, Ryoo H, Ciechanover A, Gonen H. Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways. Cell Death Differ. 2007;14:861-71 pubmed
    ..Our preliminary data suggest that the autoubiquitination serves to attenuate the ligase activity of DIAP1 towards its exogenous substrates. ..
  24. Arama E, Agapite J, Steller H. Caspase activity and a specific cytochrome C are required for sperm differentiation in Drosophila. Dev Cell. 2003;4:687-97 pubmed
    ..These observations suggest that an apoptosis-like mechanism is required for spermatid differentiation in Drosophila. ..
  25. Martin S. Destabilizing influences in apoptosis: sowing the seeds of IAP destruction. Cell. 2002;109:793-6 pubmed
    ..Recent developments suggest that ubiquitin-proteasome mediated destruction of the Drosophila IAP, DIAP1, is a key event during the initiation of programmed cell death in the fly. ..
  26. Muro I, Hay B, Clem R. The Drosophila DIAP1 protein is required to prevent accumulation of a continuously generated, processed form of the apical caspase DRONC. J Biol Chem. 2002;277:49644-50 pubmed
    ..Co-silencing of dronc or dark largely suppressed this apoptosis, indicating that DIAP1 is normally required to inhibit an activity ..
  27. Cakouros D, Daish T, Kumar S. Ecdysone receptor directly binds the promoter of the Drosophila caspase dronc, regulating its expression in specific tissues. J Cell Biol. 2004;165:631-40 pubmed
    ..b>DRONC, the Drosophila initiator caspase, is transcriptionally regulated by ecdysone during development...
  28. Lee T, Ding T, Chen Z, Rajendran V, Scherr H, Lackey M, et al. The E1 ubiquitin-activating enzyme Uba1 in Drosophila controls apoptosis autonomously and tissue growth non-autonomously. Development. 2008;135:43-52 pubmed
    ..In summary, the phenotypic analysis of Uba1 demonstrates that impaired ubiquitin conjugation has significant consequences for the organism, and may implicate Uba1 as a tumor suppressor gene. ..
  29. Xu D, Li Y, Arcaro M, Lackey M, Bergmann A. The CARD-carrying caspase Dronc is essential for most, but not all, developmental cell death in Drosophila. Development. 2005;132:2125-34 pubmed
    The initiator caspase Dronc is the only Drosophila caspase that contains a caspase activation and recruitment domain (CARD)...
  30. Xu D, Wang Y, Willecke R, Chen Z, Ding T, Bergmann A. The effector caspases drICE and dcp-1 have partially overlapping functions in the apoptotic pathway in Drosophila. Cell Death Differ. 2006;13:1697-706 pubmed
    ..Thus, these data demonstrate a barely appreciated complexity in the apoptotic pathway, and are consistent with current models about effector caspase regulation in both vertebrates and invertebrates. ..
  31. Kondo S, Senoo Matsuda N, Hiromi Y, Miura M. DRONC coordinates cell death and compensatory proliferation. Mol Cell Biol. 2006;26:7258-68 pubmed
    ..Here, we provide genetic evidence that the Drosophila initiator caspase DRONC governs both apoptosis execution and subsequent compensatory proliferation...
  32. Wells B, Johnston L. Maintenance of imaginal disc plasticity and regenerative potential in Drosophila by p53. Dev Biol. 2012;361:263-76 pubmed publisher
    ..These findings place p53 in a role as master coordinator of DNA and tissue repair following IR. ..
  33. Quinn L, Dorstyn L, Mills K, Colussi P, Chen P, Coombe M, et al. An essential role for the caspase dronc in developmentally programmed cell death in Drosophila. J Biol Chem. 2000;275:40416-24 pubmed
    b>Dronc is a caspase recruitment domain-containing Drosophila caspase that is expressed in a temporally and spatially restricted fashion during development. Dronc is the only fly caspase known to be regulated by the hormone ecdysone...
  34. Dorstyn L, Mills K, Lazebnik Y, Kumar S. The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells. J Cell Biol. 2004;167:405-10 pubmed
    In Drosophila, activation of the apical caspase DRONC requires the apoptotic protease-activating factor homologue, DARK...
  35. Huh J, Guo M, Hay B. Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role. Curr Biol. 2004;14:1262-6 pubmed
    ..Activation of the apical cell death caspase Dronc is necessary and sufficient to drive both of these processes...
  36. Cakouros D, Daish T, Mills K, Kumar S. An arginine-histone methyltransferase, CARMER, coordinates ecdysone-mediated apoptosis in Drosophila cells. J Biol Chem. 2004;279:18467-71 pubmed
    ..Thus, the chromatin-modifying protein, CARMER, modulates cell death by controlling the hormone-dependent expression of the core cell death machinery. ..
  37. Hu S, Yang X. dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD. J Biol Chem. 2000;275:30761-4 pubmed
    ..dFADD and DREDD are stabilized by their interaction. The structural and functional similarities between dFADD and FADD suggest the existence of a FADD-like apoptosis pathway in Drosophila. ..
  38. Igaki T, Kanda H, Yamamoto Goto Y, Kanuka H, Kuranaga E, Aigaki T, et al. Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway. EMBO J. 2002;21:3009-18 pubmed
    ..We also show genetically that Eiger is a physiological ligand for the Drosophila JNK pathway. Our findings demonstrate that Eiger can initiate cell death through an IAP-sensitive cell death pathway via JNK signaling. ..
  39. Tenev T, Zachariou A, Wilson R, Paul A, Meier P. Jafrac2 is an IAP antagonist that promotes cell death by liberating Dronc from DIAP1. EMBO J. 2002;21:5118-29 pubmed
    ..We show that Jafrac2 displaces Dronc from DIAP1 by competing with Dronc for the binding of DIAP1, consistent with the idea that Jafrac2 triggers cell ..
  40. Lannan E, Vandergaast R, Friesen P. Baculovirus caspase inhibitors P49 and P35 block virus-induced apoptosis downstream of effector caspase DrICE activation in Drosophila melanogaster cells. J Virol. 2007;81:9319-30 pubmed
    ..Confirming that P49 targeted DrICE and not the initiator caspase DRONC, depletion of DrICE by RNA silencing suppressed virus-induced cleavage of P49...
  41. Kuranaga E, Kanuka H, Tonoki A, Takemoto K, Tomioka T, Kobayashi M, et al. Drosophila IKK-related kinase regulates nonapoptotic function of caspases via degradation of IAPs. Cell. 2006;126:583-96 pubmed
    ..Our results demonstrate that DmIKKvarepsilon is a determinant of DIAP1 protein levels and that it establishes the threshold of activity required for the execution of nonapoptotic caspase functions...
  42. Mendes C, Arama E, Brown S, Scherr H, Srivastava M, Bergmann A, et al. Cytochrome c-d regulates developmental apoptosis in the Drosophila retina. EMBO Rep. 2006;7:933-9 pubmed
    ..in mutant retinal tissues for the Drosophila homologues of apoptotic protease-activating factor 1 (Ark) and caspase 9 (Dronc)...
  43. Amarneh B, Matthews K, Rawson R. Activation of sterol regulatory element-binding protein by the caspase Drice in Drosophila larvae. J Biol Chem. 2009;284:9674-82 pubmed publisher
    ..The initiator caspase Dronc does not cleave dSREBP, but animals lacking dS2P require both drice and dronc to complete development...
  44. Dorstyn L, Read S, Cakouros D, Huh J, Hay B, Kumar S. The role of cytochrome c in caspase activation in Drosophila melanogaster cells. J Cell Biol. 2002;156:1089-98 pubmed
    ..c remains associated with mitochondria during apoptosis of Drosophila cells and that the initiator caspase DRONC and effector caspase DRICE are activated after various death stimuli without any significant release of cytochrome ..
  45. Shlevkov E, Morata G. A dp53/JNK-dependant feedback amplification loop is essential for the apoptotic response to stress in Drosophila. Cell Death Differ. 2012;19:451-60 pubmed publisher
    ..Here we demonstrate that dp53 and JNK also function downstream of proapoptotic genes and the initiator caspase Dronc (Drosophila NEDD2-like caspase) and that they establish a feedback loop that amplifies the initial apoptotic ..
  46. Baehrecke E. Steroid regulation of programmed cell death during Drosophila development. Cell Death Differ. 2000;7:1057-62 pubmed
    ..This article reviews the current knowledge of steroid signaling and the regulation of programmed cell death during development of Drosophila. ..
  47. Choi Y, Lee G, Park J. Programmed cell death mechanisms of identifiable peptidergic neurons in Drosophila melanogaster. Development. 2006;133:2223-32 pubmed
    ..Significant delay of vCrz-cell death was observed in mutants that lack dronc or dark functions, indicating that formation of an apoptosome is necessary, but not sufficient, for timely ..
  48. Kanda H, Igaki T, Kanuka H, Yagi T, Miura M. Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling. J Biol Chem. 2002;277:28372-5 pubmed
  49. Yu S, Yoo S, Yang L, Zapata C, Srinivasan A, Hay B, et al. A pathway of signals regulating effector and initiator caspases in the developing Drosophila eye. Development. 2002;129:3269-78 pubmed
    ..It was found that the initiator caspase Dronc and the proapoptotic gene head involution defective were important for activation in vivo...
  50. Huh J, Foe I, Muro I, Chen C, Seol J, Yoo S, et al. The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis i. J Biol Chem. 2007;282:2056-68 pubmed
    ..Therefore, diap2 may identify a point of convergence between apoptosis and immune signaling pathways. ..
  51. Yin V, Thummel C, Bashirullah A. Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death. J Cell Biol. 2007;178:85-92 pubmed
    ..It also provides a molecular mechanism for the acquisition of competence in steroid signaling pathways. ..
  52. Link N, Chen P, Lu W, Pogue K, Chuong A, Mata M, et al. A collective form of cell death requires homeodomain interacting protein kinase. J Cell Biol. 2007;178:567-74 pubmed
    ..developmental stages, this unique communal form of cell death is controlled through the apoptosome proteins, Dronc and Dark, together with the IAP antagonists, Reaper, Grim, and Hid...
  53. Arama E, Bader M, Srivastava M, Bergmann A, Steller H. The two Drosophila cytochrome C proteins can function in both respiration and caspase activation. EMBO J. 2006;25:232-43 pubmed
    ..Furthermore, orthologues of the apoptosome components, Ark (Apaf-1) and Dronc (caspase-9), are also required for the proper removal of bulk cytoplasm during spermatogenesis...
  54. Fan Y, Bergmann A. Distinct mechanisms of apoptosis-induced compensatory proliferation in proliferating and differentiating tissues in the Drosophila eye. Dev Cell. 2008;14:399-410 pubmed publisher
    ..This process is under control of the initiator caspase Dronc, but not effector caspases...
  55. Kanda H, Igaki T, Okano H, Miura M. Conserved metabolic energy production pathways govern Eiger/TNF-induced nonapoptotic cell death. Proc Natl Acad Sci U S A. 2011;108:18977-82 pubmed publisher
    ..This result suggests a link between sensitivity to cell death and metabolic activity in cancer. ..
  56. Lee G, Wang Z, Sehgal R, Chen C, Kikuno K, Hay B, et al. Drosophila caspases involved in developmentally regulated programmed cell death of peptidergic neurons during early metamorphosis. J Comp Neurol. 2011;519:34-48 pubmed publisher
    ..PCD was significantly suppressed in dronc-null mutants, but not in null mutants of either dredd or strica...
  57. Lee C, Simon C, Woodard C, Baehrecke E. Genetic mechanism for the stage- and tissue-specific regulation of steroid triggered programmed cell death in Drosophila. Dev Biol. 2002;252:138-48 pubmed
    ..E93 loss-of-function mutants indicate that these genes regulate stage-specific transcription of the rpr, hid, ark, dronc, and crq cell death genes...
  58. Waldhuber M, Emoto K, Petritsch C. The Drosophila caspase DRONC is required for metamorphosis and cell death in response to irradiation and developmental signals. Mech Dev. 2005;122:914-27 pubmed
    ..Expression of the Drosophila caspase-9 homolog, DRONC, can be induced by ecdysone, a steroid hormone, which induces metamorphosis...
  59. Daish T, Cakouros D, Kumar S. Distinct promoter regions regulate spatial and temporal expression of the Drosophila caspase dronc. Cell Death Differ. 2003;10:1348-56 pubmed
    b>DRONC is an apical Drosophila caspase essential for programmed cell death during fly development...
  60. Ryoo H, Bergmann A, Gonen H, Ciechanover A, Steller H. Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. Nat Cell Biol. 2002;4:432-8 pubmed
    ..UBCD1 and Rpr specifically bind to DIAP1 and stimulate DIAP1 auto-ubiquitination in vitro. Our results identify a novel function of Rpr in stimulating DIAP1 auto-ubiquitination through UBCD1, thereby promoting its degradation. ..
  61. Keller L, Cheng L, Locke C, Muller M, Fetter R, Davis G. Glial-derived prodegenerative signaling in the Drosophila neuromuscular system. Neuron. 2011;72:760-75 pubmed publisher
    ..However, we provide evidence for the involvement of both an initiator and effector caspase, Dronc and Dcp-1, and mitochondrial-dependent signaling...
  62. Jassim O, Fink J, Cagan R. Dmp53 protects the Drosophila retina during a developmentally regulated DNA damage response. EMBO J. 2003;22:5622-32 pubmed
    ..These in vivo results demonstrate that the cellular effects of DNA damage depend on the developmental status of the tissue. ..
  63. Ryoo H, Gorenc T, Steller H. Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways. Dev Cell. 2004;7:491-501 pubmed
    ..These findings support a model where apoptotic cells activate signaling cascades for compensatory proliferation. ..
  64. Dorstyn L, Kumar S. A biochemical analysis of the activation of the Drosophila caspase DRONC. Cell Death Differ. 2008;15:461-70 pubmed
    ..In Drosophila, the only initiator caspase DRONC, is tightly inhibited by DIAP1 and removal of DIAP1 permits activation of DRONC by the Drosophila Apaf-1-related ..
  65. Fan Y, Lee T, Xu D, Chen Z, Lamblin A, Steller H, et al. Dual roles of Drosophila p53 in cell death and cell differentiation. Cell Death Differ. 2010;17:912-21 pubmed publisher
    ..These findings provide new insights into the pathways activated by Dp53 and reveal that Dp53 incorporates functions of multiple p53 family members. ..
  66. Yan N, Huh J, Schirf V, Demeler B, Hay B, Shi Y. Structure and activation mechanism of the Drosophila initiator caspase Dronc. J Biol Chem. 2006;281:8667-74 pubmed
    ..Here we demonstrate that the autocatalytic cleavage of Dronc, an important initiator caspase in Drosophila, results in a drastic enhancement of its catalytic activity in vitro...
  67. Lee T, Fan Y, Wang S, Srivastava M, Broemer M, Meier P, et al. Drosophila IAP1-mediated ubiquitylation controls activation of the initiator caspase DRONC independent of protein degradation. PLoS Genet. 2011;7:e1002261 pubmed publisher
    ..In Drosophila, the inhibitor of apoptosis protein 1 (DIAP1) is known to ubiquitylate the initiator caspase DRONC in vitro...
  68. Xu P, Vernooy S, Guo M, Hay B. The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism. Curr Biol. 2003;13:790-5 pubmed
    ..Deletion of mir-14 results in animals with increased levels of triacylglycerol and diacylglycerol, whereas increases in mir-14 copy number have the converse effect. We discuss possible relationships between these phenotypes. ..
  69. Schoenmann Z, Assa Kunik E, Tiomny S, Minis A, Haklai Topper L, Arama E, et al. Axonal degeneration is regulated by the apoptotic machinery or a NAD+-sensitive pathway in insects and mammals. J Neurosci. 2010;30:6375-86 pubmed publisher
    ..These findings indicate that two distinct autodestruction pathways act separately or in concert to regulate developmental neurite pruning. ..
  70. Kilpatrick Z, Cakouros D, Kumar S. Ecdysone-mediated up-regulation of the effector caspase DRICE is required for hormone-dependent apoptosis in Drosophila cells. J Biol Chem. 2005;280:11981-6 pubmed
    ..The apical caspase DRONC is known to be transcriptionally regulated by ecdysone during development...
  71. Moreno E, Yan M, Basler K. Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. Curr Biol. 2002;12:1263-8 pubmed
    ..Eiger-induced cell death requires the caspase-9 homolog DRONC and the Apaf-1 homolog DARK...
  72. Huh J, Vernooy S, Yu H, Yan N, Shi Y, Guo M, et al. Multiple apoptotic caspase cascades are required in nonapoptotic roles for Drosophila spermatid individualization. PLoS Biol. 2004;2:E15 pubmed
    ..death, at least in part, by disrupting interactions between the caspase inhibitor DIAP1 and the apical caspase DRONC, which is continually activated in many viable cells through interactions with ARK, the Drosophila homolog of the ..
  73. Muro I, Monser K, Clem R. Mechanism of Dronc activation in Drosophila cells. J Cell Sci. 2004;117:5035-41 pubmed
    ..Previously, we reported that, in normal living Drosophila S2 cells, the initiator caspase Dronc is continuously processed to a 40 kDa form we called Pr1 and that, during apoptosis, a second processed form of 37 ..
  74. Muro I, Berry D, Huh J, Chen C, Huang H, Yoo S, et al. The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process. Development. 2006;133:3305-15 pubmed
    ..In Drosophila, the initiator caspase Nc (previously Dronc) cleaves and activates two short-prodomain caspases, Dcp-1 and Ice (previously Drice), suggesting these as ..
  75. Meier P, Silke J, Leevers S, Evan G. The Drosophila caspase DRONC is regulated by DIAP1. EMBO J. 2000;19:598-611 pubmed
    We have isolated the recently identified Drosophila caspase DRONC through its interaction with the effector caspase drICE...
  76. Wilson R, Goyal L, Ditzel M, Zachariou A, Baker D, Agapite J, et al. The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis. Nat Cell Biol. 2002;4:445-50 pubmed
    ..show that in vivo, the RING finger of DIAP1 is essential for the regulation of apoptosis induced by Rpr, Hid and Dronc. Furthermore, we show that the RING finger of DIAP1 promotes the ubiquitination of both itself and of Dronc...
  77. Leulier F, Ribeiro P, Palmer E, Tenev T, Takahashi K, Robertson D, et al. Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery. Cell Death Differ. 2006;13:1663-74 pubmed
    ..Of the seven caspases, Dronc, drICE, Strica and Decay are rate limiting for apoptosis...